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Cell-to-cell interaction requires optimal positioning of a pilus tip adhesin modulated by gram-positive transpeptidase enzymes.

Chang C, Wu C, Osipiuk J, Siegel SD, Zhu S, Liu X, Joachimiak A, Clubb RT, Das A, Ton-That H.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):18041-18049. doi: 10.1073/pnas.1907733116. Epub 2019 Aug 19.


Is Tracheostomy Insertion an Indication for Gastrostomy Insertion?

Dvorak J, Ridder D, Martin B, Ton-That H, Baldea A, Gonzalez RP.

Am Surg. 2019 May 1;85(5):518-523.


Erratum for Siegel et al., "Structure and Mechanism of LcpA, a Phosphotransferase That Mediates Glycosylation of a Gram-Positive Bacterial Cell Wall-Anchored Protein".

Siegel SD, Amer BR, Wu C, Sawaya MR, Gosschalk JE, Clubb RT, Ton-That H.

MBio. 2019 Apr 16;10(2). pii: e00617-19. doi: 10.1128/mBio.00617-19. No abstract available.


Structure and Mechanism of LcpA, a Phosphotransferase That Mediates Glycosylation of a Gram-Positive Bacterial Cell Wall-Anchored Protein.

Siegel SD, Amer BR, Wu C, Sawaya MR, Gosschalk JE, Clubb RT, Ton-That H.

MBio. 2019 Feb 19;10(1). pii: e01580-18. doi: 10.1128/mBio.01580-18. Erratum in: MBio. 2019 Apr 16;10(2):.


Superusers: Drivers of health care resource utilization in the national trauma population.

Gil LA, Kothari AN, Brownlee SA, Ton-That H, Patel PP, Gonzalez RP, Luchette FA, Anstadt MJ.

Surgery. 2018 Oct;164(4):848-855. doi: 10.1016/j.surg.2018.04.046. Epub 2018 Aug 7.


Protein Labeling via a Specific Lysine-Isopeptide Bond Using the Pilin Polymerizing Sortase from Corynebacterium diphtheriae.

McConnell SA, Amer BR, Muroski J, Fu J, Chang C, Ogorzalek Loo RR, Loo JA, Osipiuk J, Ton-That H, Clubb RT.

J Am Chem Soc. 2018 Jul 11;140(27):8420-8423. doi: 10.1021/jacs.8b05200. Epub 2018 Jun 28.


In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking.

Chang C, Amer BR, Osipiuk J, McConnell SA, Huang IH, Hsieh V, Fu J, Nguyen HH, Muroski J, Flores E, Ogorzalek Loo RR, Loo JA, Putkey JA, Joachimiak A, Das A, Clubb RT, Ton-That H.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5477-E5486. doi: 10.1073/pnas.1800954115. Epub 2018 May 29.


Forward Genetic Dissection of Biofilm Development by Fusobacterium nucleatum: Novel Functions of Cell Division Proteins FtsX and EnvC.

Wu C, Al Mamun AAM, Luong TT, Hu B, Gu J, Lee JH, D'Amore M, Das A, Ton-That H.

MBio. 2018 Apr 24;9(2). pii: e00360-18. doi: 10.1128/mBio.00360-18.


Structural Basis of a Thiol-Disulfide Oxidoreductase in the Hedgehog-Forming Actinobacterium Corynebacterium matruchotii.

Luong TT, Tirgar R, Reardon-Robinson ME, Joachimiak A, Osipiuk J, Ton-That H.

J Bacteriol. 2018 Apr 9;200(9). pii: e00783-17. doi: 10.1128/JB.00783-17. Print 2018 May 1.


Transcriptome sequencing of the human pathogen Corynebacterium diphtheriae NCTC 13129 provides detailed insights into its transcriptional landscape and into DtxR-mediated transcriptional regulation.

Wittchen M, Busche T, Gaspar AH, Lee JH, Ton-That H, Kalinowski J, Tauch A.

BMC Genomics. 2018 Jan 25;19(1):82. doi: 10.1186/s12864-018-4481-8.


Evolution of substrate specificity in a retained enzyme driven by gene loss.

Juárez-Vázquez AL, Edirisinghe JN, Verduzco-Castro EA, Michalska K, Wu C, Noda-García L, Babnigg G, Endres M, Medina-Ruíz S, Santoyo-Flores J, Carrillo-Tripp M, Ton-That H, Joachimiak A, Henry CS, Barona-Gómez F.

