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Items: 1 to 50 of 79

1.

Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer.

Huang H, Zhang Y, Gallegos V, Sorrelle N, Zaid MM, Toombs J, Du W, Wright S, Hagopian M, Wang Z, Hosein AN, Sathe AA, Xing C, Koay EJ, Driscoll KE, Brekken RA.

EMBO Mol Med. 2019 Nov 7;11(11):e10515. doi: 10.15252/emmm.201910515. Epub 2019 Oct 14.

2.

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation.

Stefanius K, Servage K, de Souza Santos M, Gray HF, Toombs JE, Chimalapati S, Kim MS, Malladi VS, Brekken R, Orth K.

Elife. 2019 May 28;8. pii: e40226. doi: 10.7554/eLife.40226.

3.

CSF Beta-amyloid 1-42 Concentration Predicts Delirium Following Elective Arthroplasty Surgery in an Observational Cohort Study.

Cunningham EL, McGuinness B, McAuley DF, Toombs J, Mawhinney T, O'Brien S, Beverland D, Schott JM, Lunn MP, Zetterberg H, Passmore AP.

Ann Surg. 2019 Jun;269(6):1200-1205. doi: 10.1097/SLA.0000000000002684.

PMID:
31082921
4.

Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta.

Arber C, Toombs J, Lovejoy C, Ryan NS, Paterson RW, Willumsen N, Gkanatsiou E, Portelius E, Blennow K, Heslegrave A, Schott JM, Hardy J, Lashley T, Fox NC, Zetterberg H, Wray S.

Mol Psychiatry. 2019 Apr 12. doi: 10.1038/s41380-019-0410-8. [Epub ahead of print]

PMID:
30980041
5.

Spinal epidural lipomatosis presenting to a U.S. Veterans Affairs pain and rehabilitation department: a report of two cases.

Silcox KM, Daniels CJ, Bub GA, Wakefield PJ, Toombs JD.

Chiropr Man Therap. 2018 Oct 2;26:33. doi: 10.1186/s12998-018-0203-1. eCollection 2018.

6.

Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios.

Toombs J, Foiani MS, Wellington H, Paterson RW, Arber C, Heslegrave A, Lunn MP, Schott JM, Wray S, Zetterberg H.

Alzheimers Dement (Amst). 2018 Mar 22;10:311-321. doi: 10.1016/j.dadm.2018.02.005. eCollection 2018.

7.

Molecular biomarkers of Alzheimer's disease: progress and prospects.

Lashley T, Schott JM, Weston P, Murray CE, Wellington H, Keshavan A, Foti SC, Foiani M, Toombs J, Rohrer JD, Heslegrave A, Zetterberg H.

Dis Model Mech. 2018 May 8;11(5). pii: dmm031781. doi: 10.1242/dmm.031781. Review.

8.

Cerebrospinal fluid in the differential diagnosis of Alzheimer's disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic.

Paterson RW, Slattery CF, Poole T, Nicholas JM, Magdalinou NK, Toombs J, Chapman MD, Lunn MP, Heslegrave AJ, Foiani MS, Weston PSJ, Keshavan A, Rohrer JD, Rossor MN, Warren JD, Mummery CJ, Blennow K, Fox NC, Zetterberg H, Schott JM.

Alzheimers Res Ther. 2018 Mar 20;10(1):32. doi: 10.1186/s13195-018-0361-3.

9.

CSF Beta-amyloid 1-42 Concentration Predicts Delirium Following Elective Arthroplasty Surgery in an Observational Cohort Study.

Cunningham EL, McGuinness B, McAuley DF, Toombs J, Mawhinney T, O'Brien S, Beverland D, Schott JM, Lunn MP, Zetterberg H, Passmore AP.

Ann Surg. 2018 Feb 2. doi: 10.1097/SLA.0000000000002684. [Epub ahead of print]

PMID:
29401106
10.

Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer.

Ludwig KF, Du W, Sorrelle NB, Wnuk-Lipinska K, Topalovski M, Toombs JE, Cruz VH, Yabuuchi S, Rajeshkumar NV, Maitra A, Lorens JB, Brekken RA.

Cancer Res. 2018 Jan 1;78(1):246-255. doi: 10.1158/0008-5472.CAN-17-1973. Epub 2017 Nov 27.

11.

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.

Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L.

Nat Cell Biol. 2017 Oct;19(10):1226-1236. doi: 10.1038/ncb3616. Epub 2017 Sep 25.

12.

Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration.

Toombs J, Foiani MS, Paterson RW, Heslegrave A, Wray S, Schott JM, Fox NC, Lunn MP, Blennow K, Zetterberg H.

