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Items: 1 to 50 of 56

1.

Metabolomic Analysis of Toxoplasma gondii Tachyzoites.

King EFB, Cobbold SA, Uboldi AD, Tonkin CJ, McConville MJ.

Methods Mol Biol. 2020;2071:435-452. doi: 10.1007/978-1-4939-9857-9_22.

PMID:
31758465
2.

Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes.

Wilde ML, Triglia T, Marapana D, Thompson JK, Kouzmitchev AA, Bullen HE, Gilson PR, Cowman AF, Tonkin CJ.

mBio. 2019 Oct 8;10(5). pii: e01972-19. doi: 10.1128/mBio.01972-19.

3.

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii.

Yang L, Uboldi AD, Seizova S, Wilde ML, Coffey MJ, Katris NJ, Yamaryo-Botté Y, Kocan M, Bathgate RAD, Stewart RJ, McConville MJ, Thompson PE, Botté CY, Tonkin CJ.

J Biol Chem. 2019 May 31;294(22):8959-8972. doi: 10.1074/jbc.RA118.005491. Epub 2019 Apr 16.

PMID:
30992368
4.

Impaired social behaviour and molecular mediators of associated neural circuits during chronic Toxoplasma gondii infection in female mice.

Tyebji S, Seizova S, Garnham AL, Hannan AJ, Tonkin CJ.

Brain Behav Immun. 2019 Aug;80:88-108. doi: 10.1016/j.bbi.2019.02.028. Epub 2019 Feb 23.

PMID:
30807837
5.

Characterization of the ATP4 ion pump in Toxoplasma gondii.

Lehane AM, Dennis ASM, Bray KO, Li D, Rajendran E, McCoy JM, McArthur HM, Winterberg M, Rahimi F, Tonkin CJ, Kirk K, van Dooren GG.

J Biol Chem. 2019 Apr 5;294(14):5720-5734. doi: 10.1074/jbc.RA118.006706. Epub 2019 Feb 5.

PMID:
30723156
6.

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.

Gilson PR, Nguyen W, Poole WA, Teixeira JE, Thompson JK, Guo K, Stewart RJ, Ashton TD, White KL, Sanz LM, Gamo FJ, Charman SA, Wittlin S, Duffy J, Tonkin CJ, Tham WH, Crabb BS, Cooke BM, Huston CD, Cowman AF, Sleebs BE.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01804-18. doi: 10.1128/AAC.01804-18. Print 2019 Mar.

7.

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.

Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, Czabotar PE, de Jongh WA, Tham WH, Webb AI, Yu Z, Cowman AF.

Nature. 2019 Jan;565(7737):118-121. doi: 10.1038/s41586-018-0779-6. Epub 2018 Dec 12.

PMID:
30542156
8.

Protein O-fucosyltransferase 2-mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection.

Khurana S, Coffey MJ, John A, Uboldi AD, Huynh MH, Stewart RJ, Carruthers VB, Tonkin CJ, Goddard-Borger ED, Scott NE.

J Biol Chem. 2019 Feb 1;294(5):1541-1553. doi: 10.1074/jbc.RA118.005357. Epub 2018 Dec 4.

9.

Toxoplasmosis: A pathway to neuropsychiatric disorders.

Tyebji S, Seizova S, Hannan AJ, Tonkin CJ.

Neurosci Biobehav Rev. 2019 Jan;96:72-92. doi: 10.1016/j.neubiorev.2018.11.012. Epub 2018 Nov 23. Review.

PMID:
30476506
10.

Aspartyl Protease 5 Matures Dense Granule Proteins That Reside at the Host-Parasite Interface in Toxoplasma gondii.

Coffey MJ, Dagley LF, Seizova S, Kapp EA, Infusini G, Roos DS, Boddey JA, Webb AI, Tonkin CJ.

mBio. 2018 Oct 30;9(5). pii: e01796-18. doi: 10.1128/mBio.01796-18.

11.

Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii.

Uboldi AD, Wilde ML, McRae EA, Stewart RJ, Dagley LF, Yang L, Katris NJ, Hapuarachchi SV, Coffey MJ, Lehane AM, Botte CY, Waller RF, Webb AI, McConville MJ, Tonkin CJ.

PLoS Biol. 2018 Sep 12;16(9):e2005642. doi: 10.1371/journal.pbio.2005642. eCollection 2018 Sep.

12.

Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase.

Seidi A, Muellner-Wong LS, Rajendran E, Tjhin ET, Dagley LF, Aw VY, Faou P, Webb AI, Tonkin CJ, van Dooren GG.

