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The target hemoglobin content values of reticulocytes for efficient anemia improvement are achieved by low ferritin levels and moderate transferrin saturation: a retrospective observational study.

Ogawa C, Tsuchiya K, Tomosugi N, Shimada K, Kanda F, Maeda K.

Hematology. 2020 Dec;25(1):71-78. doi: 10.1080/16078454.2020.1720103.


Tips for erythropoiesis-stimulating agent treatment of renal anemia.

Tomosugi N, Koshino Y.

Clin Exp Nephrol. 2020 Jan;24(1):105-106. doi: 10.1007/s10157-019-01791-w. Epub 2019 Oct 16. No abstract available.


Differential Impacts of Intravenous Iron Administration and Iron-Containing Phosphate Binders on Serum Intact Fibroblast Growth Factor 23 Levels.

Honda H, Tanaka K, Michihata T, Shibagaki K, Yuza T, Hirao K, Tomosugi N, Shibata T.

Blood Purif. 2019;47 Suppl 2:63-69. doi: 10.1159/000496640. Epub 2019 Apr 3.


GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T cells.

Kiuchi Z, Nishibori Y, Kutsuna S, Kotani M, Hada I, Kimura T, Fukutomi T, Fukuhara D, Ito-Nitta N, Kudo A, Takata T, Ishigaki Y, Tomosugi N, Tanaka H, Matsushima S, Ogasawara S, Hirayama Y, Takematsu H, Yan K.

FASEB J. 2019 Jun;33(6):7387-7402. doi: 10.1096/fj.201800344RR. Epub 2019 Mar 12.


Immuno-detection of mRNA-binding protein complex in human cells under transmission electron microscopy.

Ma Q, Tatsuno T, Nakamura Y, Izumi SI, Tomosugi N, Ishigaki Y.

Microsc Res Tech. 2019 Jun;82(6):680-688. doi: 10.1002/jemt.23214. Epub 2019 Jan 14.


Provisional standardization of hepcidin assays: creating a traceability chain with a primary reference material, candidate reference method and a commutable secondary reference material.

Diepeveen LE, Laarakkers CMM, Martos G, Pawlak ME, Uğuz FF, Verberne KESA, van Swelm RPL, Klaver S, de Haan AFJ, Pitts KR, Bansal SS, Abbas IM, Fillet M, Lefebvre T, Geurts-Moespot AJ, Girelli D, Castagna A, Herkert M, Itkonen O, Olbina G, Tomosugi N, Westerman ME, Delatour V, Weykamp CW, Swinkels DW.

Clin Chem Lab Med. 2019 May 27;57(6):864-872. doi: 10.1515/cclm-2018-0783.


[Corrigendum] Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm.

Tatsuno T, Nakamura Y, Ma S, Tomosugi N, Ishigaki Y.

Mol Med Rep. 2017 Dec;16(6):8573. doi: 10.3892/mmr.2017.7593. Epub 2017 Sep 25.


Low levels of serum ferritin and moderate transferrin saturation lead to adequate hemoglobin levels in hemodialysis patients, retrospective observational study.

Ogawa C, Tsuchiya K, Tomosugi N, Kanda F, Maeda K, Maeda T.

PLoS One. 2017 Jun 29;12(6):e0179608. doi: 10.1371/journal.pone.0179608. eCollection 2017.


Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency.

Kobayashi M, Kato H, Hada H, Itoh-Nakadai A, Fujiwara T, Muto A, Inoguchi Y, Ichiyanagi K, Hojo W, Tomosugi N, Sasaki H, Harigae H, Igarashi K.

Haematologica. 2017 Mar;102(3):454-465. doi: 10.3324/haematol.2016.151043. Epub 2016 Dec 7.


High pretransplant hepcidin levels are associated with poor overall survival and delayed platelet engraftment after allogeneic hematopoietic stem cell transplantation.

Sakamoto S, Kawabata H, Kanda J, Uchiyama T, Mizumoto C, Kitano T, Kondo T, Hishizawa M, Tomosugi N, Takaori-Kondo A.

