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Items: 43

1.

Development of a Broad-Spectrum Antimicrobial Combination for the Treatment of Staphylococcus aureus and Pseudomonas aeruginosa Corneal Infections.

Chojnacki M, Philbrick A, Wucher B, Reed JN, Tomaras A, Dunman PM, Wozniak RAF.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01929-18. doi: 10.1128/AAC.01929-18. Print 2019 Jan.

2.

A call to arms: Unifying the fight against resistance.

Kaushansky A, Hedstrom L, Goldman A, Singh J, Yang PL, Rathod PK, Cynamon M, Wodarz D, Mahadevan D, Tomaras A, Navia MA, Schiffer CA.

Sci Signal. 2018 Oct 23;11(553). pii: eaav0442. doi: 10.1126/scisignal.aav0442.

3.

Prospective Evaluation of Light Scatter Technology Paired with Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Rapid Diagnosis of Urinary Tract Infections.

Montgomery S, Roman K, Ngyuen L, Cardenas AM, Knox J, Tomaras AP, Graf EH.

J Clin Microbiol. 2017 Jun;55(6):1802-1811. doi: 10.1128/JCM.00027-17. Epub 2017 Mar 29.

4.

Editorial overview: Antimicrobials.

Dunman PM, Tomaras AP.

Curr Opin Microbiol. 2015 Oct;27:v-vii. doi: 10.1016/j.mib.2015.09.001. Epub 2015 Sep 15. No abstract available.

PMID:
26384621
5.

Translational deficiencies in antibacterial discovery and new screening paradigms.

Dunman PM, Tomaras AP.

Curr Opin Microbiol. 2015 Oct;27:108-13. doi: 10.1016/j.mib.2015.08.006. Epub 2015 Sep 8. Review.

6.

In the midst of the antimicrobial discovery conundrum: an overview.

Tomaras AP, Dunman PM.

Curr Opin Microbiol. 2015 Oct;27:103-7. doi: 10.1016/j.mib.2015.08.005. Epub 2015 Sep 8. Review. No abstract available.

PMID:
26356257
7.

Role of the carboxy terminus of SecA in iron acquisition, protein translocation, and virulence of the bacterial pathogen Acinetobacter baumannii.

Fiester SE, Nwugo CC, Penwell WF, Neary JM, Beckett AC, Arivett BA, Schmidt RE, Geiger SC, Connerly PL, Menke SM, Tomaras AP, Actis LA.

Infect Immun. 2015 Apr;83(4):1354-65. doi: 10.1128/IAI.02925-14. Epub 2015 Jan 20.

8.

Potentiation of antibacterial activity of the MB-1 siderophore-monobactam conjugate using an efflux pump inhibitor.

Tomaras AP, Crandon JL, McPherson CJ, Nicolau DP.

Antimicrob Agents Chemother. 2015 Apr;59(4):2439-42. doi: 10.1128/AAC.04172-14. Epub 2015 Jan 20.

9.

Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors.

Montgomery JI, Smith JF, Tomaras AP, Zaniewski R, McPherson CJ, McAllister LA, Hartman-Neumann S, Arcari JT, Lescoe M, Gutierrez J, Yuan Y, Limberakis C, Miller AA.

J Antibiot (Tokyo). 2015 Jun;68(6):361-7. doi: 10.1038/ja.2014.163. Epub 2014 Dec 3.

PMID:
25464974
10.

LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens.

Tomaras AP, McPherson CJ, Kuhn M, Carifa A, Mullins L, George D, Desbonnet C, Eidem TM, Montgomery JI, Brown MF, Reilly U, Miller AA, O'Donnell JP.

MBio. 2014 Sep 30;5(5):e01551-14. doi: 10.1128/mBio.01551-14.

11.

Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.

Starr J, Brown MF, Aschenbrenner L, Caspers N, Che Y, Gerstenberger BS, Huband M, Knafels JD, Lemmon MM, Li C, McCurdy SP, McElroy E, Rauckhorst MR, Tomaras AP, Young JA, Zaniewski RP, Shanmugasundaram V, Han S.

J Med Chem. 2014 May 8;57(9):3845-55. doi: 10.1021/jm500219c. Epub 2014 Apr 21.

PMID:
24694215
12.

Adaptation-based resistance to siderophore-conjugated antibacterial agents by Pseudomonas aeruginosa.

Tomaras AP, Crandon JL, McPherson CJ, Banevicius MA, Finegan SM, Irvine RL, Brown MF, O'Donnell JP, Nicolau DP.

Antimicrob Agents Chemother. 2013 Sep;57(9):4197-207. doi: 10.1128/AAC.00629-13. Epub 2013 Jun 17.

13.

Pyridone-conjugated monobactam antibiotics with gram-negative activity.

Brown MF, Mitton-Fry MJ, Arcari JT, Barham R, Casavant J, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Lall MS, Lemmon MM, Li C, Lin J, McCurdy SP, McElroy E, McPherson C, Marr ES, Mueller JP, Mullins L, Nikitenko AA, Noe MC, Penzien J, Plummer MS, Schuff BP, Shanmugasundaram V, Starr JT, Sun J, Tomaras A, Young JA, Zaniewski RP.