Elife. 2018 Sep 11;7. pii: e38131. doi: 10.7554/eLife.38131.

13.

Plasmodium falciparum subtilisin-like ookinete protein SOPT plays an important and conserved role during ookinete infection of the Anopheles stephensi midgut.

Armistead JS, Jennison C, O'Neill MT, Lopaticki S, Liehl P, Hanson KK, Annoura T, Rajasekaran P, Erickson SM, Tonkin CJ, Khan SM, Mota MM, Boddey JA.

Mol Microbiol. 2018 Aug;109(4):458-473. doi: 10.1111/mmi.13993. Epub 2018 Sep 15.

PMID:
29873127
14.

MYR1-Dependent Effectors Are the Major Drivers of a Host Cell's Early Response to Toxoplasma, Including Counteracting MYR1-Independent Effects.

Naor A, Panas MW, Marino N, Coffey MJ, Tonkin CJ, Boothroyd JC.

mBio. 2018 Apr 3;9(2). pii: e02401-17. doi: 10.1128/mBio.02401-17.

15.

Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria.

Fernandez-Ruiz D, Lau LS, Ghazanfari N, Jones CM, Ng WY, Davey GM, Berthold D, Holz L, Kato Y, Enders MH, Bayarsaikhan G, Hendriks SH, Lansink LIM, Engel JA, Soon MSF, James KR, Cozijnsen A, Mollard V, Uboldi AD, Tonkin CJ, de Koning-Ward TF, Gilson PR, Kaisho T, Haque A, Crabb BS, Carbone FR, McFadden GI, Heath WR.

J Immunol. 2017 Dec 15;199(12):4165-4179. doi: 10.4049/jimmunol.1700186. Epub 2017 Oct 30.

16.

The Molecular Basis of Erythrocyte Invasion by Malaria Parasites.

Cowman AF, Tonkin CJ, Tham WH, Duraisingh MT.

Cell Host Microbe. 2017 Aug 9;22(2):232-245. doi: 10.1016/j.chom.2017.07.003. Review.

17.

A forward genetic screen identifies a negative regulator of rapid Ca2+-dependent cell egress (MS1) in the intracellular parasite Toxoplasma gondii.

McCoy JM, Stewart RJ, Uboldi AD, Li D, Schröder J, Scott NE, Papenfuss AT, Lehane AM, Foster LJ, Tonkin CJ.

J Biol Chem. 2017 May 5;292(18):7662-7674. doi: 10.1074/jbc.M117.775114. Epub 2017 Mar 3.

18.

Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion.

Johnson S, Rahmani R, Drew DR, Williams MJ, Wilkinson M, Tan YH, Huang JX, Tonkin CJ, Beeson JG, Baum J, Smith BJ, Baell JB.

J Med Chem. 2016 Dec 22;59(24):10994-11005. doi: 10.1021/acs.jmedchem.6b01109. Epub 2016 Dec 2.

19.

Analysis of Ca2+ mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules.

Stewart RJ, Whitehead L, Nijagal B, Sleebs BE, Lessene G, McConville MJ, Rogers KL, Tonkin CJ.

Cell Microbiol. 2017 Apr;19(4). doi: 10.1111/cmi.12685. Epub 2017 Jan 9.

PMID:
27781359
20.

Role of the ER and Golgi in protein export by Apicomplexa.

Coffey MJ, Jennison C, Tonkin CJ, Boddey JA.

Curr Opin Cell Biol. 2016 Aug;41:18-24. doi: 10.1016/j.ceb.2016.03.007. Epub 2016 Mar 25. Review.

PMID:
27019341
21.

Regulation of Starch Stores by a Ca(2+)-Dependent Protein Kinase Is Essential for Viable Cyst Development in Toxoplasma gondii.

Uboldi AD, McCoy JM, Blume M, Gerlic M, Ferguson DJ, Dagley LF, Beahan CT, Stapleton DI, Gooley PR, Bacic A, Masters SL, Webb AI, McConville MJ, Tonkin CJ.

Cell Host Microbe. 2015 Dec 9;18(6):670-81. doi: 10.1016/j.chom.2015.11.004.

22.

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell.

Coffey MJ, Sleebs BE, Uboldi AD, Garnham A, Franco M, Marino ND, Panas MW, Ferguson DJ, Enciso M, O'Neill MT, Lopaticki S, Stewart RJ, Dewson G, Smyth GK, Smith BJ, Masters SL, Boothroyd JC, Boddey JA, Tonkin CJ.

Elife. 2015 Nov 18;4. pii: e10809. doi: 10.7554/eLife.10809.

