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Items: 36


SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170.

Rezazadeh S, Yang D, Tombline G, Simon M, Regan SP, Seluanov A, Gorbunova V.

Nucleic Acids Res. 2019 Sep 5;47(15):7914-7928. doi: 10.1093/nar/gkz528.


SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V.

Cell. 2019 Apr 18;177(3):622-638.e22. doi: 10.1016/j.cell.2019.03.043.


Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming.

Tan L, Ke Z, Tombline G, Macoretta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu NV, Yuan ZF, Garcia BA, Shi YG, Shi Y, Seluanov A, Gorbunova V.

Stem Cell Reports. 2017 Nov 14;9(5):1721-1734. doi: 10.1016/j.stemcr.2017.10.001. Epub 2017 Oct 26.


Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae.

Tombline G, Millen JI, Polevoda B, Rapaport M, Baxter B, Van Meter M, Gilbertson M, Madrey J, Piazza GA, Rasmussen L, Wennerberg K, White EL, Nitiss JL, Goldfarb DS.

Aging (Albany NY). 2017 Jan 5;9(1):68-97. doi: 10.18632/aging.101114.


JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.

Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A.

Cell Rep. 2016 Sep 6;16(10):2641-2650. doi: 10.1016/j.celrep.2016.08.006. Epub 2016 Aug 25.


Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture.

Snyder NW, Tombline G, Worth AJ, Parry RC, Silvers JA, Gillespie KP, Basu SS, Millen J, Goldfarb DS, Blair IA.

Anal Biochem. 2015 Apr 1;474:59-65. doi: 10.1016/j.ab.2014.12.014. Epub 2015 Jan 6.


Evidence of histidine and aspartic acid phosphorylation in human prostate cancer cells.

Lapek JD Jr, Tombline G, Kellersberger KA, Friedman MR, Friedman AE.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Feb;388(2):161-73. doi: 10.1007/s00210-014-1063-4. Epub 2014 Nov 6.


Alteration of the flexible loop in 1-deoxy-D-xylulose-5-phosphate reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin.

Kholodar SA, Tombline G, Liu J, Tan Z, Allen CL, Gulick AM, Murkin AS.

Biochemistry. 2014 Jun 3;53(21):3423-31. doi: 10.1021/bi5004074. Epub 2014 May 22.


Pseudomonas aeruginosa PA1006, which plays a role in molybdenum homeostasis, is required for nitrate utilization, biofilm formation, and virulence.

Filiatrault MJ, Tombline G, Wagner VE, Van Alst N, Rumbaugh K, Sokol P, Schwingel J, Iglewski BH.

PLoS One. 2013;8(2):e55594. doi: 10.1371/journal.pone.0055594. Epub 2013 Feb 8.


Pseudomonas aeruginosa PA1006 is a persulfide-modified protein that is critical for molybdenum homeostasis.

Tombline G, Schwingel JM, Lapek JD Jr, Friedman AE, Darrah T, Maguire M, Van Alst NE, Filiatrault MJ, Iglewski BH.

PLoS One. 2013;8(2):e55593. doi: 10.1371/journal.pone.0055593. Epub 2013 Feb 8.


Mass spectrometry detection of histidine phosphorylation on NM23-H1.

Lapek JD Jr, Tombline G, Friedman AE.

J Proteome Res. 2011 Feb 4;10(2):751-5. doi: 10.1021/pr100905m. Epub 2010 Dec 28.


Rhodamine inhibitors of P-glycoprotein: an amide/thioamide "switch" for ATPase activity.

Gannon MK 2nd, Holt JJ, Bennett SM, Wetzel BR, Loo TW, Bartlett MC, Clarke DM, Sawada GA, Higgins JW, Tombline G, Raub TJ, Detty MR.

J Med Chem. 2009 May 28;52(10):3328-41. doi: 10.1021/jm900253g.


Chalcogenopyrylium dyes as inhibitors/modulators of P-glycoprotein in multidrug-resistant cells.

Sawada GA, Raub TJ, William Higgins J, Brennan NK, Moore TM, Tombline G, Detty MR.

Bioorg Med Chem. 2008 Nov 15;16(22):9745-56. doi: 10.1016/j.bmc.2008.09.065. Epub 2008 Sep 30.


ATP occlusion by P-glycoprotein as a surrogate measure for drug coupling.

Tombline G, Holt JJ, Gannon MK, Donnelly DJ, Wetzel B, Sawada GA, Raub TJ, Detty MR.

Biochemistry. 2008 Mar 11;47(10):3294-307. doi: 10.1021/bi7021393. Epub 2008 Feb 15.


A cationic chalcogenoxanthylium photosensitizer effective in vitro in chemosensitive and multidrug-resistant cells.

