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Items: 37


WNT Signaling in Disease.

Ng LF, Kaur P, Bunnag N, Suresh J, Sung ICH, Tan QH, Gruber J, Tolwinski NS.

Cells. 2019 Aug 3;8(8). pii: E826. doi: 10.3390/cells8080826. Review.


Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling.

Admasu TD, Chaithanya Batchu K, Barardo D, Ng LF, Lam VYM, Xiao L, Cazenave-Gassiot A, Wenk MR, Tolwinski NS, Gruber J.

Dev Cell. 2018 Oct 8;47(1):67-79.e5. doi: 10.1016/j.devcel.2018.09.001. Epub 2018 Sep 27.


Introduction: Drosophila-A Model System for Developmental Biology.

Tolwinski NS.

J Dev Biol. 2017 Sep 20;5(3). pii: E9. doi: 10.3390/jdb5030009.


Modeling the Role of Wnt Signaling in Human and Drosophila Stem Cells.

Kaur P, Jin HJ, Lusk JB, Tolwinski NS.

Genes (Basel). 2018 Feb 16;9(2). pii: E101. doi: 10.3390/genes9020101.


Coupling optogenetics and light-sheet microscopy, a method to study Wnt signaling during embryogenesis.

Kaur P, Saunders TE, Tolwinski NS.

Sci Rep. 2017 Nov 30;7(1):16636. doi: 10.1038/s41598-017-16879-0.


An embryonic system to assess direct and indirect Wnt transcriptional targets.

Suresh J, Harmston N, Lim KK, Kaur P, Jin HJ, Lusk JB, Petretto E, Tolwinski NS.

Sci Rep. 2017 Sep 11;7(1):11092. doi: 10.1038/s41598-017-11519-z.


Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5.

Kaur P, Lam VYM, Mannava AG, Suresh J, Jenny A, Tolwinski NS.

Sci Rep. 2017 Jul 31;7(1):6934. doi: 10.1038/s41598-017-04414-0.


'Lnc'-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling.

Ong MS, Cai W, Yuan Y, Leong HC, Tan TZ, Mohammad A, You ML, Arfuso F, Goh BC, Warrier S, Sethi G, Tolwinski NS, Lobie PE, Yap CT, Hooi SC, Huang RY, Kumar AP.

Br J Pharmacol. 2017 Dec;174(24):4684-4700. doi: 10.1111/bph.13958. Epub 2017 Aug 23. Review.


Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo.

Huang A, Amourda C, Zhang S, Tolwinski NS, Saunders TE.

Elife. 2017 Jul 10;6. pii: e26258. doi: 10.7554/eLife.26258.


Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer.

Lusk JB, Lam VY, Tolwinski NS.

Cancers (Basel). 2017 Feb 7;9(2). pii: E16. doi: 10.3390/cancers9020016. Review.


The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing.

Hong SY, Ng LT, Ng LF, Inoue T, Tolwinski NS, Hagen T, Gruber J.

PLoS One. 2016 Dec 29;11(12):e0168752. doi: 10.1371/journal.pone.0168752. eCollection 2016.


Developmental Drift and the Role of Wnt Signaling in Aging.

Gruber J, Yee Z, Tolwinski NS.

Cancers (Basel). 2016 Aug 2;8(8). pii: E73. doi: 10.3390/cancers8080073. Review.


Ptk7 and Mcc, Unfancied Components in Non-Canonical Wnt Signaling and Cancer.

Dunn NR, Tolwinski NS.

Cancers (Basel). 2016 Jul 16;8(7). pii: E68. doi: 10.3390/cancers8070068. Review.


Wnt pathway activation by ADP-ribosylation.

Yang E, Tacchelly-Benites O, Wang Z, Randall MP, Tian A, Benchabane H, Freemantle S, Pikielny C, Tolwinski NS, Lee E, Ahmed Y.

Nat Commun. 2016 May 3;7:11430. doi: 10.1038/ncomms11430.


Membrane bound GSK-3 activates Wnt signaling through disheveled and arrow.

Mannava AG, Tolwinski NS.

PLoS One. 2015 Apr 7;10(4):e0121879. doi: 10.1371/journal.pone.0121879. eCollection 2015.


The many roles of PTK7: a versatile regulator of cell-cell communication.

