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Effect of circadian rhythm type on serum lipid levels in shift workers: A 5-year cohort study.

Tomizawa A, Nogawa K, Watanabe Y, Oishi M, Tanaka K, Sakata K, Suwazono Y.

Chronobiol Int. 2019 Jun;36(6):751-757. doi: 10.1080/07420528.2018.1549563. Epub 2019 Apr 24.


Vasodilator-stimulated phosphoprotein (VASP) is not a major mediator of platelet aggregation, thrombogenesis, haemostasis, and antiplatelet effect of prasugrel in rats.

Ito Y, Ohno K, Morikawa Y, Tomizawa A, Mizuno M, Sugidachi A.

Sci Rep. 2018 Jul 2;8(1):9955. doi: 10.1038/s41598-018-28181-8.


Absolute Structures of Wedelolide Derivatives and Structure-Activity Relationships of Protein Tyrosine Phosphatase 1B Inhibitory ent-Kaurene Diterpenes from Aerial Parts of Wedelia spp. Collected in Indonesia and Japan.

Abdjul DB, Yamazaki H, Kanno SI, Kirikoshi R, Tomizawa A, Takahashi O, Maarisit W, Losung F, Rotinsulu H, Wewengkang DS, Sumilat DA, Kapojos MM, Namikoshi M.

Chem Pharm Bull (Tokyo). 2018;66(6):682-687. doi: 10.1248/cpb.c18-00117.


Induction of Diabetes Abolishes the Antithrombotic Effect of Clopidogrel in Apolipoprotein E-Deficient Mice.

Sugidachi A, Ohno K, Jakubowski JA, Ito Y, Tomizawa A, Mizuno M.

TH Open. 2017 Aug 10;1(2):e92-e100. doi: 10.1055/s-0037-1605361. eCollection 2017 Jul.


Glutathione peroxidase 3 is a protective factor against acetaminophen‑induced hepatotoxicity in vivo and in vitro.

Kanno SI, Tomizawa A, Yomogida S, Hara A.

Int J Mol Med. 2017 Sep;40(3):748-754. doi: 10.3892/ijmm.2017.3049. Epub 2017 Jul 3.


Age-, sex-, and diagnosis-specific incidence rate of medically certified long-term sick leave among private sector employees: The Japan Epidemiology Collaboration on Occupational Health (J-ECOH) study.

Nishiura C, Nanri A, Kashino I, Hori A, Kinugawa C, Endo M, Kato N, Tomizawa A, Uehara A, Yamamoto M, Nakagawa T, Yamamoto S, Honda T, Imai T, Okino A, Miyamoto T, Sasaki N, Tomita K, Nagahama S, Kochi T, Eguchi M, Okazaki H, Murakami T, Shimizu C, Shimizu M, Kabe I, Mizoue T, Sone T, Dohi S.

J Epidemiol. 2017 Dec;27(12):590-595. doi: 10.1016/ Epub 2017 Jun 23.


An anti-mycobacterial bisfunctionalized sphingolipid and new bromopyrrole alkaloid from the Indonesian marine sponge Agelas sp.

Abdjul DB, Yamazaki H, Kanno SI, Tomizawa A, Rotinsulu H, Wewengkang DS, Sumilat DA, Ukai K, Kapojos MM, Namikoshi M.

J Nat Med. 2017 Jul;71(3):531-536. doi: 10.1007/s11418-017-1085-6. Epub 2017 Mar 31.


A child with severe inner ear malformations with favorable hearing utilization and balance functions after wearing hearing aids.

Kimura Y, Masuda T, Tomizawa A, Sakata H, Kaga K.

J Otol. 2017 Mar;12(1):41-46. doi: 10.1016/j.joto.2017.03.002. Epub 2017 Mar 21.


A tetramic acid derivative with protein tyrosine phosphatase 1B inhibitory activity and a new nortriterpene glycoside from the Indonesian marine sponge Petrosia sp.

Maarisit W, Yamazaki H, Kanno SI, Tomizawa A, Rotinsulu H, Wewengkang DS, Sumilat DA, Ukai K, Kapojos MM, Namikoshi M.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):999-1002. doi: 10.1016/j.bmcl.2016.12.077. Epub 2016 Dec 31.


Optimal dosage of cefmetazole for intraoperative antimicrobial prophylaxis in patients undergoing surgery for colorectal cancer.

Tomizawa A, Nakamura T, Komatsu T, Inano H, Kondo R, Watanabe M, Atsuda K.

J Pharm Health Care Sci. 2017 Jan 7;3:1. doi: 10.1186/s40780-016-0071-6. eCollection 2017.


