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Items: 8


The binding landscape of a partially-selective isopeptidase inhibitor with potent pro-death activity, based on the bis(arylidene)cyclohexanone scaffold.

Ciotti S, Sgarra R, Sgorbissa A, Penzo C, Tomasella A, Casarsa F, Benedetti F, Berti F, Manfioletti G, Brancolini C.

Cell Death Dis. 2018 Feb 7;9(2):184. doi: 10.1038/s41419-017-0259-1.


The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells.

Tomasella A, Picco R, Ciotti S, Sgorbissa A, Bianchi E, Manfredini R, Benedetti F, Trimarco V, Frezzato F, Trentin L, Semenzato G, Delia D, Brancolini C.

Oncotarget. 2016 Jul 19;7(29):45429-45443. doi: 10.18632/oncotarget.9742.


Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent.

Cersosimo U, Sgorbissa A, Foti C, Drioli S, Angelica R, Tomasella A, Picco R, Semrau MS, Storici P, Benedetti F, Berti F, Brancolini C.

J Med Chem. 2015 Feb 26;58(4):1691-704. doi: 10.1021/jm501336h. Epub 2015 Feb 12.


Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain.

Picco R, Tomasella A, Fogolari F, Brancolini C.

PLoS One. 2014 Oct 16;9(10):e110610. doi: 10.1371/journal.pone.0110610. eCollection 2014.


The DeISGylase USP18 limits TRAIL-induced apoptosis through the regulation of TRAIL levels: Cellular levels of TRAIL influences responsiveness to TRAIL-induced apoptosis.

Manini I, Sgorbissa A, Potu H, Tomasella A, Brancolini C.

Cancer Biol Ther. 2013 Dec;14(12):1158-66. doi: 10.4161/cbt.26525. Epub 2013 Sep 19.


Type I IFNs signaling and apoptosis resistance in glioblastoma cells.

Sgorbissa A, Tomasella A, Potu H, Manini I, Brancolini C.

Apoptosis. 2011 Dec;16(12):1229-44. doi: 10.1007/s10495-011-0639-4.


Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system.

Foti C, Florean C, Pezzutto A, Roncaglia P, Tomasella A, Gustincich S, Brancolini C.

Mol Cancer Ther. 2009 Nov;8(11):3140-50. doi: 10.1158/1535-7163.MCT-09-0431. Epub 2009 Nov 3.

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