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Items: 1 to 50 of 197

1.

NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes.

He C, Hu X, Weston TA, Jung RS, Heizer P, Tu Y, Ellison R, Matsumoto K, Gerhardt H, Tontonoz P, Fong LG, Young SG, Jiang H.

Biochem Biophys Res Commun. 2018 Sep 14. pii: S0006-291X(18)31969-7. doi: 10.1016/j.bbrc.2018.09.051. [Epub ahead of print]

PMID:
30224066
2.

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.

Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P.

Cell. 2018 Sep 8. pii: S0092-8674(18)31094-8. doi: 10.1016/j.cell.2018.08.033. [Epub ahead of print]

PMID:
30220461
3.

Macrophages release plasma membrane-derived particles rich in accessible cholesterol.

He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8499-E8508. doi: 10.1073/pnas.1810724115. Epub 2018 Aug 20.

PMID:
30127022
4.

Liver X receptors in lipid signalling and membrane homeostasis.

Wang B, Tontonoz P.

Nat Rev Endocrinol. 2018 Jun 14. doi: 10.1038/s41574-018-0037-x. [Epub ahead of print] Review.

PMID:
29904174
5.

KDM4B protects against obesity and metabolic dysfunction.

Cheng Y, Yuan Q, Vergnes L, Rong X, Youn JY, Li J, Yu Y, Liu W, Cai H, Lin JD, Tontonoz P, Hong C, Reue K, Wang CY.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5566-E5575. doi: 10.1073/pnas.1721814115. Epub 2018 May 29.

PMID:
29844188
6.

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism.

Seldin MM, Koplev S, Rajbhandari P, Vergnes L, Rosenberg GM, Meng Y, Pan C, Phuong TMN, Gharakhanian R, Che N, Mäkinen S, Shih DM, Civelek M, Parks BW, Kim ED, Norheim F, Chella Krishnan K, Hasin-Brumshtein Y, Mehrabian M, Laakso M, Drevon CA, Koistinen HA, Tontonoz P, Reue K, Cantor RM, Björkegren JLM, Lusis AJ.

Cell Metab. 2018 May 1;27(5):1138-1155.e6. doi: 10.1016/j.cmet.2018.03.015.

PMID:
29719227
7.

NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes.

He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H.

Cell Metab. 2018 May 1;27(5):1055-1066.e3. doi: 10.1016/j.cmet.2018.03.017.

PMID:
29719224
8.

LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis.

Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A.

Mol Cell Biol. 2018 Mar 5. pii: MCB.00534-17. doi: 10.1128/MCB.00534-17. [Epub ahead of print]

PMID:
29507185
9.

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.

Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P.

Nat Med. 2018 Mar;24(3):304-312. doi: 10.1038/nm.4479. Epub 2018 Feb 12.

10.

Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis.

Wang B, Rong X, Palladino END, Wang J, Fogelman AM, Martín MG, Alrefai WA, Ford DA, Tontonoz P.

Cell Stem Cell. 2018 Feb 1;22(2):206-220.e4. doi: 10.1016/j.stem.2017.12.017.

PMID:
29395055
11.

Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress.

Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL.

J Biol Chem. 2018 Mar 30;293(13):4735-4751. doi: 10.1074/jbc.M117.805069. Epub 2018 Jan 29.

PMID:
29378845
12.

Long Noncoding RNA Discovery in Cardiovascular Disease: Decoding Form to Function.

Sallam T, Sandhu J, Tontonoz P.

Circ Res. 2018 Jan 5;122(1):155-166. doi: 10.1161/CIRCRESAHA.117.311802. Review.

13.

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure.

Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P.

Cell. 2018 Jan 11;172(1-2):218-233.e17. doi: 10.1016/j.cell.2017.11.019. Epub 2017 Dec 14.

PMID:
29249357
14.

A Novel Type 2 Diabetes Mouse Model of Combined Diabetic Kidney Disease and Atherosclerosis.

Bornfeldt KE, Kramer F, Batorsky A, Choi J, Hudkins KL, Tontonoz P, Alpers CE, Kanter JE.

Am J Pathol. 2018 Feb;188(2):343-352. doi: 10.1016/j.ajpath.2017.10.012. Epub 2017 Dec 15.

PMID:
29154962
15.

Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.

Zhang L, Rajbhandari P, Priest C, Sandhu J, Wu X, Temel R, Castrillo A, de Aguiar Vallim TQ, Sallam T, Tontonoz P.

Elife. 2017 Oct 25;6. pii: e28766. doi: 10.7554/eLife.28766.

16.

The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning.

Gao J, Marosi M, Choi J, Achiro JM, Kim S, Li S, Otis K, Martin KC, Portera-Cailliau C, Tontonoz P.

Elife. 2017 Sep 11;6. pii: e29178. doi: 10.7554/eLife.29178.

17.

ER phospholipid composition modulates lipogenesis during feeding and in obesity.