J Med Chem. 2013 Jul 11;56(13):5541-52. doi: 10.1021/jm400560z. Epub 2013 Jun 27.

PMID:
23755848
14.

Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.

Magee TV, Brown MF, Starr JT, Ackley DC, Abramite JA, Aubrecht J, Butler A, Crandon JL, Dib-Hajj F, Flanagan ME, Granskog K, Hardink JR, Huband MD, Irvine R, Kuhn M, Leach KL, Li B, Lin J, Luke DR, MacVane SH, Miller AA, McCurdy S, McKim JM Jr, Nicolau DP, Nguyen TT, Noe MC, O'Donnell JP, Seibel SB, Shen Y, Stepan AF, Tomaras AP, Wilga PC, Zhang L, Xu J, Chen JM.

J Med Chem. 2013 Jun 27;56(12):5079-93. doi: 10.1021/jm400416u. Epub 2013 Jun 18.

PMID:
23735048
15.

Non-traditional antibacterial screening approaches for the identification of novel inhibitors of the glyoxylate shunt in gram-negative pathogens.

Fahnoe KC, Flanagan ME, Gibson G, Shanmugasundaram V, Che Y, Tomaras AP.

PLoS One. 2012;7(12):e51732. doi: 10.1371/journal.pone.0051732. Epub 2012 Dec 11.

16.

Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents.

McAllister LA, Montgomery JI, Abramite JA, Reilly U, Brown MF, Chen JM, Barham RA, Che Y, Chung SW, Menard CA, Mitton-Fry M, Mullins LM, Noe MC, O'Donnell JP, Oliver RM 3rd, Penzien JB, Plummer M, Price LM, Shanmugasundaram V, Tomaras AP, Uccello DP.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6832-8. doi: 10.1016/j.bmcl.2012.09.058. Epub 2012 Sep 24.

PMID:
23046961
17.

Inhibition of LpxC protects mice from resistant Acinetobacter baumannii by modulating inflammation and enhancing phagocytosis.

Lin L, Tan B, Pantapalangkoor P, Ho T, Baquir B, Tomaras A, Montgomery JI, Reilly U, Barbacci EG, Hujer K, Bonomo RA, Fernandez L, Hancock RE, Adams MD, French SW, Buslon VS, Spellberg B.

MBio. 2012 Oct 2;3(5). pii: e00312-12. doi: 10.1128/mBio.00312-12. Print 2012.

18.

Clinically relevant Gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam.

McPherson CJ, Aschenbrenner LM, Lacey BM, Fahnoe KC, Lemmon MM, Finegan SM, Tadakamalla B, O'Donnell JP, Mueller JP, Tomaras AP.

Antimicrob Agents Chemother. 2012 Dec;56(12):6334-42. doi: 10.1128/AAC.01345-12. Epub 2012 Oct 1.

19.

Identification and evaluation of twin-arginine translocase inhibitors.

Vasil ML, Tomaras AP, Pritchard AE.

Antimicrob Agents Chemother. 2012 Dec;56(12):6223-34. doi: 10.1128/AAC.01575-12. Epub 2012 Sep 24.

20.

Early insights into the interactions of different β-lactam antibiotics and β-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3.

Papp-Wallace KM, Senkfor B, Gatta J, Chai W, Taracila MA, Shanmugasundaram V, Han S, Zaniewski RP, Lacey BM, Tomaras AP, Skalweit MJ, Harris ME, Rice LB, Buynak JD, Bonomo RA.

Antimicrob Agents Chemother. 2012 Nov;56(11):5687-92. doi: 10.1128/AAC.01027-12. Epub 2012 Aug 20.

21.

Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.

Montgomery JI, Brown MF, Reilly U, Price LM, Abramite JA, Arcari J, Barham R, Che Y, Chen JM, Chung SW, Collantes EM, Desbonnet C, Doroski M, Doty J, Engtrakul JJ, Harris TM, Huband M, Knafels JD, Leach KL, Liu S, Marfat A, McAllister L, McElroy E, Menard CA, Mitton-Fry M, Mullins L, Noe MC, O'Donnell J, Oliver R, Penzien J, Plummer M, Shanmugasundaram V, Thoma C, Tomaras AP, Uccello DP, Vaz A, Wishka DG.

J Med Chem. 2012 Feb 23;55(4):1662-70. doi: 10.1021/jm2014875. Epub 2012 Feb 8.

PMID:
22257165
22.

Distinctive attributes of β-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics.

Han S, Caspers N, Zaniewski RP, Lacey BM, Tomaras AP, Feng X, Geoghegan KF, Shanmugasundaram V.

J Am Chem Soc. 2011 Dec 21;133(50):20536-45. doi: 10.1021/ja208835z. Epub 2011 Nov 28.

PMID:
22050378
23.

Molecular Investigations of PenA-mediated β-lactam Resistance in Burkholderia pseudomallei.

Rholl DA, Papp-Wallace KM, Tomaras AP, Vasil ML, Bonomo RA, Schweizer HP.

Front Microbiol. 2011 Jul 1;2:139. doi: 10.3389/fmicb.2011.00139. eCollection 2011.