Protein tyrosine phosphatase 1B inhibitory properties of seco-cucurbitane triterpenes obtained from fruiting bodies of Russula lepida.

Maarisit W, Yamazaki H, Kanno SI, Tomizawa A, Lee JS, Namikoshi M.

J Nat Med. 2017 Jan;71(1):334-337. doi: 10.1007/s11418-016-1061-6. Epub 2016 Nov 19.


The active metabolite of prasugrel, R-138727, improves cerebral blood flow and reduces cerebral infarction and neurologic deficits in a non-human primate model of acute ischaemic stroke.

Sugidachi A, Mizuno M, Ohno K, Jakubowski JA, Tomizawa A.

Eur J Pharmacol. 2016 Oct 5;788:132-139. doi: 10.1016/j.ejphar.2016.06.023. Epub 2016 Jun 16.


A Novel Model of Intravital Platelet Imaging Using CD41-ZsGreen1 Transgenic Rats.

Mizuno M, Tomizawa A, Ohno K, Jakubowski JA, Sugidachi A.

PLoS One. 2016 Apr 29;11(4):e0154661. doi: 10.1371/journal.pone.0154661. eCollection 2016.


Prasugrel, a Platelet P2Y12 Receptor Antagonist, Improves Abnormal Gait in a Novel Murine Model of Thrombotic Hindlimb Ischemia.

Ohno K, Tomizawa A, Mizuno M, Jakubowski JA, Sugidachi A.

J Am Heart Assoc. 2016 Apr 6;5(4):e002889. doi: 10.1161/JAHA.115.002889.


Detecting mRNA Predictors of Acetaminophen-Induced Hepatotoxicity in Mouse Blood Using Quantitative Real-Time PCR.

Kanno S, Tomizawa A, Yomogida S.

Biol Pharm Bull. 2016;39(3):440-5. doi: 10.1248/bpb.b15-00734. Epub 2015 Dec 25.


Prevention of occlusive arterial thrombus formation by a single loading dose of prasugrel suppresses neointimal hyperplasia in mice.

Ohno K, Tomizawa A, Jakubowski JA, Mizuno M, Sugidachi A.

Thromb Res. 2015 Dec;136(6):1245-51. doi: 10.1016/j.thromres.2015.10.010. Epub 2015 Oct 9.


Prasugrel reduces ischaemic infarct volume and ameliorates neurological deficits in a non-human primate model of middle cerebral artery thrombosis.

Tomizawa A, Ohno K, Jakubowski JA, Mizuno M, Sugidachi A.

Thromb Res. 2015 Dec;136(6):1224-30. doi: 10.1016/j.thromres.2015.09.013. Epub 2015 Sep 11.


Characterization of platelet aggregation responses in microminipigs: Comparison with miniature pigs and the influence of dual antiplatelet administration of aspirin plus prasugrel.

Ohno K, Tomizawa A, Jakubowski JA, Mizuno M, Sugidachi A.

Thromb Res. 2015 May;135(5):933-8. doi: 10.1016/j.thromres.2015.02.014. Epub 2015 Feb 21.


[Subjective evaluation of cochlear implants through a questionnaire survey in 100 long term adult cochlear implant users].

Shirai K, Kawano A, Nishiyama N, Hagiwara A, Kawaguchi S, Saito Y, Tomizawa A, Keshino Y, Nonami N, Suzuki M.

Nihon Jibiinkoka Gakkai Kaiho. 2014 Nov;117(11):1329-38. Japanese.


Pifithrin-alpha has a p53-independent cytoprotective effect on docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma HepG2 cells.

Kanno S, Kurauchi K, Tomizawa A, Yomogida S, Ishikawa M.

Toxicol Lett. 2015 Jan 22;232(2):393-402. doi: 10.1016/j.toxlet.2014.11.016. Epub 2014 Nov 18.


Platelet activation biomarkers in Berkeley sickle cell mice and the response to prasugrel.

Ohno K, Tanaka H, Samata N, Jakubowski JA, Tomizawa A, Mizuno M, Sugidachi A.

Thromb Res. 2014 Oct;134(4):889-94. doi: 10.1016/j.thromres.2014.07.035. Epub 2014 Aug 6.


Molecular interactions with CO2 for controlling the regioselectivity of liquid phase hydrogenation of 2,4-dinitroaniline.

Yoshida H, Tomizawa A, Tachikawa H, Fujita S, Arai M.

Phys Chem Chem Phys. 2014 Sep 21;16(35):18955-65. doi: 10.1039/c4cp02114b.


Combined effect of papuamine and doxorubicin in human breast cancer MCF-7 cells.

