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Items: 1 to 50 of 175

1.

DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease.

Krishnan N, Felice C, Rivera K, Pappin DJ, Tonks NK.

Genes Dev. 2018 Jul 1;32(13-14):944-952. doi: 10.1101/gad.314658.118. Epub 2018 Jun 26.

2.

Spatial regulation of signaling by the coordinated action of the protein tyrosine kinases MET and FER.

Zhang J, Wang Z, Zhang S, Chen Y, Xiong X, Li X, Tonks NK, Fan G.

Cell Signal. 2018 Oct;50:100-110. doi: 10.1016/j.cellsig.2018.06.006. Epub 2018 Jun 18.

PMID:
29920310
3.

Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development.

Krishnan N, Bonham CA, Rus IA, Shrestha OK, Gauss CM, Haque A, Tocilj A, Joshua-Tor L, Tonks NK.

Nat Commun. 2018 Jan 18;9(1):283. doi: 10.1038/s41467-017-02252-2.

4.

A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models.

Krishnan N, Konidaris KF, Gasser G, Tonks NK.

J Biol Chem. 2018 Feb 2;293(5):1517-1525. doi: 10.1074/jbc.C117.819110. Epub 2017 Dec 7.

5.

Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase.

Zhang S, Fan G, Hao Y, Hammell M, Wilkinson JE, Tonks NK.

Genes Dev. 2017 Oct 1;31(19):1939-1957. doi: 10.1101/gad.304261.117. Epub 2017 Oct 24.

6.

Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.

Gurung P, Fan G, Lukens JR, Vogel P, Tonks NK, Kanneganti TD.

Immunity. 2017 Apr 18;46(4):635-648. doi: 10.1016/j.immuni.2017.03.014. Epub 2017 Apr 11.

7.

HGF-independent regulation of MET and GAB1 by nonreceptor tyrosine kinase FER potentiates metastasis in ovarian cancer.

Fan G, Zhang S, Gao Y, Greer PA, Tonks NK.

Genes Dev. 2016 Jul 1;30(13):1542-57. doi: 10.1101/gad.284166.116.

8.

PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.

Krishnan N, Krishnan K, Connors CR, Choy MS, Page R, Peti W, Van Aelst L, Shea SD, Tonks NK.

J Clin Invest. 2015 Aug 3;125(8):3163-77. doi: 10.1172/JCI80323. Epub 2015 Jul 27.

9.

Anxious moments for the protein tyrosine phosphatase PTP1B.

Krishnan N, Tonks NK.

Trends Neurosci. 2015 Aug;38(8):462-5. doi: 10.1016/j.tins.2015.06.006. Epub 2015 Jul 9.

10.

Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.

Fan G, Aleem S, Yang M, Miller WT, Tonks NK.

J Biol Chem. 2015 Jun 26;290(26):15934-47. doi: 10.1074/jbc.M115.651703. Epub 2015 Apr 20.

11.

PTP1B: mediating ROS signaling to silence genes.

Boivin B, Tonks NK.

Mol Cell Oncol. 2015 Feb 26;2(2):e975633. doi: 10.4161/23723556.2014.975633. eCollection 2015 Apr-Jun.

12.

A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells.

Ramesh M, Krishnan N, Muthuswamy SK, Tonks NK.

J Biol Chem. 2015 Apr 10;290(15):9646-59. doi: 10.1074/jbc.M114.627968. Epub 2015 Feb 13.

13.

A quantitative proteomics-based signature of platinum sensitivity in ovarian cancer cell lines.

Fan G, Wrzeszczynski KO, Fu C, Su G, Pappin DJ, Lucito R, Tonks NK.

Biochem J. 2015 Feb 1;465(3):433-42. doi: 10.1042/BJ20141087.

14.

Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity.

Chaudhary F, Lucito R, Tonks NK.

Biochem J. 2015 Jan 1;465(1):89-101. doi: 10.1042/BJ20140573.

15.

Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence.

Yang M, Haase AD, Huang FK, Coulis G, Rivera KD, Dickinson BC, Chang CJ, Pappin DJ, Neubert TA, Hannon GJ, Boivin B, Tonks NK.

Mol Cell. 2014 Sep 4;55(5):782-90. doi: 10.1016/j.molcel.2014.07.018. Epub 2014 Aug 28.

16.

A unified nomenclature and amino acid numbering for human PTEN.

Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR.

Sci Signal. 2014 Jul 1;7(332):pe15. doi: 10.1126/scisignal.2005560.

17.

Reactivation of oxidized PTP1B and PTEN by thioredoxin 1.

