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The Staphylococcal Cell Wall.

Sobral R, Tomasz A.

Microbiol Spectr. 2019 Jul;7(4). doi: 10.1128/microbiolspec.GPP3-0068-2019.


The Cell Wall of Streptococcus pneumoniae.

Vollmer W, Massidda O, Tomasz A.

Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.GPP3-0018-2018.


Staphylococcus aureus Infecting and Colonizing Experimental Animals, Macaques, in a Research Animal Facility.

Pardos de la Gandara M, Diaz L, Euler CW, Chung M, Gonzalez A, Cheleuitte C, Freiwald W, Tomasz A, Fischetti VA, de Lencastre H.

Microb Drug Resist. 2019 Jan/Feb;25(1):54-62. doi: 10.1089/mdr.2018.0232. Epub 2018 Nov 27.


Phenotypic signatures and genetic determinants of oxacillin tolerance in a laboratory mutant of Staphylococcus aureus.

Chung M, Borges V, Gomes JP, de Lencastre H, Tomasz A.

PLoS One. 2018 Jul 3;13(7):e0199707. doi: 10.1371/journal.pone.0199707. eCollection 2018.


Correction for Pardos de la Gandara et al., "Genetic Determinants of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus".

Pardos de la Gandara M, Borges V, Chung M, Milheiriço C, Gomes JP, de Lencastre H, Tomasz A.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e01096-18. doi: 10.1128/AAC.01096-18. Print 2018 Jul. No abstract available.


Genetic Determinants of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus.

Pardos de la Gandara M, Borges V, Chung M, Milheiriço C, Gomes JP, de Lencastre H, Tomasz A.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00206-18. doi: 10.1128/AAC.00206-18. Print 2018 Jun. Erratum in: Antimicrob Agents Chemother. 2018 Jun 26;62(7):.


Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice.

Harkins CP, Pichon B, Doumith M, Parkhill J, Westh H, Tomasz A, de Lencastre H, Bentley SD, Kearns AM, Holden MTG.

Genome Biol. 2017 Jul 20;18(1):130. doi: 10.1186/s13059-017-1252-9.


Antibiotic Resistance as a Stress Response: Recovery of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus "Auxiliary" (fem) Mutants by Induction of the Stringent Stress Response.

Kim CK, Milheiriço C, de Lencastre H, Tomasz A.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00313-17. doi: 10.1128/AAC.00313-17. Print 2017 Aug.


Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci.

Rolo J, Worning P, Boye Nielsen J, Sobral R, Bowden R, Bouchami O, Damborg P, Guardabassi L, Perreten V, Westh H, Tomasz A, de Lencastre H, Miragaia M.

PLoS Genet. 2017 Apr 10;13(4):e1006674. doi: 10.1371/journal.pgen.1006674. eCollection 2017 Apr.


Evolutionary Origin of the Staphylococcal Cassette Chromosome mec (SCCmec).

Rolo J, Worning P, Nielsen JB, Bowden R, Bouchami O, Damborg P, Guardabassi L, Perreten V, Tomasz A, Westh H, de Lencastre H, Miragaia M.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02302-16. doi: 10.1128/AAC.02302-16. Print 2017 Jun.


High-Level Resistance of Staphylococcus aureus to β-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4).

Hamilton SM, Alexander JAN, Choo EJ, Basuino L, da Costa TM, Severin A, Chung M, Aedo S, Strynadka NCJ, Tomasz A, Chatterjee SS, Chambers HF.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02727-16. doi: 10.1128/AAC.02727-16. Print 2017 Jun.


From the Bench to the Barbershop: Community Engagement to Raise Awareness About Community-Acquired Methicillin-Resistant Staphylococcus aureus and Hepatitis C Virus Infection.

Leinberger-Jabari A, Kost RG, D'Orazio B, Burgess R, Khalida C, Tsang A, Mitchell D, Tomasz A, de Lencastre H, Pardos de la Gandara M, Evering TH, Holder T, Coller BS, Tobin JN.

Prog Community Health Partnersh. 2016;10(3):413-423. doi: 10.1353/cpr.2016.0048.


Full-Genome Sequencing Identifies in the Genetic Background Several Determinants That Modulate the Resistance Phenotype in Methicillin-Resistant Staphylococcus aureus Strains Carrying the Novel mecC Gene.

Milheiriço C, de Lencastre H, Tomasz A.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02500-16. doi: 10.1128/AAC.02500-16. Print 2017 Mar.


Heterogeneous oxacillin-resistant phenotypes and production of PBP2A by oxacillin-susceptible/mecA-positive MRSA strains from Africa.

Chung M, Kim CK, Conceição T, Aires-De-Sousa M, De Lencastre H, Tomasz A.