Elife. 2017 Mar 31;6. pii: e22679. doi: 10.7554/eLife.22679.


Reoxidation of the Thiol-Disulfide Oxidoreductase MdbA by a Bacterial Vitamin K Epoxide Reductase in the Biofilm-Forming Actinobacterium Actinomyces oris.

Luong TT, Reardon-Robinson ME, Siegel SD, Ton-That H.

J Bacteriol. 2017 Apr 25;199(10). pii: e00817-16. doi: 10.1128/JB.00817-16. Print 2017 May 15.


Physiologic Response to HIPEC: Sifting Through Perturbation to Identify Markers of Complications.

Plackett TP, Ton-That HH, Mosier MJ, Abood GJ, Kuo PC, Pappas SG.

J Am Osteopath Assoc. 2017 Jan 1;117(1):16-23. doi: 10.7556/jaoa.2017.003.


Biogenesis of the Gram-positive bacterial cell envelope.

Siegel SD, Liu J, Ton-That H.

Curr Opin Microbiol. 2016 Dec;34:31-37. doi: 10.1016/j.mib.2016.07.015. Epub 2016 Aug 4. Review.


Genetics and Cell Morphology Analyses of the Actinomyces oris srtA Mutant.

Wu C, Reardon-Robinson ME, Ton-That H.

Methods Mol Biol. 2016;1440:109-22. doi: 10.1007/978-1-4939-3676-2_9.


A Type I Signal Peptidase Is Required for Pilus Assembly in the Gram-Positive, Biofilm-Forming Bacterium Actinomyces oris.

Siegel SD, Wu C, Ton-That H.

J Bacteriol. 2016 Jul 13;198(15):2064-73. doi: 10.1128/JB.00353-16. Print 2016 Aug 1.


Anchoring of LPXTG-Like Proteins to the Gram-Positive Cell Wall Envelope.

Siegel SD, Reardon ME, Ton-That H.

Curr Top Microbiol Immunol. 2017;404:159-175. doi: 10.1007/82_2016_8. Review.


Role of the Emp Pilus Subunits of Enterococcus faecium in Biofilm Formation, Adherence to Host Extracellular Matrix Components, and Experimental Infection.

Montealegre MC, Singh KV, Somarajan SR, Yadav P, Chang C, Spencer R, Sillanpää J, Ton-That H, Murray BE.

Infect Immun. 2016 Apr 22;84(5):1491-1500. doi: 10.1128/IAI.01396-15. Print 2016 May.


CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks.

Echelman DJ, Alegre-Cebollada J, Badilla CL, Chang C, Ton-That H, Fernández JM.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2490-5. doi: 10.1073/pnas.1522946113. Epub 2016 Feb 16.


Disulfide-Bond-Forming Pathways in Gram-Positive Bacteria.

Reardon-Robinson ME, Ton-That H.

J Bacteriol. 2015 Dec 7;198(5):746-54. doi: 10.1128/JB.00769-15. Review.


A thiol-disulfide oxidoreductase of the Gram-positive pathogen Corynebacterium diphtheriae is essential for viability, pilus assembly, toxin production and virulence.

Reardon-Robinson ME, Osipiuk J, Jooya N, Chang C, Joachimiak A, Das A, Ton-That H.

Mol Microbiol. 2015 Dec;98(6):1037-50. doi: 10.1111/mmi.13172. Epub 2015 Sep 25.


A Disulfide Bond-forming Machine Is Linked to the Sortase-mediated Pilus Assembly Pathway in the Gram-positive Bacterium Actinomyces oris.

Reardon-Robinson ME, Osipiuk J, Chang C, Wu C, Jooya N, Joachimiak A, Das A, Ton-That H.

J Biol Chem. 2015 Aug 28;290(35):21393-405. doi: 10.1074/jbc.M115.672253. Epub 2015 Jul 13.


Screening for at-risk drinking behavior in trauma patients.

Plackett TP, Ton-That HH, Mueller J, Grimley KM, Kovacs EJ, Esposito TJ.

J Am Osteopath Assoc. 2015 Jun;115(6):376-82. doi: 10.7556/jaoa.2015.078.


Cervical spine clearance when unable to be cleared clinically: a pooled analysis of combined computed tomography and magnetic resonance imaging.

Plackett TP, Wright F, Baldea AJ, Mosier MJ, Thomas C, Luchette FA, Ton-That HH, Esposito TJ.

