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A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity.

Lopez VA, Park BC, Nowak D, Sreelatha A, Zembek P, Fernandez J, Servage KA, Gradowski M, Hennig J, Tomchick DR, Pawłowski K, Krzymowska M, Tagliabracci VS.

Cell. 2019 Sep 7. pii: S0092-8674(19)30908-0. doi: 10.1016/j.cell.2019.08.020. [Epub ahead of print]


Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases.

Black MH, Osinski A, Gradowski M, Servage KA, Pawłowski K, Tomchick DR, Tagliabracci VS.

Science. 2019 May 24;364(6442):787-792. doi: 10.1126/science.aaw7446.


High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers.

Peng W, de Souza Santos M, Li Y, Tomchick DR, Orth K.

PLoS One. 2019 May 2;14(5):e0213423. doi: 10.1371/journal.pone.0213423. eCollection 2019.


Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone.

Padavannil A, Sarkar P, Kim SJ, Cagatay T, Jiou J, Brautigam CA, Tomchick DR, Sali A, D'Arcy S, Chook YM.

Elife. 2019 Mar 11;8. pii: e43630. doi: 10.7554/eLife.43630.


Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes.

Endapally S, Frias D, Grzemska M, Gay A, Tomchick DR, Radhakrishnan A.

Cell. 2019 Feb 21;176(5):1040-1053.e17. doi: 10.1016/j.cell.2018.12.042. Epub 2019 Jan 31.


Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.

White J, Dhingra SK, Deng X, El Mazouni F, Lee MCS, Afanador GA, Lawong A, Tomchick DR, Ng CL, Bath J, Rathod PK, Fidock DA, Phillips MA.

ACS Infect Dis. 2019 Jan 11;5(1):90-101. doi: 10.1021/acsinfecdis.8b00211. Epub 2018 Nov 13.


Protein AMPylation by an Evolutionarily Conserved Pseudokinase.

Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urbańska M, Łobocka M, Grishin NV, Orth K, Kucharczyk R, Pawłowski K, Tomchick DR, Tagliabracci VS.

Cell. 2018 Oct 18;175(3):809-821.e19. doi: 10.1016/j.cell.2018.08.046. Epub 2018 Sep 27.


Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs.

Afanador GA, Tomchick DR, Phillips MA.

Structure. 2018 Nov 6;26(11):1499-1512.e5. doi: 10.1016/j.str.2018.07.012. Epub 2018 Sep 6.


SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.

Bae SJ, Ni L, Osinski A, Tomchick DR, Brautigam CA, Luo X.

Elife. 2017 Oct 24;6. pii: e30278. doi: 10.7554/eLife.30278.


Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.

Voleti R, Tomchick DR, Südhof TC, Rizo J.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8518-E8527. doi: 10.1073/pnas.1710708114. Epub 2017 Sep 18.


Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.

Xu J, Camacho M, Xu Y, Esser V, Liu X, Trimbuch T, Pan YZ, Ma C, Tomchick DR, Rosenmund C, Rizo J.

Elife. 2017 Feb 8;6. pii: e22567. doi: 10.7554/eLife.22567.


Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.

Brautigam CA, Deka RK, Liu WZ, Tomchick DR, Norgard MV.

Protein Sci. 2017 Apr;26(4):847-856. doi: 10.1002/pro.3133. Epub 2017 Mar 23.


Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.

Volkov OA, Kinch L, Ariagno C, Deng X, Zhong S, Grishin N, Tomchick DR, Chen Z, Phillips MA.

Elife. 2016 Dec 15;5. pii: e20198. doi: 10.7554/eLife.20198.


Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy.

Kikuchi S, Borek DM, Otwinowski Z, Tomchick DR, Yu H.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12444-12449. Epub 2016 Oct 18.


A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.

Phillips MA, White KL, Kokkonda S, Deng X, White J, El Mazouni F, Marsh K, Tomchick DR, Manjalanagara K, Rudra KR, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Shackleford DM, Chiu FC, Campbell M, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Martinez MS, Lafuente-Monasterio M, Kaminsky W, Silue K, Zeeman AM, Kocken C, Leroy D, Blasco B, Rossignol E, Rueckle T, Matthews D, Burrows JN, Waterson D, Palmer MJ, Rathod PK, Charman SA.

ACS Infect Dis. 2016 Dec 9;2(12):945-957. Epub 2016 Oct 4.


Bile salt receptor complex activates a pathogenic type III secretion system.

Li P, Rivera-Cancel G, Kinch LN, Salomon D, Tomchick DR, Grishin NV, Orth K.

Elife. 2016 Jul 5;5. pii: e15718. doi: 10.7554/eLife.15718.