23.

Phosphorylation of αSNAP is Required for Secretory Organelle Biogenesis in Toxoplasma gondii.

Stewart RJ, Ferguson DJ, Whitehead L, Bradin CH, Wu HJ, Tonkin CJ.

Traffic. 2016 Feb;17(2):102-16. doi: 10.1111/tra.12348. Epub 2015 Dec 14.

24.

Two Essential Light Chains Regulate the MyoA Lever Arm To Promote Toxoplasma Gliding Motility.

Williams MJ, Alonso H, Enciso M, Egarter S, Sheiner L, Meissner M, Striepen B, Smith BJ, Tonkin CJ.

mBio. 2015 Sep 15;6(5):e00845-15. doi: 10.1128/mBio.00845-15.

25.

Disassembly activity of actin-depolymerizing factor (ADF) is associated with distinct cellular processes in apicomplexan parasites.

Haase S, Zimmermann D, Olshina MA, Wilkinson M, Fisher F, Tan YH, Stewart RJ, Tonkin CJ, Wong W, Kovar DR, Baum J.

Mol Biol Cell. 2015 Sep 1;26(17):3001-12. doi: 10.1091/mbc.E14-10-1427. Epub 2015 Jul 8.

26.

Association between femur size and a focal defect of the superior femoral neck.

Gee AH, Treece GM, Tonkin CJ, Black DM, Poole KES.

Bone. 2015 Dec;81:60-66. doi: 10.1016/j.bone.2015.06.024. Epub 2015 Jul 2.

27.

Rhomboid proteases in invasion and replication of Apicomplexa.

Stewart RJ, Tonkin CJ.

Mol Microbiol. 2015 Jul;97(2):185-8. doi: 10.1111/mmi.13032. Epub 2015 May 26.

28.

Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites.

Howard BL, Harvey KL, Stewart RJ, Azevedo MF, Crabb BS, Jennings IG, Sanders PR, Manallack DT, Thompson PE, Tonkin CJ, Gilson PR.

ACS Chem Biol. 2015 Apr 17;10(4):1145-54. doi: 10.1021/cb501004q. Epub 2015 Feb 4.

PMID:
25555060
29.

An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes.

Kremer K, Kamin D, Rittweger E, Wilkes J, Flammer H, Mahler S, Heng J, Tonkin CJ, Langsley G, Hell SW, Carruthers VB, Ferguson DJ, Meissner M.

PLoS Pathog. 2013 Mar;9(3):e1003213. doi: 10.1371/journal.ppat.1003213. Epub 2013 Mar 7.

30.

TgCDPK3 regulates calcium-dependent egress of Toxoplasma gondii from host cells.

McCoy JM, Whitehead L, van Dooren GG, Tonkin CJ.

PLoS Pathog. 2012;8(12):e1003066. doi: 10.1371/journal.ppat.1003066. Epub 2012 Dec 4.

31.

Calcium and repression in malaria sex: knowing when the time is right.

McCoy JM, Tonkin CJ.

Cell Host Microbe. 2012 Jul 19;12(1):1-2. doi: 10.1016/j.chom.2012.07.003.

32.

Spatial localisation of actin filaments across developmental stages of the malaria parasite.

Angrisano F, Riglar DT, Sturm A, Volz JC, Delves MJ, Zuccala ES, Turnbull L, Dekiwadia C, Olshina MA, Marapana DS, Wong W, Mollard V, Bradin CH, Tonkin CJ, Gunning PW, Ralph SA, Whitchurch CB, Sinden RE, Cowman AF, McFadden GI, Baum J.

PLoS One. 2012;7(2):e32188. doi: 10.1371/journal.pone.0032188. Epub 2012 Feb 28.

33.

Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex.

Nebl T, Prieto JH, Kapp E, Smith BJ, Williams MJ, Yates JR 3rd, Cowman AF, Tonkin CJ.

PLoS Pathog. 2011 Sep;7(9):e1002222. doi: 10.1371/journal.ppat.1002222. Epub 2011 Sep 29.

34.

Microbiology. A tail of division.

Cowman AF, Tonkin CJ.

Science. 2011 Jan 28;331(6016):409-10. doi: 10.1126/science.1201692. No abstract available.

PMID:
21273475
35.

Potential epigenetic regulatory proteins localise to distinct nuclear sub-compartments in Plasmodium falciparum.

Volz J, Carvalho TG, Ralph SA, Gilson P, Thompson J, Tonkin CJ, Langer C, Crabb BS, Cowman AF.