Rong X, Wang B, Palladino EN, de Aguiar Vallim TQ, Ford DA, Tontonoz P.

J Clin Invest. 2017 Oct 2;127(10):3640-3651. doi: 10.1172/JCI93616. Epub 2017 Aug 28.

18.

Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation.

Yao J, Guihard PJ, Wu X, Blazquez-Medela AM, Spencer MJ, Jumabay M, Tontonoz P, Fogelman AM, Boström KI, Yao Y.

J Cell Biol. 2017 Oct 2;216(10):3369-3385. doi: 10.1083/jcb.201612122. Epub 2017 Aug 24.

19.

Long Noncoding RNA Facilitated Gene Therapy Reduces Atherosclerosis in a Murine Model of Familial Hypercholesterolemia.

Tontonoz P, Wu X, Jones M, Zhang Z, Salisbury D, Sallam T.

Circulation. 2017 Aug 22;136(8):776-778. doi: 10.1161/CIRCULATIONAHA.117.029002. No abstract available.

20.

Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum.

Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman HR, Meriwether D, Williams K, Bensinger S, Moller T, Faull KF, Lusis AJ, Iruela-Arispe ML, Bostrom KI, Tontonoz P, Reddy ST, Fogelman AM.

J Lipid Res. 2017 Aug;58(8):1636-1647. doi: 10.1194/jlr.M076554. Epub 2017 Jun 7.

21.

Pioneering EBF2 remodels the brown fat chromatin landscape.

Wang J, Tontonoz P.

Genes Dev. 2017 Apr 1;31(7):632-633. doi: 10.1101/gad.299644.117.

22.

Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia.

Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG.

N Engl J Med. 2017 Apr 27;376(17):1647-1658. doi: 10.1056/NEJMoa1611930. Epub 2017 Apr 5.

23.

Phenamil, an amiloride derivative, restricts long bone growth and alters keeled-sternum bone architecture in growing chickens.

Price TR, Moncada K, Leyva-Jimenez H, Park KW, Tontonoz P, Walzem RL.

Poult Sci. 2017 Jul 1;96(7):2471-2479. doi: 10.3382/ps/pex034.

24.

RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs.

Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, Tontonoz P.

J Clin Invest. 2017 Mar 1;127(3):987-1004. doi: 10.1172/JCI89484. Epub 2017 Feb 13.

25.

High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS.

He C, Hu X, Jung RS, Weston TA, Sandoval NP, Tontonoz P, Kilburn MR, Fong LG, Young SG, Jiang H.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2000-2005. doi: 10.1073/pnas.1621432114. Epub 2017 Feb 6.

26.

Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease.

Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P.

Immunity. 2016 Dec 20;45(6):1311-1326. doi: 10.1016/j.immuni.2016.11.008.

27.

Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2.

Kim DH, Kim J, Kwon JS, Sandhu J, Tontonoz P, Lee SK, Lee S, Lee JW.

Cell Rep. 2016 Nov 1;17(6):1671-1682. doi: 10.1016/j.celrep.2016.10.023.

28.

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.

Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, Jenkins D, Martini M, Armando AM, Quehenberger O, Cloughesy TF, Furnari FB, Cavenee WK, Tontonoz P, Gahman TC, Shiau AK, Cravatt BF, Mischel PS.

Cancer Cell. 2016 Nov 14;30(5):683-693. doi: 10.1016/j.ccell.2016.09.008. Epub 2016 Oct 13.

29.

Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation.

Song NJ, Kim S, Jang BH, Chang SH, Yun UJ, Park KM, Waki H, Li DY, Tontonoz P, Park KW.

PLoS One. 2016 Sep 9;11(9):e0162228. doi: 10.1371/journal.pone.0162228. eCollection 2016.

30.

sLRP1ng Up Glucose: LRP1 Regulates Hepatic Insulin Responses.

Lee SD, Tontonoz P.

EBioMedicine. 2016 May;7:17-8. doi: 10.1016/j.ebiom.2016.05.018. Epub 2016 May 19. No abstract available.

31.

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.

Sallam T, Jones MC, Gilliland T, Zhang L, Wu X, Eskin A, Sandhu J, Casero D, Vallim TQ, Hong C, Katz M, Lee R, Whitelegge J, Tontonoz P.

Nature. 2016 Jun 2;534(7605):124-8. doi: 10.1038/nature17674. Epub 2016 May 11.

32.

Prdm4 induction by the small molecule butein promotes white adipose tissue browning.

Song NJ, Choi S, Rajbhandari P, Chang SH, Kim S, Vergnes L, Kwon SM, Yoon JH, Lee S, Ku JM, Lee JS, Reue K, Koo SH, Tontonoz P, Park KW.

Nat Chem Biol. 2016 Jul;12(7):479-81. doi: 10.1038/nchembio.2081. Epub 2016 May 9.

33.

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females.

Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL.

Sci Transl Med. 2016 Apr 13;8(334):334ra54. doi: 10.1126/scitranslmed.aad3815.