Phosphorylation of spore coat proteins by a family of atypical protein kinases.

Nguyen KB, Sreelatha A, Durrant ES, Lopez-Garrido J, Muszewska A, Dudkiewicz M, Grynberg M, Yee S, Pogliano K, Tomchick DR, Pawłowski K, Dixon JE, Tagliabracci VS.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3482-91. doi: 10.1073/pnas.1605917113. Epub 2016 May 16.


Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.

Kokkonda S, Deng X, White KL, Coteron JM, Marco M, de Las Heras L, White J, El Mazouni F, Tomchick DR, Manjalanagara K, Rudra KR, Chen G, Morizzi J, Ryan E, Kaminsky W, Leroy D, Martínez-Martínez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Waterson D, Burrows JN, Matthews D, Charman SA, Phillips MA, Rathod PK.

J Med Chem. 2016 Jun 9;59(11):5416-31. doi: 10.1021/acs.jmedchem.6b00275. Epub 2016 May 21.


Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics.

Ouyang Z, Zheng G, Tomchick DR, Luo X, Yu H.

Mol Cell. 2016 Apr 21;62(2):248-259. doi: 10.1016/j.molcel.2016.02.033. Epub 2016 Mar 10.


Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches.

Dodd DW, Tomchick DR, Corey DR, Gagnon KT.

Biochemistry. 2016 Mar 8;55(9):1283-6. doi: 10.1021/acs.biochem.6b00136. Epub 2016 Feb 22.


Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm.

Deka RK, Brautigam CA, Liu WZ, Tomchick DR, Norgard MV.

Microbiologyopen. 2016 Feb;5(1):21-38. doi: 10.1002/mbo3.306. Epub 2015 Dec 2.


A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA.

Sci Transl Med. 2015 Jul 15;7(296):296ra111. doi: 10.1126/scitranslmed.aaa6645.


Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution.

Brewer KD, Bacaj T, Cavalli A, Camilloni C, Swarbrick JD, Liu J, Zhou A, Zhou P, Barlow N, Xu J, Seven AB, Prinslow EA, Voleti R, Häussinger D, Bonvin AM, Tomchick DR, Vendruscolo M, Graham B, Südhof TC, Rizo J.

Nat Struct Mol Biol. 2015 Jul;22(7):555-64. doi: 10.1038/nsmb.3035. Epub 2015 Jun 1.


Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization.

Guo Y, Scheuermann TH, Partch CL, Tomchick DR, Gardner KH.

J Biol Chem. 2015 Mar 20;290(12):7707-21. doi: 10.1074/jbc.M114.632786. Epub 2015 Jan 27.


Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation.

Rivera-Cancel G, Ko WH, Tomchick DR, Correa F, Gardner KH.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17839-44. doi: 10.1073/pnas.1413983111. Epub 2014 Dec 2.


Substrate-specific activation of the mitotic kinase Bub1 through intramolecular autophosphorylation and kinetochore targeting.

Lin Z, Jia L, Tomchick DR, Luo X, Yu H.

Structure. 2014 Nov 4;22(11):1616-27. doi: 10.1016/j.str.2014.08.020. Epub 2014 Oct 9.


Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.

Hara K, Zheng G, Qu Q, Liu H, Ouyang Z, Chen Z, Tomchick DR, Yu H.

Nat Struct Mol Biol. 2014 Oct;21(10):864-70. doi: 10.1038/nsmb.2880. Epub 2014 Aug 31.


Re-examining how complexin inhibits neurotransmitter release.

Trimbuch T, Xu J, Flaherty D, Tomchick DR, Rizo J, Rosenmund C.

Elife. 2014 May 8;3:e02391. doi: 10.7554/eLife.02391.


Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection.

Fortune DE, Lin YP, Deka RK, Groshong AM, Moore BP, Hagman KE, Leong JM, Tomchick DR, Blevins JS.

Infect Immun. 2014 Aug;82(8):3186-98. doi: 10.1128/IAI.02036-14. Epub 2014 May 19.


Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2.

Xu J, Bacaj T, Zhou A, Tomchick DR, Südhof TC, Rizo J.

Structure. 2014 Feb 4;22(2):269-80. doi: 10.1016/j.str.2013.11.011. Epub 2013 Dec 26.


The bacterial effector VopL organizes actin into filament-like structures.

Zahm JA, Padrick SB, Chen Z, Pak CW, Yunus AA, Henry L, Tomchick DR, Chen Z, Rosen MK.

Cell. 2013 Oct 10;155(2):423-34. doi: 10.1016/j.cell.2013.09.019.


Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5.

Ni L, Li S, Yu J, Min J, Brautigam CA, Tomchick DR, Pan D, Luo X.

