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Items: 32


Preferred end coordinates and somatic variants as signatures of circulating tumor DNA associated with hepatocellular carcinoma.

Jiang P, Sun K, Tong YK, Cheng SH, Cheng THT, Heung MMS, Wong J, Wong VWS, Chan HLY, Chan KCA, Lo YMD, Chiu RWK.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10925-E10933. doi: 10.1073/pnas.1814616115. Epub 2018 Oct 29.


Sequencing-based counting and size profiling of plasma Epstein-Barr virus DNA enhance population screening of nasopharyngeal carcinoma.

Lam WKJ, Jiang P, Chan KCA, Cheng SH, Zhang H, Peng W, Tse OYO, Tong YK, Gai W, Zee BCY, Ma BBY, Hui EP, Chan ATC, Woo JKS, Chiu RWK, Lo YMD.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5115-E5124. doi: 10.1073/pnas.1804184115. Epub 2018 May 14.


Gestational Age Assessment by Methylation and Size Profiling of Maternal Plasma DNA: A Feasibility Study.

Jiang P, Tong YK, Sun K, Cheng SH, Leung TY, Chan KC, Chiu RW, Lo YM.

Clin Chem. 2017 Feb;63(2):606-608. doi: 10.1373/clinchem.2016.265702. Epub 2016 Dec 15. No abstract available.


Universal Haplotype-Based Noninvasive Prenatal Testing for Single Gene Diseases.

Hui WW, Jiang P, Tong YK, Lee WS, Cheng YK, New MI, Kadir RA, Chan KC, Leung TY, Lo YM, Chiu RW.

Clin Chem. 2017 Feb;63(2):513-524. doi: 10.1373/clinchem.2016.268375. Epub 2016 Dec 8.


Second generation noninvasive fetal genome analysis reveals de novo mutations, single-base parental inheritance, and preferred DNA ends.

Chan KC, Jiang P, Sun K, Cheng YK, Tong YK, Cheng SH, Wong AI, Hudecova I, Leung TY, Chiu RW, Lo YM.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8159-E8168. Epub 2016 Oct 31.


Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments.

Sun K, Jiang P, Chan KC, Wong J, Cheng YK, Liang RH, Chan WK, Ma ES, Chan SL, Cheng SH, Chan RW, Tong YK, Ng SS, Wong RS, Hui DS, Leung TN, Leung TY, Lai PB, Chiu RW, Lo YM.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5503-12. doi: 10.1073/pnas.1508736112. Epub 2015 Sep 21.


Noninvasive prenatal diagnosis of congenital adrenal hyperplasia using cell-free fetal DNA in maternal plasma.

New MI, Tong YK, Yuen T, Jiang P, Pina C, Chan KC, Khattab A, Liao GJ, Yau M, Kim SM, Chiu RW, Sun L, Zaidi M, Lo YM.

J Clin Endocrinol Metab. 2014 Jun;99(6):E1022-30. doi: 10.1210/jc.2014-1118. Epub 2014 Feb 28.


Technical concerns about immunoprecipitation of methylated fetal DNA for noninvasive trisomy 21 diagnosis.

Tong YK, Chiu RW, Chan KC, Leung TY, Lo YM.

Nat Med. 2012 Sep;18(9):1327-8; author reply 1328-9. doi: 10.1038/nm.2915. No abstract available.


Proteomic analysis reveals platelet factor 4 and beta-thromboglobulin as prognostic markers in severe acute respiratory syndrome.

Poon TC, Pang RT, Chan KC, Lee NL, Chiu RW, Tong YK, Chim SS, Ngai SM, Sung JJ, Lo YM.

Electrophoresis. 2012 Jul;33(12):1894-900. doi: 10.1002/elps.201200002.


Epigenetic-genetic chromosome dosage approach for fetal trisomy 21 detection using an autosomal genetic reference marker.

Tong YK, Chiu RW, Akolekar R, Leung TY, Lau TK, Nicolaides KH, Lo YM.

PLoS One. 2010 Dec 20;5(12):e15244. doi: 10.1371/journal.pone.0015244.


Proteomic profiling in SARS: diagnostic and prognostic applications.

Poon TC, Pang RT, Chan KC, Lee NL, Chiu RW, Tong YK, Chim SS, Ngai SM, Sung JJ, Lo YM.

Hong Kong Med J. 2009 Dec;15 Suppl 8:15-8. No abstract available.


Noninvasive prenatal detection of trisomy 21 by an epigenetic-genetic chromosome-dosage approach.

Tong YK, Jin S, Chiu RW, Ding C, Chan KC, Leung TY, Yu L, Lau TK, Lo YM.

Clin Chem. 2010 Jan;56(1):90-8. doi: 10.1373/clinchem.2009.134114. Epub 2009 Oct 22.


Real-time PCR detection of male-specific coliphages.

Yong SF, Ngeow YF, Tong YK, Ong JT.

Malays J Pathol. 2006 Dec;28(2):79-82.


Systematic search for placental DNA-methylation markers on chromosome 21: toward a maternal plasma-based epigenetic test for fetal trisomy 21.

Chim SS, Jin S, Lee TY, Lun FM, Lee WS, Chan LY, Jin Y, Yang N, Tong YK, Leung TY, Lau TK, Ding C, Chiu RW, Lo YM.

Clin Chem. 2008 Mar;54(3):500-11. doi: 10.1373/clinchem.2007.098731. Epub 2008 Jan 17.