Schwertassek U, Haque A, Krishnan N, Greiner R, Weingarten L, Dick TP, Tonks NK.

FEBS J. 2014 Aug;281(16):3545-58. doi: 10.1111/febs.12898. Epub 2014 Jul 23.

18.

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.

Krishnan N, Koveal D, Miller DH, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss CM, Page R, Blackledge M, Muthuswamy SK, Peti W, Tonks NK.

Nat Chem Biol. 2014 Jul;10(7):558-66. doi: 10.1038/nchembio.1528. Epub 2014 May 20.

19.

Nox4 redox regulation of PTP1B contributes to the proliferation and migration of glioblastoma cells by modulating tyrosine phosphorylation of coronin-1C.

Mondol AS, Tonks NK, Kamata T.

Free Radic Biol Med. 2014 Feb;67:285-91. doi: 10.1016/j.freeradbiomed.2013.11.005. Epub 2013 Nov 13.

PMID:
24239742
20.

Receptor protein-tyrosine phosphatase α regulates focal adhesion kinase phosphorylation and ErbB2 oncoprotein-mediated mammary epithelial cell motility.

Boivin B, Chaudhary F, Dickinson BC, Haque A, Pero SC, Chang CJ, Tonks NK.

J Biol Chem. 2013 Dec 27;288(52):36926-35. doi: 10.1074/jbc.M113.527564. Epub 2013 Nov 11.

21.

Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling.

Dagnell M, Frijhoff J, Pader I, Augsten M, Boivin B, Xu J, Mandal PK, Tonks NK, Hellberg C, Conrad M, Arnér ES, Östman A.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13398-403. doi: 10.1073/pnas.1302891110. Epub 2013 Jul 30.

22.

Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.

Fan G, Lin G, Lucito R, Tonks NK.

J Biol Chem. 2013 Aug 23;288(34):24923-34. doi: 10.1074/jbc.M113.482737. Epub 2013 Jun 28.

23.

The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases.

Krishnan N, Bencze G, Cohen P, Tonks NK.

FEBS J. 2013 Jun;280(12):2830-41. doi: 10.1111/febs.12283. Epub 2013 May 9.

24.

Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action.

Lindtner C, Scherer T, Zielinski E, Filatova N, Fasshauer M, Tonks NK, Puchowicz M, Buettner C.

Sci Transl Med. 2013 Jan 30;5(170):170ra14. doi: 10.1126/scitranslmed.3005123.

25.

Special issue: Protein phosphatases: from molecules to networks: introduction.

Tonks NK.

FEBS J. 2013 Jan;280(2):323. doi: 10.1111/febs.12098. Epub 2013 Jan 17.

26.

Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction.

Tonks NK.

FEBS J. 2013 Jan;280(2):346-78. doi: 10.1111/febs.12077. Epub 2013 Jan 17. Review.

27.

The use of phage display to generate conformation-sensor recombinant antibodies.

Haque A, Tonks NK.

Nat Protoc. 2012 Dec;7(12):2127-43. doi: 10.1038/nprot.2012.132. Epub 2012 Nov 15.

28.

Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation.

Yu M, Lin G, Arshadi N, Kalatskaya I, Xue B, Haider S, Nguyen F, Boutros PC, Elson A, Muthuswamy LB, Tonks NK, Muthuswamy SK.

Mol Cell Biol. 2012 Oct;32(19):3913-24. doi: 10.1128/MCB.00068-12. Epub 2012 Jul 30.

29.

Functional analysis of the protein phosphatase activity of PTEN.

Zhang XC, Piccini A, Myers MP, Van Aelst L, Tonks NK.

Biochem J. 2012 Jun 15;444(3):457-64. doi: 10.1042/BJ20120098.

30.

H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.

Krishnan N, Fu C, Pappin DJ, Tonks NK.

Sci Signal. 2011 Dec 13;4(203):ra86. doi: 10.1126/scisignal.2002329.

31.

Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity.

Haque A, Andersen JN, Salmeen A, Barford D, Tonks NK.

Cell. 2011 Sep 30;147(1):185-98. doi: 10.1016/j.cell.2011.08.036.

32.

Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'.

Lin G, Aranda V, Muthuswamy SK, Tonks NK.

Genes Dev. 2011 Jul 1;25(13):1412-25. doi: 10.1101/gad.2018911.

33.

Diverse injurious stimuli reduce protein tyrosine phosphatase-μ expression and enhance epidermal growth factor receptor signaling in human airway epithelia.

Hyun SW, Anglin IE, Liu A, Yang S, Sorkin JD, Lillehoj E, Tonks NK, Passaniti A, Goldblum SE.