Structure. 2013 Oct 8;21(10):1757-68. doi: 10.1016/j.str.2013.07.008. Epub 2013 Aug 22.


Structure of the human cohesin inhibitor Wapl.

Ouyang Z, Zheng G, Song J, Borek DM, Otwinowski Z, Brautigam CA, Tomchick DR, Rankin S, Yu H.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11355-60. doi: 10.1073/pnas.1304594110. Epub 2013 Jun 17.


The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis.

Deka RK, Brautigam CA, Liu WZ, Tomchick DR, Norgard MV.

J Biol Chem. 2013 Apr 19;288(16):11106-21. doi: 10.1074/jbc.M113.449975. Epub 2013 Feb 27.


Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.

Tian W, Li B, Warrington R, Tomchick DR, Yu H, Luo X.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18419-24. doi: 10.1073/pnas.1213438109. Epub 2012 Oct 22.


Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis.

Brautigam CA, Deka RK, Ouyang Z, Machius M, Knutsen G, Tomchick DR, Norgard MV.

J Bacteriol. 2012 Dec;194(24):6771-81. doi: 10.1128/JB.01494-12. Epub 2012 Oct 5.


Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT).

Brautigam CA, Deka RK, Schuck P, Tomchick DR, Norgard MV.

J Mol Biol. 2012 Jun 29;420(1-2):70-86. doi: 10.1016/j.jmb.2012.04.001. Epub 2012 Apr 11.


Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting.

Kim S, Sun H, Tomchick DR, Yu H, Luo X.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6549-54. doi: 10.1073/pnas.1118210109. Epub 2012 Apr 9.


Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing.

Matos MF, Xu Y, Dulubova I, Otwinowski Z, Richardson JM, Tomchick DR, Rizo J, Ho A.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3802-7. doi: 10.1073/pnas.1119075109. Epub 2012 Feb 21.


Structural, bioinformatic, and in vivo analyses of two Treponema pallidum lipoproteins reveal a unique TRAP transporter.

Deka RK, Brautigam CA, Goldberg M, Schuck P, Tomchick DR, Norgard MV.

J Mol Biol. 2012 Mar 9;416(5):678-96. doi: 10.1016/j.jmb.2012.01.015. Epub 2012 Jan 27.


Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5).

Thompson JW, Salahudeen AA, Chollangi S, Ruiz JC, Brautigam CA, Makris TM, Lipscomb JD, Tomchick DR, Bruick RK.

J Biol Chem. 2012 Mar 2;287(10):7357-65. doi: 10.1074/jbc.M111.308684. Epub 2012 Jan 17.


The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors.

Li W, Ma C, Guan R, Xu Y, Tomchick DR, Rizo J.

Structure. 2011 Oct 12;19(10):1443-55. doi: 10.1016/j.str.2011.07.012.


A single active-site mutation of P450BM-3 dramatically enhances substrate binding and rate of product formation.

Haines DC, Hegde A, Chen B, Zhao W, Bondlela M, Humphreys JM, Mullin DA, Tomchick DR, Machius M, Peterson JA.

Biochemistry. 2011 Oct 4;50(39):8333-41. doi: 10.1021/bi201099j. Epub 2011 Sep 6.


Mechanism of actin filament nucleation by the bacterial effector VopL.

Yu B, Cheng HC, Brautigam CA, Tomchick DR, Rosen MK.

Nat Struct Mol Biol. 2011 Aug 28;18(9):1068-74. doi: 10.1038/nsmb.2110.


The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.

Selyunin AS, Sutton SE, Weigele BA, Reddick LE, Orchard RC, Bresson SM, Tomchick DR, Alto NM.

Nature. 2011 Jan 6;469(7328):107-11. doi: 10.1038/nature09593. Epub 2010 Dec 19.


Crystal structure of the Formin mDia1 in autoinhibited conformation.

Otomo T, Tomchick DR, Otomo C, Machius M, Rosen MK.

PLoS One. 2010 Sep 30;5(9). pii: e12896. doi: 10.1371/journal.pone.0012896.


Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.

Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J.

PLoS One. 2010 Sep 2;5(9). pii: e12544. doi: 10.1371/journal.pone.0012544.


Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.

Deng X, Lee J, Michael AJ, Tomchick DR, Goldsmith EJ, Phillips MA.

J Biol Chem. 2010 Aug 13;285(33):25708-19. doi: 10.1074/jbc.M110.121137. Epub 2010 Jun 8.


Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain.

Luong P, Kinch LN, Brautigam CA, Grishin NV, Tomchick DR, Orth K.

J Biol Chem. 2010 Jun 25;285(26):20155-63. doi: 10.1074/jbc.M110.114884. Epub 2010 Apr 21.

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