Am J Surg. 2016 Jan;211(1):115-21. doi: 10.1016/j.amjsurg.2014.12.041. Epub 2015 Apr 23. Review.


Re-evaluating the need for hospital admission and observation of pediatric traumatic brain injury after a normal head CT.

Plackett TP, Asturias S, Tadlock M, Wright F, Ton-That H, Demetriades D, Esposito T, Inaba K.

J Pediatr Surg. 2015 Oct;50(10):1758-61. doi: 10.1016/j.jpedsurg.2015.03.067. Epub 2015 Apr 28.


The identification and functional characterization of WxL proteins from Enterococcus faecium reveal surface proteins involved in extracellular matrix interactions.

Galloway-Peña JR, Liang X, Singh KV, Yadav P, Chang C, La Rosa SL, Shelburne S, Ton-That H, Höök M, Murray BE.

J Bacteriol. 2015 Mar;197(5):882-92. doi: 10.1128/JB.02288-14. Epub 2014 Dec 15.


Lethality of sortase depletion in Actinomyces oris caused by excessive membrane accumulation of a surface glycoprotein.

Wu C, Huang IH, Chang C, Reardon-Robinson ME, Das A, Ton-That H.

Mol Microbiol. 2014 Dec;94(6):1227-41. doi: 10.1111/mmi.12780. Epub 2014 Sep 17.


Circumferential subcutaneous wound approximation improves wound healing after ileostomy reversal.

Baker TA, Ton-That HH, Hayden D, Saclarides T, Eberhardt JM, Shoup M.

Am Surg. 2014 Aug;80(8):E252-4. No abstract available.


A slow-forming isopeptide bond in the structure of the major pilin SpaD from Corynebacterium diphtheriae has implications for pilus assembly.

Kang HJ, Paterson NG, Kim CU, Middleditch M, Chang C, Ton-That H, Baker EN.

Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1190-201. doi: 10.1107/S1399004714001400. Epub 2014 Apr 26.


Pilus hijacking by a bacterial coaggregation factor critical for oral biofilm development.

Reardon-Robinson ME, Wu C, Mishra A, Chang C, Bier N, Das A, Ton-That H.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3835-40. doi: 10.1073/pnas.1321417111. Epub 2014 Feb 24.


Contribution of individual Ebp Pilus subunits of Enterococcus faecalis OG1RF to pilus biogenesis, biofilm formation and urinary tract infection.

Sillanpää J, Chang C, Singh KV, Montealegre MC, Nallapareddy SR, Harvey BR, Ton-That H, Murray BE.

PLoS One. 2013 Jul 11;8(7):e68813. doi: 10.1371/journal.pone.0068813. Print 2013.


Making the case for de-escalation therapy in ventilator-associated pneumonia once again.

Mosier MJ, Ton-That H.

Crit Care Med. 2013 Jul;41(7):1810-1. doi: 10.1097/CCM.0b013e31828ce949. No abstract available.


Pilus gene pool variation and the virulence of Corynebacterium diphtheriae clinical isolates during infection of a nematode.

Broadway MM, Rogers EA, Chang C, Huang IH, Dwivedi P, Yildirim S, Schmitt MP, Das A, Ton-That H.

J Bacteriol. 2013 Aug;195(16):3774-83. doi: 10.1128/JB.00500-13. Epub 2013 Jun 14.


Structure of Streptococcus agalactiae tip pilin GBS104: a model for GBS pili assembly and host interactions.

Krishnan V, Dwivedi P, Kim BJ, Samal A, Macon K, Ma X, Mishra A, Doran KS, Ton-That H, Narayana SV.

Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1073-89. doi: 10.1107/S0907444913004642. Epub 2013 May 15.


Visualization of Gram-positive bacterial pili.

Chang C, Huang IH, Hendrickx AP, Ton-That H.

Methods Mol Biol. 2013;966:77-95. doi: 10.1007/978-1-62703-245-2_5.


Comparison of Objective Screening and Self-Report for Alcohol and Drug Use in Traumatically Injured Patients.

Sakai LM, Esposito TJ, Ton-That HH, Omi EC, Kovacs EJ, Schermer CR.

Alcohol Treat Q. 2012 Oct 1;30(4):433-442. Epub 2012 Oct 12.


Pangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia.

Trost E, Blom J, Soares Sde C, Huang IH, Al-Dilaimi A, Schröder J, Jaenicke S, Dorella FA, Rocha FS, Miyoshi A, Azevedo V, Schneider MP, Silva A, Camello TC, Sabbadini PS, Santos CS, Santos LS, Hirata R Jr, Mattos-Guaraldi AL, Efstratiou A, Schmitt MP, Ton-That H, Tauch A.

