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Items: 1 to 50 of 95

1.

LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells.

Morgan RG, Ridsdale J, Payne M, Heesom KJ, Wilson MC, Davidson A, Greenhough A, Davies S, Williams AC, Blair A, Waterman ML, Tonks A, Darley RL.

Haematologica. 2019 Jul;104(7):1365-1377. doi: 10.3324/haematol.2018.202846. Epub 2019 Jan 10.

2.

TET-2 up-regulation is associated with the anti-inflammatory action of Vicenin-2.

Hassan N, Ali A, Withycombe C, Ahluwalia M, Al-Nasseri RH, Tonks A, Morris K.

Cytokine. 2018 Aug;108:37-42. doi: 10.1016/j.cyto.2018.03.016. Epub 2018 Mar 19.

PMID:
29567563
3.

Airway expression of Transient Receptor Potential (TRP) Vanniloid-1 and Ankyrin-1 channels is not increased in patients with Idiopathic Pulmonary Fibrosis.

Hutchinson NX, Gibbs A, Tonks A, Hope-Gill BD.

PLoS One. 2017 Nov 17;12(11):e0187847. doi: 10.1371/journal.pone.0187847. eCollection 2017.

4.

Cord Blood-Derived Quiescent CD34+ Cells Are More Transcriptionally Matched to AML Blasts Than Cytokine-Induced Normal Human Hematopoietic CD34+ Cells.

Munje C, Hills RK, Whetton A, Burnett AK, Darley RL, Tonks A.

Gene Expr. 2015;16(4):169-175. doi: 10.3727/105221615X14399878166159.

5.

A review of pregnancies complicated by congenital sacrococcygeal teratoma in the West Midlands region over an 18-year period: population-based, cohort study.

Ayed A, Tonks AM, Lander A, Kilby MD.

Prenat Diagn. 2015 Nov;35(11):1037-47. doi: 10.1002/pd.4641. Epub 2015 Aug 4. Review.

PMID:
26114890
6.

The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse.

Coles SJ, Gilmour MN, Reid R, Knapper S, Burnett AK, Man S, Tonks A, Darley RL.

Leukemia. 2015 Sep;29(9):1952-4. doi: 10.1038/leu.2015.62. Epub 2015 Mar 9. No abstract available.

PMID:
25748687
7.

Epidemiology of partial urorectal septum malformation sequence (or 'persistent cloaca'): a population-based study in seven regions of England and Wales, 1985-2010.

Tennant PW, Glinianaia SV, Wellesley D, Draper ES, Kurinczuk JJ, Tonks AM, Tucker DF, Wreyford B, Rankin J.

Arch Dis Child Fetal Neonatal Ed. 2014 Sep;99(5):F413-8. doi: 10.1136/archdischild-2014-306027. Epub 2014 May 28.

PMID:
25115921
8.

Factors affecting the nuclear localization of β-catenin in normal and malignant tissue.

Morgan RG, Ridsdale J, Tonks A, Darley RL.

J Cell Biochem. 2014 Aug;115(8):1351-61. doi: 10.1002/jcb.24803. Review.

PMID:
24610469
9.

The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts.

Zabkiewicz J, Pearn L, Hills RK, Morgan RG, Tonks A, Burnett AK, Darley RL.

Haematologica. 2014 May;99(5):858-64. doi: 10.3324/haematol.2013.096487. Epub 2013 Dec 13.

10.

Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling.

Hole PS, Zabkiewicz J, Munje C, Newton Z, Pearn L, White P, Marquez N, Hills RK, Burnett AK, Tonks A, Darley RL.

Blood. 2013 Nov 7;122(19):3322-30. doi: 10.1182/blood-2013-04-491944. Epub 2013 Oct 2.

11.

Trisomies 18 and 13: trends in prevalence and prenatal diagnosis - population based study.

Tonks AM, Gornall AS, Larkins SA, Gardosi JO.

Prenat Diagn. 2013 Aug;33(8):742-50. doi: 10.1002/pd.4117. Epub 2013 May 18.

PMID:
23553654
12.

γ-Catenin is expressed throughout normal human hematopoietic development and is required for normal PU.1-dependent monocyte differentiation.

Morgan RG, Liddiard K, Pearn L, Pumford SL, Burnett AK, Darley RL, Tonks A.

Leukemia. 2013 Oct;27(10):2096-100. doi: 10.1038/leu.2013.96. Epub 2013 Apr 2. No abstract available.

PMID:
23545990
13.

Doctors call for changes in the law to allow use of second hand cardioverter defibrillators.

Tonks A.

BMJ. 2012 Oct 18;345:e7053. doi: 10.1136/bmj.e7053. No abstract available.

PMID:
23078964
14.

Congenital lower urinary tract obstruction: a population-based epidemiological study.

Malin G, Tonks AM, Morris RK, Gardosi J, Kilby MD.

BJOG. 2012 Nov;119(12):1455-64. doi: 10.1111/j.1471-0528.2012.03476.x. Epub 2012 Aug 24.

15.

γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin.

Morgan RG, Pearn L, Liddiard K, Pumford SL, Burnett AK, Tonks A, Darley RL.