24.

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.

Han S, Zaniewski RP, Marr ES, Lacey BM, Tomaras AP, Evdokimov A, Miller JR, Shanmugasundaram V.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22002-7. doi: 10.1073/pnas.1013092107. Epub 2010 Dec 6.

25.
26.

Iron acquisition functions expressed by the human pathogen Acinetobacter baumannii.

Zimbler DL, Penwell WF, Gaddy JA, Menke SM, Tomaras AP, Connerly PL, Actis LA.

Biometals. 2009 Feb;22(1):23-32. doi: 10.1007/s10534-008-9202-3. Epub 2009 Jan 7. Review.

PMID:
19130255
27.

Characterization of a two-component regulatory system from Acinetobacter baumannii that controls biofilm formation and cellular morphology.

Tomaras AP, Flagler MJ, Dorsey CW, Gaddy JA, Actis LA.

Microbiology. 2008 Nov;154(Pt 11):3398-409. doi: 10.1099/mic.0.2008/019471-0.

PMID:
18957593
28.

The influence of iron on Pseudomonas aeruginosa physiology: a regulatory link between iron and quorum sensing.

Oglesby AG, Farrow JM 3rd, Lee JH, Tomaras AP, Greenberg EP, Pesci EC, Vasil ML.

J Biol Chem. 2008 Jun 6;283(23):15558-67. doi: 10.1074/jbc.M707840200. Epub 2008 Apr 18.

29.

Pseudomonas aeruginosa twitching motility-mediated chemotaxis towards phospholipids and fatty acids: specificity and metabolic requirements.

Miller RM, Tomaras AP, Barker AP, Voelker DR, Chan ED, Vasil AI, Vasil ML.

J Bacteriol. 2008 Jun;190(11):4038-49. doi: 10.1128/JB.00129-08. Epub 2008 Apr 4.

30.

Klebsiella pneumoniae multiresistance plasmid pMET1: similarity with the Yersinia pestis plasmid pCRY and integrative conjugative elements.

Soler Bistué AJ, Birshan D, Tomaras AP, Dandekar M, Tran T, Newmark J, Bui D, Gupta N, Hernandez K, Sarno R, Zorreguieta A, Actis LA, Tolmasky ME.

PLoS One. 2008 Mar 19;3(3):e1800. doi: 10.1371/journal.pone.0001800.

31.

Characterization of two distinct phospholipase C enzymes from Burkholderia pseudomallei.

Korbsrisate S, Tomaras AP, Damnin S, Ckumdee J, Srinon V, Lengwehasatit I, Vasil ML, Suparak S.

Microbiology. 2007 Jun;153(Pt 6):1907-15.

PMID:
17526847
32.

Iron acquisition in the dental pathogen Actinobacillus actinomycetemcomitans: what does it use as a source and how does it get this essential metal?

Rhodes ER, Menke S, Shoemaker C, Tomaras AP, McGillivary G, Actis LA.

Biometals. 2007 Jun;20(3-4):365-77. Epub 2007 Jan 6. Review.

PMID:
17206384
33.

Transport of Escherichia coli bacteria through laboratory columns of glacial-outwash sediments: estimating model parameter values based on sediment characteristics.

Levy J, Sun K, Findlay RH, Farruggia FT, Porter J, Mumy KL, Tomaras J, Tomaras A.

J Contam Hydrol. 2007 Jan 5;89(1-2):71-106. Epub 2006 Nov 13.

PMID:
17095116
34.

Sequence and organization of pMAC, an Acinetobacter baumannii plasmid harboring genes involved in organic peroxide resistance.

Dorsey CW, Tomaras AP, Actis LA.

Plasmid. 2006 Sep;56(2):112-23. Epub 2006 Mar 13.

PMID:
16530832
35.

Genetic and functional analyses of the Actinobacillus actinomycetemcomitans AfeABCD siderophore-independent iron acquisition system.

Rhodes ER, Tomaras AP, McGillivary G, Connerly PL, Actis LA.

Infect Immun. 2005 Jun;73(6):3758-63.

36.
37.

The siderophore-mediated iron acquisition systems of Acinetobacter baumannii ATCC 19606 and Vibrio anguillarum 775 are structurally and functionally related.

Dorsey CW, Tomaras AP, Connerly PL, Tolmasky ME, Crosa JH, Actis LA.

Microbiology. 2004 Nov;150(Pt 11):3657-67.

PMID:
15528653
38.
39.
40.
41.

Data security in medical information systems: technical aspects of a proposed legislation.

Gritzalis D, Katsikas S, Keklikoglou J, Tomaras A.

Med Inform (Lond). 1991 Oct-Dec;16(4):371-83.

PMID:
1762473
42.

Medical data protection: a proposal for a deontology code.

Gritzalis D, Tomaras A, Katsikas S, Keklikoglou J.

J Med Syst. 1990 Dec;14(6):375-86.

PMID:
2132044
43.

Colleges of osteopathic medicine: a profile of growth.

Ward WD, Tomaras A.

J Am Osteopath Assoc. 1985 Nov;85(11):719-21. No abstract available.

PMID:
3841105

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