Cancer Med. 2017 Jan;6(1):120-128. doi: 10.1002/cam4.974. Epub 2016 Dec 1.


[The Cutting-edge of Medicine ; Hepcidin and renal anemia].

Tomosugi N.

Nihon Naika Gakkai Zasshi. 2016 Dec;105(12):2450-2457. Japanese. No abstract available.


Potential contribution of the hepcidin-macrophage axis to plaque vulnerability in acute myocardial infarction in human.

Sasai M, Iso Y, Mizukami T, Tomosugi N, Sambe T, Miyazaki A, Suzuki H.

Int J Cardiol. 2017 Jan 15;227:114-121. doi: 10.1016/j.ijcard.2016.11.147. Epub 2016 Nov 9.


Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans.

Tomosugi N, Yamamoto S, Takeuchi M, Yonekura H, Ishigaki Y, Numata N, Katsuda S, Sakai Y.

J Atheroscler Thromb. 2017 May 1;24(5):530-538. doi: 10.5551/jat.36293. Epub 2016 Oct 6.


A Novel Phenotype of a Hereditary Hemochromatosis Type 4 with Ferroportin-1 Mutation, Presenting with Juvenile Cataracts.

Yamakawa N, Oe K, Yukawa N, Murakami K, Nakashima R, Imura Y, Yoshifuji H, Ohmura K, Miura Y, Tomosugi N, Kawabata H, Takaori-Kondo A, Mimori T.

Intern Med. 2016;55(18):2697-701. doi: 10.2169/internalmedicine.55.6565. Epub 2016 Sep 15.


Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm.

Tatsuno T, Nakamura Y, Ma S, Tomosugi N, Ishigaki Y.

Mol Med Rep. 2016 Jul;14(1):655-60. doi: 10.3892/mmr.2016.5331. Epub 2016 May 24. Erratum in: Mol Med Rep. 2017 Dec;16(6):8573.


Toward Worldwide Hepcidin Assay Harmonization: Identification of a Commutable Secondary Reference Material.

van der Vorm LN, Hendriks JC, Laarakkers CM, Klaver S, Armitage AE, Bamberg A, Geurts-Moespot AJ, Girelli D, Herkert M, Itkonen O, Konrad RJ, Tomosugi N, Westerman M, Bansal SS, Campostrini N, Drakesmith H, Fillet M, Olbina G, Pasricha SR, Pitts KR, Sloan JH, Tagliaro F, Weykamp CW, Swinkels DW.

Clin Chem. 2016 Jul;62(7):993-1001. doi: 10.1373/clinchem.2016.256768. Epub 2016 May 12.


Associations among Erythroferrone and Biomarkers of Erythropoiesis and Iron Metabolism, and Treatment with Long-Term Erythropoiesis-Stimulating Agents in Patients on Hemodialysis.

Honda H, Kobayashi Y, Onuma S, Shibagaki K, Yuza T, Hirao K, Yamamoto T, Tomosugi N, Shibata T.

PLoS One. 2016 Mar 15;11(3):e0151601. doi: 10.1371/journal.pone.0151601. eCollection 2016.


Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation.

Ikeda T, Yoshitomi Y, Saito H, Shimasaki T, Yamaya H, Kobata T, Ishigaki Y, Tomosugi N, Yoshitake Y, Yonekura H.

Mol Cell Biochem. 2016 Feb;413(1-2):155-64. doi: 10.1007/s11010-015-2649-y. Epub 2016 Jan 4.


Effects of Long-Term Erythropoiesis-Stimulating Agents on Iron Metabolism in Patients on Hemodialysis.

Onuma S, Honda H, Kobayashi Y, Yamamoto T, Michihata T, Shibagaki K, Yuza T, Hirao K, Tomosugi N, Shibata T.

Ther Apher Dial. 2015 Dec;19(6):582-9. doi: 10.1111/1744-9987.12322. Epub 2015 Oct 20.


Low Serum Neutrophil Gelatinase-associated Lipocalin Level as a Marker of Malnutrition in Maintenance Hemodialysis Patients.

