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Items: 48


The effect of cassia seed extract on the regulation of the LKB1-AMPK-GLUT4 signaling pathway in the skeletal muscle of diabetic rats to improve the insulin sensitivity of the skeletal muscle.

Wang QY, Tong AH, Pan YY, Zhang XD, Ding WY, Xiong W.

Diabetol Metab Syndr. 2019 Dec 19;11:108. doi: 10.1186/s13098-019-0504-0. eCollection 2019.


High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting.

Mair B, Aldridge PM, Atwal RS, Philpott D, Zhang M, Masud SN, Labib M, Tong AHY, Sargent EH, Angers S, Moffat J, Kelley SO.

Nat Biomed Eng. 2019 Oct;3(10):796-805. doi: 10.1038/s41551-019-0454-8. Epub 2019 Sep 23.


Pooled CRISPR-Based Genetic Screens in Mammalian Cells.

Chan K, Tong AHY, Brown KR, Mero P, Moffat J.

J Vis Exp. 2019 Sep 4;(151). doi: 10.3791/59780.


Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.

Mair B, Tomic J, Masud SN, Tonge P, Weiss A, Usaj M, Tong AHY, Kwan JJ, Brown KR, Titus E, Atkins M, Chan KSK, Munsie L, Habsid A, Han H, Kennedy M, Cohen B, Keller G, Moffat J.

Cell Rep. 2019 Apr 9;27(2):599-615.e12. doi: 10.1016/j.celrep.2019.02.041.


Overexpression of RYBP inhibits proliferation, invasion, and chemoresistance to cisplatin in anaplastic thyroid cancer cells via the EGFR pathway.

Tong AH, Tan J, Zhang JH, Xu FJ, Li FY, Cao CY.

J Biochem Mol Toxicol. 2019 Feb;33(2):e22241. doi: 10.1002/jbt.22241. Epub 2018 Nov 15.


Pooled Lentiviral CRISPR-Cas9 Screens for Functional Genomics in Mammalian Cells.

Aregger M, Chandrashekhar M, Tong AHY, Chan K, Moffat J.

Methods Mol Biol. 2019;1869:169-188. doi: 10.1007/978-1-4939-8805-1_15.


Whole transcriptome analysis reveals differential gene expression profile reflecting macrophage polarization in response to influenza A H5N1 virus infection.

Zhang N, Bao YJ, Tong AH, Zuyderduyn S, Bader GD, Malik Peiris JS, Lok S, Lee SM.

BMC Med Genomics. 2018 Feb 23;11(1):20. doi: 10.1186/s12920-018-0335-0.


Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.

Hart T, Tong AHY, Chan K, Van Leeuwen J, Seetharaman A, Aregger M, Chandrashekhar M, Hustedt N, Seth S, Noonan A, Habsid A, Sizova O, Nedyalkova L, Climie R, Tworzyanski L, Lawson K, Sartori MA, Alibeh S, Tieu D, Masud S, Mero P, Weiss A, Brown KR, Usaj M, Billmann M, Rahman M, Constanzo M, Myers CL, Andrews BJ, Boone C, Durocher D, Moffat J.

G3 (Bethesda). 2017 Aug 7;7(8):2719-2727. doi: 10.1534/g3.117.041277.


De Novo Genome and Transcriptome Assembly of the Canadian Beaver (Castor canadensis).

Lok S, Paton TA, Wang Z, Kaur G, Walker S, Yuen RK, Sung WW, Whitney J, Buchanan JA, Trost B, Singh N, Apresto B, Chen N, Coole M, Dawson TJ, Ho K, Hu Z, Pullenayegum S, Samler K, Shipstone A, Tsoi F, Wang T, Pereira SL, Rostami P, Ryan CA, Tong AH, Ng K, Sundaravadanam Y, Simpson JT, Lim BK, Engstrom MD, Dutton CJ, Kerr KC, Franke M, Rapley W, Wintle RF, Scherer SW.

G3 (Bethesda). 2017 Feb 9;7(2):755-773. doi: 10.1534/g3.116.038208.


Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes.

Li JW, Lee HM, Wang Y, Tong AH, Yip KY, Tsui SK, Lok S, Ozaki R, Luk AO, Kong AP, So WY, Ma RC, Chan JC, Chan TF.

