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Cepharanthine blocks TSH receptor peptide presentation by HLA-DR3: Therapeutic implications to Graves' disease.

Li CW, Osman R, Menconi F, Concepcion E, Tomer Y.

J Autoimmun. 2020 Mar;108:102402. doi: 10.1016/j.jaut.2020.102402. Epub 2020 Jan 21.


Hepatitis C Virus Infection of Human Thyrocytes: Metabolic, Hormonal, and Immunological Implications.

Hammerstad SS, Blackard JT, Lombardi A, Owen RP, Concepcion E, Yi Z, Zhang W, Tomer Y.

J Clin Endocrinol Metab. 2020 Apr 1;105(4). pii: dgz241. doi: 10.1210/clinem/dgz241.


In utero gene editing for monogenic lung disease.

Alapati D, Zacharias WJ, Hartman HA, Rossidis AC, Stratigis JD, Ahn NJ, Coons B, Zhou S, Li H, Singh K, Katzen J, Tomer Y, Chadwick AC, Musunuru K, Beers MF, Morrisey EE, Peranteau WH.

Sci Transl Med. 2019 Apr 17;11(488). pii: eaav8375. doi: 10.1126/scitranslmed.aav8375.


Epithelial Expression of an Interstitial Lung Disease-Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in Mice.

Venosa A, Katzen J, Tomer Y, Kopp M, Jamil S, Russo SJ, Mulugeta S, Beers MF.

J Immunol. 2019 May 1;202(9):2760-2771. doi: 10.4049/jimmunol.1900039. Epub 2019 Mar 25.


An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.

Katzen J, Wagner BD, Venosa A, Kopp M, Tomer Y, Russo SJ, Headen AC, Basil MC, Stark JM, Mulugeta S, Deterding RR, Beers MF.

JCI Insight. 2019 Mar 21;4(6). pii: 126125. doi: 10.1172/jci.insight.126125. eCollection 2019 Mar 21.


Epigenetic modulation of β cells by interferon-α via PNPT1/mir-26a/TET2 triggers autoimmune diabetes.

Stefan-Lifshitz M, Karakose E, Cui L, Ettela A, Yi Z, Zhang W, Tomer Y.

JCI Insight. 2019 Mar 7;4(5). pii: 126663. doi: 10.1172/jci.insight.126663. eCollection 2019 Mar 7.


Interferon alpha: The key trigger of type 1 diabetes.

Lombardi A, Tsomos E, Hammerstad SS, Tomer Y.

J Autoimmun. 2018 Nov;94:7-15. doi: 10.1016/j.jaut.2018.08.003. Epub 2018 Aug 14. Review.


Interferon-α Triggers Autoimmune Thyroid Diseases via Lysosomal-Dependent Degradation of Thyroglobulin.

Faustino LC, Lombardi A, Madrigal-Matute J, Owen RP, Libutti SK, Tomer Y.

J Clin Endocrinol Metab. 2018 Oct 1;103(10):3678-3687. doi: 10.1210/jc.2018-00541.


Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis.

Nureki SI, Tomer Y, Venosa A, Katzen J, Russo SJ, Jamil S, Barrett M, Nguyen V, Kopp M, Mulugeta S, Beers MF.

J Clin Invest. 2018 Aug 31;128(9):4008-4024. doi: 10.1172/JCI99287. Epub 2018 Aug 13.


Intrauterine Reprogramming of the Polycystic Ovary Syndrome: Evidence from a Pilot Study of Cord Blood Global Methylation Analysis.

Lambertini L, Saul SR, Copperman AB, Hammerstad SS, Yi Z, Zhang W, Tomer Y, Kase N.

Front Endocrinol (Lausanne). 2017 Dec 18;8:352. doi: 10.3389/fendo.2017.00352. eCollection 2017.


A preliminary analysis of hepatitis C virus in pancreatic islet cells.

Blackard JT, Kong L, Lombardi A, Homann D, Hammerstad SS, Tomer Y.

Virol J. 2017 Dec 20;14(1):237. doi: 10.1186/s12985-017-0905-3.


Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress.

Lombardi A, Tomer Y.

