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Items: 17


A three-dimensional ParF meshwork assembles through the nucleoid to mediate plasmid segregation.

McLeod BN, Allison-Gamble GE, Barge MT, Tonthat NK, Schumacher MA, Hayes F, Barillà D.

Nucleic Acids Res. 2017 Apr 7;45(6):3158-3171. doi: 10.1093/nar/gkw1302.


Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.

Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA.

mBio. 2016 Apr 26;7(2):e00492-16. doi: 10.1128/mBio.00492-16.


Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages.

Schumacher MA, Tonthat NK, Lee J, Rodriguez-Castañeda FA, Chinnam NB, Kalliomaa-Sanford AK, Ng IW, Barge MT, Shaw PL, Barillà D.

Science. 2015 Sep 4;349(6252):1120-4. doi: 10.1126/science.aaa9046. Erratum in: Science. 2016 Aug 26;353(6302). pii: aai8230. doi: 10.1126/science.aai8230.


Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides.

Lee SC, Li A, Calo S, Inoue M, Tonthat NK, Bain JM, Louw J, Shinohara ML, Erwig LP, Schumacher MA, Ko DC, Heitman J.

Mol Microbiol. 2015 Sep;97(5):844-65. doi: 10.1111/mmi.13071. Epub 2015 Jun 17.


Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis.

Hover BM, Tonthat NK, Schumacher MA, Yokoyama K.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):6347-52. doi: 10.1073/pnas.1500697112. Epub 2015 May 4.


Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis.

Schumacher MA, Chinnam NB, Cuthbert B, Tonthat NK, Whitfill T.

Genes Dev. 2015 Feb 15;29(4):451-64. doi: 10.1101/gad.254714.114.


Structural basis of lipid binding for the membrane-embedded tetraacyldisaccharide-1-phosphate 4'-kinase LpxK.

Emptage RP, Tonthat NK, York JD, Schumacher MA, Zhou P.

J Biol Chem. 2014 Aug 29;289(35):24059-68. doi: 10.1074/jbc.M114.589986. Epub 2014 Jul 14.


Mechanism of staphylococcal multiresistance plasmid replication origin assembly by the RepA protein.

Schumacher MA, Tonthat NK, Kwong SM, Chinnam NB, Liu MA, Skurray RA, Firth N.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9121-6. doi: 10.1073/pnas.1406065111. Epub 2014 Jun 9.


Ligand concentration regulates the pathways of coupled protein folding and binding.

Daniels KG, Tonthat NK, McClure DR, Chang YC, Liu X, Schumacher MA, Fierke CA, Schmidler SC, Oas TG.

J Am Chem Soc. 2014 Jan 22;136(3):822-5. doi: 10.1021/ja4086726. Epub 2014 Jan 9.


Structures of the Bacillus subtilis glutamine synthetase dodecamer reveal large intersubunit catalytic conformational changes linked to a unique feedback inhibition mechanism.

Murray DS, Chinnam N, Tonthat NK, Whitfill T, Wray LV Jr, Fisher SH, Schumacher MA.

J Biol Chem. 2013 Dec 13;288(50):35801-11. doi: 10.1074/jbc.M113.519496. Epub 2013 Oct 24.


The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus.

Birukou I, Tonthat NK, Seo SM, Schindler BD, Kaatz GW, Brennan RG.

mBio. 2013 Aug 27;4(5):e00528-13. doi: 10.1128/mBio.00528-13.


SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid.

Tonthat NK, Milam SL, Chinnam N, Whitfill T, Margolin W, Schumacher MA.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10586-91. doi: 10.1073/pnas.1221036110. Epub 2013 Jun 10. Erratum in: Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15163.


Structures of the Escherichia coli transcription activator and regulator of diauxie, XylR: an AraC DNA-binding family member with a LacI/GalR ligand-binding domain.

Ni L, Tonthat NK, Chinnam N, Schumacher MA.

Nucleic Acids Res. 2013 Feb 1;41(3):1998-2008. doi: 10.1093/nar/gks1207. Epub 2012 Dec 14.


Molecular basis for a protein-mediated DNA-bridging mechanism that functions in condensation of the E. coli chromosome.

Dupaigne P, Tonthat NK, Espéli O, Whitfill T, Boccard F, Schumacher MA.

Mol Cell. 2012 Nov 30;48(4):560-71. doi: 10.1016/j.molcel.2012.09.009. Epub 2012 Oct 18.


Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8.

Takeda K, Tonthat NK, Glover T, Xu W, Koonin EV, Yanagida M, Schumacher MA.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16950-5. doi: 10.1073/pnas.1103617108. Epub 2011 Oct 5.


Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT.

Gu D, Tonthat NK, Lee M, Ji H, Bhat KP, Hollingsworth F, Aldape KD, Schumacher MA, Zwaka TP, McCrea PD.

J Biol Chem. 2011 Jul 1;286(26):23178-88. doi: 10.1074/jbc.M110.167544. Epub 2011 May 11.


Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check.

Tonthat NK, Arold ST, Pickering BF, Van Dyke MW, Liang S, Lu Y, Beuria TK, Margolin W, Schumacher MA.

EMBO J. 2011 Jan 5;30(1):154-64. doi: 10.1038/emboj.2010.288. Epub 2010 Nov 26.

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