Sci Rep. 2016 Oct 18;6:35228. doi: 10.1038/srep35228.


Mutations enabling displacement of tryptophan by 4-fluorotryptophan as a canonical amino acid of the genetic code.

Yu AC, Yim AK, Mat WK, Tong AH, Lok S, Xue H, Tsui SK, Wong JT, Chan TF.

Genome Biol Evol. 2014 Mar;6(3):629-41. doi: 10.1093/gbe/evu044.


Biased diversity metrics revealed by bacterial 16S pyrotags derived from different primer sets.

Cai L, Ye L, Tong AH, Lok S, Zhang T.

PLoS One. 2013;8(1):e53649. doi: 10.1371/journal.pone.0053649. Epub 2013 Jan 14.


Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.

Chen L, Li Y, Lin CH, Chan TH, Chow RK, Song Y, Liu M, Yuan YF, Fu L, Kong KL, Qi L, Li Y, Zhang N, Tong AH, Kwong DL, Man K, Lo CM, Lok S, Tenen DG, Guan XY.

Nat Med. 2013 Feb;19(2):209-16. doi: 10.1038/nm.3043. Epub 2013 Jan 6.


Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma.

Ma S, Bao JYJ, Kwan PS, Chan YP, Tong CM, Fu L, Zhang N, Tong AHY, Qin YR, Tsao SW, Chan KW, Lok S, Guan XY.

Gastroenterology. 2012 Sep;143(3):675-686.e12. doi: 10.1053/j.gastro.2012.06.007. Epub 2012 Jun 13.


Molecular characterization of the 2011 Hong Kong scarlet fever outbreak.

Tse H, Bao JY, Davies MR, Maamary P, Tsoi HW, Tong AH, Ho TC, Lin CH, Gillen CM, Barnett TC, Chen JH, Lee M, Yam WC, Wong CK, Ong CL, Chan YW, Wu CW, Ng T, Lim WW, Tsang TH, Tse CW, Dougan G, Walker MJ, Lok S, Yuen KY.

J Infect Dis. 2012 Aug 1;206(3):341-51. doi: 10.1093/infdis/jis362. Epub 2012 May 21.


Genomic sequencing and comparative analysis of Epstein-Barr virus genome isolated from primary nasopharyngeal carcinoma biopsy.

Kwok H, Tong AH, Lin CH, Lok S, Farrell PJ, Kwong DL, Chiang AK.

PLoS One. 2012;7(5):e36939. doi: 10.1371/journal.pone.0036939. Epub 2012 May 10.


Dissemination of pHK01-like incompatibility group IncFII plasmids encoding CTX-M-14 in Escherichia coli from human and animal sources.

Ho PL, Lo WU, Yeung MK, Li Z, Chan J, Chow KH, Yam WC, Tong AH, Bao JY, Lin CH, Lok S, Chiu SS.

Vet Microbiol. 2012 Jul 6;158(1-2):172-9. doi: 10.1016/j.vetmic.2012.02.004. Epub 2012 Feb 11.


Increased exonic de novo mutation rate in individuals with schizophrenia.

Girard SL, Gauthier J, Noreau A, Xiong L, Zhou S, Jouan L, Dionne-Laporte A, Spiegelman D, Henrion E, Diallo O, Thibodeau P, Bachand I, Bao JY, Tong AH, Lin CH, Millet B, Jaafari N, Joober R, Dion PA, Lok S, Krebs MO, Rouleau GA.

Nat Genet. 2011 Jul 10;43(9):860-3. doi: 10.1038/ng.886.


Ammonia-oxidizing archaea and ammonia-oxidizing bacteria in six full-scale wastewater treatment bioreactors.

Zhang T, Ye L, Tong AH, Shao MF, Lok S.

Appl Microbiol Biotechnol. 2011 Aug;91(4):1215-25. doi: 10.1007/s00253-011-3408-y. Epub 2011 Jun 25.


Analysis of the bacterial community in a laboratory-scale nitrification reactor and a wastewater treatment plant by 454-pyrosequencing.

Ye L, Shao MF, Zhang T, Tong AH, Lok S.

Water Res. 2011 Oct 1;45(15):4390-8. doi: 10.1016/j.watres.2011.05.028. Epub 2011 May 31.


Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong.

Ho PL, Lo WU, Yeung MK, Lin CH, Chow KH, Ang I, Tong AH, Bao JY, Lok S, Lo JY.

PLoS One. 2011 Mar 21;6(3):e17989. doi: 10.1371/journal.pone.0017989.


Complete sequencing of the FII plasmid pHK01, encoding CTX-M-14, and molecular analysis of its variants among Escherichia coli from Hong Kong.

Ho PL, Lo WU, Wong RC, Yeung MK, Chow KH, Que TL, Tong AH, Bao JY, Lok S, Wong SS.

J Antimicrob Chemother. 2011 Apr;66(4):752-6. doi: 10.1093/jac/dkr010. Epub 2011 Feb 7.


Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection.

Suzuki Y, St Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, Lehár J, Roth FP.

Nat Methods. 2011 Feb;8(2):159-64. doi: 10.1038/nmeth.1550. Epub 2011 Jan 9.


The genetic landscape of a cell.

Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JL, Toufighi K, Mostafavi S, Prinz J, St Onge RP, VanderSluis B, Makhnevych T, Vizeacoumar FJ, Alizadeh S, Bahr S, Brost RL, Chen Y, Cokol M, Deshpande R, Li Z, Lin ZY, Liang W, Marback M, Paw J, San Luis BJ, Shuteriqi E, Tong AH, van Dyk N, Wallace IM, Whitney JA, Weirauch MT, Zhong G, Zhu H, Houry WA, Brudno M, Ragibizadeh S, Papp B, Pál C, Roth FP, Giaever G, Nislow C, Troyanskaya OG, Bussey H, Bader GD, Gingras AC, Morris QD, Kim PM, Kaiser CA, Myers CL, Andrews BJ, Boone C.

Science. 2010 Jan 22;327(5964):425-31. doi: 10.1126/science.1180823.


Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae.

Federovitch CM, Jones YZ, Tong AH, Boone C, Prinz WA, Hampton RY.

Mol Biol Cell. 2008 Oct;19(10):4506-20. doi: 10.1091/mbc.E07-11-1188. Epub 2008 Jul 30.


Genetic interactions of MAF1 identify a role for Med20 in transcriptional repression of ribosomal protein genes.

Willis IM, Chua G, Tong AH, Brost RL, Hughes TR, Boone C, Moir RD.

PLoS Genet. 2008 Jul 4;4(7):e1000112. doi: 10.1371/journal.pgen.1000112.


Ybp2 associates with the central kinetochore of Saccharomyces cerevisiae and mediates proper mitotic progression.

Ohkuni K, Abdulle R, Tong AH, Boone C, Kitagawa K.

PLoS One. 2008 Feb 20;3(2):e1617. doi: 10.1371/journal.pone.0001617.


Genome-wide, as opposed to local, antisilencing is mediated redundantly by the euchromatic factors Set1 and H2A.Z.

Venkatasubrahmanyam S, Hwang WW, Meneghini MD, Tong AH, Madhani HD.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16609-14. Epub 2007 Oct 9.


Pol32 is required for Pol zeta-dependent translesion synthesis and prevents double-strand breaks at the replication fork.

Hanna M, Ball LG, Tong AH, Boone C, Xiao W.

Mutat Res. 2007 Dec 1;625(1-2):164-76. Epub 2007 Jun 28.


Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle.

Gao XD, Sperber LM, Kane SA, Tong Z, Tong AH, Boone C, Bi E.

Mol Biol Cell. 2007 Jul;18(7):2542-60. Epub 2007 Apr 25.


Inorganic phosphate deprivation causes tRNA nuclear accumulation via retrograde transport in Saccharomyces cerevisiae.

Hurto RL, Tong AH, Boone C, Hopper AK.

Genetics. 2007 Jun;176(2):841-52. Epub 2007 Apr 3.


Genetic and molecular interactions of the Erv41p-Erv46p complex involved in transport between the endoplasmic reticulum and Golgi complex.

Welsh LM, Tong AH, Boone C, Jensen ON, Otte S.

J Cell Sci. 2006 Nov 15;119(Pt 22):4730-40. Epub 2006 Oct 31.


A network of multi-tasking proteins at the DNA replication fork preserves genome stability.

