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Items: 40


Methionine Adenosyltransferase α1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression.

Murray B, Peng H, Barbier-Torres L, Robinson AE, Li TWH, Fan W, Tomasi ML, Gottlieb RA, Van Eyk J, Lu Z, Martínez-Chantar ML, Liangpunsakul S, Skill NJ, Mato JM, Lu SC.

Hepatology. 2019 May 11. doi: 10.1002/hep.30762. [Epub ahead of print]


MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes.

Simile MM, Peitta G, Tomasi ML, Brozzetti S, Feo CF, Porcu A, Cigliano A, Calvisi DF, Feo F, Pascale RM.

Oncotarget. 2019 Apr 19;10(29):2835-2854. doi: 10.18632/oncotarget.26838. eCollection 2019 Apr 19.


Star-related lipid transfer protein 10 (STARD10): a novel key player in alcohol-induced breast cancer progression.

Floris A, Luo J, Frank J, Zhou J, Orrù S, Biancolella M, Pucci S, Orlandi A, Campagna P, Balzano A, Ramani K, Tomasi ML.

J Exp Clin Cancer Res. 2019 Jan 5;38(1):4. doi: 10.1186/s13046-018-1013-y.


SUMOylation and phosphorylation cross-talk in hepatocellular carcinoma.

Tomasi ML, Ramani K.

Transl Gastroenterol Hepatol. 2018 Apr 23;3:20. doi: 10.21037/tgh.2018.04.04. eCollection 2018. Review.


SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease.

Tomasi ML, Ramani K, Ryoo M, Cossu C, Floris A, Murray BJ, Iglesias-Ara A, Spissu Y, Mavila N.

FASEB J. 2018 Jun;32(6):3278-3288. doi: 10.1096/fj.201701124R. Epub 2018 Jan 18.


Role of A-Kinase Anchoring Protein Phosphorylation in Alcohol-Induced Liver Injury and Hepatic Stellate Cell Activation.

Ramani K, Tomasi ML, Berlind J, Mavila N, Sun Z.

Am J Pathol. 2018 Mar;188(3):640-655. doi: 10.1016/j.ajpath.2017.11.017. Epub 2018 Jan 2.


S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis.

Tomasi ML, Cossu C, Spissu Y, Floris A, Ryoo M, Iglesias-Ara A, Wang Q, Pandol SJ, Bhowmick NA, Seki E, Posadas EM, Lu SC.

Oncotarget. 2017 Aug 12;8(45):78851-78869. doi: 10.18632/oncotarget.20234. eCollection 2017 Oct 3.


Ubiquitin-Conjugating Enzyme 9 Phosphorylation as a Novel Mechanism for Potentiation of the Inflammatory Response.

Tomasi ML, Ramani K, Ryoo M.

Am J Pathol. 2016 Sep;186(9):2326-36. doi: 10.1016/j.ajpath.2016.05.007.


Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury.

Osna NA, Carter WG, Ganesan M, Kirpich IA, McClain CJ, Petersen DR, Shearn CT, Tomasi ML, Kharbanda KK.

World J Gastroenterol. 2016 Jul 21;22(27):6192-200. doi: 10.3748/wjg.v22.i27.6192. Review.


Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease.

Simile MM, Latte G, Demartis MI, Brozzetti S, Calvisi DF, Porcu A, Feo CF, Seddaiu MA, Daino L, Berasain C, Tomasi ML, Avila MA, Feo F, Pascale RM.

Oncotarget. 2016 Aug 2;7(31):49194-49216. doi: 10.18632/oncotarget.10246.


Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.

Tomasi ML, Ryoo M, Ramani K, Tomasi I, Giordano P, Mato JM, Lu SC.

Oncotarget. 2015 Nov 10;6(35):37706-23. doi: 10.18632/oncotarget.5342.


Role of methionine adenosyltransferase α2 and β phosphorylation and stabilization in human hepatic stellate cell trans-differentiation.

Ramani K, Donoyan S, Tomasi ML, Park S.

J Cell Physiol. 2015 May;230(5):1075-85. doi: 10.1002/jcp.24839.


Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice.

Tomasi ML, Ryoo M, Yang H, Iglesias Ara A, Ko KS, Lu SC.

Free Radic Biol Med. 2014 Mar;68:148-58. doi: 10.1016/j.freeradbiomed.2013.11.018. Epub 2013 Dec 1.


Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value.

Evert M, Frau M, Tomasi ML, Latte G, Simile MM, Seddaiu MA, Zimmermann A, Ladu S, Staniscia T, Brozzetti S, Solinas G, Dombrowski F, Feo F, Pascale RM, Calvisi DF.

Br J Cancer. 2013 Nov 12;109(10):2654-64. doi: 10.1038/bjc.2013.606. Epub 2013 Oct 17.


Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.

Tomasi ML, Ryoo M, Skay A, Tomasi I, Giordano P, Mato JM, Lu SC.

Exp Cell Res. 2013 Jul 15;319(12):1902-11. doi: 10.1016/j.yexcr.2013.04.005. Epub 2013 Apr 12.


Long-term CB₁ receptor blockade enhances vulnerability to anxiogenic-like effects of cannabinoids.

Tambaro S, Tomasi ML, Bortolato M.

Neuropharmacology. 2013 Jul;70:268-77. doi: 10.1016/j.neuropharm.2013.02.009. Epub 2013 Feb 24.


Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma.

Tschaharganeh DF, Chen X, Latzko P, Malz M, Gaida MM, Felix K, Ladu S, Singer S, Pinna F, Gretz N, Sticht C, Tomasi ML, Delogu S, Evert M, Fan B, Ribback S, Jiang L, Brozzetti S, Bergmann F, Dombrowski F, Schirmacher P, Calvisi DF, Breuhahn K.

Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16.


Deregulation of signalling pathways in prognostic subtypes of hepatocellular carcinoma: novel insights from interspecies comparison.

Calvisi DF, Frau M, Tomasi ML, Feo F, Pascale RM.

Biochim Biophys Acta. 2012 Aug;1826(1):215-37. Review.


MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer.

Peng H, Dara L, Li TW, Zheng Y, Yang H, Tomasi ML, Tomasi I, Giordano P, Mato JM, Lu SC.

Hepatology. 2013 Jun;57(6):2299-313. doi: 10.1002/hep.26258. Epub 2013 May 14.


Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis.

Ramani K, Tomasi ML, Yang H, Ko K, Lu SC.

J Biol Chem. 2012 Oct 19;287(43):36341-55. doi: 10.1074/jbc.M112.370775. Epub 2012 Aug 31.


An expression signature of phenotypic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis.

Frau M, Simile MM, Tomasi ML, Demartis MI, Daino L, Seddaiu MA, Brozzetti S, Feo CF, Massarelli G, Solinas G, Feo F, Lee JS, Pascale RM.

Cell Oncol (Dordr). 2012 Jun;35(3):163-73. doi: 10.1007/s13402-011-0067-z. Epub 2012 Mar 21.


S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers.

Tomasi ML, Tomasi I, Ramani K, Pascale RM, Xu J, Giordano P, Mato JM, Lu SC.

Hepatology. 2012 Sep;56(3):982-93. doi: 10.1002/hep.25701. Epub 2012 Jul 12.


Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.

Frau M, Tomasi ML, Simile MM, Demartis MI, Salis F, Latte G, Calvisi DF, Seddaiu MA, Daino L, Feo CF, Brozzetti S, Solinas G, Yamashita S, Ushijima T, Feo F, Pascale RM.

Hepatology. 2012 Jul;56(1):165-75. doi: 10.1002/hep.25643. Epub 2012 Jun 5.


Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation.

Tomasi ML, Li TW, Li M, Mato JM, Lu SC.

J Cell Physiol. 2012 Apr;227(4):1583-91. doi: 10.1002/jcp.22875.


Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53.

Calvisi DF, Simile MM, Ladu S, Frau M, Evert M, Tomasi ML, Demartis MI, Daino L, Seddaiu MA, Brozzetti S, Feo F, Pascale RM.

Hepatology. 2011 Apr;53(4):1226-36. doi: 10.1002/hep.24174.


Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.

Frau M, Ladu S, Calvisi DF, Simile MM, Bonelli P, Daino L, Tomasi ML, Seddaiu MA, Feo F, Pascale RM.

J Hepatol. 2011 Jul;55(1):111-9. doi: 10.1016/j.jhep.2010.10.031. Epub 2010 Dec 7.


Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice.

Ko KS, Tomasi ML, Iglesias-Ara A, French BA, French SW, Ramani K, Lozano JJ, Oh P, He L, Stiles BL, Li TW, Yang H, Martínez-Chantar ML, Mato JM, Lu SC.