J Antimicrob Chemother. 2016 Oct;71(10):2804-9. doi: 10.1093/jac/dkw209. Epub 2016 Jun 7.


MRSA Causing Infections in Hospitals in Greater Metropolitan New York: Major Shift in the Dominant Clonal Type between 1996 and 2014.

Pardos de la Gandara M, Curry M, Berger J, Burstein D, Della-Latta P, Kopetz V, Quale J, Spitzer E, Tan R, Urban C, Wang G, Whittier S, de Lencastre H, Tomasz A.

PLoS One. 2016 Jun 7;11(6):e0156924. doi: 10.1371/journal.pone.0156924. eCollection 2016.


Role of the Stringent Stress Response in the Antibiotic Resistance Phenotype of Methicillin-Resistant Staphylococcus aureus.

Aedo S, Tomasz A.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2311-7. doi: 10.1128/AAC.02697-15. Print 2016 Apr.


Ability of Antibiotic-Resistant Nonvaccine-Type Pneumococcal Clones to Cause Otitis Media in an Infant Mouse Model of Pneumococcal-Influenza Virus Coinfection.

Frazão N, Hermans P, van Selm S, Sá-Leão R, de Lencastre H, Tomasz A, Diavatopoulos D.

Microb Drug Resist. 2016 Jan;22(1):97-101. doi: 10.1089/mdr.2015.0109. Epub 2015 Sep 14.


Molecular Types of Methicillin-Resistant Staphylococcus aureus and Methicillin-Sensitive S. aureus Strains Causing Skin and Soft Tissue Infections and Nasal Colonization, Identified in Community Health Centers in New York City.

Pardos de la Gandara M, Raygoza Garay JA, Mwangi M, Tobin JN, Tsang A, Khalida C, D'Orazio B, Kost RG, Leinberger-Jabari A, Coffran C, Evering TH, Coller BS, Balachandra S, Urban T, Parola C, Salvato S, Jenks N, Wu D, Burgess R, Chung M, de Lencastre H, Tomasz A.

J Clin Microbiol. 2015 Aug;53(8):2648-58. doi: 10.1128/JCM.00591-15. Epub 2015 Jun 10.


Recurrent furunculosis caused by a community-acquired Staphylococcus aureus strain belonging to the USA300 clone.

Balachandra S, Pardos de la Gandara M, Salvato S, Urban T, Parola C, Khalida C, Kost RG, Evering TH, Pastagia M, D'Orazio BM, Tomasz A, de Lencastre H, Tobin JN.

Microb Drug Resist. 2015 Apr;21(2):237-43. doi: 10.1089/mdr.2014.0283. Epub 2015 Feb 10.


Diagnostic validity Polish language version of the questionnaire MINI-KID (Mini International Neuropsychiatry Interview for Children and Adolescent).

Adamowska S, Adamowski T, Frydecka D, Kiejna A.

Compr Psychiatry. 2014 Oct;55(7):1744-50. doi: 10.1016/j.comppsych.2014.05.019. Epub 2014 Jun 7. Erratum in: Compr Psychiatry.. Sylwia, Adamowska [corrected to Adamowska, Sylwia]; Tomasz, Adamowski [corrected to Adamowski, Tomasz]; Dorota, Frydecka [corrected to Frydecka, Dorota]; Andrzej, Kiejna [corrected to Kiejna, Andrzej].


Mechanisms of vancomycin resistance in Staphylococcus aureus.

Gardete S, Tomasz A.

J Clin Invest. 2014 Jul;124(7):2836-40. doi: 10.1172/JCI68834. Epub 2014 Jul 1. Review.


Variable recombination dynamics during the emergence, transmission and 'disarming' of a multidrug-resistant pneumococcal clone.

Croucher NJ, Hanage WP, Harris SR, McGee L, van der Linden M, de Lencastre H, Sá-Leão R, Song JH, Ko KS, Beall B, Klugman KP, Parkhill J, Tomasz A, Kristinsson KG, Bentley SD.

BMC Biol. 2014 Jun 23;12:49. doi: 10.1186/1741-7007-12-49.


Intermediate-type vancomycin resistance (VISA) in genetically-distinct Staphylococcus aureus isolates is linked to specific, reversible metabolic alterations.

Alexander EL, Gardete S, Bar HY, Wells MT, Tomasz A, Rhee KY.

PLoS One. 2014 May 9;9(5):e97137. doi: 10.1371/journal.pone.0097137. eCollection 2014.


Novel determinants of antibiotic resistance: identification of mutated loci in highly methicillin-resistant subpopulations of methicillin-resistant Staphylococcus aureus.

Dordel J, Kim C, Chung M, Pardos de la Gándara M, Holden MT, Parkhill J, de Lencastre H, Bentley SD, Tomasz A.