Int J Parasitol. 2010 Jan;40(1):109-21. doi: 10.1016/j.ijpara.2009.09.002. Epub 2009 Sep 16.

PMID:
19765590
36.

A novel family of Apicomplexan glideosome-associated proteins with an inner membrane-anchoring role.

Bullen HE, Tonkin CJ, O'Donnell RA, Tham WH, Papenfuss AT, Gould S, Cowman AF, Crabb BS, Gilson PR.

J Biol Chem. 2009 Sep 11;284(37):25353-63. doi: 10.1074/jbc.M109.036772. Epub 2009 Jun 26.

37.

Characterization of two putative protein translocation components in the apicoplast of Plasmodium falciparum.

Kalanon M, Tonkin CJ, McFadden GI.

Eukaryot Cell. 2009 Aug;8(8):1146-54. doi: 10.1128/EC.00061-09. Epub 2009 Jun 5.

38.

Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum.

Tonkin CJ, Carret CK, Duraisingh MT, Voss TS, Ralph SA, Hommel M, Duffy MF, Silva LM, Scherf A, Ivens A, Speed TP, Beeson JG, Cowman AF.

PLoS Biol. 2009 Apr 14;7(4):e84. doi: 10.1371/journal.pbio.1000084.

39.

Evolution of malaria parasite plastid targeting sequences.

Tonkin CJ, Foth BJ, Ralph SA, Struck N, Cowman AF, McFadden GI.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4781-5. doi: 10.1073/pnas.0707827105. Epub 2008 Mar 19.

40.

A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion.

Baum J, Tonkin CJ, Paul AS, Rug M, Smith BJ, Gould SB, Richard D, Pollard TD, Cowman AF.

Cell Host Microbe. 2008 Mar 13;3(3):188-98. doi: 10.1016/j.chom.2008.02.006.

41.

Protein targeting to the malaria parasite plastid.

Tonkin CJ, Kalanon M, McFadden GI.

Traffic. 2008 Feb;9(2):166-75. Epub 2007 Nov 13. Review.

42.

Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum.

Voss TS, Tonkin CJ, Marty AJ, Thompson JK, Healer J, Crabb BS, Cowman AF.

Mol Microbiol. 2007 Oct;66(1):139-50. Epub 2007 Aug 28.

43.

High level expression of proteins using sequences from the ferritin heavy chain gene locus.

Prentice HL, Tonkin CJ, Caamano L, Sisk WP.

J Biotechnol. 2007 Jan 30;128(1):50-60. Epub 2006 Nov 2.

PMID:
17083990
44.

Differences in trabecular structure between knees with and without osteoarthritis quantified by macro and standard radiography, respectively.

Messent EA, Ward RJ, Tonkin CJ, Buckland-Wright C.

Osteoarthritis Cartilage. 2006 Dec;14(12):1302-5. Epub 2006 Sep 20.

45.

N-terminal positively charged amino acids, but not their exact position, are important for apicoplast transit peptide fidelity in Toxoplasma gondii.

Tonkin CJ, Roos DS, McFadden GI.

Mol Biochem Parasitol. 2006 Dec;150(2):192-200. Epub 2006 Aug 28.

PMID:
16963133
46.

Osteophytes, juxta-articular radiolucencies and cancellous bone changes in the proximal tibia of patients with knee osteoarthritis.

Messent EA, Ward RJ, Tonkin CJ, Buckland-Wright C.

Osteoarthritis Cartilage. 2007 Feb;15(2):179-86. Epub 2006 Aug 14.

47.

Protein targeting to destinations of the secretory pathway in the malaria parasite Plasmodium falciparum.

Tonkin CJ, Pearce JA, McFadden GI, Cowman AF.

Curr Opin Microbiol. 2006 Aug;9(4):381-7. Epub 2006 Jul 7. Review.

PMID:
16828333
48.

Evidence for Golgi-independent transport from the early secretory pathway to the plastid in malaria parasites.

Tonkin CJ, Struck NS, Mullin KA, Stimmler LM, McFadden GI.

Mol Microbiol. 2006 Aug;61(3):614-30. Epub 2006 Jun 20.

49.

Cancellous bone changes in hip osteoarthritis: a short-term longitudinal study using fractal signature analysis.

Papaloucas CD, Ward RJ, Tonkin CJ, Buckland-Wright C.

Osteoarthritis Cartilage. 2005 Nov;13(11):998-1003. Epub 2005 Sep 9.

50.

Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes.

Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, Duraisingh MT, Maier AG, Winzeler EA, Cowman AF.

Science. 2005 Aug 26;309(5739):1384-7.

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