34.

Palmoplantar Keratoderma in Slurp2-Deficient Mice.

Allan CM, Procaccia S, Tran D, Tu Y, Barnes RH 2nd, Larsson M, Allan BB, Young LC, Hong C, Tontonoz P, Fong LG, Young SG, Beigneux AP.

J Invest Dermatol. 2016 Feb;136(2):436-43. doi: 10.1016/j.jid.2015.11.003. Epub 2015 Nov 18.

35.

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet.

Wang B, Rong X, Duerr MA, Hermanson DJ, Hedde PN, Wong JS, Vallim TQ, Cravatt BF, Gratton E, Ford DA, Tontonoz P.

Cell Metab. 2016 Mar 8;23(3):492-504. doi: 10.1016/j.cmet.2016.01.001. Epub 2016 Jan 28.

36.

The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis.

Choi J, Gao J, Kim J, Hong C, Kim J, Tontonoz P.

Sci Transl Med. 2015 Nov 18;7(314):314ra184. doi: 10.1126/scitranslmed.aad1904.

PMID:
26582899
37.

Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis.

Briot A, Civelek M, Seki A, Hoi K, Mack JJ, Lee SD, Kim J, Hong C, Yu J, Fishbein GA, Vakili L, Fogelman AM, Fishbein MC, Lusis AJ, Tontonoz P, Navab M, Berliner JA, Iruela-Arispe ML.

J Exp Med. 2015 Nov 16;212(12):2147-63. doi: 10.1084/jem.20150603. Epub 2015 Nov 9.

38.

Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance.

Tian XY, Ganeshan K, Hong C, Nguyen KD, Qiu Y, Kim J, Tangirala RK, Tontonoz P, Chawla A.

Cell Metab. 2016 Jan 12;23(1):165-78. doi: 10.1016/j.cmet.2015.10.003. Epub 2015 Nov 5. Erratum in: Cell Metab. 2016 Feb 9;23(2):386. Tonotonoz, Peter [corrected to Tontonoz, Peter].

39.

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling.

Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P.

Elife. 2015 Jul 14;4:e08009. doi: 10.7554/eLife.08009.

40.

Liver X receptors at the intersection of lipid metabolism and atherogenesis.

Lee SD, Tontonoz P.

Atherosclerosis. 2015 Sep;242(1):29-36. doi: 10.1016/j.atherosclerosis.2015.06.042. Epub 2015 Jul 2. Review. No abstract available.

41.

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion.

Rong X, Wang B, Dunham MM, Hedde PN, Wong JS, Gratton E, Young SG, Ford DA, Tontonoz P.

Elife. 2015 Mar 25;4. doi: 10.7554/eLife.06557.

42.

Genetic architecture of insulin resistance in the mouse.

Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang WP, Neuhaus I, Gargalovic PS, Kirchgessner TG, Graham M, Lee R, Tontonoz P, Gerszten RE, Hevener AL, Lusis AJ.

Cell Metab. 2015 Feb 3;21(2):334-347. doi: 10.1016/j.cmet.2015.01.002.

43.

The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice.

Tontonoz P, Cortez-Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, Conneely O, Metzger D, Chao LC.

Mol Cell Biol. 2015 Apr;35(7):1125-38. doi: 10.1128/MCB.00715-14. Epub 2015 Jan 20.

44.

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.

Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM.

Cell Rep. 2015 Jan 14. pii: S2211-1247(14)01065-1. doi: 10.1016/j.celrep.2014.12.036. [Epub ahead of print]

45.

Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression.

Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL.

J Biol Chem. 2015 Feb 27;290(9):5566-81. doi: 10.1074/jbc.M114.606459. Epub 2014 Dec 2.

46.

The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice.

Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, Temel RE, Tontonoz P.

Cell Metab. 2014 Nov 4;20(5):910-918. doi: 10.1016/j.cmet.2014.10.001. Epub 2014 Nov 4.

47.

Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon.

Ma F, Liu SY, Razani B, Arora N, Li B, Kagechika H, Tontonoz P, Núñez V, Ricote M, Cheng G.

Nat Commun. 2014 Nov 24;5:5494. doi: 10.1038/ncomms6494.

48.

SUMOylation places LRH-1 in PROXimity to lipid metabolism.

Priest C, Tontonoz P.

Cell Metab. 2014 Oct 7;20(4):558-9. doi: 10.1016/j.cmet.2014.09.008.

49.

Enhanced thermogenesis in the blinc of an eye.

Jones M, Tontonoz P.

Mol Cell. 2014 Aug 7;55(3):343-4. doi: 10.1016/j.molcel.2014.07.015.

50.

2014 American Society for Clinical Investigation Presidential Address. Leading by example: pastors, mentors, physician-scientists, and the ASCI.

Tontonoz P.

J Clin Invest. 2014 Jul;124(7):2816-21. doi: 10.1172/JCI77200. Epub 2014 Jul 1. No abstract available.

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