Leukemia. 2013 Feb;27(2):336-43. doi: 10.1038/leu.2012.221. Epub 2012 Aug 3.

16.

Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells.

Coles SJ, Hills RK, Wang EC, Burnett AK, Man S, Darley RL, Tonks A.

Leukemia. 2012 Sep;26(9):2146-8. doi: 10.1038/leu.2012.75. Epub 2012 Mar 20. No abstract available.

17.

Expression of CD200 on AML blasts directly suppresses memory T-cell function.

Coles SJ, Hills RK, Wang EC, Burnett AK, Man S, Darley RL, Tonks A.

Leukemia. 2012 Sep;26(9):2148-51. doi: 10.1038/leu.2012.77. Epub 2012 Mar 20. No abstract available.

18.

Pulse oximetry as a screening test for congenital heart defects in newborn infants: a test accuracy study with evaluation of acceptability and cost-effectiveness.

Ewer AK, Furmston AT, Middleton LJ, Deeks JJ, Daniels JP, Pattison HM, Powell R, Roberts TE, Barton P, Auguste P, Bhoyar A, Thangaratinam S, Tonks AM, Satodia P, Deshpande S, Kumararatne B, Sivakumar S, Mupanemunda R, Khan KS.

Health Technol Assess. 2012;16(2):v-xiii, 1-184. doi: 10.3310/hta16020.

19.

RUNX1-ETO deregulates the proliferation and growth factor responsiveness of human hematopoietic progenitor cells downstream of the myeloid transcription factor, MYCT1.

Liddiard K, Burnett AK, Darley RL, Tonks A.

Leukemia. 2012 Jan;26(1):177-9. doi: 10.1038/leu.2011.188. Epub 2011 Jul 29. No abstract available.

20.

Monitoring the prenatal detection of structural fetal congenital anomalies in England and Wales: register-based study.

Boyd PA, Tonks AM, Rankin J, Rounding C, Wellesley D, Draper ES; BINOCAR Working Group.

J Med Screen. 2011;18(1):2-7. doi: 10.1258/jms.2011.010139.

PMID:
21536809
21.

Do reactive oxygen species play a role in myeloid leukemias?

Hole PS, Darley RL, Tonks A.

Blood. 2011 Jun 2;117(22):5816-26. doi: 10.1182/blood-2011-01-326025. Epub 2011 Mar 11. Review. Erratum in: Blood. 2014 Jan 30;123(5):798.

22.

CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia.

Coles SJ, Wang EC, Man S, Hills RK, Burnett AK, Tonks A, Darley RL.

Leukemia. 2011 May;25(5):792-9. doi: 10.1038/leu.2011.1. Epub 2011 Jan 28.

23.

OGG1 is a novel prognostic indicator in acute myeloid leukaemia.

Liddiard K, Hills R, Burnett AK, Darley RL, Tonks A.

Oncogene. 2010 Apr 1;29(13):2005-12. doi: 10.1038/onc.2009.462. Epub 2009 Dec 21.

PMID:
20023702
24.

Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells.

Hole PS, Pearn L, Tonks AJ, James PE, Burnett AK, Darley RL, Tonks A.

Blood. 2010 Feb 11;115(6):1238-46. doi: 10.1182/blood-2009-06-222869. Epub 2009 Dec 10.

25.

Congenital abnormalities: data needed to establish causes.

Draper ES, Rankin J, Tonks A, Boyd P, Wellesley D, Tucker D, Budd J; BINOCAR Management Committee.

BMJ. 2009 Aug 25;339:b3428. doi: 10.1136/bmj.b3428. No abstract available.

PMID:
19706660
26.

Patient makes good recovery after transplant of a bioengineered airway.

Tonks A.

BMJ. 2008 Nov 21;337:a2676. doi: 10.1136/bmj.a2676. No abstract available.

PMID:
19028782
27.

Lysophospholipid acyltransferases: novel potential regulators of the inflammatory response and target for new drug discovery.

Jackson SK, Abate W, Tonks AJ.

Pharmacol Ther. 2008 Jul;119(1):104-14. doi: 10.1016/j.pharmthera.2008.04.001. Epub 2008 Apr 23. Review.

PMID:
18538854
28.

Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling.

Al Shaer L, Walsby E, Gilkes A, Tonks A, Walsh V, Mills K, Burnett A, Rowntree C.

Br J Haematol. 2008 May;141(4):483-93. doi: 10.1111/j.1365-2141.2008.07053.x. Epub 2008 Mar 27.

PMID:
18373709
29.

DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB.

Morris RH, Tonks AJ, Jones KP, Ahluwalia MK, Thomas AW, Tonks A, Jackson SK.

Biochem Biophys Res Commun. 2008 May 23;370(1):174-8. doi: 10.1016/j.bbrc.2008.03.052. Epub 2008 Mar 18.

PMID:
18355441
30.

Cabin fever.

Tonks A.

BMJ. 2008 Mar 15;336(7644):584-6. doi: 10.1136/bmj.39511.444618.AD. Review. No abstract available.

31.