Imamaki H, Ishii A, Yokoi H, Kasahara M, Kuwabara T, Mori KP, Kato Y, Kuwahara T, Satoh M, Nakatani K, Saito Y, Tomosugi N, Sugawara A, Nakao K, Mukoyama M, Yanagita M, Mori K.

PLoS One. 2015 Jul 10;10(7):e0132539. doi: 10.1371/journal.pone.0132539. eCollection 2015.


A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression.

Kawabata H, Uchiyama T, Sakamoto S, Kanda J, Oishi S, Fujii N, Tomosugi N, Kadowaki N, Takaori-Kondo A.

Exp Hematol. 2015 May;43(5):404-413.e5. doi: 10.1016/j.exphem.2015.01.005. Epub 2015 Jan 26.


Effect of Saikokeishito, a Kampo medicine, on hydrogen peroxide-induced premature senescence of normal human dermal fibroblasts.

Takata T, Motoo Y, Tomosugi N.

J Integr Med. 2014 Nov;12(6):495-503. doi: 10.1016/S2095-4964(14)60052-2.


Phosphorylation status of human RNA-binding protein 8A in cells and its inhibitory regulation by Magoh.

Ishigaki Y, Nakamura Y, Tatsuno T, Ma S, Tomosugi N.

Exp Biol Med (Maywood). 2015 Apr;240(4):438-45. doi: 10.1177/1535370214556945. Epub 2014 Oct 27.


Regulation of Hepcidin-25 by Short- and Long-Acting rhEPO May Be Dependent on Ferritin and Predict the Response to rhEPO in Hemodialysis Patients.

Takasawa K, Tomosugi N, Takaeda C, Maeda T, Ueda N.

Nephron Extra. 2014 Apr 16;4(1):55-63. doi: 10.1159/000362212. eCollection 2014 Jan.


Long-term administration and efficacy of oxaliplatin with no neurotoxicity in a patient with rectal cancer: Association between neurotoxicity and the GSTP1 polymorphism.

Kitade H, Shimasaki T, Igarashi S, Sakuma H, Mori M, Tomosugi N, Nakai M.

Oncol Lett. 2014 May;7(5):1499-1502. Epub 2014 Feb 18.


Comparative evaluation of the effects of treatment with tocilizumab and TNF-α inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients.

Song SN, Iwahashi M, Tomosugi N, Uno K, Yamana J, Yamana S, Isobe T, Ito H, Kawabata H, Yoshizaki K.

Arthritis Res Ther. 2013 Oct 2;15(5):R141. doi: 10.1186/ar4323.


Reply by authors.

Maru S, Ishigaki Y, Shinohara N, Takata T, Tomosugi N, Nonomura K.

J Urol. 2013 Nov;190(5):1957. No abstract available.


A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease.

Fujiwara T, Ikeda T, Nagasaka Y, Okitsu Y, Katsuoka Y, Fukuhara N, Onishi Y, Ishizawa K, Ichinohasama R, Tomosugi N, Harigae H.

PLoS One. 2013 Sep 27;8(9):e75568. doi: 10.1371/journal.pone.0075568. eCollection 2013.


Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells.

Ishigaki Y, Nakamura Y, Tatsuno T, Hashimoto M, Shimasaki T, Iwabuchi K, Tomosugi N.

Exp Biol Med (Maywood). 2013 Aug 1;238(8):889-97. doi: 10.1177/1535370213494646.


RNA-binding protein RBM8A (Y14) and MAGOH localize to centrosome in human A549 cells.

Ishigaki Y, Nakamura Y, Tatsuno T, Hashimoto M, Iwabuchi K, Tomosugi N.

Histochem Cell Biol. 2014 Jan;141(1):101-9. doi: 10.1007/s00418-013-1135-4. Epub 2013 Aug 15.


Greater potency of darbepoetin-α than erythropoietin in suppression of serum hepcidin-25 and utilization of iron for erythropoiesis in hemodialysis patients.

Shoji S, Inaba M, Tomosugi N, Okuno S, Ichii M, Yamakawa T, Kurihara S.