J Autoimmun. 2017 Jun;80:48-55. doi: 10.1016/j.jaut.2017.02.002. Epub 2017 Feb 24.


Aberrant lung remodeling in a mouse model of surfactant dysregulation induced by modulation of the Abca3 gene.

Beers MF, Knudsen L, Tomer Y, Maronn J, Zhao M, Ochs M, Mulugeta S.

Ann Anat. 2017 Mar;210:135-146. doi: 10.1016/j.aanat.2016.11.015. Epub 2016 Dec 26.


CD40 Signaling in Graves Disease Is Mediated Through Canonical and Noncanonical Thyroidal Nuclear Factor κB Activation.

Lee HJ, Lombardi A, Stefan M, Li CW, Inabnet WB 3rd, Owen RP, Concepcion E, Tomer Y.

Endocrinology. 2017 Feb 1;158(2):410-418. doi: 10.1210/en.2016-1609.


Hepatitis C Virus E2 Protein Induces Upregulation of IL-8 Pathways and Production of Heat Shock Proteins in Human Thyroid Cells.

Hammerstad SS, Stefan M, Blackard J, Owen RP, Lee HJ, Concepcion E, Yi Z, Zhang W, Tomer Y.

J Clin Endocrinol Metab. 2017 Feb 1;102(2):689-697. doi: 10.1210/jc.2016-3403.


Flexible peptide recognition by HLA-DR triggers specific autoimmune T-cell responses in autoimmune thyroiditis and diabetes.

Li CW, Osman R, Menconi F, Concepcion ES, Tomer Y.

J Autoimmun. 2017 Jan;76:1-9. doi: 10.1016/j.jaut.2016.09.007. Epub 2016 Sep 23.


Dissecting the Genetic Susceptibility to Graves' Disease in a Cohort of Patients of Italian Origin.

Lombardi A, Menconi F, Greenberg D, Concepcion E, Leo M, Rocchi R, Marinó M, Keddache M, Tomer Y.

Front Endocrinol (Lausanne). 2016 Mar 8;7:21. doi: 10.3389/fendo.2016.00021. eCollection 2016.


Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis.

Li CW, Menconi F, Osman R, Mezei M, Jacobson EM, Concepcion E, David CS, Kastrinsky DB, Ohlmeyer M, Tomer Y.

J Biol Chem. 2016 Feb 19;291(8):4079-90. doi: 10.1074/jbc.M115.694687. Epub 2015 Dec 24.


Linkage Analysis of Genomic Regions Contributing to the Expression of Type 1 Diabetes Microvascular Complications and Interaction with HLA.

Lipner EM, Tomer Y, Noble JA, Monti MC, Lonsdale JT, Corso B, Greenberg DA.

J Diabetes Res. 2015;2015:694107. doi: 10.1155/2015/694107. Epub 2015 Oct 11.


Diabetes and Hepatitis C: A Two-Way Association.

Hammerstad SS, Grock SF, Lee HJ, Hasham A, Sundaram N, Tomer Y.

Front Endocrinol (Lausanne). 2015 Sep 14;6:134. doi: 10.3389/fendo.2015.00134. eCollection 2015. Review.


Immunogenetics of autoimmune thyroid diseases: A comprehensive review.

Lee HJ, Li CW, Hammerstad SS, Stefan M, Tomer Y.

J Autoimmun. 2015 Nov;64:82-90. doi: 10.1016/j.jaut.2015.07.009. Epub 2015 Jul 30. Review.


Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes.

Tomer Y, Dolan LM, Kahaly G, Divers J, D'Agostino RB Jr, Imperatore G, Dabelea D, Marcovina S, Black MH, Pihoker C, Hasham A, Hammerstad SS, Greenberg DA, Lotay V, Zhang W, Monti MC, Matheis N; SEARCH for Diabetes in Youth Study.

J Autoimmun. 2015 Jun;60:32-9. doi: 10.1016/j.jaut.2015.03.006. Epub 2015 Apr 27.


Dr. J. Lester Gabrilove: a master clinician, scientist, and educator (1916-2014).

Tomer Y, Levine AC.