Poor communication, poor training, and chaotic drug rounds contribute to drug errors.

Tonks A.

BMJ. 2008 Mar 15;336(7644):581. doi: 10.1136/bmj.39518.355880.DB. No abstract available.

32.

Outcome following prenatal diagnosis of complete atrioventricular septal defect.

Rasiah SV, Ewer AK, Miller P, Wright JG, Tonks A, Kilby MD.

Prenat Diagn. 2008 Feb;28(2):95-101. doi: 10.1002/pd.1922.

PMID:
18236422
33.

Patient safety: Safer by design.

Tonks A.

BMJ. 2008 Jan 26;336(7637):186-8. doi: 10.1136/bmj.39426.511759.AD. No abstract available. Erratum in: BMJ. 2008 Feb 23. doi. 10.1136/bmj.39497.690741.AD.

34.

Recreational drug use: a major risk factor for gastroschisis?

Draper ES, Rankin J, Tonks AM, Abrams KR, Field DJ, Clarke M, Kurinczuk JJ.

Am J Epidemiol. 2008 Feb 15;167(4):485-91. Epub 2007 Dec 5.

PMID:
18063593
35.

Lyme wars.

Tonks A.

BMJ. 2007 Nov 3;335(7626):910-2. Review. No abstract available.

36.

Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia.

Tonks A, Pearn L, Musson M, Gilkes A, Mills KI, Burnett AK, Darley RL.

Leukemia. 2007 Dec;21(12):2495-505. Epub 2007 Sep 27.

PMID:
17898786
37.

FUS expression alters the differentiation response to all-trans retinoic acid in NB4 and NB4R2 cells.

Walsby EJ, Gilkes AF, Tonks A, Darley RL, Mills KI.

Br J Haematol. 2007 Oct;139(1):94-7.

PMID:
17854312
38.

A 5.8-kDa component of manuka honey stimulates immune cells via TLR4.

Tonks AJ, Dudley E, Porter NG, Parton J, Brazier J, Smith EL, Tonks A.

J Leukoc Biol. 2007 Nov;82(5):1147-55. Epub 2007 Aug 3.

PMID:
17675558
39.

Oral vaccines: A spoonful of antigen.

Tonks A.

BMJ. 2007 Jul 28;335(7612):180-2. Review. No abstract available.

40.

Quest for the AIDS vaccine.

Tonks A.

BMJ. 2007 Jun 30;334(7608):1346-8. Review. No abstract available.

41.

Too much of a good thing.

Tonks A.

BMJ. 2007 May 12;334(7601):978-80. Review. No abstract available.

42.

Termination of pregnancy for fetal anomaly: a population-based study 1995 to 2004.

Wyldes MP, Tonks AM.

BJOG. 2007 May;114(5):639-42. Epub 2007 Mar 12.

43.

An epidemiological study of holoprosencephaly from a regional congenital anomaly register: 1995-2004.

Ong S, Tonks A, Woodward ER, Wyldes MP, Kilby MD.

Prenat Diagn. 2007 Apr;27(4):340-7.

PMID:
17286306
44.

CD200 as a prognostic factor in acute myeloid leukaemia.

Tonks A, Hills R, White P, Rosie B, Mills KI, Burnett AK, Darley RL.

Leukemia. 2007 Mar;21(3):566-8. Epub 2007 Jan 25. No abstract available.

PMID:
17252007
45.

The sensitivity of human cells expressing RUNX1-RUNX1T1 to chemotherapeutic agents.

Tonks A, Pearn L, Mills KI, Burnett AK, Darley RL.

Leukemia. 2006 Oct;20(10):1883-5. Epub 2006 Aug 17. No abstract available.

PMID:
16932340
46.

Three-stage contingent screening for Down syndrome.

Wright D, Bradbury I, Cuckle H, Gardosi J, Tonks A, Standing S, Benn P.

Prenat Diagn. 2006 Jun;26(6):528-34.

PMID:
16634118
47.

Classification of stillbirth by relevant condition at death (ReCoDe): population based cohort study.

Gardosi J, Kady SM, McGeown P, Francis A, Tonks A.

BMJ. 2005 Nov 12;331(7525):1113-7. Epub 2005 Oct 19.

48.

Are isolated facial cleft lip and palate associated with increased perinatal mortality? A cohort study from the West Midlands Region, 1995-1997.

Ngai CW, Martin WL, Tonks A, Wyldes MP, Kilby MD.

J Matern Fetal Neonatal Med. 2005 Mar;17(3):203-6.

PMID:
16147824
49.

Optimized retroviral transduction protocol which preserves the primitive subpopulation of human hematopoietic cells.

Tonks A, Tonks AJ, Pearn L, Mohamad Z, Burnett AK, Darley RL.

Biotechnol Prog. 2005 May-Jun;21(3):953-8.

PMID:
15932279
50.

Surfactant phospholipid DPPC downregulates monocyte respiratory burst via modulation of PKC.

Tonks A, Parton J, Tonks AJ, Morris RH, Finall A, Jones KP, Jackson SK.

Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1070-80. Epub 2005 Jan 28.

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