J Alzheimers Dis. 2017;56(3):885-891. doi: 10.3233/JAD-161126.

PMID:
28059797
13.

Xenopus Piwi proteins interact with a broad proportion of the oocyte transcriptome.

Toombs JA, Sytnikova YA, Chirn GW, Ang I, Lau NC, Blower MD.

RNA. 2017 Apr;23(4):504-520. doi: 10.1261/rna.058859.116. Epub 2016 Dec 28.

14.

A Narrative Review of Lumbar Fusion Surgery With Relevance to Chiropractic Practice.

Daniels CJ, Wakefield PJ, Bub GA, Toombs JD.

J Chiropr Med. 2016 Dec;15(4):259-271. Epub 2016 Oct 18. Review.

15.

A targeted proteomic multiplex CSF assay identifies increased malate dehydrogenase and other neurodegenerative biomarkers in individuals with Alzheimer's disease pathology.

Paterson RW, Heywood WE, Heslegrave AJ, Magdalinou NK, Andreasson U, Sirka E, Bliss E, Slattery CF, Toombs J, Svensson J, Johansson P, Fox NC, Zetterberg H, Mills K, Schott JM.

Transl Psychiatry. 2016 Nov 15;6(11):e952. doi: 10.1038/tp.2016.194.

16.

Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia.

Rohrer JD, Woollacott IO, Dick KM, Brotherhood E, Gordon E, Fellows A, Toombs J, Druyeh R, Cardoso MJ, Ourselin S, Nicholas JM, Norgren N, Mead S, Andreasson U, Blennow K, Schott JM, Fox NC, Warren JD, Zetterberg H.

Neurology. 2016 Sep 27;87(13):1329-36. doi: 10.1212/WNL.0000000000003154. Epub 2016 Aug 31.

17.

Tris DBA palladium is highly effective against growth and metastasis of pancreatic cancer in an orthotopic model.

Díaz B, Ostapoff KT, Toombs JE, Lo J, Bonner MY, Curatolo A, Adsay V, Brekken RA, Arbiser JL.

Oncotarget. 2016 Aug 9;7(32):51569-51580. doi: 10.18632/oncotarget.10514.

18.

Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation.

Bergström P, Agholme L, Nazir FH, Satir TM, Toombs J, Wellington H, Strandberg J, Bontell TO, Kvartsberg H, Holmström M, Boreström C, Simonsson S, Kunath T, Lindahl A, Blennow K, Hanse E, Portelius E, Wray S, Zetterberg H.

Sci Rep. 2016 Jul 7;6:29200. doi: 10.1038/srep29200.

19.

Do cerebrospinal fluid transfer methods affect measured amyloid β42, total tau, and phosphorylated tau in clinical practice?

Paterson RW, Toombs J, Chapman MD, Nicholas JM, Heslegrave AJ, Slattery CF, Foulkes AJ, Clark CN, Lane CA, Weston PS, Lunn MP, Fox NC, Zetterberg H, Schott JM.

Alzheimers Dement (Amst). 2015 Jul 2;1(3):380-4. doi: 10.1016/j.dadm.2015.06.003. eCollection 2015 Sep.

20.

Identification of lipid-phosphatidylserine (PS) as the target of unbiasedly selected cancer specific peptide-peptoid hybrid PPS1.

Desai TJ, Toombs JE, Minna JD, Brekken RA, Udugamasooriya DG.

Oncotarget. 2016 May 24;7(21):30678-90. doi: 10.18632/oncotarget.8929.

21.

Using florbetapir positron emission tomography to explore cerebrospinal fluid cut points and gray zones in small sample sizes.

Weston PS, Paterson RW, Modat M, Burgos N, Cardoso MJ, Magdalinou N, Lehmann M, Dickson JC, Barnes A, Bomanji JB, Kayani I, Cash DM, Ourselin S, Toombs J, Lunn MP, Mummery CJ, Warren JD, Rossor MN, Fox NC, Zetterberg H, Schott JM.

Alzheimers Dement (Amst). 2015 Nov 2;1(4):440-446. eCollection 2015 Dec.

22.

Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer.

Wang M, Topalovski M, Toombs JE, Wright CM, Moore ZR, Boothman DA, Yanagisawa H, Wang H, Witkiewicz A, Castrillon DH, Brekken RA.

Cancer Res. 2015 Dec 1;75(23):5058-69. doi: 10.1158/0008-5472.CAN-15-0744. Epub 2015 Nov 17.

23.

Dissecting IWG-2 typical and atypical Alzheimer's disease: insights from cerebrospinal fluid analysis.

Paterson RW, Toombs J, Slattery CF, Nicholas JM, Andreasson U, Magdalinou NK, Blennow K, Warren JD, Mummery CJ, Rossor MN, Lunn MP, Crutch SJ, Fox NC, Zetterberg H, Schott JM.

