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Items: 46


Testosterone Reduces Fear and Causes Drastic Hypomethylation of Arginine Vasopressin Promoter in Medial Extended Amygdala of Male Mice.

Tong WH, Abdulai-Saiku S, Vyas A.

Front Behav Neurosci. 2019 Feb 26;13:33. doi: 10.3389/fnbeh.2019.00033. eCollection 2019.


TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation.

Tong WH, Maio N, Zhang DL, Palmieri EM, Ollivierre H, Ghosh MC, McVicar DW, Rouault TA.

Blood Adv. 2018 May 22;2(10):1146-1156. doi: 10.1182/bloodadvances.2018015669.


Comment on 'Blinatumomab vs historical standard therapy of adult relapsed/refractory acute lymphoblastic leukemia'.

Tong WH.

Blood Cancer J. 2016 Dec 9;6(12):e509. doi: 10.1038/bcj.2016.119. No abstract available.


A vertical-flow bioreactor array compacts hepatocytes for enhanced polarity and functions.

Zhu L, Xia H, Wang Z, Fong EL, Fan J, Tong WH, Seah YP, Zhang W, Li Q, Yu H.

Lab Chip. 2016 Oct 5;16(20):3898-3908.


Constrained spheroids for prolonged hepatocyte culture.

Tong WH, Fang Y, Yan J, Hong X, Hari Singh N, Wang SR, Nugraha B, Xia L, Fong ELS, Iliescu C, Yu H.

Biomaterials. 2016 Feb;80:106-120. doi: 10.1016/j.biomaterials.2015.11.036. Epub 2015 Dec 3.


Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients.

Wang L, Liu LH, Tong WH, Wang MX, Lu SC.

Genet Mol Res. 2015 Nov 26;14(4):15148-57. doi: 10.4238/2015.November.25.3.


Inactivation of GDP-fucose transporter gene (Slc35c1) in CHO cells by ZFNs, TALENs and CRISPR-Cas9 for production of fucose-free antibodies.

Chan KF, Shahreel W, Wan C, Teo G, Hayati N, Tay SJ, Tong WH, Yang Y, Rudd PM, Zhang P, Song Z.

Biotechnol J. 2016 Mar;11(3):399-414. doi: 10.1002/biot.201500331. Epub 2015 Dec 11.


Ammonia Levels Should Not Be Used as a Surrogate Marker of Levels of Asparaginase Activity in Acute Lymphoblastic Leukemia Patients.

Tong WH, Pieters R, van der Sluis IM.

Pediatr Blood Cancer. 2016 Mar;63(3):564-5. doi: 10.1002/pbc.25767. Epub 2015 Sep 23. No abstract available.


Establishment of a three-step purification scheme for a recombinant protein rG17PE38 and its characteristics identification.

Feng XL, Liu ZS, Liu XL, Lu SY, Li YS, Hu P, Yan DM, Tong WH, Wang Q, Zhou Y, Jin W, Ding YX, Gai DX, Ren HL.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Feb 15;981-982:48-56. doi: 10.1016/j.jchromb.2015.01.008. Epub 2015 Jan 12.


Biochemical and biophysical methods for studying mitochondrial iron metabolism.

Holmes-Hampton GP, Tong WH, Rouault TA.

Methods Enzymol. 2014;547:275-307. doi: 10.1016/B978-0-12-801415-8.00015-1.


The toxicity of very prolonged courses of PEGasparaginase or Erwinia asparaginase in relation to asparaginase activity, with a special focus on dyslipidemia.

Tong WH, Pieters R, de Groot-Kruseman HA, Hop WC, Boos J, Tissing WJ, van der Sluis IM.

Haematologica. 2014 Nov;99(11):1716-21. doi: 10.3324/haematol.2014.109413. Epub 2014 Aug 22.


Disturbed CXCR4/CXCL12 axis in paediatric precursor B-cell acute lymphoblastic leukaemia.

van den Berk LC, van der Veer A, Willemse ME, Theeuwes MJ, Luijendijk MW, Tong WH, van der Sluis IM, Pieters R, den Boer ML.

Br J Haematol. 2014 Jul;166(2):240-9. doi: 10.1111/bjh.12883. Epub 2014 Apr 4.


Desensitization protocol should not be used in acute lymphoblastic leukemia patients with silent inactivation of PEGasparaginase.

Tong WH, Pieters R, Tissing WJ, van der Sluis IM.

Haematologica. 2014 Jul;99(7):e102-4. doi: 10.3324/haematol.2013.099663. Epub 2014 Mar 28. No abstract available.


Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery.