MBio. 2014 Apr 8;5(2):e01000. doi: 10.1128/mBio.01000-13.


The glucosaminidase domain of Atl - the major Staphylococcus aureus autolysin - has DNA-binding activity.

Grilo IR, Ludovice AM, Tomasz A, de Lencastre H, Sobral RG.

Microbiologyopen. 2014 Apr;3(2):247-56. doi: 10.1002/mbo3.165. Epub 2014 Mar 3.


The mechanism of heterogeneous beta-lactam resistance in MRSA: key role of the stringent stress response.

Kim C, Mwangi M, Chung M, Milheiriço C, de Lencastre H, Tomasz A.

PLoS One. 2013 Dec 9;8(12):e82814. doi: 10.1371/journal.pone.0082814. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/7775dee3-7a91-4c44-9125-c7634bf909e4. Milheirço, Catarina [corrected to Milheiriço, Catarina].


Virulence potential and genome-wide characterization of drug resistant Streptococcus pneumoniae clones selected in vivo by the 7-valent pneumococcal conjugate vaccine.

Frazão N, Hiller NL, Powell E, Earl J, Ahmed A, Sá-Leão R, de Lencastre H, Ehrlich GD, Tomasz A.

PLoS One. 2013 Sep 19;8(9):e74867. doi: 10.1371/journal.pone.0074867. eCollection 2013.


Whole-genome sequencing reveals a link between β-lactam resistance and synthetases of the alarmone (p)ppGpp in Staphylococcus aureus.

Mwangi MM, Kim C, Chung M, Tsai J, Vijayadamodar G, Benitez M, Jarvie TP, Du L, Tomasz A.

Microb Drug Resist. 2013 Jun;19(3):153-9. doi: 10.1089/mdr.2013.0053. Epub 2013 May 9.


The use of whole genome sequencing to solve an epidemiological puzzle.

Tomasz A.

EMBO Mol Med. 2013 Apr;5(4):486-7. doi: 10.1002/emmm.201302622. No abstract available.


Alternative mutational pathways to intermediate resistance to vancomycin in methicillin-resistant Staphylococcus aureus.

Vidaillac C, Gardete S, Tewhey R, Sakoulas G, Kaatz GW, Rose WE, Tomasz A, Rybak MJ.

J Infect Dis. 2013 Jul;208(1):67-74. doi: 10.1093/infdis/jit127. Epub 2013 Mar 28.


In vivo capsular switch in Streptococcus pneumoniae--analysis by whole genome sequencing.

Hu FZ, Eutsey R, Ahmed A, Frazao N, Powell E, Hiller NL, Hillman T, Buchinsky FJ, Boissy R, Janto B, Kress-Bennett J, Longwell M, Ezzo S, Post JC, Nesin M, Tomasz A, Ehrlich GD.

PLoS One. 2012;7(11):e47983. doi: 10.1371/journal.pone.0047983. Epub 2012 Nov 8.


Properties of a novel PBP2A protein homolog from Staphylococcus aureus strain LGA251 and its contribution to the β-lactam-resistant phenotype.

Kim C, Milheiriço C, Gardete S, Holmes MA, Holden MT, de Lencastre H, Tomasz A.

J Biol Chem. 2012 Oct 26;287(44):36854-63. doi: 10.1074/jbc.M112.395962. Epub 2012 Sep 12.


Guidelines for reporting novel mecA gene homologues.

Ito T, Hiramatsu K, Tomasz A, de Lencastre H, Perreten V, Holden MT, Coleman DC, Goering R, Giffard PM, Skov RL, Zhang K, Westh H, O'Brien F, Tenover FC, Oliveira DC, Boyle-Vavra S, Laurent F, Kearns AM, Kreiswirth B, Ko KS, Grundmann H, Sollid JE, John JF Jr, Daum R, Soderquist B, Buist G; International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC).

Antimicrob Agents Chemother. 2012 Oct;56(10):4997-9. Epub 2012 Aug 6. No abstract available.


Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300.

Gardete S, Kim C, Hartmann BM, Mwangi M, Roux CM, Dunman PM, Chambers HF, Tomasz A.

PLoS Pathog. 2012 Feb;8(2):e1002505. doi: 10.1371/journal.ppat.1002505. Epub 2012 Feb 2.


Identification of genetic determinants and enzymes involved with the amidation of glutamic acid residues in the peptidoglycan of Staphylococcus aureus.

Figueiredo TA, Sobral RG, Ludovice AM, Almeida JM, Bui NK, Vollmer W, de Lencastre H, Tomasz A.

PLoS Pathog. 2012 Jan;8(1):e1002508. doi: 10.1371/journal.ppat.1002508. Epub 2012 Jan 26.


Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone.

