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Items: 19


Recognition of the β-lactam carboxylate triggers acylation of Neisseria gonorrhoeae penicillin-binding protein 2.

Singh A, Tomberg J, Nicholas RA, Davies C.

J Biol Chem. 2019 Sep 20;294(38):14020-14032. doi: 10.1074/jbc.RA119.009942. Epub 2019 Jul 30.


Detection of tuberculosis: the structure of primary health care.

Spagnolo LML, Tomberg JO, Martins MDDR, Antunes LB, Gonzales RIC.

Rev Gaucha Enferm. 2018 Nov 29;39:e20180157. doi: 10.1590/1983-1447.2018.20180157. Portuguese, English.


Detection of tuberculosis: respiratory symptoms flow and results achieved.

Spagnolo LML, Tomberg JO, Vieira DA, Gonzales RIC.

Rev Bras Enferm. 2018 Sep-Oct;71(5):2543-2551. doi: 10.1590/0034-7167-2017-0457. English, Portuguese.


Properly folded and functional PorB from Neisseria gonorrhoeae inhibits dendritic cell stimulation of CD4+ T cell proliferation.

Zhu W, Tomberg J, Knilans KJ, Anderson JE, McKinnon KP, Sempowski GD, Nicholas RA, Duncan JA.

J Biol Chem. 2018 Jul 13;293(28):11218-11229. doi: 10.1074/jbc.RA117.001209. Epub 2018 May 11.


In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae.

Vincent LR, Kerr SR, Tan Y, Tomberg J, Raterman EL, Dunning Hotopp JC, Unemo M, Nicholas RA, Jerse AE.

mBio. 2018 Apr 3;9(2). pii: e01905-17. doi: 10.1128/mBio.01905-17.


Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness.

Tomberg J, Fedarovich A, Vincent LR, Jerse AE, Unemo M, Davies C, Nicholas RA.

Biochemistry. 2017 Feb 28;56(8):1140-1150. doi: 10.1021/acs.biochem.6b01030. Epub 2017 Feb 16.


Monitoring and assessment of outcome in cases of tuberculosis in a municipality of Southern Brazil.

Lima LM, Harter J, Tomberg JO, Vieira DA, Antunes ML, Cardozo-Gonzales RI.

Rev Gaucha Enferm. 2016 Mar;37(1):e51467. doi: 10.1590/1983-1447.2016.01.51467. Epub 2016 Mar 1. English, Portuguese.


Diffusion of antibiotics through the PilQ secretin in Neisseria gonorrhoeae occurs through the immature, sodium dodecyl sulfate-labile form.

Nandi S, Swanson S, Tomberg J, Nicholas RA.

J Bacteriol. 2015 Apr;197(8):1308-21. doi: 10.1128/JB.02628-14. Epub 2015 Jan 20.


Structural effect of the Asp345a insertion in penicillin-binding protein 2 from penicillin-resistant strains of Neisseria gonorrhoeae.

Fedarovich A, Cook E, Tomberg J, Nicholas RA, Davies C.

Biochemistry. 2014 Dec 9;53(48):7596-603. doi: 10.1021/bi5011317. Epub 2014 Dec 1.


Identification of amino acids conferring high-level resistance to expanded-spectrum cephalosporins in the penA gene from Neisseria gonorrhoeae strain H041.

Tomberg J, Unemo M, Ohnishi M, Davies C, Nicholas RA.

Antimicrob Agents Chemother. 2013 Jul;57(7):3029-36. doi: 10.1128/AAC.00093-13. Epub 2013 Apr 15.


Crystal structures of covalent complexes of β-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity.

Nicola G, Tomberg J, Pratt RF, Nicholas RA, Davies C.

Biochemistry. 2010 Sep 21;49(37):8094-104. doi: 10.1021/bi100879m.


Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae.

Zhao S, Duncan M, Tomberg J, Davies C, Unemo M, Nicholas RA.

Antimicrob Agents Chemother. 2009 Sep;53(9):3744-51. doi: 10.1128/AAC.00304-09. Epub 2009 Jun 15.


Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistance.

Powell AJ, Tomberg J, Deacon AM, Nicholas RA, Davies C.

J Biol Chem. 2009 Jan 9;284(2):1202-12. doi: 10.1074/jbc.M805761200. Epub 2008 Nov 4.


Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae.

Fedarovich A, Tomberg J, Nicholas RA, Davies C.

Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):971-9. Epub 2006 Aug 19.


Overexpression and enzymatic characterization of Neisseria gonorrhoeae penicillin-binding protein 4.

Stefanova ME, Tomberg J, Davies C, Nicholas RA, Gutheil WG.

Eur J Biochem. 2004 Jan;271(1):23-32.


Neisseria gonorrhoeae penicillin-binding protein 3 exhibits exceptionally high carboxypeptidase and beta-lactam binding activities.

Stefanova ME, Tomberg J, Olesky M, Höltje JV, Gutheil WG, Nicholas RA.

Biochemistry. 2003 Dec 16;42(49):14614-25.


Crystal structure of wild-type penicillin-binding protein 5 from Escherichia coli: implications for deacylation of the acyl-enzyme complex.

Nicholas RA, Krings S, Tomberg J, Nicola G, Davies C.

J Biol Chem. 2003 Dec 26;278(52):52826-33. Epub 2003 Oct 10.

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