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Items: 48

1.

Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells.

Noy PJ, Gavin RL, Colombo D, Haining EJ, Reyat JS, Payne H, Thielmann I, Lokman AB, Neag G, Yang J, Lloyd T, Harrison N, Heath VL, Gardiner C, Whitworth KM, Robinson J, Koo CZ, Di Maio A, Harrison P, Lee SP, Michelangeli F, Kalia N, Rainger GE, Nieswandt B, Brill A, Watson SP, Tomlinson MG.

Haematologica. 2018 Dec 20. pii: haematol.2018.194241. doi: 10.3324/haematol.2018.194241. [Epub ahead of print]

2.

C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37.

de Winde CM, Matthews AL, van Deventer S, van der Schaaf A, Tomlinson ND, Jansen E, Eble JA, Nieswandt B, McGettrick HM, Figdor CG, Tomlinson MG, Acton SE, van Spriel AB.

J Cell Sci. 2018 Oct 2;131(19). pii: jcs214551. doi: 10.1242/jcs.214551.

3.

Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI.

Nicolson PLR, Hughes CE, Watson S, Nock SH, Hardy AT, Watson CN, Montague SJ, Clifford H, Huissoon AP, Malcor JD, Thomas MR, Pollitt AY, Tomlinson MG, Pratt G, Watson SP.

Haematologica. 2018 Dec;103(12):2097-2108. doi: 10.3324/haematol.2018.193391. Epub 2018 Jul 19.

4.

Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10.

Matthews AL, Koo CZ, Szyroka J, Harrison N, Kanhere A, Tomlinson MG.

Front Immunol. 2018 Jul 2;9:1451. doi: 10.3389/fimmu.2018.01451. eCollection 2018. Review.

5.

The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation.

Brummer T, Pigoni M, Rossello A, Wang H, Noy PJ, Tomlinson MG, Blobel CP, Lichtenthaler SF.

FASEB J. 2018 Jul;32(7):3560-3573. doi: 10.1096/fj.201700823RR. Epub 2018 Feb 7.

6.

TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice.

Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A.

Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):344-352. doi: 10.1161/ATVBAHA.117.310391. Epub 2017 Nov 16.

PMID:
29146750
7.

Eye-Opening Potential for Tetraspanin Tspan12 as a Therapeutic Target for Diseases of the Retinal Vasculature.

Tomlinson MG.

Circulation. 2017 Jul 11;136(2):196-199. doi: 10.1161/CIRCULATIONAHA.117.028521. No abstract available.

PMID:
28696267
8.

Quantitative Phosphoproteomics Reveals a Role for Collapsin Response Mediator Protein 2 in PDGF-Induced Cell Migration.

Sarhan AR, Szyroka J, Begum S, Tomlinson MG, Hotchin NA, Heath JK, Cunningham DL.

Sci Rep. 2017 Jun 21;7(1):3970. doi: 10.1038/s41598-017-04015-x.

9.

Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.

Matthews AL, Szyroka J, Collier R, Noy PJ, Tomlinson MG.

Biochem Soc Trans. 2017 Jun 15;45(3):719-730. doi: 10.1042/BST20160290. Review.

10.

ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.

Reyat JS, Chimen M, Noy PJ, Szyroka J, Rainger GE, Tomlinson MG.

J Immunol. 2017 Jul 15;199(2):666-676. doi: 10.4049/jimmunol.1600713. Epub 2017 Jun 9.

11.

Utilizing Lentiviral Gene Transfer in Primary Endothelial Cells to Assess Lymphocyte-Endothelial Interactions.

Reyat JS, Tomlinson MG, Noy PJ.

Methods Mol Biol. 2017;1591:155-168. doi: 10.1007/978-1-4939-6931-9_11.

PMID:
28349481
12.

Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.

Haining EJ, Matthews AL, Noy PJ, Romanska HM, Harris HJ, Pike J, Morowski M, Gavin RL, Yang J, Milhiet PE, Berditchevski F, Nieswandt B, Poulter NS, Watson SP, Tomlinson MG.

Platelets. 2017 Nov;28(7):629-642. doi: 10.1080/09537104.2016.1254175. Epub 2016 Dec 29.

13.

LAR protein tyrosine phosphatase regulates focal adhesions through CDK1.

Sarhan AR, Patel TR, Cowell AR, Tomlinson MG, Hellberg C, Heath JK, Cunningham DL, Hotchin NA.

J Cell Sci. 2016 Aug 1;129(15):2962-71. doi: 10.1242/jcs.191379. Epub 2016 Jun 27.

14.

Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids.

Matthews AL, Noy PJ, Reyat JS, Tomlinson MG.