Maio N, Singh A, Uhrigshardt H, Saxena N, Tong WH, Rouault TA.

Cell Metab. 2014 Mar 4;19(3):445-57. doi: 10.1016/j.cmet.2014.01.015.


A prospective study on drug monitoring of PEGasparaginase and Erwinia asparaginase and asparaginase antibodies in pediatric acute lymphoblastic leukemia.

Tong WH, Pieters R, Kaspers GJ, te Loo DM, Bierings MB, van den Bos C, Kollen WJ, Hop WC, Lanvers-Kaminsky C, Relling MV, Tissing WJ, van der Sluis IM.

Blood. 2014 Mar 27;123(13):2026-33. doi: 10.1182/blood-2013-10-534347. Epub 2014 Jan 21.


Laparoscopic radical resection of low rectal carcinoma integrating transanal endoscopic microsurgery: a case report.

Yang JP, Tong WH, Wang Q, Suo J, Sun DH.

Indian J Surg. 2013 Jun;75(Suppl 1):280-2. doi: 10.1007/s12262-012-0671-9. Epub 2012 Jul 7.


Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle.

Crooks DR, Natarajan TG, Jeong SY, Chen C, Park SY, Huang H, Ghosh MC, Tong WH, Haller RG, Wu C, Rouault TA.

Hum Mol Genet. 2014 Jan 1;23(1):24-39. doi: 10.1093/hmg/ddt393. Epub 2013 Aug 13.


Asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.

Tong WH, Pieters R, Hop WC, van der Sluis IM.

Pediatr Blood Cancer. 2013 Nov;60(11):1914. doi: 10.1002/pbc.24661. Epub 2013 Jun 29. No abstract available.


Cost-analysis of treatment of childhood acute lymphoblastic leukemia with asparaginase preparations: the impact of expensive chemotherapy.

Tong WH, van der Sluis IM, Alleman CJ, van Litsenburg RR, Kaspers GJ, Pieters R, Uyl-de Groot CA.

Haematologica. 2013 May;98(5):753-9. doi: 10.3324/haematol.2012.073510. Epub 2013 Feb 12.


Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

Ghosh MC, Zhang DL, Jeong SY, Kovtunovych G, Ollivierre-Wilson H, Noguchi A, Tu T, Senecal T, Robinson G, Crooks DR, Tong WH, Ramaswamy K, Singh A, Graham BB, Tuder RM, Yu ZX, Eckhaus M, Lee J, Springer DA, Rouault TA.

Cell Metab. 2013 Feb 5;17(2):271-81. doi: 10.1016/j.cmet.2012.12.016.


Tissue specificity of a human mitochondrial disease: differentiation-enhanced mis-splicing of the Fe-S scaffold gene ISCU renders patient cells more sensitive to oxidative stress in ISCU myopathy.

Crooks DR, Jeong SY, Tong WH, Ghosh MC, Olivierre H, Haller RG, Rouault TA.

J Biol Chem. 2012 Nov 23;287(48):40119-30. doi: 10.1074/jbc.M112.418889. Epub 2012 Oct 3.


No evidence of increased asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.

Tong WH, Pieters R, Hop WC, Lanvers-Kaminsky C, Boos J, van der Sluis IM.

Pediatr Blood Cancer. 2013 Feb;60(2):258-61. doi: 10.1002/pbc.24292. Epub 2012 Sep 7.


Tethered spheroids as an in vitro hepatocyte model for drug safety screening.

Xia L, Sakban RB, Qu Y, Hong X, Zhang W, Nugraha B, Tong WH, Ananthanarayanan A, Zheng B, Chau IY, Jia R, McMillian M, Silva J, Dallas S, Yu H.

Biomaterials. 2012 Mar;33(7):2165-76. doi: 10.1016/j.biomaterials.2011.12.006. Epub 2011 Dec 19.


Successful management of extreme hypertriglyceridemia in a child with acute lymphoblastic leukemia by temporarily omitting dexamethasone while continuing asparaginase.

Tong WH, Pieters R, van der Sluis IM.

Pediatr Blood Cancer. 2012 Feb;58(2):317-8. doi: 10.1002/pbc.23266. Epub 2011 Aug 29. No abstract available.


Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes.

Cameron JM, Janer A, Levandovskiy V, Mackay N, Rouault TA, Tong WH, Ogilvie I, Shoubridge EA, Robinson BH.

Am J Hum Genet. 2011 Oct 7;89(4):486-95. doi: 10.1016/j.ajhg.2011.08.011. Epub 2011 Sep 22.


The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.

