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Items: 1 to 50 of 88

1.

Excellent Durability of the Mosaic Porcine Aortic Bioprosthesis at Extended Follow Up.

Celiento M, Ravenni G, Tomei L, Pratali S, Milano AD, Bortolotti U.

J Heart Valve Dis. 2018 Jan;27(1):97-103.

PMID:
30560605
2.

Development of a Broadly Applicable Assay for Measurement of Glycan-Directed Enzymatic Activity.

Bresciani A, Cecchetti O, Missineo A, Pacifici PG, Tomei L, Rodems S.

SLAS Discov. 2018 Oct;23(9):941-950. doi: 10.1177/2472555218782625. Epub 2018 Jun 22.

PMID:
29932789
3.

Polypharmacy through Phage Display: Selection of Glucagon and GLP-1 Receptor Co-agonists from a Phage-Displayed Peptide Library.

Demartis A, Lahm A, Tomei L, Beghetto E, Di Biasio V, Orvieto F, Frattolillo F, Carrington PE, Mumick S, Hawes B, Bianchi E, Palani A, Pessi A.

Sci Rep. 2018 Jan 12;8(1):585. doi: 10.1038/s41598-017-18494-5.

4.

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).

Bresciani A, Missineo A, Gallo M, Cerretani M, Fezzardi P, Tomei L, Cicero DO, Altamura S, Santoprete A, Ingenito R, Bianchi E, Pacifici R, Dominguez C, Munoz-Sanjuan I, Harper S, Toledo-Sherman L, Park LC.

Arch Biochem Biophys. 2017 Oct 1;631:31-41. doi: 10.1016/j.abb.2017.08.003. Epub 2017 Aug 8. Review.

PMID:
28801166
5.

High Affinity Binders to EphA2 Isolated from Abdurin Scaffold Libraries; Characterization, Binding and Tumor Targeting.

Ullman C, Mathonet P, Oleksy A, Diamandakis A, Tomei L, Demartis A, Nardi C, Sambucini S, Missineo A, Alt K, Hagemeyer CE, Harris M, Hedt A, Weis R, Gehlsen KR.

PLoS One. 2015 Aug 27;10(8):e0135278. doi: 10.1371/journal.pone.0135278. eCollection 2015.

6.

Food safety considerations in relation to Anisakis pegreffii in anchovies (Engraulis encrasicolus) and sardines (Sardina pilchardus) fished off the Ligurian Coast (Cinque Terre National Park, NW Mediterranean).

Serracca L, Battistini R, Rossini I, Carducci A, Verani M, Prearo M, Tomei L, De Montis G, Ercolini C.

Int J Food Microbiol. 2014 Nov 3;190:79-83. doi: 10.1016/j.ijfoodmicro.2014.08.025. Epub 2014 Aug 21.

PMID:
25203618
7.

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.

Ontoria JM, Rydberg EH, Di Marco S, Tomei L, Attenni B, Malancona S, Martin Hernando JI, Gennari N, Koch U, Narjes F, Rowley M, Summa V, Carroll SS, Olsen DB, De Francesco R, Altamura S, Migliaccio G, Carfì A.

J Med Chem. 2009 Aug 27;52(16):5217-27. doi: 10.1021/jm900517t.

PMID:
19877603
8.

2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.

Pacini B, Avolio S, Ercolani C, Koch U, Migliaccio G, Narjes F, Pacini L, Tomei L, Harper S.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6245-9. doi: 10.1016/j.bmcl.2009.06.106. Epub 2009 Jul 17.

PMID:
19800789
9.

2-D Difference in gel electrophoresis combined with Pro-Q Diamond staining: a successful approach for the identification of kinase/phosphatase targets.

Orsatti L, Forte E, Tomei L, Caterino M, Pessi A, Talamo F.

Electrophoresis. 2009 Jul;30(14):2469-76. doi: 10.1002/elps.200800780.

PMID:
19639567
10.

Mycobacterium tuberculosis DNA detection in soluble fraction of urine from pulmonary tuberculosis patients.

Cannas A, Goletti D, Girardi E, Chiacchio T, Calvo L, Cuzzi G, Piacentini M, Melkonyan H, Umansky SR, Lauria FN, Ippolito G, Tomei LD.

Int J Tuberc Lung Dis. 2008 Feb;12(2):146-51.

PMID:
18230246
11.

Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3.

Forte E, Orsatti L, Talamo F, Barbato G, De Francesco R, Tomei L.

Biochim Biophys Acta. 2008 Feb;1783(2):334-44. Epub 2007 Nov 21.

12.

Novel applications of polymerase chain reaction to urinary nucleic acid analysis.

Lichtenstein AV, Melkonyan HS, Tomei LD, Umansky SR.

Methods Mol Biol. 2006;336:145-54.

PMID:
16916260
13.

Transrenal DNA testing: progress and perspectives.