Holt JJ, Gannon MK 2nd, Tombline G, McCarty TA, Page PM, Bright FV, Detty MR.

Bioorg Med Chem. 2006 Dec 15;14(24):8635-43. Epub 2006 Aug 30.


Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine: coupling of drug binding at the "R" site to the ATP hydrolysis transition state.

Tombline G, Donnelly DJ, Holt JJ, You Y, Ye M, Gannon MK, Nygren CL, Detty MR.

Biochemistry. 2006 Jul 4;45(26):8034-47.


The occluded nucleotide conformation of p-glycoprotein.

Tombline G, Senior AE.

J Bioenerg Biomembr. 2005 Dec;37(6):497-500. Review.


Magnesium influences the discrimination and release of ADP by human RAD51.

Shim KS, Tombline G, Heinen CD, Charbonneau N, Schmutte C, Fishel R.

DNA Repair (Amst). 2006 Jun 10;5(6):704-17. Epub 2006 Apr 19.


Expression, purification, and characterization of cysteine-free mouse P-glycoprotein.

Tombline G, Urbatsch IL, Virk N, Muharemagic A, White LB, Senior AE.

Arch Biochem Biophys. 2006 Jan 1;445(1):124-8. Epub 2005 Nov 28.


Nucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy.

Delannoy S, Urbatsch IL, Tombline G, Senior AE, Vogel PD.

Biochemistry. 2005 Oct 25;44(42):14010-9.


Involvement of the "occluded nucleotide conformation" of P-glycoprotein in the catalytic pathway.

Tombline G, Muharemagić A, White LB, Senior AE.

Biochemistry. 2005 Sep 27;44(38):12879-86.


Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues.

Tombline G, Bartholomew LA, Tyndall GA, Gimi K, Urbatsch IL, Senior AE.

J Biol Chem. 2004 Nov 5;279(45):46518-26. Epub 2004 Aug 23.


Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly.

Tombline G, Bartholomew LA, Urbatsch IL, Senior AE.

J Biol Chem. 2004 Jul 23;279(30):31212-20. Epub 2004 May 24.


hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51.

Shim KS, Schmutte C, Tombline G, Heinen CD, Fishel R.

J Biol Chem. 2004 Jul 16;279(29):30385-94. Epub 2004 May 3.


Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis.

Tombline G, Bartholomew L, Gimi K, Tyndall GA, Senior AE.

J Biol Chem. 2004 Feb 13;279(7):5363-73. Epub 2003 Nov 24.


Signaling mismatch repair: the mechanics of an adenosine-nucleotide molecular switch.

Fishel R, Acharya S, Berardini M, Bocker T, Charbonneau N, Cranston A, Gradia S, Guerrette S, Heinen CD, Mazurek A, Snowden T, Schmutte C, Shim KS, Tombline G, Wilson T.

Cold Spring Harb Symp Quant Biol. 2000;65:217-24. Review. No abstract available.


P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state.

Urbatsch IL, Tyndall GA, Tombline G, Senior AE.

J Biol Chem. 2003 Jun 20;278(25):23171-9. Epub 2003 Apr 1.


Biochemical characterization of the human RAD51 protein. III. Modulation of DNA binding by adenosine nucleotides.

Tombline G, Heinen CD, Shim KS, Fishel R.

J Biol Chem. 2002 Apr 26;277(17):14434-42. Epub 2002 Feb 11.


Biochemical characterization of the human RAD51 protein. II. Adenosine nucleotide binding and competition.

Tombline G, Shim KS, Fishel R.

J Biol Chem. 2002 Apr 26;277(17):14426-33. Epub 2002 Feb 11.


Biochemical characterization of the human RAD51 protein. I. ATP hydrolysis.

Tombline G, Fishel R.

J Biol Chem. 2002 Apr 26;277(17):14417-25. Epub 2002 Feb 11.


BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.

Slupianek A, Schmutte C, Tombline G, Nieborowska-Skorska M, Hoser G, Nowicki MO, Pierce AJ, Fishel R, Skorski T.

Mol Cell. 2001 Oct;8(4):795-806.


Characterization of the human Rad51 genomic locus and examination of tumors with 15q14-15 loss of heterozygosity (LOH).

Schmutte C, Tombline G, Rhiem K, Sadoff MM, Schmutzler R, von Deimling A, Fishel R.

Cancer Res. 1999 Sep 15;59(18):4564-9.


BRCA1, BRCA2, and DNA damage response: collision or collusion?

Zhang H, Tombline G, Weber BL.

Cell. 1998 Feb 20;92(4):433-6. Review. No abstract available.


Short-patch reverse transcription in Escherichia coli.

Thaler DS, Tombline G, Zahn K.

Genetics. 1995 Jul;140(3):909-15.

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