Detection of restriction enzyme-digested target DNA by PCR amplification using a stem-loop primer: application to the detection of hypomethylated fetal DNA in maternal plasma.

Tong YK, Chiu RW, Leung TY, Ding C, Lau TK, Leung TN, Lo YM.

Clin Chem. 2007 Nov;53(11):1906-14. Epub 2007 Sep 27.


Hypermethylation of RASSF1A in human and rhesus placentas.

Chiu RW, Chim SS, Wong IH, Wong CS, Lee WS, To KF, Tong JH, Yuen RK, Shum AS, Chan JK, Chan LY, Yuen JW, Tong YK, Weier JF, Ferlatte C, Leung TN, Lau TK, Lo KW, Lo YM.

Am J Pathol. 2007 Mar;170(3):941-50.


Noninvasive prenatal detection of fetal trisomy 18 by epigenetic allelic ratio analysis in maternal plasma: Theoretical and empirical considerations.

Tong YK, Ding C, Chiu RW, Gerovassili A, Chim SS, Leung TY, Leung TN, Lau TK, Nicolaides KH, Lo YM.

Clin Chem. 2006 Dec;52(12):2194-202. Epub 2006 Oct 13.


Serum amyloid A is not useful in the diagnosis of severe acute respiratory syndrome.

Pang RT, Poon TC, Chan KC, Lee NL, Chiu RW, Tong YK, Chim SS, Sung JJ, Lo YM.

Clin Chem. 2006 Jun;52(6):1202-4. No abstract available.


Plasma epigenetic markers for cancer detection and prenatal diagnosis.

Tong YK, Lo YM.

Front Biosci. 2006 Sep 1;11:2647-56. Review.


Serum proteomic fingerprints of adult patients with severe acute respiratory syndrome.

Pang RT, Poon TC, Chan KC, Lee NL, Chiu RW, Tong YK, Wong RM, Chim SS, Ngai SM, Sung JJ, Lo YM.

Clin Chem. 2006 Mar;52(3):421-9. Epub 2006 Jan 19.


Detection of the placental epigenetic signature of the maspin gene in maternal plasma.

Chim SS, Tong YK, Chiu RW, Lau TK, Leung TN, Chan LY, Oudejans CB, Ding C, Lo YM.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14753-8. Epub 2005 Oct 3.


Diagnostic developments involving cell-free (circulating) nucleic acids.

Tong YK, Lo YM.

Clin Chim Acta. 2006 Jan;363(1-2):187-96. Epub 2005 Aug 26. Review.


Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study.

Chan KC, Tang NL, Hui DS, Chung GT, Wu AK, Chim SS, Chiu RW, Lee N, Choi KW, Sung YM, Chan PK, Tong YK, Lai ST, Yu WC, Tsang O, Lo YM.

BMC Infect Dis. 2005 Apr 9;5:26.


Tracing SARS-coronavirus variant with large genomic deletion.

Chiu RW, Chim SS, Tong YK, Fung KS, Chan PK, Zhao GP, Lo YM.

Emerg Infect Dis. 2005 Jan;11(1):168-70. No abstract available.


ACE2 gene polymorphisms do not affect outcome of severe acute respiratory syndrome.

Chiu RW, Tang NL, Hui DS, Chung GT, Chim SS, Chan KC, Sung YM, Chan LY, Tong YK, Lee WS, Chan PK, Lo YM.

Clin Chem. 2004 Sep;50(9):1683-6. No abstract available.


Serial analysis of plasma proteomic signatures in pediatric patients with severe acute respiratory syndrome and correlation with viral load.

Poon TC, Chan KC, Ng PC, Chiu RW, Ang IL, Tong YK, Ng EK, Cheng FW, Li AM, Hon EK, Fok TF, Lo YM.

Clin Chem. 2004 Aug;50(8):1452-5. Epub 2004 Jun 3. No abstract available.


Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling.

Tsui NB, Chim SS, Chiu RW, Lau TK, Ng EK, Leung TN, Tong YK, Chan KC, Lo YM.

J Med Genet. 2004 Jun;41(6):461-7. No abstract available.


Genomic sequencing of a SARS coronavirus isolate that predated the Metropole Hotel case cluster in Hong Kong.

Chim SS, Tong YK, Hung EC, Chiu RW, Lo YM.

Clin Chem. 2004 Jan;50(1):231-3. No abstract available.


Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong.

Chim SS, Tsui SK, Chan KC, Au TC, Hung EC, Tong YK, Chiu RW, Ng EK, Chan PK, Chu CM, Sung JJ, Tam JS, Fung KP, Waye MM, Lee CY, Yuen KY, Lo YM; CUHK Molecular SARS Research Group.

Lancet. 2003 Nov 29;362(9398):1807-8.


Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome.

Hung EC, Chim SS, Chan PK, Tong YK, Ng EK, Chiu RW, Leung CB, Sung JJ, Tam JS, Lo YM.

Clin Chem. 2003 Dec;49(12):2108-9. No abstract available.


Quantitative analysis and prognostic implication of SARS coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome.

Ng EK, Hui DS, Chan KC, Hung EC, Chiu RW, Lee N, Wu A, Chim SS, Tong YK, Sung JJ, Tam JS, Lo YM.

Clin Chem. 2003 Dec;49(12):1976-80.


12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs.

Han ZT, Tong YK, He LM, Zhang Y, Sun JZ, Wang TY, Zhang H, Cui YL, Newmark HL, Conney AH, Chang RL.

Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5362-5.

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