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Items: 22


The anaphase-promoting complex regulates the degradation of the inner nuclear membrane protein Mps3.

Koch BA, Jin H, Tomko RJ Jr, Yu HG.

J Cell Biol. 2019 Feb 8. pii: jcb.201808024. doi: 10.1083/jcb.201808024. [Epub ahead of print]


An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes.

Nemec AA, Peterson AK, Warnock JL, Reed RG, Tomko RJ Jr.

Cell Rep. 2019 Jan 8;26(2):483-495.e5. doi: 10.1016/j.celrep.2018.12.042.


Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating.

Eisele MR, Reed RG, Rudack T, Schweitzer A, Beck F, Nagy I, Pfeifer G, Plitzko JM, Baumeister W, Tomko RJ Jr, Sakata E.

Cell Rep. 2018 Jul 31;24(5):1301-1315.e5. doi: 10.1016/j.celrep.2018.07.004.


Autophagic clearance of proteasomes in yeast requires the conserved sorting nexin Snx4.

Nemec AA, Howell LA, Peterson AK, Murray MA, Tomko RJ Jr.

J Biol Chem. 2017 Dec 29;292(52):21466-21480. doi: 10.1074/jbc.M117.817999. Epub 2017 Nov 6.


Proteasomes, caught in the act.

Tomko RJ Jr.

Cell Res. 2017 Mar;27(3):307-308. doi: 10.1038/cr.2017.22. Epub 2017 Feb 21.


A Single α Helix Drives Extensive Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly.

Tomko RJ Jr, Taylor DW, Chen ZA, Wang HW, Rappsilber J, Hochstrasser M.

Cell. 2015 Oct 8;163(2):432-44. doi: 10.1016/j.cell.2015.09.022.


Proteasomes: Isolation and Activity Assays.

Li Y, Tomko RJ Jr, Hochstrasser M.

Curr Protoc Cell Biol. 2015 Jun 1;67:3.43.1-20. doi: 10.1002/0471143030.cb0343s67.


The intrinsically disordered Sem1 protein functions as a molecular tether during proteasome lid biogenesis.

Tomko RJ Jr, Hochstrasser M.

Mol Cell. 2014 Feb 6;53(3):433-43. doi: 10.1016/j.molcel.2013.12.009. Epub 2014 Jan 9.


A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway.

Sá-Moura B, Funakoshi M, Tomko RJ Jr, Dohmen RJ, Wu Z, Peng J, Hochstrasser M.

J Biol Chem. 2013 Nov 22;288(47):33682-96. doi: 10.1074/jbc.M113.521088. Epub 2013 Oct 11.


Molecular architecture and assembly of the eukaryotic proteasome.

Tomko RJ Jr, Hochstrasser M.

Annu Rev Biochem. 2013;82:415-45. doi: 10.1146/annurev-biochem-060410-150257. Epub 2013 Mar 13. Review.


Incorporation of the Rpn12 subunit couples completion of proteasome regulatory particle lid assembly to lid-base joining.

Tomko RJ Jr, Hochstrasser M.

Mol Cell. 2011 Dec 23;44(6):907-17. doi: 10.1016/j.molcel.2011.11.020.


Order of the proteasomal ATPases and eukaryotic proteasome assembly.

Tomko RJ Jr, Hochstrasser M.

Cell Biochem Biophys. 2011 Jun;60(1-2):13-20. doi: 10.1007/s12013-011-9178-4. Review.


3'-5' tRNAHis guanylyltransferase in bacteria.

Heinemann IU, Randau L, Tomko RJ Jr, Söll D.

FEBS Lett. 2010 Aug 20;584(16):3567-72. doi: 10.1016/j.febslet.2010.07.023. Epub 2010 Jul 23.


Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly.

Tomko RJ Jr, Funakoshi M, Schneider K, Wang J, Hochstrasser M.

Mol Cell. 2010 May 14;38(3):393-403. doi: 10.1016/j.molcel.2010.02.035.


microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.

Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko RJ Jr, Lazo JS, Wang Z, Zhang L, Yu J.

Cancer Res. 2009 Oct 15;69(20):8157-65. doi: 10.1158/0008-5472.CAN-09-1996. Epub 2009 Oct 13.


Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base.

Funakoshi M, Tomko RJ Jr, Kobayashi H, Hochstrasser M.

Cell. 2009 May 29;137(5):887-99. doi: 10.1016/j.cell.2009.04.061. Epub 2009 May 14.


Nitrosative stress suppresses checkpoint activation after DNA synthesis inhibition.

Tomko RJ Jr, Azang-Njaah NN, Lazo JS.

Cell Cycle. 2009 Jan 15;8(2):299-305. Epub 2009 Jan 10.


Multimodal control of Cdc25A by nitrosative stress.

Tomko RJ Jr, Lazo JS.

Cancer Res. 2008 Sep 15;68(18):7457-65. doi: 10.1158/0008-5472.CAN-08-0625.


Is a step backwards in S-phase-targeted chemotherapy a step forward?

Queiroz de Oliveira PE, Tomko RJ Jr, Lazo JS.

Mol Interv. 2008 Jun;8(3):137-40. doi: 10.1124/mi.8.3.6. No abstract available.


Independent mechanistic inhibition of cdc25 phosphatases by a natural product caulibugulone.

Brisson M, Foster C, Wipf P, Joo B, Tomko RJ Jr, Nguyen T, Lazo JS.

Mol Pharmacol. 2007 Jan;71(1):184-92. Epub 2006 Oct 3.


Airing out an antioxidant role for the tumor suppressor p53.

Tomko RJ Jr, Bansal P, Lazo JS.

Mol Interv. 2006 Feb;6(1):23-5, 2.


Regioselective organocadmium alkylations of substituted quinones.

Aponick A, Buzdygon RS, Tomko RJ Jr, Fazal AN, Shughart EL, McMaster DM, Myers MC, Pitcock WH Jr, Wigal CT.

J Org Chem. 2002 Jan 11;67(1):242-4.


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