Endocr Pract. 2015 Mar;21(3):220. No abstract available.


Dissecting the role of the FOXP3 gene in the joint genetic susceptibility to autoimmune thyroiditis and diabetes: a genetic and functional analysis.

Li CW, Concepcion E, Tomer Y.

Gene. 2015 Feb 10;556(2):142-8. doi: 10.1016/j.gene.2014.11.064. Epub 2014 Dec 3.


Endoplasmic reticulum stress as a novel mechanism in amiodarone-induced destructive thyroiditis.

Lombardi A, Inabnet WB 3rd, Owen R, Farenholtz KE, Tomer Y.

J Clin Endocrinol Metab. 2015 Jan;100(1):E1-10. doi: 10.1210/jc.2014-2745.


Genetic-epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity.

Stefan M, Wei C, Lombardi A, Li CW, Concepcion ES, Inabnet WB 3rd, Owen R, Zhang W, Tomer Y.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12562-7. doi: 10.1073/pnas.1408821111. Epub 2014 Aug 13.


Genetic analysis in young-age-of-onset Graves' disease reveals new susceptibility loci.

Brown RS, Lombardi A, Hasham A, Greenberg DA, Gordon J, Concepcion E, Hammerstad SS, Lotay V, Zhang W, Tomer Y.

J Clin Endocrinol Metab. 2014 Jul;99(7):E1387-91. doi: 10.1210/jc.2013-4358. Epub 2014 Mar 31.


Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics.

Tomer Y.

Annu Rev Pathol. 2014;9:147-56. doi: 10.1146/annurev-pathol-012513-104713. Review.


DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.

Stefan M, Zhang W, Concepcion E, Yi Z, Tomer Y.

J Autoimmun. 2014 May;50:33-7. doi: 10.1016/j.jaut.2013.10.001. Epub 2013 Nov 7.


Disruption of N-linked glycosylation promotes proteasomal degradation of the human ATP-binding cassette transporter ABCA3.

Beers MF, Zhao M, Tomer Y, Russo SJ, Zhang P, Gonzales LW, Guttentag SH, Mulugeta S.

Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L970-80. doi: 10.1152/ajplung.00184.2013. Epub 2013 Oct 18.


Genetic analysis of interferon induced thyroiditis (IIT): evidence for a key role for MHC and apoptosis related genes and pathways.

Hasham A, Zhang W, Lotay V, Haggerty S, Stefan M, Concepcion E, Dieterich DT, Tomer Y.

J Autoimmun. 2013 Aug;44:61-70. doi: 10.1016/j.jaut.2013.04.002. Epub 2013 May 15.


Clinical review: Clinical utility of TSH receptor antibodies.

Barbesino G, Tomer Y.

J Clin Endocrinol Metab. 2013 Jun;98(6):2247-55. doi: 10.1210/jc.2012-4309. Epub 2013 Mar 28. Review.


HLA class I and II alleles are associated with microvascular complications of type 1 diabetes.

Lipner EM, Tomer Y, Noble JA, Monti MC, Lonsdale JT, Corso B, Stewart WC, Greenberg DA.

Hum Immunol. 2013 May;74(5):538-44. doi: 10.1016/j.humimm.2013.01.013. Epub 2013 Jan 29.


Hepatitis C virus infection of a thyroid cell line: implications for pathogenesis of hepatitis C virus and thyroiditis.

Blackard JT, Kong L, Huber AK, Tomer Y.

Thyroid. 2013 Jul;23(7):863-70. doi: 10.1089/thy.2012.0507. Epub 2013 Jun 21.


Fine mapping of loci linked to autoimmune thyroid disease identifies novel susceptibility genes.

Tomer Y, Hasham A, Davies TF, Stefan M, Concepcion E, Keddache M, Greenberg DA.

J Clin Endocrinol Metab. 2013 Jan;98(1):E144-52. doi: 10.1210/jc.2012-2408. Epub 2012 Nov 1.


Genetically driven target tissue overexpression of CD40: a novel mechanism in autoimmune disease.

Huber AK, Finkelman FD, Li CW, Concepcion E, Smith E, Jacobson E, Latif R, Keddache M, Zhang W, Tomer Y.

