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CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts.

Aoki M, Koga K, Miyazaki M, Hamasaki M, Koshikawa N, Oyama M, Kozuka-Hata H, Seiki M, Toole BP, Nabeshima K.

BMC Cancer. 2019 Sep 12;19(1):912. doi: 10.1186/s12885-019-6127-x.


The CD147-HYALURONAN Axis in Cancer.

Toole BP.

Anat Rec (Hoboken). 2019 May 14. doi: 10.1002/ar.24147. [Epub ahead of print]


Role of heme oxygenase-1 in the pathogenesis and tumorigenicity of Kaposi's sarcoma-associated herpesvirus.

Dai L, Qiao J, Nguyen D, Struckhoff AP, Doyle L, Bonstaff K, Del Valle L, Parsons C, Toole BP, Renne R, Qin Z.

Oncotarget. 2016 Mar 1;7(9):10459-71. doi: 10.18632/oncotarget.7227.


CD147 and downstream ADAMTSs promote the tumorigenicity of Kaposi's sarcoma-associated herpesvirus infected endothelial cells.

Dai L, Trillo-Tinoco J, Chen Y, Bonstaff K, Del Valle L, Parsons C, Ochoa AC, Zabaleta J, Toole BP, Qin Z.

Oncotarget. 2016 Jan 26;7(4):3806-18. doi: 10.18632/oncotarget.6584.


How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity.

Grass GD, Toole BP.

Biosci Rep. 2015 Nov 24;36(1):e00283. doi: 10.1042/BSR20150256. Review.


CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance.

Grass GD, Dai L, Qin Z, Parsons C, Toole BP.

Adv Cancer Res. 2014;123:351-73. doi: 10.1016/B978-0-12-800092-2.00013-7. Review.


Cancer may be a pathway to cell survival under persistent hypoxia and elevated ROS: a model for solid-cancer initiation and early development.

Zhang C, Cao S, Toole BP, Xu Y.

Int J Cancer. 2015 May 1;136(9):2001-11. doi: 10.1002/ijc.28975. Epub 2014 May 27. Review.


Serglycin proteoglycan is required for multiple myeloma cell adhesion, in vivo growth, and vascularization.

Purushothaman A, Toole BP.

J Biol Chem. 2014 Feb 28;289(9):5499-509. doi: 10.1074/jbc.M113.532143. Epub 2014 Jan 8.


BMP-2 induces versican and hyaluronan that contribute to post-EMT AV cushion cell migration.

Inai K, Burnside JL, Hoffman S, Toole BP, Sugi Y.

PLoS One. 2013 Oct 11;8(10):e77593. doi: 10.1371/journal.pone.0077593. eCollection 2013.


CD147, CD44, and the epidermal growth factor receptor (EGFR) signaling pathway cooperate to regulate breast epithelial cell invasiveness.

Grass GD, Tolliver LB, Bratoeva M, Toole BP.

J Biol Chem. 2013 Sep 6;288(36):26089-104. doi: 10.1074/jbc.M113.497685. Epub 2013 Jul 25.


Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment.

Spaeth EL, Labaff AM, Toole BP, Klopp A, Andreeff M, Marini FC.

Cancer Res. 2013 Sep 1;73(17):5347-59. doi: 10.1158/0008-5472.CAN-13-0087. Epub 2013 Jul 9.


Emmprin and KSHV: new partners in viral cancer pathogenesis.

Dai L, Bai L, Lu Y, Xu Z, Reiss K, Del Valle L, Kaleeba J, Toole BP, Parsons C, Qin Z.

Cancer Lett. 2013 Sep 1;337(2):161-6. doi: 10.1016/j.canlet.2013.05.037. Epub 2013 Jun 3. Review.


CD147-dependent heterogeneity in malignant and chemoresistant properties of cancer cells.

Dai L, Guinea MC, Slomiany MG, Bratoeva M, Grass GD, Tolliver LB, Maria BL, Toole BP.

Am J Pathol. 2013 Feb;182(2):577-85. doi: 10.1016/j.ajpath.2012.10.011. Epub 2012 Nov 22.


Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection.

Qin Z, Dai L, Defee M, Findlay VJ, Watson DK, Toole BP, Cameron J, Peruzzi F, Kirkwood K, Parsons C.

J Virol. 2013 Jan;87(1):621-35. doi: 10.1128/JVI.01441-12. Epub 2012 Oct 24.


Regulation of invadopodia formation and activity by CD147.

Grass GD, Bratoeva M, Toole BP.

J Cell Sci. 2012 Feb 1;125(Pt 3):777-88. doi: 10.1242/jcs.097956.


Kaposi sarcoma-associated herpesvirus (KSHV) induces a functional tumor-associated phenotype for oral fibroblasts.