Tong WH, Sourbier C, Kovtunovych G, Jeong SY, Vira M, Ghosh M, Romero VV, Sougrat R, Vaulont S, Viollet B, Kim YS, Lee S, Trepel J, Srinivasan R, Bratslavsky G, Yang Y, Linehan WM, Rouault TA.

Cancer Cell. 2011 Sep 13;20(3):315-27. doi: 10.1016/j.ccr.2011.07.018.


Exploitation of physical and chemical constraints for three-dimensional microtissue construction in microfluidics.

Choudhury D, Mo X, Iliescu C, Tan LL, Tong WH, Yu H.

Biomicrofluidics. 2011 Jun;5(2):22203. doi: 10.1063/1.3593407. Epub 2011 Jun 29.


Omphalocele: comparison of outcome following prenatal or postnatal diagnosis.

Cohen-Overbeek TE, Tong WH, Hatzmann TR, Wilms JF, Govaerts LC, Galjaard RJ, Steegers EA, Hop WC, Wladimiroff JW, Tibboel D.

Ultrasound Obstet Gynecol. 2010 Dec;36(6):687-92. doi: 10.1002/uog.7698. Epub 2010 May 27.


Increased adverse perinatal outcome of hospital delivery at night.

de Graaf JP, Ravelli AC, Visser GH, Hukkelhoven C, Tong WH, Bonsel GJ, Steegers EA.

BJOG. 2010 Aug;117(9):1098-107. doi: 10.1111/j.1471-0528.2010.02611.x. Epub 2010 May 25.


Iron control of erythroid development by a novel aconitase-associated regulatory pathway.

Bullock GC, Delehanty LL, Talbot AL, Gonias SL, Tong WH, Rouault TA, Dewar B, Macdonald JM, Chruma JJ, Goldfarb AN.

Blood. 2010 Jul 8;116(1):97-108. doi: 10.1182/blood-2009-10-251496. Epub 2010 Apr 20.


Cell culture on MEMS platforms: a review.

Ni M, Tong WH, Choudhury D, Rahim NA, Iliescu C, Yu H.

Int J Mol Sci. 2009 Dec 18;10(12):5411-41. doi: 10.3390/ijms10125411. Review.


Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.

Crooks DR, Ghosh MC, Haller RG, Tong WH, Rouault TA.

Blood. 2010 Jan 28;115(4):860-9. doi: 10.1182/blood-2009-09-243105. Epub 2009 Nov 25.


Tangled up in red: intertwining of the heme and iron-sulfur cluster biogenesis pathways.

Rouault TA, Tong WH.

Cell Metab. 2009 Aug;10(2):80-1. doi: 10.1016/j.cmet.2009.07.007.


Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis.

Shi Y, Ghosh MC, Tong WH, Rouault TA.

Hum Mol Genet. 2009 Aug 15;18(16):3014-25. doi: 10.1093/hmg/ddp239. Epub 2009 May 18.


Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice.

Ghosh MC, Tong WH, Zhang D, Ollivierre-Wilson H, Singh A, Krishna MC, Mitchell JB, Rouault TA.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12028-33. doi: 10.1073/pnas.0805361105. Epub 2008 Aug 6.


Iron-sulfur cluster biogenesis and human disease.

Rouault TA, Tong WH.

Trends Genet. 2008 Aug;24(8):398-407. doi: 10.1016/j.tig.2008.05.008. Epub 2008 Jul 5. Review.


Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.

Mochel F, Knight MA, Tong WH, Hernandez D, Ayyad K, Taivassalo T, Andersen PM, Singleton A, Rouault TA, Fischbeck KH, Haller RG.

Am J Hum Genet. 2008 Mar;82(3):652-60. doi: 10.1016/j.ajhg.2007.12.012. Epub 2008 Feb 14.


Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis.

Tong WH, Rouault TA.

Biometals. 2007 Jun;20(3-4):549-64. Epub 2007 Jan 5. Review.


Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly.

Li K, Tong WH, Hughes RM, Rouault TA.

J Biol Chem. 2006 May 5;281(18):12344-51. Epub 2006 Mar 9.


Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis.

Rouault TA, Tong WH.

Nat Rev Mol Cell Biol. 2005 Apr;6(4):345-51. Review.


Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster.

Tong WH, Jameson GN, Huynh BH, Rouault TA.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9762-7. Epub 2003 Jul 28.


Use of rapid kinetics methods to study the assembly of the diferric-tyrosyl radical cofactor of E. coli ribonucleotide reductase.

Bollinger JM Jr, Tong WH, Ravi N, Huynh BH, Edmondson DE, Stubbe JA.

Methods Enzymol. 1995;258:278-303.


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