Kanno SI, Yomogida S, Tomizawa A, Yamazaki H, Ukai K, Mangindaan RE, Namikoshi M, Ishikawa M.

Oncol Lett. 2014 Aug;8(2):547-550. Epub 2014 Jun 3.


Cytotoxic effects of caffeic acid undecyl ester are involved in the inhibition of telomerase activity in NALM-6 human B-cell leukemia cells.

Tomizawa A, Kanno SI, Osanai Y, Yomogida S, Ishikawa M.

Oncol Lett. 2013 Oct;6(4):875-877. Epub 2013 Jul 23.


Papuamine causes autophagy following the reduction of cell survival through mitochondrial damage and JNK activation in MCF-7 human breast cancer cells.

Kanno S, Yomogida S, Tomizawa A, Yamazaki H, Ukai K, Mangindaan RE, Namikoshi M, Ishikawa M.

Int J Oncol. 2013 Nov;43(5):1413-9. doi: 10.3892/ijo.2013.2093. Epub 2013 Sep 10.


Tissue concentrations of antibiotics given prophylactically during colorectal cancer surgery.

Nakamura T, Tomizawa A, Inano H, Sato T, Yago K, Watanabe M.

Hepatogastroenterology. 2013 Sep;60(126):1371-5. doi: 10.5754/hge13070.


Comparison of antiplatelet effects of prasugrel and ticagrelor in cynomolgus monkeys by an ELISA-based VASP phosphorylation assay and platelet aggregation.

Tomizawa A, Ohno K, Jakubowski JA, Mizuno M, Sugidachi A.

Thromb Haemost. 2013 Oct;110(4):769-76. doi: 10.1160/TH13-03-0260. Epub 2013 Aug 1.


A comparison of the pharmacological profiles of prasugrel and ticagrelor assessed by platelet aggregation, thrombus formation and haemostasis in rats.

Sugidachi A, Ohno K, Ogawa T, Jakubowski J, Hashimoto M, Tomizawa A.

Br J Pharmacol. 2013 May;169(1):82-9. doi: 10.1111/bph.12108.


Exogenous albumin inhibits sorafenib-induced cytotoxicity in human cancer cell lines.

Kanno SI, Itoh K, Suzuki N, Tomizawa A, Yomogida S, Ishikawa M.

Mol Clin Oncol. 2013 Jan;1(1):29-34. Epub 2012 Jun 27.


Induction of apoptosis by a potent caffeic acid derivative, caffeic acid undecyl ester, is mediated by mitochondrial damage in NALM-6 human B cell leukemia cells.

Tomizawa A, Kanno S, Osanai Y, Goto A, Sato C, Yomogida S, Ishikawa M.

Oncol Rep. 2013 Feb;29(2):425-9. doi: 10.3892/or.2012.2163. Epub 2012 Dec 3.


Involvement of p21waf1/cip1 expression in the cytotoxicity of the potent histone deacetylase inhibitor spiruchostatin B towards susceptible NALM-6 human B cell leukemia cells.

Kanno S, Maeda N, Tomizawa A, Yomogida S, Katoh T, Ishikawa M.

Int J Oncol. 2012 May;40(5):1391-6. doi: 10.3892/ijo.2011.1323. Epub 2011 Dec 30.


Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade.

Watanabe K, Kanno S, Tomizawa A, Yomogida S, Ishikawa M.

Oncol Rep. 2012 Jan;27(1):204-9. doi: 10.3892/or.2011.1498. Epub 2011 Oct 12.


Carbamoyl-PROXYL-enhanced MRI detects very small disruptions in brain vascular permeability induced by dietary cholesterol.

Tomizawa A, Ishii I, Zhelev Z, Aoki I, Shibata S, Kitada M, Bakalova R.

Biochim Biophys Acta. 2011 Dec;1810(12):1309-16. doi: 10.1016/j.bbagen.2011.06.011. Epub 2011 Jun 29.


Nitroxide derivatives for imaging of hypercholesterolemia-induced kidney dysfunction and assessing the effectiveness of antilipidemic drugs.

Tomizawa A, Hadjidekov G, Ishii I, Bakalova R, Zhelev Z, Aoki I, Saga T, Kitada M.

Mol Pharm. 2011 Oct 3;8(5):1962-9. doi: 10.1021/mp200087v. Epub 2011 Aug 15.


Selective blockade of P2Y12 receptors by prasugrel inhibits myocardial infarction induced by thrombotic coronary artery occlusion in rats.

Sugidachi A, Yamaguchi S, Jakubowski JA, Ohno K, Tomizawa A, Hashimoto M, Niitsu Y.