J Neurol. 2015 Dec;262(12):2722-30. doi: 10.1007/s00415-015-7904-3. Epub 2015 Sep 26.

PMID:
26410752
24.

Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis.

Kirane A, Ludwig KF, Sorrelle N, Haaland G, Sandal T, Ranaweera R, Toombs JE, Wang M, Dineen SP, Micklem D, Dellinger MT, Lorens JB, Brekken RA.

Cancer Res. 2015 Sep 15;75(18):3699-705. doi: 10.1158/0008-5472.CAN-14-2887-T. Epub 2015 Jul 23.

25.

The impact of Tween 20 on repeatability of amyloid β and tau measurements in cerebrospinal fluid.

Toombs J, Paterson RW, Nicholas JM, Petzold A, Schott JM, Zetterberg H.

Clin Chem Lab Med. 2015 Nov;53(12):e329-32. doi: 10.1515/cclm-2015-0414. No abstract available.

26.

RIPOSTE: a framework for improving the design and analysis of laboratory-based research.

Masca NG, Hensor EM, Cornelius VR, Buffa FM, Marriott HM, Eales JM, Messenger MP, Anderson AE, Boot C, Bunce C, Goldin RD, Harris J, Hinchliffe RF, Junaid H, Kingston S, Martin-Ruiz C, Nelson CP, Peacock J, Seed PT, Shinkins B, Staples KJ, Toombs J, Wright AK, Teare MD.

Elife. 2015 May 7;4. doi: 10.7554/eLife.05519.

27.

Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B.

Potts MB, McMillan EA, Rosales TI, Kim HS, Ou YH, Toombs JE, Brekken RA, Minden MD, MacMillan JB, White MA.

Nat Chem Biol. 2015 Jun;11(6):401-8. doi: 10.1038/nchembio.1797. Epub 2015 Apr 13.

28.

Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease.

Guerreiro R, Bras J, Toombs J, Heslegrave A, Hardy J, Zetterberg H.

Curr Genet Med Rep. 2015;3:19-25. Review.

29.

Amyloid-beta 42 adsorption following serial tube transfer.

Toombs J, Paterson RW, Schott JM, Zetterberg H.

Alzheimers Res Ther. 2014 Jan 28;6(1):5. doi: 10.1186/alzrt236. eCollection 2014.

30.

Direct estimates of natural selection in Iberia indicate calcium absorption was not the only driver of lactase persistence in Europe.

Sverrisdóttir OÓ, Timpson A, Toombs J, Lecoeur C, Froguel P, Carretero JM, Arsuaga Ferreras JL, Götherström A, Thomas MG.

Mol Biol Evol. 2014 Apr;31(4):975-83. doi: 10.1093/molbev/msu049. Epub 2014 Jan 21.

PMID:
24448642
31.

Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma.

Aguilera KY, Rivera LB, Hur H, Carbon JG, Toombs JE, Goldstein CD, Dellinger MT, Castrillon DH, Brekken RA.

Cancer Res. 2014 Feb 15;74(4):1032-44. doi: 10.1158/0008-5472.CAN-13-2800. Epub 2013 Dec 17.

32.

Biomarker modelling of early molecular changes in Alzheimer's disease.

Paterson RW, Toombs J, Slattery CF, Schott JM, Zetterberg H.

Mol Diagn Ther. 2014 Apr;18(2):213-27. doi: 10.1007/s40291-013-0069-9. Review.

PMID:
24281842
33.

Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer.

Kim HS, Mendiratta S, Kim J, Pecot CV, Larsen JE, Zubovych I, Seo BY, Kim J, Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs JE, Wei S, Peyton M, Williams N, Gazdar AF, Posner BA, Brekken RA, Sood AK, Deberardinis RJ, Roth MG, Minna JD, White MA.

Cell. 2013 Oct 24;155(3):552-66. doi: 10.1016/j.cell.2013.09.041. Epub 2013 Oct 24.

34.

Combining different mRNA capture methods to analyze the transcriptome: analysis of the Xenopus laevis transcriptome.

Blower MD, Jambhekar A, Schwarz DS, Toombs JA.

PLoS One. 2013 Oct 15;8(10):e77700. doi: 10.1371/journal.pone.0077700. eCollection 2013.

35.

Identification of an important potential confound in CSF AD studies: aliquot volume.

Toombs J, Paterson RW, Lunn MP, Nicholas JM, Fox NC, Chapman MD, Schott JM, Zetterberg H.

Clin Chem Lab Med. 2013 Dec;51(12):2311-7. doi: 10.1515/cclm-2013-0293.