Peradziryi H, Tolwinski NS, Borchers A.

Arch Biochem Biophys. 2012 Aug 1;524(1):71-6. doi: 10.1016/ Epub 2012 Jan 3. Review.


PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling.

Peradziryi H, Kaplan NA, Podleschny M, Liu X, Wehner P, Borchers A, Tolwinski NS.

EMBO J. 2011 Jul 19;30(18):3729-40. doi: 10.1038/emboj.2011.236.


Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.

Kaplan NA, Colosimo PF, Liu X, Tolwinski NS.

PLoS One. 2011 Apr 5;6(4):e18616. doi: 10.1371/journal.pone.0018616.


Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis.

Kaplan NA, Tolwinski NS.

J Cell Sci. 2010 Sep 15;123(Pt 18):3157-65. doi: 10.1242/jcs.069898. Epub 2010 Aug 24.


Epithelial polarity: interactions between junctions and apical-basal machinery.

Kaplan NA, Liu X, Tolwinski NS.

Genetics. 2009 Nov;183(3):897-904. doi: 10.1534/genetics.109.108878. Epub 2009 Sep 7.


GSK3beta affects apical-basal polarity and cell-cell adhesion by regulating aPKC levels.

Colosimo PF, Liu X, Kaplan NA, Tolwinski NS.

Dev Dyn. 2010 Jan;239(1):115-25. doi: 10.1002/dvdy.21963.


Membrane bound axin is sufficient for Wingless signaling in Drosophila embryos.

Tolwinski NS.

Genetics. 2009 Mar;181(3):1169-73. doi: 10.1534/genetics.108.098236. Epub 2009 Jan 5.


Advances in pattern formation: Signaling and transcription.

Tolwinski NS.

Fly (Austin). 2008 May-Jun;2(3):156-8. Epub 2008 May 26.


An insect symbiosis is influenced by bacterium-specific polymorphisms in outer-membrane protein A.

Weiss BL, Wu Y, Schwank JJ, Tolwinski NS, Aksoy S.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15088-93. doi: 10.1073/pnas.0805666105. Epub 2008 Sep 24.


Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control.

Diop SB, Bertaux K, Vasanthi D, Sarkeshik A, Goirand B, Aragnol D, Tolwinski NS, Cole MD, Pradel J, Yates JR 3rd, Mishra RK, Graba Y, Saurin AJ.

EMBO Rep. 2008 Mar;9(3):260-6. doi: 10.1038/embor.2008.8. Epub 2008 Feb 8.


New advances in signaling and pattern formation.

Tolwinski NS.

Fly (Austin). 2007 Mar-Apr;1(2):116-7. No abstract available.


A nuclear escort for beta-catenin.

Tolwinski NS, Wieschaus E.

Nat Cell Biol. 2004 Jul;6(7):579-80. No abstract available.


Rethinking WNT signaling.

Tolwinski NS, Wieschaus E.

Trends Genet. 2004 Apr;20(4):177-81. Review.


A nuclear function for armadillo/beta-catenin.

Tolwinski NS, Wieschaus E.

PLoS Biol. 2004 Apr;2(4):E95. Epub 2004 Feb 10.


Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity.

Tolwinski NS, Wehrli M, Rives A, Erdeniz N, DiNardo S, Wieschaus E.

Dev Cell. 2003 Mar;4(3):407-18.


Pharmacologic inhibitors of MKK1 and MKK2.

Ahn NG, Nahreini TS, Tolwinski NS, Resing KA.

Methods Enzymol. 2001;332:417-31. No abstract available.


Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation.

Shapiro PS, Whalen AM, Tolwinski NS, Wilsbacher J, Froelich-Ammon SJ, Garcia M, Osheroff N, Ahn NG.

Mol Cell Biol. 1999 May;19(5):3551-60.


Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen.

Shapiro PS, Vaisberg E, Hunt AJ, Tolwinski NS, Whalen AM, McIntosh JR, Ahn NG.

J Cell Biol. 1998 Sep 21;142(6):1533-45.


Hyaluronidase generates a single-cell suspension from cultured mouse lung epithelial cells.

Tolwinski NS, Kano-Sueoka T.

Biotechniques. 1997 May;22(5):856-8, 860. No abstract available.

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