J Cardiovasc Pharmacol. 2011 Sep;58(3):329-34. doi: 10.1097/FJC.0b013e3182244a6f.


Comparative study between high-dose fluvastatin and low-dose fluvastatin and ezetimibe with regard to the effect on endothelial function in diabetic patients.

Kawagoe Y, Hattori Y, Nakano A, Aoki C, Tanaka S, Ohta S, Iijima T, Tomizawa A, Jojima T, Kase H, Kasai K.

Endocr J. 2011;58(3):171-5. Epub 2011 Feb 4.


Albumin modulates docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma cell lines.

Kanno S, Kurauchi K, Tomizawa A, Yomogida S, Ishikawa M.

Toxicol Lett. 2011 Feb 5;200(3):154-61. doi: 10.1016/j.toxlet.2010.11.009. Epub 2010 Nov 23.


A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells.

Hattori Y, Jojima T, Tomizawa A, Satoh H, Hattori S, Kasai K, Hayashi T.

Diabetologia. 2010 Oct;53(10):2256-63. doi: 10.1007/s00125-010-1831-8. Epub 2010 Jul 1. Retraction in: Diabetologia. 2012 Feb;55(2):533.


Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate-activated protein kinase activation.

Tomizawa A, Hattori Y, Inoue T, Hattori S, Kasai K.

Metabolism. 2011 Apr;60(4):513-22. doi: 10.1016/j.metabol.2010.04.020. Epub 2010 Jun 26.


An ACTH-secreting pituitary adenoma within the sphenoid sinus.

Suzuki K, Hattori Y, Aoki C, Nakano A, Tomizawa A, Kase H, Kasai K.

Intern Med. 2010;49(8):763-6. Epub 2010 Apr 15.


Anti-inflammatory role of cilostazol in vascular smooth muscle cells in vitro and in vivo.

Aoki C, Hattori Y, Tomizawa A, Jojima T, Kasai K.

J Atheroscler Thromb. 2010 May;17(5):503-9. Epub 2010 Feb 24.


Pharmacodynamic and pharmacokinetic evaluation of CS-526 in cynomolgus monkeys.

Ito K, Kinoshita K, Yamamura N, Tomizawa A, Inaba F, Morikawa-Inomata Y, Tabata K, Shibakawa N.

Biol Pharm Bull. 2009 Dec;32(12):2010-7.


Induction of gene expression in response to globular adiponectin in vascular endothelial cells.

Tomizawa A, Hattori Y, Kasai K.

Life Sci. 2009 Sep 9;85(11-12):457-61. doi: 10.1016/j.lfs.2009.07.012. Epub 2009 Aug 6.


Effects of statins on vascular endothelial function in hypercholesterolemic patients with type 2 diabetes mellitus: fluvastatin vs. rosuvastatin.

Tomizawa A, Hattori Y, Suzuki K, Okayasu T, Kase H, Satoh H, Kasai K.

Int J Cardiol. 2010 Sep 24;144(1):108-9. doi: 10.1016/j.ijcard.2008.12.146. Epub 2009 Jan 26. No abstract available.


Cilostazol inhibits cytokine-induced nuclear factor-kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.

Hattori Y, Suzuki K, Tomizawa A, Hirama N, Okayasu T, Hattori S, Satoh H, Akimoto K, Kasai K.

Cardiovasc Res. 2009 Jan 1;81(1):133-9. doi: 10.1093/cvr/cvn226. Epub 2008 Aug 14. Retraction in: Cardiovasc Res. 2011 Oct 1;92(1):181.


High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells.

Hattori Y, Nakano Y, Hattori S, Tomizawa A, Inukai K, Kasai K.

FEBS Lett. 2008 May 28;582(12):1719-24. doi: 10.1016/j.febslet.2008.04.037. Epub 2008 May 1.


The effect of subchronic administration of 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methylcyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526), a novel acid pump antagonist, on gastric acid secretion and gastrin levels in rats.

Ito K, Kinoshita K, Tomizawa A, Morikawa-Inomata Y, Inaba F, Fujita Y, Tabata K, Shibakawa N.

J Pharmacol Exp Ther. 2008 Jul;326(1):163-70. doi: 10.1124/jpet.108.137299. Epub 2008 Apr 14.


PPARalpha activators upregulate eNOS activity and inhibit cytokine-induced NF-kappaB activation through AMP-activated protein kinase activation.

Okayasu T, Tomizawa A, Suzuki K, Manaka K, Hattori Y.

Life Sci. 2008 Apr 9;82(15-16):884-91. doi: 10.1016/j.lfs.2008.02.002. Epub 2008 Feb 16.


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