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Items: 35

1.

Temozolomide induces senescence and repression of DNA repair pathways in glioblastoma cells via activation of ATR-CHK1, p21, and NF-kB.

Aasland D, Götzinger L, Hauck L, Berte N, Meyer J, Effenberger M, Schneider S, Reuber EE, Roos WP, Tomicic MT, Kaina B, Christmann M.

Cancer Res. 2018 Oct 25. pii: canres.1733.2018. doi: 10.1158/0008-5472.CAN-18-1733. [Epub ahead of print]

PMID:
30361254
2.

Differential Effects of Integrin αv Knockdown and Cilengitide on Sensitization of Triple-Negative Breast Cancer and Melanoma Cells to Microtubule Poisons.

Stojanović N, Dekanić A, Paradžik M, Majhen D, Ferenčak K, Ruščić J, Bardak I, Supina C, Tomicic MT, Christmann M, Osmak M, Ambriović-Ristov A.

Mol Pharmacol. 2018 Dec;94(6):1334-1351. doi: 10.1124/mol.118.113027. Epub 2018 Sep 27.

PMID:
30262596
4.

Sensitization of colorectal cancer cells to irinotecan by the Survivin inhibitor LLP3 depends on XAF1 proficiency in the context of mutated p53.

Steigerwald C, Rasenberger B, Christmann M, Tomicic MT.

Arch Toxicol. 2018 Aug;92(8):2645-2648. doi: 10.1007/s00204-018-2240-x. Epub 2018 Jun 8.

PMID:
29947891
5.

Repair gene O6 -methylguanine-DNA methyltransferase is controlled by SP1 and up-regulated by glucocorticoids, but not by temozolomide and radiation.

Aasland D, Reich TR, Tomicic MT, Switzeny OJ, Kaina B, Christmann M.

J Neurochem. 2018 Jan;144(2):139-151. doi: 10.1111/jnc.14262. Epub 2018 Jan 1.

PMID:
29164620
6.

Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome.

Reich TR, Switzeny OJ, Renovanz M, Sommer C, Kaina B, Christmann M, Tomicic MT.

Oncotarget. 2017 Feb 28;8(9):15071-15084. doi: 10.18632/oncotarget.14748.

7.

Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells.

Schäfer C, Göder A, Beyer M, Kiweler N, Mahendrarajah N, Rauch A, Nikolova T, Stojanovic N, Wieczorek M, Reich TR, Tomicic MT, Linnebacher M, Sonnemann J, Dietrich S, Sellmer A, Mahboobi S, Heinzel T, Schneider G, Krämer OH.

Cell Signal. 2017 Jan;29:218-225. doi: 10.1016/j.cellsig.2016.11.002. Epub 2016 Nov 9.

PMID:
27838375
8.

Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations.

Christmann M, Boisseau C, Kitzinger R, Berac C, Allmann S, Sommer T, Aasland D, Kaina B, Tomicic MT.

Nucleic Acids Res. 2016 Dec 15;44(22):10727-10743. Epub 2016 Sep 30.

9.

Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair.

Christmann M, Diesler K, Majhen D, Steigerwald C, Berte N, Freund H, Stojanović N, Kaina B, Osmak M, Ambriović-Ristov A, Tomicic MT.

Oncotarget. 2017 Apr 25;8(17):27754-27771. doi: 10.18632/oncotarget.10897.

10.

Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM.

Tomicic MT, Meise R, Aasland D, Berte N, Kitzinger R, Krämer OH, Kaina B, Christmann M.

Oncotarget. 2015 Oct 20;6(32):33755-68. doi: 10.18632/oncotarget.5274.

11.

Translesion polymerase η is upregulated by cancer therapeutics and confers anticancer drug resistance.

Tomicic MT, Aasland D, Naumann SC, Meise R, Barckhausen C, Kaina B, Christmann M.

Cancer Res. 2014 Oct 1;74(19):5585-96. doi: 10.1158/0008-5472.CAN-14-0953. Epub 2014 Aug 14.

12.

Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs.

Tomicic MT, Aasland D, Nikolova T, Kaina B, Christmann M.

Biochim Biophys Acta. 2013 Aug;1833(8):1832-43. doi: 10.1016/j.bbamcr.2013.03.029. Epub 2013 Apr 8.

13.

Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors.

Tomicic MT, Kaina B.