Eur J Haematol. 2013 Mar;90(3):237-44. doi: 10.1111/ejh.12067.


Effects of erythropoietin administration on iron status in patients with ST-elevation myocardial infarction who underwent successful percutaneous coronary intervention.

Suzuki T, Toba K, Kato K, Ozawa T, Suzuki H, Tomosugi N, Saitoh H, Aizawa Y.

Int J Cardiol. 2013 Aug 20;167(4):1644-5. doi: 10.1016/j.ijcard.2012.11.026. Epub 2012 Nov 23. No abstract available.


Acidic milieu augments the expression of hepcidin, the central regulator of iron homeostasis.

Mizumoto C, Kawabata H, Uchiyama T, Sakamoto S, Kanda J, Tomosugi N, Takaori-Kondo A.

Int J Hematol. 2012 Dec;96(6):701-9. doi: 10.1007/s12185-012-1223-6. Epub 2012 Nov 23.


Inhibition of mTORC2 but not mTORC1 up-regulates E-cadherin expression and inhibits cell motility by blocking HIF-2α expression in human renal cell carcinoma.

Maru S, Ishigaki Y, Shinohara N, Takata T, Tomosugi N, Nonomura K.

J Urol. 2013 May;189(5):1921-9. doi: 10.1016/j.juro.2012.11.010. Epub 2012 Nov 9.


Serum ferritin levels adversely affect cardiac function in patients with ST-elevation myocardial infarction who underwent successful percutaneous coronary intervention.

Suzuki T, Toba K, Kato K, Ozawa T, Higasimura M, Kitajima T, Oda H, Tsuchida K, Tomosugi N, Saitoh H, Aizawa Y.

Int J Cardiol. 2013 Jul 15;167(1):286-8. doi: 10.1016/j.ijcard.2012.09.205. Epub 2012 Oct 15. No abstract available.


Characterization of proteins secreted by pancreatic cancer cells with anticancer drug treatment in vitro.

Takata T, Ishigaki Y, Shimasaki T, Tsuchida H, Motoo Y, Hayashi A, Tomosugi N.

Oncol Rep. 2012 Dec;28(6):1968-76. doi: 10.3892/or.2012.2020. Epub 2012 Sep 5.


Clinicopathological study of Japanese patients with genetic iron overload syndromes.

Hattori A, Miyajima H, Tomosugi N, Tatsumi Y, Hayashi H, Wakusawa S.

Pathol Int. 2012 Sep;62(9):612-8. doi: 10.1111/j.1440-1827.2012.02848.x.


Expression pattern of Galectin 4 in rat placentation.

Arikawa T, Simamura E, Shimada H, Nishi N, Tatsuno T, Ishigaki Y, Tomosugi N, Yamashiro C, Hata T, Takegami T, Mogami H, Yamaguchi K, Nakamura T, Otani H, Hatta T, Shoji H.

Placenta. 2012 Oct;33(10):885-7. doi: 10.1016/j.placenta.2012.07.013. Epub 2012 Aug 9.


Analysis of hepcidin expression: in situ hybridization and quantitative polymerase chain reaction from paraffin sections.

Sakuraoka Y, Sawada T, Shiraki T, Park K, Sakurai Y, Tomosugi N, Kubota K.

World J Gastroenterol. 2012 Jul 28;18(28):3727-31. doi: 10.3748/wjg.v18.i28.3727.


Serum hepcidin-25 levels predict the progression of renal anemia in patients with non-dialysis chronic kidney disease.

Niihata K, Tomosugi N, Uehata T, Shoji T, Mitsumoto K, Shimizu M, Kawabata H, Sakaguchi Y, Suzuki A, Hayashi T, Okada N, Isaka Y, Rakugi H, Tsubakihara Y.

Nephrol Dial Transplant. 2012 Dec;27(12):4378-85; discussion 4384-5. doi: 10.1093/ndt/gfs322. Epub 2012 Jul 24.


Hepcidin expression in iron overload diseases is variably modulated by circulating factors.