Umansky SR, Tomei LD.

Expert Rev Mol Diagn. 2006 Mar;6(2):153-63. Review.

PMID:
16512776
14.

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.

Koch U, Attenni B, Malancona S, Colarusso S, Conte I, Di Filippo M, Harper S, Pacini B, Giomini C, Thomas S, Incitti I, Tomei L, De Francesco R, Altamura S, Matassa VG, Narjes F.

J Med Chem. 2006 Mar 9;49(5):1693-705.

PMID:
16509585
15.

HCV antiviral resistance: the impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase.

Tomei L, Altamura S, Paonessa G, De Francesco R, Migliaccio G.

Antivir Chem Chemother. 2005;16(4):225-45. Review.

PMID:
16130521
16.

Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase.

Harper S, Avolio S, Pacini B, Di Filippo M, Altamura S, Tomei L, Paonessa G, Di Marco S, Carfi A, Giuliano C, Padron J, Bonelli F, Migliaccio G, De Francesco R, Laufer R, Rowley M, Narjes F.

J Med Chem. 2005 Jul 14;48(14):4547-57.

PMID:
15999993
17.

Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site.

Di Marco S, Volpari C, Tomei L, Altamura S, Harper S, Narjes F, Koch U, Rowley M, De Francesco R, Migliaccio G, Carfí A.

J Biol Chem. 2005 Aug 19;280(33):29765-70. Epub 2005 Jun 13.

18.

Transrenal DNA as a diagnostic tool: important technical notes.

Su YH, Wang M, Block TM, Landt O, Botezatu I, Serdyuk O, Lichtenstein A, Melkonyan H, Tomei LD, Umansky S.

Ann N Y Acad Sci. 2004 Jun;1022:81-9.

PMID:
15251944
19.

Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase.

Summa V, Petrocchi A, Pace P, Matassa VG, De Francesco R, Altamura S, Tomei L, Koch U, Neuner P.

J Med Chem. 2004 Jan 1;47(1):14-7.

PMID:
14695815
20.

Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

Tomei L, Altamura S, Bartholomew L, Bisbocci M, Bailey C, Bosserman M, Cellucci A, Forte E, Incitti I, Orsatti L, Koch U, De Francesco R, Olsen DB, Carroll SS, Migliaccio G.

J Virol. 2004 Jan;78(2):938-46.

21.

Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Tomei L, Altamura S, Bartholomew L, Biroccio A, Ceccacci A, Pacini L, Narjes F, Gennari N, Bisbocci M, Incitti I, Orsatti L, Harper S, Stansfield I, Rowley M, De Francesco R, Migliaccio G.

J Virol. 2003 Dec;77(24):13225-31.

22.

Prevention of rat neonatal cardiomyocyte apoptosis induced by simulated in vitro ischemia and reperfusion.

Umansky SR, Shapiro JP, Cuenco GM, Foehr MW, Bathurst IC, Tomei LD.

Cell Death Differ. 1997 Oct;4(7):608-16.

23.

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.

Migliaccio G, Tomassini JE, Carroll SS, Tomei L, Altamura S, Bhat B, Bartholomew L, Bosserman MR, Ceccacci A, Colwell LF, Cortese R, De Francesco R, Eldrup AB, Getty KL, Hou XS, LaFemina RL, Ludmerer SW, MacCoss M, McMasters DR, Stahlhut MW, Olsen DB, Hazuda DJ, Flores OA.

J Biol Chem. 2003 Dec 5;278(49):49164-70. Epub 2003 Sep 8.

24.

Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.

De Francesco R, Tomei L, Altamura S, Summa V, Migliaccio G.

Antiviral Res. 2003 Mar;58(1):1-16. Review.

PMID:
12719002
25.

Apoptosis in the myocardium: much is still expected.

Umansky SR, Tomei LD.

Expert Opin Ther Targets. 2003 Feb;7(1):61-9. Review.

PMID:
12556203
26.
27.

Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides.

Bressanelli S, Tomei L, Rey FA, De Francesco R.

J Virol. 2002 Apr;76(7):3482-92.

28.

Apoptosis and the heart: a brief review.

Tomei LD, Umansky SR.

Ann N Y Acad Sci. 2001 Nov;946:160-8. Review.

PMID:
11762984
29.

Circulating nucleic acids and apoptosis.

Lichtenstein AV, Melkonyan HS, Tomei LD, Umansky SR.

Ann N Y Acad Sci. 2001 Sep;945:239-49. Review.

PMID:
11708486
30.

Apoptosis induction and cell cycle perturbation in established cell lines by peroxysomicine A1 (T-514).

Martinez FJ, Zeng GQ, Piñeyro A, Garza-Ocañas L, Tomei LD, Umansky SR.

Drug Chem Toxicol. 2001 Aug;24(3):287-99.

PMID:
11452400
31.