36.

Stromal platelet-derived growth factor receptor α (PDGFRα) provides a therapeutic target independent of tumor cell PDGFRα expression in lung cancer xenografts.

Gerber DE, Gupta P, Dellinger MT, Toombs JE, Peyton M, Duignan I, Malaby J, Bailey T, Burns C, Brekken RA, Loizos N.

Mol Cancer Ther. 2012 Nov;11(11):2473-82. doi: 10.1158/1535-7163.MCT-12-0431. Epub 2012 Aug 28.

37.

Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer.

Kirane A, Toombs JE, Ostapoff K, Carbon JG, Zaknoen S, Braunfeld J, Schwarz RE, Burrows FJ, Brekken RA.

Clin Cancer Res. 2012 Sep 15;18(18):5031-42. doi: 10.1158/1078-0432.CCR-12-0453. Epub 2012 Jul 24.

38.

Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib.

Kirane A, Toombs JE, Larsen JE, Ostapoff KT, Meshaw KR, Zaknoen S, Brekken RA, Burrows FJ.

Carcinogenesis. 2012 Sep;33(9):1639-46. doi: 10.1093/carcin/bgs195. Epub 2012 Jun 7.

39.

De novo design of synthetic prion domains.

Toombs JA, Petri M, Paul KR, Kan GY, Ben-Hur A, Ross ED.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6519-24. doi: 10.1073/pnas.1119366109. Epub 2012 Apr 2.

40.

Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFβ activation.

Arnold SA, Rivera LB, Carbon JG, Toombs JE, Chang CL, Bradshaw AD, Brekken RA.

PLoS One. 2012;7(2):e31384. doi: 10.1371/journal.pone.0031384. Epub 2012 Feb 14.

41.

[PSI+] maintenance is dependent on the composition, not primary sequence, of the oligopeptide repeat domain.

Toombs JA, Liss NM, Cobble KR, Ben-Musa Z, Ross ED.

PLoS One. 2011;6(7):e21953. doi: 10.1371/journal.pone.0021953. Epub 2011 Jul 8.

42.

Mechanical evaluation of a tapered thread-run-out half-pin designed for external skeletal fixation in small animals.

Griffin H, Toombs JP, Bronson DG, Ross JD, Browne RH.

Vet Comp Orthop Traumatol. 2011;24(4):257-61. doi: 10.3415/VCOT-10-04-0054. Epub 2011 May 20.

PMID:
21597646
43.

Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer.

Awasthi N, Kirane A, Schwarz MA, Toombs JE, Brekken RA, Schwarz RE.

BMC Cancer. 2011 Jan 12;11:15. doi: 10.1186/1471-2407-11-15.

44.

r84, a novel therapeutic antibody against mouse and human VEGF with potent anti-tumor activity and limited toxicity induction.

Sullivan LA, Carbon JG, Roland CL, Toombs JE, Nyquist-Andersen M, Kavlie A, Schlunegger K, Richardson JA, Brekken RA.

PLoS One. 2010 Aug 6;5(8):e12031. doi: 10.1371/journal.pone.0012031.

45.
46.

Tumor-derived intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic xenografts.

Roland CL, Dineen SP, Toombs JE, Carbon JG, Smith CW, Brekken RA, Barnett CC Jr.

Exp Biol Med (Maywood). 2010 Feb;235(2):263-70. doi: 10.1258/ebm.2009.009215.

PMID:
20404043
47.

Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer.

Dineen SP, Roland CL, Greer R, Carbon JG, Toombs JE, Gupta P, Bardeesy N, Sun H, Williams N, Minna JD, Brekken RA.

Cancer Res. 2010 Apr 1;70(7):2852-61. doi: 10.1158/0008-5472.CAN-09-3892. Epub 2010 Mar 23.

48.

Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer.

Roland CL, Lynn KD, Toombs JE, Dineen SP, Udugamasooriya DG, Brekken RA.

PLoS One. 2009 Nov 3;4(11):e7669. doi: 10.1371/journal.pone.0007669.

49.

Compositional determinants of prion formation in yeast.

Toombs JA, McCarty BR, Ross ED.

Mol Cell Biol. 2010 Jan;30(1):319-32. doi: 10.1128/MCB.01140-09.

50.

Determinants of histone H4 N-terminal domain function during nucleosomal array oligomerization: roles of amino acid sequence, domain length, and charge density.

McBryant SJ, Klonoski J, Sorensen TC, Norskog SS, Williams S, Resch MG, Toombs JA 3rd, Hobdey SE, Hansen JC.

J Biol Chem. 2009 Jun 19;284(25):16716-22. doi: 10.1074/jbc.M109.011288. Epub 2009 Apr 24.

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