Ravasi G, Pelucchi S, Trombini P, Mariani R, Tomosugi N, Modignani GL, Pozzi M, Nemeth E, Ganz T, Hayashi H, Barisani D, Piperno A.

PLoS One. 2012;7(5):e36425. doi: 10.1371/journal.pone.0036425. Epub 2012 May 7.


A case of congenital dyserythropoietic anemia type 1 in a Japanese adult with a CDAN1 gene mutation and an inappropriately low serum hepcidin-25 level.

Kawabata H, Doisaki S, Okamoto A, Uchiyama T, Sakamoto S, Hama A, Hosoda K, Fujikura J, Kanno H, Fujii H, Tomosugi N, Nakao K, Kojima S, Takaori-Kondo A.

Intern Med. 2012;51(8):917-20. Epub 2012 Apr 15.


Observation of live ticks (Haemaphysalis flava) by scanning electron microscopy under high vacuum pressure.

Ishigaki Y, Nakamura Y, Oikawa Y, Yano Y, Kuwabata S, Nakagawa H, Tomosugi N, Takegami T.

PLoS One. 2012;7(3):e32676. doi: 10.1371/journal.pone.0032676. Epub 2012 Mar 14. Erratum in: PLoS One. 2012;7(8): doi/10.1371/annotation/c81bc3a4-63e1-44a6-bf1e-f923087bfa71.


Surgical inflammation induces hepcidin production after abdominal surgery.

Park KH, Sawada T, Kosuge T, Kita J, Shimoda M, Tomosugi N, Kubota K.

World J Surg. 2012 Apr;36(4):800-6. doi: 10.1007/s00268-012-1473-8.


Identification of a novel mutation in the HAMP gene that causes non-detectable hepcidin molecules in a Japanese male patient with juvenile hemochromatosis.

Hattori A, Tomosugi N, Tatsumi Y, Suzuki A, Hayashi K, Katano Y, Inagaki Y, Ishikawa T, Hayashi H, Goto H, Wakusawa S.

Blood Cells Mol Dis. 2012 Mar 15;48(3):179-82. doi: 10.1016/j.bcmd.2012.01.002. Epub 2012 Jan 30.


Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine.

Shimasaki T, Ishigaki Y, Nakamura Y, Takata T, Nakaya N, Nakajima H, Sato I, Zhao X, Kitano A, Kawakami K, Tanaka T, Takegami T, Tomosugi N, Minamoto T, Motoo Y.

J Gastroenterol. 2012 Mar;47(3):321-33. doi: 10.1007/s00535-011-0484-9. Epub 2011 Nov 1.


A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details.

Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Sumida T, Mimori T, Tanaka Y, Tsubota K, Yoshino T, Kawa S, Suzuki R, Takegami T, Tomosugi N, Kurose N, Ishigaki Y, Azumi A, Kojima M, Nakamura S, Inoue D; Research Program for Intractable Disease by Ministry of Health, Labor and Welfare (MHLW) Japan G4 team.

Mod Rheumatol. 2012 Feb;22(1):1-14. doi: 10.1007/s10165-011-0508-6. Epub 2011 Sep 1. Review.


Serum hepcidin-25 levels and anemia in non-dialysis chronic kidney disease patients: a cross-sectional study.

Uehata T, Tomosugi N, Shoji T, Sakaguchi Y, Suzuki A, Kaneko T, Okada N, Yamamoto R, Nagasawa Y, Kato K, Isaka Y, Rakugi H, Tsubakihara Y.

Nephrol Dial Transplant. 2012 Mar;27(3):1076-83. doi: 10.1093/ndt/gfr431. Epub 2011 Jul 28.


Comparative study of hydrophilic and hydrophobic ionic liquids for observing cultured human cells by scanning electron microscopy.

Ishigaki Y, Nakamura Y, Takehara T, Kurihara T, Koga H, Takegami T, Nakagawa H, Nemoto N, Tomosugi N, Kuwabata S, Miyazawa S.

Microsc Res Tech. 2011 Dec;74(12):1104-8. doi: 10.1002/jemt.21001. Epub 2011 Apr 29.


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