Exp Lung Res. 2011 Aug;37(6):327-43. doi: 10.3109/01902148.2011.566673. Epub 2011 Jun 7.

34.

Targeting the reversibly oxidized protein tyrosine phosphatase superfamily.

Boivin B, Yang M, Tonks NK.

Sci Signal. 2010 Aug 31;3(137):pl2. doi: 10.1126/scisignal.3137pl2. Review.

35.

Analysis of the redox regulation of protein tyrosine phosphatase superfamily members utilizing a cysteinyl-labeling assay.

Boivin B, Tonks NK.

Methods Enzymol. 2010;474:35-50. doi: 10.1016/S0076-6879(10)74003-9. Epub 2010 Jun 20.

PMID:
20609903
36.

Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis.

Schwertassek U, Buckley DA, Xu CF, Lindsay AJ, McCaffrey MW, Neubert TA, Tonks NK.

FEBS J. 2010 Jun;277(11):2463-73. doi: 10.1111/j.1742-4658.2010.07661.x.

37.

The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation.

Hinton SD, Myers MP, Roggero VR, Allison LA, Tonks NK.

Biochem J. 2010 Apr 14;427(3):349-57. doi: 10.1042/BJ20091383.

38.

Pseudophosphatases: grab and hold on.

Tonks NK.

Cell. 2009 Oct 30;139(3):464-5. doi: 10.1016/j.cell.2009.10.008.

39.

Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor.

Jung SK, Jeong DG, Chung SJ, Kim JH, Park BC, Tonks NK, Ryu SE, Kim SJ.

FASEB J. 2010 Feb;24(2):560-9. doi: 10.1096/fj.09-143891. Epub 2009 Oct 26.

40.

Reactive oxygen species enhance insulin sensitivity.

Loh K, Deng H, Fukushima A, Cai X, Boivin B, Galic S, Bruce C, Shields BJ, Skiba B, Ooms LM, Stepto N, Wu B, Mitchell CA, Tonks NK, Watt MJ, Febbraio MA, Crack PJ, Andrikopoulos S, Tiganis T.

Cell Metab. 2009 Oct;10(4):260-72. doi: 10.1016/j.cmet.2009.08.009.

41.

Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent.

Krishnan N, Jeong DG, Jung SK, Ryu SE, Xiao A, Allis CD, Kim SJ, Tonks NK.

J Biol Chem. 2009 Jun 12;284(24):16066-70. doi: 10.1074/jbc.C900032200. Epub 2009 Apr 7.

42.

A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells.

Boivin B, Zhang S, Arbiser JL, Zhang ZY, Tonks NK.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9959-64. doi: 10.1073/pnas.0804336105. Epub 2008 Jul 16.

43.

Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR.

Tabet F, Schiffrin EL, Callera GE, He Y, Yao G, Ostman A, Kappert K, Tonks NK, Touyz RM.

Circ Res. 2008 Jul 18;103(2):149-58. doi: 10.1161/CIRCRESAHA.108.178608. Epub 2008 Jun 19.

PMID:
18566342
44.

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling.

Juarez JC, Manuia M, Burnett ME, Betancourt O, Boivin B, Shaw DE, Tonks NK, Mazar AP, Doñate F.

Proc Natl Acad Sci U S A. 2008 May 20;105(20):7147-52. doi: 10.1073/pnas.0709451105. Epub 2008 May 14.

45.

Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells.

Lou YW, Chen YY, Hsu SF, Chen RK, Lee CL, Khoo KH, Tonks NK, Meng TC.

FEBS J. 2008 Jan;275(1):69-88. Epub 2007 Dec 6.

46.

A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer.

Tonks NK, Muthuswamy SK.

Cancer Cell. 2007 Mar;11(3):214-6.

47.

Protein tyrosine phosphatases: from genes, to function, to disease.

Tonks NK.

Nat Rev Mol Cell Biol. 2006 Nov;7(11):833-46. Review.

PMID:
17057753
48.

Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs.

Nelson KK, Subbaram S, Connor KM, Dasgupta J, Ha XF, Meng TC, Tonks NK, Melendez JA.

J Biol Chem. 2006 May 19;281(20):14100-10. Epub 2006 Mar 28.

49.

Redox redux: revisiting PTPs and the control of cell signaling.

Tonks NK.

Cell. 2005 Jun 3;121(5):667-70. Review.

50.

Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia.

Sui XF, Kiser TD, Hyun SW, Angelini DJ, Del Vecchio RL, Young BA, Hasday JD, Romer LH, Passaniti A, Tonks NK, Goldblum SE.

Am J Pathol. 2005 Apr;166(4):1247-58.

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