Hiller NL, Eutsey RA, Powell E, Earl JP, Janto B, Martin DP, Dawid S, Ahmed A, Longwell MJ, Dahlgren ME, Ezzo S, Tettelin H, Daugherty SC, Mitchell TJ, Hillman TA, Buchinsky FJ, Tomasz A, de Lencastre H, Sá-Leão R, Post JC, Hu FZ, Ehrlich GD.

PLoS One. 2011;6(12):e28850. doi: 10.1371/journal.pone.0028850. Epub 2011 Dec 19.


Isolation and analysis of cell wall components from Streptococcus pneumoniae.

Bui NK, Eberhardt A, Vollmer D, Kern T, Bougault C, Tomasz A, Simorre JP, Vollmer W.

Anal Biochem. 2012 Feb 15;421(2):657-66. doi: 10.1016/j.ab.2011.11.026. Epub 2011 Dec 1.


Tackling antibiotic resistance.

Bush K, Courvalin P, Dantas G, Davies J, Eisenstein B, Huovinen P, Jacoby GA, Kishony R, Kreiswirth BN, Kutter E, Lerner SA, Levy S, Lewis K, Lomovskaya O, Miller JH, Mobashery S, Piddock LJ, Projan S, Thomas CM, Tomasz A, Tulkens PM, Walsh TR, Watson JD, Witkowski J, Witte W, Wright G, Yeh P, Zgurskaya HI.

Nat Rev Microbiol. 2011 Nov 2;9(12):894-6. doi: 10.1038/nrmicro2693. Review.


The CEM-NET initiative: molecular biology and epidemiology in alliance--tracking antibiotic-resistant staphylococci and pneumococci in hospitals and in the community.

de Lencastre H, Tomasz A.

Int J Med Microbiol. 2011 Dec;301(8):623-9. doi: 10.1016/j.ijmm.2011.09.010. Epub 2011 Oct 13. Review.


Rapid pneumococcal evolution in response to clinical interventions.

Croucher NJ, Harris SR, Fraser C, Quail MA, Burton J, van der Linden M, McGee L, von Gottberg A, Song JH, Ko KS, Pichon B, Baker S, Parry CM, Lambertsen LM, Shahinas D, Pillai DR, Mitchell TJ, Dougan G, Tomasz A, Klugman KP, Parkhill J, Hanage WP, Bentley SD.

Science. 2011 Jan 28;331(6016):430-4. doi: 10.1126/science.1198545.



Marinelli F, Tomasz A.

Curr Opin Microbiol. 2010 Oct;13(5):547-50. doi: 10.1016/j.mib.2010.09.010. Epub 2010 Sep 27. No abstract available.


Abundance and structure of microbial loop components (bacteria and protists) in lakes of different trophic status.

Ryszard CJ, Tomasz A, Kalinowska K, Skowronska A.

J Microbiol Biotechnol. 2009 Sep;19(9):858-68.


Role of teichoic acid choline moieties in the virulence of Streptococcus pneumoniae.

Gehre F, Spisek R, Kharat AS, Matthews P, Kukreja A, Anthony RM, Dhodapkar MV, Vollmer W, Tomasz A.

Infect Immun. 2009 Jul;77(7):2824-31. doi: 10.1128/IAI.00986-08. Epub 2009 May 11.


Evidence for a dual role of PBP1 in the cell division and cell separation of Staphylococcus aureus.

Pereira SF, Henriques AO, Pinho MG, de Lencastre H, Tomasz A.

Mol Microbiol. 2009 May;72(4):895-904. doi: 10.1111/j.1365-2958.2009.06687.x. Epub 2009 Apr 27.


Different pathways of choline metabolism in two choline-independent strains of Streptococcus pneumoniae and their impact on virulence.

Kharat AS, Denapaite D, Gehre F, Brückner R, Vollmer W, Hakenbeck R, Tomasz A.

J Bacteriol. 2008 Sep;190(17):5907-14. doi: 10.1128/JB.00628-08. Epub 2008 Jul 11.


Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.

Chung M, Antignac A, Kim C, Tomasz A.

Antimicrob Agents Chemother. 2008 Aug;52(8):2709-17. doi: 10.1128/AAC.00266-08. Epub 2008 May 27.


Essential role of choline for pneumococcal virulence in an experimental model of meningitis.

Gehre F, Leib SL, Grandgirard D, Kummer J, Bühlmann A, Simon F, Gäumann R, Kharat AS, Täuber MG, Tomasz A.

J Intern Med. 2008 Aug;264(2):143-54. doi: 10.1111/j.1365-2796.2008.01930.x. Epub 2008 Mar 5.


Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.

Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG.

J Biol Chem. 2008 Mar 7;283(10):6402-17. Epub 2007 Dec 12.


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