Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 13

1.

Designing novel building blocks is an overlooked strategy to improve compound quality.

Goldberg FW, Kettle JG, Kogej T, Perry MW, Tomkinson NP.

Drug Discov Today. 2015 Jan;20(1):11-7. doi: 10.1016/j.drudis.2014.09.023. Epub 2014 Oct 2. Review.

PMID:
25281855
2.

Predictivity of Simulated ADME AutoQSAR Models over Time.

Rodgers SL, Davis AM, Tomkinson NP, van de Waterbeemd H.

Mol Inform. 2011 Mar 14;30(2-3):256-66. doi: 10.1002/minf.201000160. Epub 2011 Mar 17.

PMID:
27466779
3.

A rapid computational filter for predicting the rate of human renal clearance.

Paine SW, Barton P, Bird J, Denton R, Menochet K, Smith A, Tomkinson NP, Chohan KK.

J Mol Graph Model. 2010 Dec;29(4):529-37. doi: 10.1016/j.jmgm.2010.10.003. Epub 2010 Oct 20.

PMID:
21075652
4.

Identification of a putative intracellular allosteric antagonist binding-site in the CXC chemokine receptors 1 and 2.

Nicholls DJ, Tomkinson NP, Wiley KE, Brammall A, Bowers L, Grahames C, Gaw A, Meghani P, Shelton P, Wright TJ, Mallinder PR.

Mol Pharmacol. 2008 Nov;74(5):1193-202. doi: 10.1124/mol.107.044610. Epub 2008 Aug 1.

PMID:
18676678
5.

QSAR modeling using automatically updating correction libraries: application to a human plasma protein binding model.

Rodgers SL, Davis AM, Tomkinson NP, van de Waterbeemd H.

J Chem Inf Model. 2007 Nov-Dec;47(6):2401-7. Epub 2007 Sep 22.

PMID:
17887744
6.

Components of successful lead generation.

Davis AM, Keeling DJ, Steele J, Tomkinson NP, Tinker AC.

Curr Top Med Chem. 2005;5(4):421-39. Review.

PMID:
15892684
7.

Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.

Kirton SB, Kemp CA, Tomkinson NP, St-Gallay S, Sutcliffe MJ.

Proteins. 2002 Nov 1;49(2):216-31.

PMID:
12211002
8.

P2T purinoceptor antagonists. A QSAR study of some 2-substituted ATP analogues.

Tomkinson NP, Marriott DP, Cage PA, Cox D, Davis AM, Flower DR, Gensmantel NP, Humphries RG, Ingall AH, Kindon ND.

J Pharm Pharmacol. 1996 Feb;48(2):206-9.

PMID:
8935173
9.

Design of potential angiogenin inhibitors.

Howlin BJ, Tomkinson NP, Chen J, Webb GA.

J Comput Aided Mol Des. 1994 Jun;8(3):223-30.

PMID:
7964923
10.

Pulse radiolysis and related studies on the Ru-modified His 16 derivative of Anabaena variabilis [2Fe-2S] ferredoxin.

Lloyd E, Tomkinson NP, Salmon GA, Sykes AG.

Biochim Biophys Acta. 1993 Sep 3;1202(1):113-20.

PMID:
8373814
11.

Reactivity patterns for redox reactions of monomer forms of myoglobin, hemocyanin and hemerythrin.

Zhang BJ, Andrew CR, Tomkinson NP, Sykes AG.

Biochim Biophys Acta. 1992 Sep 25;1102(2):245-52.

PMID:
1390826
12.

Synthetic analogues of chymostatin. Inhibition of chymotrypsin and Streptomyces griseus proteinase A.

Tomkinson NP, Galpin IJ, Beynon RJ.

Biochem J. 1992 Sep 1;286 ( Pt 2):475-80.

13.

Inhibition of chymotrypsin by phenyl N-phenyl-phosphoramidochloridate.

Parkin J, Tomkinson NP, Virden R.

Biochem Soc Trans. 1992 Aug;20(3):283S. No abstract available.

PMID:
1426567

Supplemental Content

Loading ...
Support Center