Dai L, Qin Z, Defee M, Toole BP, Kirkwood KL, Parsons C.

Cancer Lett. 2012 May 28;318(2):214-20. doi: 10.1016/j.canlet.2011.12.019. Epub 2011 Dec 17.


Extracellular Hsp90 serves as a co-factor for NF-κB activation and cellular pathogenesis induced by an oncogenic herpesvirus.

Defee MR, Qin Z, Dai L, Toole BP, Isaacs JS, Parsons CH.

Am J Cancer Res. 2011;1(5):687-700. Epub 2011 Apr 27.


KSHV activation of VEGF secretion and invasion for endothelial cells is mediated through viral upregulation of emmprin-induced signal transduction.

Dai L, Bratoeva M, Toole BP, Qin Z, Parsons C.

Int J Cancer. 2012 Aug 15;131(4):834-43. doi: 10.1002/ijc.26428. Epub 2011 Oct 24.


Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.

Harten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB.

J Gerontol A Biol Sci Med Sci. 2011 Nov;66(11):1201-7. doi: 10.1093/gerona/glr137. Epub 2011 Aug 17.


Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts.

Kawakami T, Sameshima T, Hojo H, Koga K, Nakahara Y, Toole BP, Suzumiya J, Okada Y, Iwasaki A, Nabeshima K.

BMC Cancer. 2011 Jul 17;11:300. doi: 10.1186/1471-2407-11-300.


Cooperative roles for emmprin and LYVE-1 in the regulation of chemoresistance for primary effusion lymphoma.

Qin Z, Dai L, Bratoeva M, Slomiany MG, Toole BP, Parsons C.

Leukemia. 2011 Oct;25(10):1598-609. doi: 10.1038/leu.2011.144. Epub 2011 Jun 10.


Synthetic emmprin peptides inhibit tumor cell-fibroblast interaction-stimulated upregulation of MMP-2 and tumor cell invasion.

Koga K, Aoki M, Sameshima T, Hamasaki M, Egawa N, Seiki M, Toole BP, Suzumiya J, Nabeshima K.

Int J Oncol. 2011 Sep;39(3):657-64. doi: 10.3892/ijo.2011.1060. Epub 2011 May 31.


Direct activation of emmprin and associated pathogenesis by an oncogenic herpesvirus.

Qin Z, Dai L, Slomiany MG, Toole BP, Parsons C.

Cancer Res. 2010 May 15;70(10):3884-9. doi: 10.1158/0008-5472.CAN-09-4663. Epub 2010 Apr 20.


Glycosylation Changes in Cancer.

Varki A, Kannagi R, Toole BP.

In: Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME, editors. Essentials of Glycobiology. 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. Chapter 44.


Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities.

Toole BP.

Clin Cancer Res. 2009 Dec 15;15(24):7462-7468.


Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan Oligosaccharides.

Slomiany MG, Dai L, Tolliver LB, Grass GD, Zeng Y, Toole BP.

Clin Cancer Res. 2009 Dec 15;15(24):7593-7601.


Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb.

Matsumoto K, Li Y, Jakuba C, Sugiyama Y, Sayo T, Okuno M, Dealy CN, Toole BP, Takeda J, Yamaguchi Y, Kosher RA.

Development. 2009 Aug;136(16):2825-35. doi: 10.1242/dev.038505.


Abrogating drug resistance in malignant peripheral nerve sheath tumors by disrupting hyaluronan-CD44 interactions with small hyaluronan oligosaccharides.

Slomiany MG, Dai L, Bomar PA, Knackstedt TJ, Kranc DA, Tolliver L, Maria BL, Toole BP.

Cancer Res. 2009 Jun 15;69(12):4992-8. doi: 10.1158/0008-5472.CAN-09-0143. Epub 2009 May 26.


Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells.

Slomiany MG, Grass GD, Robertson AD, Yang XY, Maria BL, Beeson C, Toole BP.

Cancer Res. 2009 Feb 15;69(4):1293-301. doi: 10.1158/0008-5472.CAN-08-2491. Epub 2009 Jan 27.


Hyaluronan regulates ceruloplasmin production by gliomas and their treatment-resistant multipotent progenitors.

Tye SL, Gilg AG, Tolliver LB, Wheeler WG, Toole BP, Maria BL.

J Child Neurol. 2008 Oct;23(10):1221-30. doi: 10.1177/0883073808321066.


Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas.

Maria BL, Gupta N, Gilg AG, Abdel-Wahab M, Leonard AP, Slomiany M, Wheeler WG, Tolliver LB, Babcock MA, Lucas JT Jr, Toole BP.

J Child Neurol. 2008 Oct;23(10):1214-20. doi: 10.1177/0883073808321771. Review.