J Immunol. 2012 Sep 15;189(6):3043-53. doi: 10.4049/jimmunol.1200311. Epub 2012 Aug 10.


Apathetic thyrotoxicosis secondary to atypical subacute thyroiditis.

Carluccio AL, Sundaram NK, Yanagisawa RT, Tomer Y.

Endocr Pract. 2012 Sep-Oct;18(5):e127-9. doi: 10.4158/EP11373.CR.


Genetic and epigenetic mechanisms in thyroid autoimmunity.

Hasham A, Tomer Y.

Immunol Res. 2012 Dec;54(1-3):204-13. doi: 10.1007/s12026-012-8302-x. Review.


Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism.

Stefan M, Jacobson EM, Huber AK, Greenberg DA, Li CW, Skrabanek L, Conception E, Fadlalla M, Ho K, Tomer Y.

J Biol Chem. 2011 Sep 9;286(36):31168-79. doi: 10.1074/jbc.M111.247510. Epub 2011 Jul 12.


The recent rise in the frequency of type 1 diabetes: who pulled the trigger?

Hasham A, Tomer Y.

J Autoimmun. 2011 Aug;37(1):1-2. doi: 10.1016/j.jaut.2011.04.001. No abstract available.


cDNA immunization of mice with human thyroglobulin generates both humoral and T cell responses: a novel model of thyroid autoimmunity.

Jacobson EM, Concepcion E, Ho K, Kopp P, Vono Toniolo J, Tomer Y.

PLoS One. 2011 Apr 29;6(4):e19200. doi: 10.1371/journal.pone.0019200.


IFN-α mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms.

Akeno N, Smith EP, Stefan M, Huber AK, Zhang W, Keddache M, Tomer Y.

J Immunol. 2011 Apr 15;186(8):4693-706. doi: 10.4049/jimmunol.1002631. Epub 2011 Mar 14.


Environmental triggers of thyroiditis: hepatitis C and interferon-α.

Menconi F, Hasham A, Tomer Y.

J Endocrinol Invest. 2011 Jan;34(1):78-84. doi: 10.3275/7499. Epub 2010 Feb 28. Review.


Cutting edge: the etiology of autoimmune thyroid diseases.

Eschler DC, Hasham A, Tomer Y.

Clin Rev Allergy Immunol. 2011 Oct;41(2):190-7. doi: 10.1007/s12016-010-8245-8. Review.


Analysis of immune regulatory genes' copy number variants in Graves' disease.

Huber AK, Concepcion ES, Gandhi A, Menconi F, Smith EP, Keddache M, Tomer Y.

Thyroid. 2011 Jan;21(1):69-74. doi: 10.1089/thy.2010.0262. Epub 2010 Nov 8.


Shared molecular amino acid signature in the HLA-DR peptide binding pocket predisposes to both autoimmune diabetes and thyroiditis.

Menconi F, Osman R, Monti MC, Greenberg DA, Concepcion ES, Tomer Y.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16899-903. doi: 10.1073/pnas.1009511107. Epub 2010 Sep 13.


Genetic susceptibility to autoimmune thyroid disease: past, present, and future.

Tomer Y.

Thyroid. 2010 Jul;20(7):715-25. doi: 10.1089/thy.2010.1644. Review.


Thyroid disorders: it's very personal.

Tomer Y, Sarapura V, Kahaly GJ.

Thyroid. 2010 Jul;20(7):677-9. doi: 10.1089/thy.2010.1650. No abstract available.


Tg.2098 is a major human thyroglobulin T-cell epitope.

Menconi F, Huber A, Osman R, Concepcion E, Jacobson EM, Stefan M, David CS, Tomer Y.

J Autoimmun. 2010 Aug;35(1):45-51. doi: 10.1016/j.jaut.2010.01.004. Epub 2010 Mar 19.


Opportunistic autoimmune disorders: from immunotherapy to immune dysregulation.

Kong YC, Wei WZ, Tomer Y.

Ann N Y Acad Sci. 2010 Jan;1183:222-36. doi: 10.1111/j.1749-6632.2009.05138.x. Review.

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