Platelets. 2017 Jun;28(4):333-341. doi: 10.1080/09537104.2016.1184751. Epub 2016 Jun 2. Review.

15.

Regulation of Platelet Derived Growth Factor Signaling by Leukocyte Common Antigen-related (LAR) Protein Tyrosine Phosphatase: A Quantitative Phosphoproteomics Study.

Sarhan AR, Patel TR, Creese AJ, Tomlinson MG, Hellberg C, Heath JK, Hotchin NA, Cunningham DL.

Mol Cell Proteomics. 2016 Jun;15(6):1823-36. doi: 10.1074/mcp.M115.053652. Epub 2016 Apr 13.

16.

TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS.

Noy PJ, Yang J, Reyat JS, Matthews AL, Charlton AE, Furmston J, Rogers DA, Rainger GE, Tomlinson MG.

J Biol Chem. 2016 Feb 12;291(7):3145-57. doi: 10.1074/jbc.M115.703058. Epub 2015 Dec 14.

17.

SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.

Cherpokova D, Bender M, Morowski M, Kraft P, Schuhmann MK, Akbar SM, Sultan CS, Hughes CE, Kleinschnitz C, Stoll G, Dragone LL, Watson SP, Tomlinson MG, Nieswandt B.

Blood. 2015 Jan 1;125(1):185-94. doi: 10.1182/blood-2014-06-580597. Epub 2014 Oct 9.

18.

The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.

Haining EJ, Yang J, Bailey RL, Khan K, Collier R, Tsai S, Watson SP, Frampton J, Garcia P, Tomlinson MG.

J Biol Chem. 2012 Nov 16;287(47):39753-65. doi: 10.1074/jbc.M112.416503. Epub 2012 Oct 3.

19.

Circulating DBP level and prognosis in operated lung cancer: an exploration of pathophysiology.

Turner AM, McGowan L, Millen A, Rajesh P, Webster C, Langman G, Rock G, Tachibana I, Tomlinson MG, Berditchevski F, Naidu B.

Eur Respir J. 2013 Feb;41(2):410-6. doi: 10.1183/09031936.00002912. Epub 2012 May 3.

20.

The emerging role of tetraspanin microdomains on endothelial cells.

Bailey RL, Herbert JM, Khan K, Heath VL, Bicknell R, Tomlinson MG.

Biochem Soc Trans. 2011 Dec;39(6):1667-73. doi: 10.1042/BST20110745. Review.

PMID:
22103505
21.

Tetraspanin microdomains: fine-tuning platelet function.

Haining EJ, Yang J, Tomlinson MG.

Biochem Soc Trans. 2011 Apr;39(2):518-23. doi: 10.1042/BST0390518. Review.

PMID:
21428931
22.

CLEC-2 activates Syk through dimerization.

Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP.

Blood. 2010 Apr 8;115(14):2947-55. doi: 10.1182/blood-2009-08-237834. Epub 2010 Feb 12.

23.

Platelet tetraspanins: small but interesting.

Tomlinson MG.

J Thromb Haemost. 2009 Dec;7(12):2070-3. doi: 10.1111/j.1538-7836.2009.03613.x. Epub 2009 Sep 9. No abstract available.

24.

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis.

Senis YA, Tomlinson MG, Ellison S, Mazharian A, Lim J, Zhao Y, Kornerup KN, Auger JM, Thomas SG, Dhanjal T, Kalia N, Zhu JW, Weiss A, Watson SP.

Blood. 2009 May 14;113(20):4942-54. doi: 10.1182/blood-2008-08-174318. Epub 2009 Feb 25.

25.

G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2.

Mori J, Pearce AC, Spalton JC, Grygielska B, Eble JA, Tomlinson MG, Senis YA, Watson SP.

J Biol Chem. 2008 Dec 19;283(51):35419-27. doi: 10.1074/jbc.M806895200. Epub 2008 Oct 27.

26.

Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains.

Protty MB, Watkins NA, Colombo D, Thomas SG, Heath VL, Herbert JM, Bicknell R, Senis YA, Ashman LK, Berditchevski F, Ouwehand WH, Watson SP, Tomlinson MG.

Biochem J. 2009 Jan 1;417(1):391-400. doi: 10.1042/BJ20081126.

27.

Collagen promotes sustained glycoprotein VI signaling in platelets and cell lines.

Tomlinson MG, Calaminus SD, Berlanga O, Auger JM, Bori-Sanz T, Meyaard L, Watson SP.

J Thromb Haemost. 2007 Nov;5(11):2274-83. Epub 2007 Aug 22.

28.