Biochim Biophys Acta. 2013 Jan;1835(1):11-27. doi: 10.1016/j.bbcan.2012.09.002. Epub 2012 Sep 21. Review.

PMID:
23006513
14.

The chloroethylating anticancer drug ACNU induces FRA1 that is involved in drug resistance of glioma cells.

Meise R, Tomicic MT, Kaina B, Christmann M.

Biochim Biophys Acta. 2012 Jul;1823(7):1199-207. doi: 10.1016/j.bbamcr.2012.05.008. Epub 2012 May 15.

15.

Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma.

Reichert S, Rödel C, Mirsch J, Harter PN, Tomicic MT, Mittelbronn M, Kaina B, Rödel F.

Radiother Oncol. 2011 Oct;101(1):51-8. doi: 10.1016/j.radonc.2011.06.037. Epub 2011 Aug 16.

PMID:
21852011
16.

Delayed c-Fos activation in human cells triggers XPF induction and an adaptive response to UVC-induced DNA damage and cytotoxicity.

Tomicic MT, Reischmann P, Rasenberger B, Meise R, Kaina B, Christmann M.

Cell Mol Life Sci. 2011 May;68(10):1785-98. doi: 10.1007/s00018-010-0546-9. Epub 2010 Oct 26.

17.

Cisplatin resistance: preclinical findings and clinical implications.

Köberle B, Tomicic MT, Usanova S, Kaina B.

Biochim Biophys Acta. 2010 Dec;1806(2):172-82. doi: 10.1016/j.bbcan.2010.07.004. Epub 2010 Jul 17. Review.

PMID:
20647037
18.

Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage.

Christmann M, Tomicic MT, Aasland D, Berdelle N, Kaina B.

Nucleic Acids Res. 2010 Oct;38(19):6418-32. doi: 10.1093/nar/gkq455. Epub 2010 May 28.

19.

Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage.

Tomicic MT, Christmann M, Kaina B.

J Pharmacol Exp Ther. 2010 Jan;332(1):316-25. doi: 10.1124/jpet.109.159962. Epub 2009 Oct 7.

20.

WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.

Christmann M, Tomicic MT, Gestrich C, Roos WP, Bohr VA, Kaina B.

DNA Repair (Amst). 2008 Dec 1;7(12):1999-2009. doi: 10.1016/j.dnarep.2008.08.008. Epub 2008 Oct 15.

21.

c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the re-synthesis of XPF.

Christmann M, Tomicic MT, Origer J, Aasland D, Kaina B.

Nucleic Acids Res. 2006;34(22):6530-9. Epub 2006 Nov 27.

22.

A role for UV-light-induced c-Fos: Stimulation of nucleotide excision repair and protection against sustained JNK activation and apoptosis.

Christmann M, Tomicic MT, Aasland D, Kaina B.

Carcinogenesis. 2007 Jan;28(1):183-90. Epub 2006 Jul 8.

PMID:
16829684
24.

Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival.

Tomicic MT, Christmann M, Kaina B.

Cancer Res. 2005 Oct 1;65(19):8920-6.

25.

Fen1 is induced p53 dependently and involved in the recovery from UV-light-induced replication inhibition.

Christmann M, Tomicic MT, Origer J, Kaina B.

Oncogene. 2005 Dec 15;24(56):8304-13.

PMID:
16103874
26.

Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline.

Tomicic MT, Christmann M, Fabian K, Kaina B.

Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):117-22. Review.

PMID:
16019050
28.

Mechanisms of human DNA repair: an update.

Christmann M, Tomicic MT, Roos WP, Kaina B.

Toxicology. 2003 Nov 15;193(1-2):3-34. Review.

PMID:
14599765
31.

Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutSalpha mismatch-binding activity.

Christmann M, Tomicic MT, Kaina B.

Nucleic Acids Res. 2002 May 1;30(9):1959-66.

33.
34.

Hamster Bcl-2 protein is cleaved in vitro and in cells by caspase-9 and caspase-3.

Tomicic MT, Kaina B.

Biochem Biophys Res Commun. 2001 Feb 23;281(2):404-8.

PMID:
11181062
35.

Cloning and functional analysis of cDNA encoding the hamster Bcl-2 protein.

Tomicic MT, Christmann M, Kaina B.

Biochem Biophys Res Commun. 2000 Sep 7;275(3):899-903.

PMID:
10973819

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