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Items: 26


EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork-Associated DNA Damage Repair.

Saki M, Makino H, Javvadi P, Tomimatsu N, Ding LH, Clark JE, Gavin E, Takeda K, Andrews J, Saha D, Story MD, Burma S, Nirodi CS.

Mol Cancer Res. 2017 Nov;15(11):1503-1516. doi: 10.1158/1541-7786.MCR-17-0136. Epub 2017 Aug 11.


DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair.

Tomimatsu N, Mukherjee B, Harris JL, Boffo FL, Hardebeck MC, Potts PR, Khanna KK, Burma S.

J Biol Chem. 2017 Jun 30;292(26):10779-10790. doi: 10.1074/jbc.M116.772475. Epub 2017 May 17.


INT6/EIF3E Controls the RNF8-Dependent Ubiquitylation Pathway and Facilitates DNA Double-Strand Break Repair in Human Cells.

Morris C, Tomimatsu N, Burma S, Jalinot P.

Cancer Res. 2016 Oct 15;76(20):6054-6065. Epub 2016 Aug 22.


Immunofluorescence-based methods to monitor DNA end resection.

Mukherjee B, Tomimatsu N, Burma S.

Methods Mol Biol. 2015;1292:67-75. doi: 10.1007/978-1-4939-2522-3_5.


Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.

Tomimatsu N, Mukherjee B, Catherine Hardebeck M, Ilcheva M, Vanessa Camacho C, Louise Harris J, Porteus M, Llorente B, Khanna KK, Burma S.

Nat Commun. 2014 Apr 7;5:3561. doi: 10.1038/ncomms4561.


DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification.

Camacho CV, Todorova PK, Hardebeck MC, Tomimatsu N, Gil del Alcazar CR, Ilcheva M, Mukherjee B, McEllin B, Vemireddy V, Hatanpaa K, Story MD, Habib AA, Murty VV, Bachoo R, Burma S.

Oncogene. 2015 Feb 19;34(8):1064-72. doi: 10.1038/onc.2014.29. Epub 2014 Mar 17.


Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma.

Gil del Alcazar CR, Hardebeck MC, Mukherjee B, Tomimatsu N, Gao X, Yan J, Xie XJ, Bachoo R, Li L, Habib AA, Burma S.

Clin Cancer Res. 2014 Mar 1;20(5):1235-48. doi: 10.1158/1078-0432.CCR-13-1607. Epub 2013 Dec 23.


The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.

Costelloe T, Louge R, Tomimatsu N, Mukherjee B, Martini E, Khadaroo B, Dubois K, Wiegant WW, Thierry A, Burma S, van Attikum H, Llorente B.

Nature. 2012 Sep 27;489(7417):581-4. doi: 10.1038/nature11353. Epub 2012 Sep 9.


AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells.

Raghavan P, Tumati V, Yu L, Chan N, Tomimatsu N, Burma S, Bristow RG, Saha D.

Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-14. doi: 10.1016/j.ijrobp.2012.05.035. Epub 2012 Jul 12.


INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells.

Morris C, Tomimatsu N, Richard DJ, Cluet D, Burma S, Khanna KK, Jalinot P.

Cancer Res. 2012 Apr 15;72(8):2006-16. doi: 10.1158/0008-5472.CAN-11-2562.


The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses.

Mukherjee B, Tomimatsu N, Amancherla K, Camacho CV, Pichamoorthy N, Burma S.

Neoplasia. 2012 Jan;14(1):34-43.


Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions.

Tomimatsu N, Mukherjee B, Deland K, Kurimasa A, Bolderson E, Khanna KK, Burma S.

DNA Repair (Amst). 2012 Apr 1;11(4):441-8. doi: 10.1016/j.dnarep.2012.01.006. Epub 2012 Feb 11.


PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

McEllin B, Camacho CV, Mukherjee B, Hahm B, Tomimatsu N, Bachoo RM, Burma S.

Cancer Res. 2010 Jul 1;70(13):5457-64. doi: 10.1158/0008-5472.CAN-09-4295. Epub 2010 Jun 8.


Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.

Bolderson E, Tomimatsu N, Richard DJ, Boucher D, Kumar R, Pandita TK, Burma S, Khanna KK.

Nucleic Acids Res. 2010 Apr;38(6):1821-31. doi: 10.1093/nar/gkp1164. Epub 2009 Dec 17.


Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.

Tomimatsu N, Mukherjee B, Burma S.

EMBO Rep. 2009 Jun;10(6):629-35. doi: 10.1038/embor.2009.60. Epub 2009 May 15.


EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma.

Mukherjee B, McEllin B, Camacho CV, Tomimatsu N, Sirasanagandala S, Nannepaga S, Hatanpaa KJ, Mickey B, Madden C, Maher E, Boothman DA, Furnari F, Cavenee WK, Bachoo RM, Burma S.

Cancer Res. 2009 May 15;69(10):4252-9. doi: 10.1158/0008-5472.CAN-08-4853. Epub 2009 May 12.


Modulation of the DNA-damage response to HZE particles by shielding.

Mukherjee B, Camacho CV, Tomimatsu N, Miller J, Burma S.

DNA Repair (Amst). 2008 Oct 1;7(10):1717-30. doi: 10.1016/j.dnarep.2008.06.016. Epub 2008 Aug 13.


Protein kinase C-mediated protection of motoneurons from excitotoxicity.

Tomimatsu N, Arakawa Y.

Neurosci Lett. 2008 Jul 11;439(2):143-6. doi: 10.1016/j.neulet.2008.05.004. Epub 2008 May 8.


Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks.

Tomimatsu N, Tahimic CG, Otsuki A, Burma S, Fukuhara A, Sato K, Shiota G, Oshimura M, Chen DJ, Kurimasa A.

J Biol Chem. 2007 Apr 6;282(14):10138-45. Epub 2007 Feb 1.


Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells.

Tahimic CG, Tomimatsu N, Nishigaki R, Fukuhara A, Toda T, Kaibuchi K, Shiota G, Oshimura M, Kurimasa A.

Biochem Biophys Res Commun. 2006 Feb 24;340(4):1244-50. Epub 2006 Jan 5.


Shear bond strength of tooth-colored indirect restorations bonded to coronal and cervical enamel.

Shimada Y, Tomimatsu N, Suzuki T, Uzzaman MA, Burrow MF, Tagami J.

Oper Dent. 2005 Jul-Aug;30(4):468-73.


Construction of a novel expression system on a human artificial chromosome.

Otsuki A, Tahimic CG, Tomimatsu N, Katoh M, Chen DJ, Kurimasa A, Oshimura M.

Biochem Biophys Res Commun. 2005 Apr 15;329(3):1018-25.


Effects of oestrogen on hypothalamic beta-endorphin in ovariectomized and old rats.

Tomimatsu N, Hashimoto S, Akasofu K.

Maturitas. 1993 Jul;17(1):5-16.


Vaginal schwannoma.

Terada S, Suzuki N, Tomimatsu N, Akasofu K.

Arch Gynecol Obstet. 1992;251(4):203-6.


Phyllodes tumor in a patient with a preexistent fibrocystic disease.

Terada S, Tomimatsu N, Suzuki N, Iwawaki T, Akasofu K.

Gynecol Obstet Invest. 1992;34(1):61-4.


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