Hepatology. 2010 Dec;52(6):2096-108. doi: 10.1002/hep.23919. Epub 2010 Oct 1.


S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes.

Tomasi ML, Ramani K, Lopitz-Otsoa F, Rodríguez MS, Li TW, Ko K, Yang H, Bardag-Gorce F, Iglesias-Ara A, Feo F, Pascale MR, Mato JM, Lu SC.

Hepatology. 2010 Jun;51(6):2152-61. doi: 10.1002/hep.23530.


SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis.

Calvisi DF, Ladu S, Pinna F, Frau M, Tomasi ML, Sini M, Simile MM, Bonelli P, Muroni MR, Seddaiu MA, Lim DS, Feo F, Pascale RM.

Gastroenterology. 2009 Nov;137(5):1816-26.e1-10. doi: 10.1053/j.gastro.2009.08.005. Epub 2009 Aug 15.


The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease.

Calvisi DF, Pinna F, Ladu S, Muroni MR, Frau M, Demartis I, Tomasi ML, Sini M, Simile MM, Seddaiu MA, Feo F, Pascale RM.

Int J Cancer. 2010 Mar 1;126(5):1275-81. doi: 10.1002/ijc.24650.


Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma.

Feo F, Frau M, Tomasi ML, Brozzetti S, Pascale RM.

Exp Biol Med (Maywood). 2009 Jul;234(7):726-36. doi: 10.3181/0901-MR-40. Epub 2009 May 8. Review.


Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC.

Calvisi DF, Pinna F, Ladu S, Pellegrino R, Simile MM, Frau M, De Miglio MR, Tomasi ML, Sanna V, Muroni MR, Feo F, Pascale RM.

Gut. 2009 May;58(5):679-87. doi: 10.1136/gut.2008.152652. Epub 2009 Jan 9.


S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis.

Tomasi ML, Iglesias-Ara A, Yang H, Ramani K, Feo F, Pascale MR, Martínez-Chantar ML, Mato JM, Lu SC.

Gastroenterology. 2009 Mar;136(3):1025-36. doi: 10.1053/j.gastro.2008.09.026. Epub 2008 Sep 25.


Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control.

Calvisi DF, Pinna F, Pellegrino R, Sanna V, Sini M, Daino L, Simile MM, De Miglio MR, Frau M, Tomasi ML, Seddaiu MA, Muroni MR, Feo F, Pascale RM.

Int J Cancer. 2008 Nov 1;123(9):2057-64. doi: 10.1002/ijc.23720.


Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease.

Calvisi DF, Pinna F, Ladu S, Pellegrino R, Muroni MR, Simile MM, Frau M, Tomasi ML, De Miglio MR, Seddaiu MA, Daino L, Sanna V, Feo F, Pascale RM.

Carcinogenesis. 2008 Aug;29(8):1639-47. doi: 10.1093/carcin/bgn155. Epub 2008 Jun 25.


Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma.

Calvisi DF, Pinna F, Meloni F, Ladu S, Pellegrino R, Sini M, Daino L, Simile MM, De Miglio MR, Virdis P, Frau M, Tomasi ML, Seddaiu MA, Muroni MR, Feo F, Pascale RM.

Cancer Res. 2008 Jun 1;68(11):4192-200. doi: 10.1158/0008-5472.CAN-07-6157.


Altered methionine metabolism and global DNA methylation in liver cancer: relationship with genomic instability and prognosis.

Calvisi DF, Simile MM, Ladu S, Pellegrino R, De Murtas V, Pinna F, Tomasi ML, Frau M, Virdis P, De Miglio MR, Muroni MR, Pascale RM, Feo F.

Int J Cancer. 2007 Dec 1;121(11):2410-20.


Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/beta-catenin pathway and progression of early lesions in the rat.

De Miglio MR, Virdis P, Calvisi DF, Mele D, Muroni MR, Frau M, Pinna F, Tomasi ML, Simile MM, Pascale RM, Feo F.

Carcinogenesis. 2007 Nov;28(11):2367-74. Epub 2007 May 17.


[The influence of Ca++ and Mg++ on post-tetanic potentiation in neuromuscular preparations].

Tomasi ML.

Boll Soc Ital Biol Sper. 1964 Jul 15;40(13):773-6. Italian. No abstract available.


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