Budd ME, Tong AH, Polaczek P, Peng X, Boone C, Campbell JL.

PLoS Genet. 2005 Dec;1(6):e61. Epub 2005 Dec 2.


Synthetic genetic array analysis in Saccharomyces cerevisiae.

Tong AH, Boone C.

Methods Mol Biol. 2006;313:171-92.


Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network.

Zhang LV, King OD, Wong SL, Goldberg DS, Tong AH, Lesage G, Andrews B, Bussey H, Boone C, Roth FP.

J Biol. 2005;4(2):6. Epub 2005 Jun 1.


An interactional network of genes involved in chitin synthesis in Saccharomyces cerevisiae.

Lesage G, Shapiro J, Specht CA, Sdicu AM, Ménard P, Hussein S, Tong AH, Boone C, Bussey H.

BMC Genet. 2005 Feb 16;6:8.


Combining biological networks to predict genetic interactions.

Wong SL, Zhang LV, Tong AH, Li Z, Goldberg DS, King OD, Lesage G, Vidal M, Andrews B, Bussey H, Boone C, Roth FP.

Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15682-7. Epub 2004 Oct 20.


Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p.

Setty SR, Strochlic TI, Tong AH, Boone C, Burd CG.

Nat Cell Biol. 2004 May;6(5):414-9. Epub 2004 Apr 11.


Global mapping of the yeast genetic interaction network.

Tong AH, Lesage G, Bader GD, Ding H, Xu H, Xin X, Young J, Berriz GF, Brost RL, Chang M, Chen Y, Cheng X, Chua G, Friesen H, Goldberg DS, Haynes J, Humphries C, He G, Hussein S, Ke L, Krogan N, Li Z, Levinson JN, Lu H, Ménard P, Munyana C, Parsons AB, Ryan O, Tonikian R, Roberts T, Sdicu AM, Shapiro J, Sheikh B, Suter B, Wong SL, Zhang LV, Zhu H, Burd CG, Munro S, Sander C, Rine J, Greenblatt J, Peter M, Bretscher A, Bell G, Roth FP, Brown GW, Andrews B, Bussey H, Boone C.

Science. 2004 Feb 6;303(5659):808-13.


Interaction between a Ras and a Rho GTPase couples selection of a growth site to the development of cell polarity in yeast.

Kozminski KG, Beven L, Angerman E, Tong AH, Boone C, Park HO.

Mol Biol Cell. 2003 Dec;14(12):4958-70. Epub 2003 Sep 5.


Synthetic lethal analysis implicates Ste20p, a p21-activated potein kinase, in polarisome activation.

Goehring AS, Mitchell DA, Tong AH, Keniry ME, Boone C, Sprague GF Jr.

Mol Biol Cell. 2003 Apr;14(4):1501-16.


Approaches to Analyze Protein Interactions.

Fields S, Drees B, Hazbun TR, Tucker C, Tong AHY, Evangelista M, Boone C, Nardelli G, Castagnoli L, Zucconi A, Cesareni G, Bader G, Hogue C.

ScientificWorldJournal. 2002 Jan 5;2:93-94. doi: 10.1100/tsw.2002.44. eCollection 2002. No abstract available.


Systematic genetic analysis with ordered arrays of yeast deletion mutants.

Tong AH, Evangelista M, Parsons AB, Xu H, Bader GD, Pagé N, Robinson M, Raghibizadeh S, Hogue CW, Bussey H, Andrews B, Tyers M, Boone C.

Science. 2001 Dec 14;294(5550):2364-8.


A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules.

Tong AH, Drees B, Nardelli G, Bader GD, Brannetti B, Castagnoli L, Evangelista M, Ferracuti S, Nelson B, Paoluzi S, Quondam M, Zucconi A, Hogue CW, Fields S, Boone C, Cesareni G.

Science. 2002 Jan 11;295(5553):321-4. Epub 2001 Dec 13.


A role for myosin-I in actin assembly through interactions with Vrp1p, Bee1p, and the Arp2/3 complex.

Evangelista M, Klebl BM, Tong AH, Webb BA, Leeuw T, Leberer E, Whiteway M, Thomas DY, Boone C.

J Cell Biol. 2000 Jan 24;148(2):353-62.

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