J Bacteriol. 2012 Jun;194(12):3199-215. doi: 10.1128/JB.00183-12. Epub 2012 Apr 13.


Structural determinants of Actinomyces sortase SrtC2 required for membrane localization and assembly of type 2 fimbriae for interbacterial coaggregation and oral biofilm formation.

Wu C, Mishra A, Reardon ME, Huang IH, Counts SC, Das A, Ton-That H.

J Bacteriol. 2012 May;194(10):2531-9. doi: 10.1128/JB.00093-12. Epub 2012 Mar 23.


The crystal structure analysis of group B Streptococcus sortase C1: a model for the "lid" movement upon substrate binding.

Khare B, Fu ZQ, Huang IH, Ton-That H, Narayana SV.

J Mol Biol. 2011 Dec 9;414(4):563-77. doi: 10.1016/j.jmb.2011.10.017. Epub 2011 Oct 18.


Structural differences between the Streptococcus agalactiae housekeeping and pilus-specific sortases: SrtA and SrtC1.

Khare B, Krishnan V, Rajashankar KR, I-Hsiu H, Xin M, Ton-That H, Narayana SV.

PLoS One. 2011;6(8):e22995. doi: 10.1371/journal.pone.0022995. Epub 2011 Aug 30.


Two autonomous structural modules in the fimbrial shaft adhesin FimA mediate Actinomyces interactions with streptococci and host cells during oral biofilm development.

Mishra A, Devarajan B, Reardon ME, Dwivedi P, Krishnan V, Cisar JO, Das A, Narayana SV, Ton-That H.

Mol Microbiol. 2011 Sep;81(5):1205-20. doi: 10.1111/j.1365-2958.2011.07745.x. Epub 2011 Jul 27.


Adhesion by pathogenic corynebacteria.

Rogers EA, Das A, Ton-That H.

Adv Exp Med Biol. 2011;715:91-103. doi: 10.1007/978-94-007-0940-9_6. Review.


Dual function of a tip fimbrillin of Actinomyces in fimbrial assembly and receptor binding.

Wu C, Mishra A, Yang J, Cisar JO, Das A, Ton-That H.

J Bacteriol. 2011 Jul;193(13):3197-206. doi: 10.1128/JB.00173-11. Epub 2011 Apr 29.


A model for group B Streptococcus pilus type 1: the structure of a 35-kDa C-terminal fragment of the major pilin GBS80.

Vengadesan K, Ma X, Dwivedi P, Ton-That H, Narayana SV.

J Mol Biol. 2011 Apr 15;407(5):731-43. doi: 10.1016/j.jmb.2011.02.024. Epub 2011 Feb 17.


Cell surface display of minor pilin adhesins in the form of a simple heterodimeric assembly in Corynebacterium diphtheriae.

Chang C, Mandlik A, Das A, Ton-That H.

Mol Microbiol. 2011 Mar;79(5):1236-47. doi: 10.1111/j.1365-2958.2010.07515.x. Epub 2011 Jan 5.


Purification, crystallization and halide phasing of a Streptococcus agalactiae backbone pilin GBS80 fragment.

Vengadesan K, Ma X, Dwivedi P, Ton-That H, Narayana SV.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1666-9. doi: 10.1107/S1744309110043101. Epub 2010 Nov 27.


Preliminary crystallographic study of the Streptococcus agalactiae sortases, sortase A and sortase C1.

Khare B, Samal A, Vengadesan K, Rajashankar KR, Ma X, Huang IH, Ton-That H, Narayana SV.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt 9):1096-100. doi: 10.1107/S1744309110031106. Epub 2010 Aug 28.


Characterization of the ebp(fm) pilus-encoding operon of Enterococcus faecium and its role in biofilm formation and virulence in a murine model of urinary tract infection.

Sillanpää J, Nallapareddy SR, Singh KV, Prakash VP, Fothergill T, Ton-That H, Murray BE.

Virulence. 2010 Jul-Aug;1(4):236-46.


Allelic exchange in Actinomyces oris with mCherry fluorescence counterselection.

Wu C, Ton-That H.

Appl Environ Microbiol. 2010 Sep;76(17):5987-9. doi: 10.1128/AEM.00811-10. Epub 2010 Jul 2.

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