Glycoprotein VI oligomerization in cell lines and platelets.

Berlanga O, Bori-Sanz T, James JR, Frampton J, Davis SJ, Tomlinson MG, Watson SP.

J Thromb Haemost. 2007 May;5(5):1026-1033. doi: 10.1111/j.1538-7836.2007.02449.x. Epub 2007 Mar 15.

29.

The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade.

Fuller GL, Williams JA, Tomlinson MG, Eble JA, Hanna SL, Pöhlmann S, Suzuki-Inoue K, Ozaki Y, Watson SP, Pearce AC.

J Biol Chem. 2007 Apr 27;282(17):12397-409. Epub 2007 Mar 5.

30.

A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein.

Senis YA, Tomlinson MG, García A, Dumon S, Heath VL, Herbert J, Cobbold SP, Spalton JC, Ayman S, Antrobus R, Zitzmann N, Bicknell R, Frampton J, Authi KS, Martin A, Wakelam MJ, Watson SP.

Mol Cell Proteomics. 2007 Mar;6(3):548-64. Epub 2006 Dec 23.

32.

SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.

Tomlinson MG, Heath VL, Turck CW, Watson SP, Weiss A.

J Biol Chem. 2004 Dec 31;279(53):55089-96. Epub 2004 Oct 18.

33.

Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec.

Tomlinson MG, Kane LP, Su J, Kadlecek TA, Mollenauer MN, Weiss A.

Mol Cell Biol. 2004 Mar;24(6):2455-66.

34.

T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression.

Roose JP, Diehn M, Tomlinson MG, Lin J, Alizadeh AA, Botstein D, Brown PO, Weiss A.

PLoS Biol. 2003 Nov;1(2):E53. Epub 2003 Nov 17.

35.

A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells.

Tomlinson MG, Woods DB, McMahon M, Wahl MI, Witte ON, Kurosaki T, Bolen JB, Johnston JA.

BMC Immunol. 2001;2:4. Epub 2001 Jun 8.

36.

Lymphocytes with a complex: adapter proteins in antigen receptor signaling.

Tomlinson MG, Lin J, Weiss A.

Immunol Today. 2000 Nov;21(11):584-91. Review.

PMID:
11094263
37.

TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression.

Heath VL, Murphy EE, Crain C, Tomlinson MG, O'Garra A.

Eur J Immunol. 2000 Sep;30(9):2639-49.

38.

The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity.

Morimoto AM, Tomlinson MG, Nakatani K, Bolen JB, Roth RA, Herbst R.

Oncogene. 2000 Jan 13;19(2):200-9.

39.

A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets.

Pasquet JM, Bobe R, Gross B, Gratacap MP, Tomlinson MG, Payrastre B, Watson SP.

Biochem J. 1999 Aug 15;342 ( Pt 1):171-7.

40.

Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk.

Tomlinson MG, Kurosaki T, Berson AE, Fujii GH, Johnston JA, Bolen JB.

J Biol Chem. 1999 May 7;274(19):13577-85.

41.

A new transmembrane 4 superfamily molecule in the nematode, Caenorhabditis elegans.

Tomlinson MG, Wright MD.

J Mol Evol. 1996 Sep;43(3):312-4. No abstract available.

PMID:
8703098
42.

Characterisation of mouse CD37: cDNA and genomic cloning.

Tomlinson MG, Wright MD.

Mol Immunol. 1996 Jul;33(10):867-72.

PMID:
8845018
43.

Characterization of mouse CD53: epitope mapping, cellular distribution and induction by T cell receptor engagement during repertoire selection.

Tomlinson MG, Hanke T, Hughes DA, Barclay AN, Scholl E, Hünig T, Wright MD.

Eur J Immunol. 1995 Aug;25(8):2201-5.

PMID:
7545113
44.

Mapping of the genes for four members of the transmembrane 4 superfamily: mouse Cd9, Cd63, Cd81, and Cd82.

Seldin MF, Rochelle JM, Tomlinson MG, Wright MD.

Immunogenetics. 1995;42(5):422-5. No abstract available.

PMID:
7590978
45.

The ins and outs of the transmembrane 4 superfamily.

Wright MD, Tomlinson MG.

Immunol Today. 1994 Dec;15(12):588-94. Review.

PMID:
7531445
46.

The effect of various stresses, corticosteroids and adrenergic agents on phagocytosis in the rainbow trout Oncorhynchus mykiss.

Narnaware YK, Baker BI, Tomlinson MG.

Fish Physiol Biochem. 1994 May;13(1):31-40. doi: 10.1007/BF00004117.

PMID:
24203269
47.
48.

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