Biochemical and immunologic properties of the nonstructural proteins of the hepatitis C virus: implications for development of antiviral agents and vaccines.

De Francesco R, Neddermann P, Tomei L, Steinkühler C, Gallinari P, Folgori A.

Semin Liver Dis. 2000;20(1):69-83. Review.

PMID:
10895433
32.

Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence.

Tomei L, Vitale RL, Incitti I, Serafini S, Altamura S, Vitelli A, De Francesco R.

J Gen Virol. 2000 Mar;81(Pt 3):759-67.

PMID:
10675414
33.

Antiapoptotic activity of the Bowman-Birk inhibitor can be attributed to copurified phospholipids.

Foehr MW, Tomei LD, Goddard JG, Pemberton PA, Bathurst IC.

Nutr Cancer. 1999;34(2):199-205.

PMID:
10578488
34.

Identification of a novel sequence at the 3' end of the GB virus B genome.

Sbardellati A, Scarselli E, Tomei L, Kekulé AS, Traboni C.

J Virol. 1999 Dec;73(12):10546-50.

35.

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.

Bressanelli S, Tomei L, Roussel A, Incitti I, Vitale RL, Mathieu M, De Francesco R, Rey FA.

Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13034-9.

36.

Soy-derived antiapoptotic fractions protect gastrointestinal epithelium from damage caused by methotrexate treatment in the rat.

Logvinova AV, Foehr MW, Pemberton PA, Khazalpour KM, Funk-Archuleta MA, Bathurst IC, Tomei LD.

Nutr Cancer. 1999;33(1):33-9.

PMID:
10227041
37.

Rational design and functional expression of a constitutively active single-chain NS4A-NS3 proteinase.

Pasquo A, Nardi MC, Dimasi N, Tomei L, Steinkühler C, Delmastro P, Tramontano A, De Francesco R.

Fold Des. 1998;3(6):433-41.

38.

Aging and apoptosis control.

Tomei LD, Umansky SR.

Neurol Clin. 1998 Aug;16(3):735-45. Review.

PMID:
9666047
39.

Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus.

Gallinari P, Brennan D, Nardi C, Brunetti M, Tomei L, Steinkühler C, De Francesco R.

J Virol. 1998 Aug;72(8):6758-69.

40.

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form.

Yan Y, Li Y, Munshi S, Sardana V, Cole JL, Sardana M, Steinkuehler C, Tomei L, De Francesco R, Kuo LC, Chen Z.

Protein Sci. 1998 Apr;7(4):837-47.

41.

SARPs: a family of secreted apoptosis-related proteins.

Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13636-41.

42.

Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid.

Erickson JR, Wu JJ, Goddard JG, Tigyi G, Kawanishi K, Tomei LD, Kiefer MC.

J Biol Chem. 1998 Jan 16;273(3):1506-10.

43.

Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion.

Bielawska AE, Shapiro JP, Jiang L, Melkonyan HS, Piot C, Wolfe CL, Tomei LD, Hannun YA, Umansky SR.

Am J Pathol. 1997 Nov;151(5):1257-63.

44.

GB virus B and hepatitis C virus NS3 serine proteases share substrate specificity.

Scarselli E, Urbani A, Sbardellati A, Tomei L, De Francesco R, Traboni C.

J Virol. 1997 Jul;71(7):4985-9.

45.

Interferon-gamma modulates a p53-independent apoptotic pathway and apoptosis-related gene expression.

Ossina NK, Cannas A, Powers VC, Fitzpatrick PA, Knight JD, Gilbert JR, Shekhtman EM, Tomei LD, Umansky SR, Kiefer MC.

J Biol Chem. 1997 Jun 27;272(26):16351-7.

46.

The nonstructural proteins of the hepatitis C virus: structure and functions.

Neddermann P, Tomei L, Steinkühler C, Gallinari P, Tramontano A, De Francesco R.

Biol Chem. 1997 Jun;378(6):469-76. Review.

PMID:
9224925
47.

Antiapoptotic compound to enhance hypothermic liver preservation.

Wu G, Tomei LD, Bathurst IC, Zhang F, Hong CB, Issel CJ, Columbano A, Salley RK, Chien S.

Transplantation. 1997 Mar 27;63(6):803-9.

PMID:
9089218
48.

A soy-derived antiapoptotic fraction decreases methotrexate toxicity in the gastrointestinal tract of the rat.

Funk-Archuleta MA, Foehr MW, Tomei LD, Hennebold KL, Bathurst IC.

Nutr Cancer. 1997;29(3):217-21.

PMID:
9457742
49.

Apoptosis in the heart.

Umansky SR, Tomei LD.

Adv Pharmacol. 1997;41:383-407. Review. No abstract available.

PMID:
9204153
50.

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes.

Guo Z, Liliom K, Fischer DJ, Bathurst IC, Tomei LD, Kiefer MC, Tigyi G.

Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14367-72.

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