Hyaluronan oligosaccharides as a potential anticancer therapeutic.

Toole BP, Ghatak S, Misra S.

Curr Pharm Biotechnol. 2008 Aug;9(4):249-52.


Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells.

Toole BP, Slomiany MG.

Semin Cancer Biol. 2008 Aug;18(4):244-50. doi: 10.1016/j.semcancer.2008.03.009. Epub 2008 Mar 26. Review.


Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance.

Toole BP, Slomiany MG.

Drug Resist Updat. 2008 Jun;11(3):110-21. doi: 10.1016/j.drup.2008.04.002. Epub 2008 May 19. Review.


Targeting hyaluronan interactions in malignant gliomas and their drug-resistant multipotent progenitors.

Gilg AG, Tye SL, Tolliver LB, Wheeler WG, Visconti RP, Duncan JD, Kostova FV, Bolds LN, Toole BP, Maria BL.

Clin Cancer Res. 2008 Mar 15;14(6):1804-13. doi: 10.1158/1078-0432.CCR-07-1228.


Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells.

Misra S, Obeid LM, Hannun YA, Minamisawa S, Berger FG, Markwald RR, Toole BP, Ghatak S.

J Biol Chem. 2008 May 23;283(21):14335-44. doi: 10.1074/jbc.M703811200. Epub 2008 Mar 7.


Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development.

Wirrig EE, Snarr BS, Chintalapudi MR, O'neal JL, Phelps AL, Barth JL, Fresco VM, Kern CB, Mjaatvedt CH, Toole BP, Hoffman S, Trusk TC, Argraves WS, Wessels A.

Dev Biol. 2007 Oct 15;310(2):291-303. Epub 2007 Aug 9.


Hyaluronan in limb morphogenesis.

Li Y, Toole BP, Dealy CN, Kosher RA.

Dev Biol. 2007 May 15;305(2):411-20. Epub 2007 Feb 24.


Emmprin in epithelioid sarcoma: expression in tumor cell membrane and stimulation of MMP-2 production in tumor-associated fibroblasts.

Koga K, Nabeshima K, Aoki M, Kawakami T, Hamasaki M, Toole BP, Nakayama J, Iwasaki H.

Int J Cancer. 2007 Feb 15;120(4):761-8.


Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus.

Yokoyama U, Minamisawa S, Quan H, Ghatak S, Akaike T, Segi-Nishida E, Iwasaki S, Iwamoto M, Misra S, Tamura K, Hori H, Yokota S, Toole BP, Sugimoto Y, Ishikawa Y.

J Clin Invest. 2006 Nov;116(11):3026-34.


Hyaluronan constitutively regulates activation of multiple receptor tyrosine kinases in epithelial and carcinoma cells.

Misra S, Toole BP, Ghatak S.

J Biol Chem. 2006 Nov 17;281(46):34936-41. Epub 2006 Sep 7.


Synthesis of a glycosylated peptide thioester by the Boc strategy and its application to segment condensation.

Haginoya E, Hojo H, Nakahara Y, Nakahara Y, Nabeshima K, Toole BP, Watanabe Y.

Biosci Biotechnol Biochem. 2006 Jun;70(6):1338-49.


Proteolytic cleavage of versican during cardiac cushion morphogenesis.

Kern CB, Twal WO, Mjaatvedt CH, Fairey SE, Toole BP, Iruela-Arispe ML, Argraves WS.

Dev Dyn. 2006 Aug;235(8):2238-47.


Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.

Lemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS.

Mech Ageing Dev. 2006 Aug;127(8):660-9. Epub 2006 May 2.


Extracellular matrix metalloproteinase inducer regulates metalloproteinases in human uterine endometrium.

Braundmeier AG, Fazleabas AT, Lessey BA, Guo H, Toole BP, Nowak RA.

J Clin Endocrinol Metab. 2006 Jun;91(6):2358-65. Epub 2006 Mar 7.


Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction.

Schmidt R, Bültmann A, Ungerer M, Joghetaei N, Bülbül O, Thieme S, Chavakis T, Toole BP, Gawaz M, Schömig A, May AE.

Circulation. 2006 Feb 14;113(6):834-41. Epub 2006 Feb 6.


Hyaluronan: a critical component of epithelial-mesenchymal and epithelial-carcinoma transitions.

Toole BP, Zoltan-Jones A, Misra S, Ghatak S.

Cells Tissues Organs. 2005;179(1-2):66-72. Review.


Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression.

Yan L, Zucker S, Toole BP.

Thromb Haemost. 2005 Feb;93(2):199-204. Review.


Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells.

Ghatak S, Misra S, Toole BP.

J Biol Chem. 2005 Mar 11;280(10):8875-83. Epub 2005 Jan 4.

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