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Items: 1 to 50 of 106

1.

Fimepinostat, a novel dual inhibitor of HDAC and PI3K, effectively reverses HIV-1 latency ex vivo without T cell activation.

Gunst JD, Kjær K, Olesen R, Rasmussen TA, Østergaard L, Denton PW, Søgaard OS, Tolstrup M.

J Virus Erad. 2019 Sep 18;5(3):133-137.

PMID:
31700656
2.

Fimepinostat, a novel dual inhibitor of HDAC and PI3K, effectively reverses HIV-1 latency ex vivo without T cell activation.

Gunst JD, Kjær K, Olesen R, Rasmussen TA, Østergaard L, Denton PW, Søgaard OS, Tolstrup M.

J Virus Erad. 2019 Sep 18;5(3):133-137.

PMID:
31700655
3.

Impacts of HIV Cure Interventions on Viral Reservoirs in Tissues.

Denton PW, Søgaard OS, Tolstrup M.

Front Microbiol. 2019 Aug 21;10:1956. doi: 10.3389/fmicb.2019.01956. eCollection 2019. Review.

4.

IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.

Højen JF, Kristensen MLV, McKee AS, Wade MT, Azam T, Lunding LP, de Graaf DM, Swartzwelter BJ, Wegmann M, Tolstrup M, Beckman K, Fujita M, Fischer S, Dinarello CA.

Nat Immunol. 2019 Sep;20(9):1138-1149. doi: 10.1038/s41590-019-0467-1. Epub 2019 Aug 19.

PMID:
31427775
5.

TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes.

Schleimann MH, Kobberø ML, Vibholm LK, Kjær K, Giron LB, Busman-Sahay K, Chan CN, Nekorchuk M, Schmidt M, Wittig B, Damsgaard TE, Ahlburg P, Hellfritzsch MB, Zuwala K, Rothemejer FH, Olesen R, Schommers P, Klein F, Dweep H, Kossenkov A, Nyengaard JR, Estes JD, Abdel-Mohsen M, Østergaard L, Tolstrup M, Søgaard OS, Denton PW.

EBioMedicine. 2019 Jul;45:328-340. doi: 10.1016/j.ebiom.2019.07.005. Epub 2019 Jul 9.

6.

Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues.

Krüger F, Kumar V, Monge P, Conzelmann C, Smith N, Gothelf KV, Tolstrup M, Münch J, Zelikin AN.

Adv Sci (Weinh). 2019 Jan 28;6(6):1802095. doi: 10.1002/advs.201802095. eCollection 2019 Mar 20.

7.

Effects of 24-week Toll-like receptor 9 agonist treatment in HIV type 1+ individuals.

Vibholm LK, Konrad CV, Schleimann MH, Frattari G, Winckelmann A, Klastrup V, Jensen NM, Jensen SS, Schmidt M, Wittig B, Zuwala K, Mack K, Olesen R, Hua S, Lichterfeld M, Østergaard L, Denton PW, Tolstrup M, Søgaard OS.

AIDS. 2019 Jul 1;33(8):1315-1325. doi: 10.1097/QAD.0000000000002213.

PMID:
30932955
8.

cAIMP administration in humanized mice induces a chimerization-level-dependent STING response.

Andersen AHF, Olesen R, Jønsson KL, Højen JF, Krapp C, Mack K, Thomsen MK, Østergaard L, Tolstrup M, Dagnaes-Hansen F, Jakobsen MR, Denton PW.

Immunology. 2019 Jun;157(2):163-172. doi: 10.1111/imm.13061. Epub 2019 May 6.

PMID:
30919991
9.

In-vivo administration of histone deacetylase inhibitors does not impair natural killer cell function in HIV+ individuals.

Garrido C, Tolstrup M, Søgaard OS, Rasmussen TA, Allard B, Soriano-Sarabia N, Archin NM, Margolis DM.

AIDS. 2019 Mar 15;33(4):605-613. doi: 10.1097/QAD.0000000000002112.

PMID:
30830886
10.

Readmission and reoperation rates following negative diagnostic laparoscopy for clinically suspected appendicitis: The "normal" appendix should not be removed - A retrospective cohort study.

Sørensen AK, Bang-Nielsen A, Levic-Souzani K, Pommergaard HC, Jørgensen AB, Tolstrup MB, Rud B, Kovacevic B, Bulut O.

Int J Surg. 2019 Apr;64:1-4. doi: 10.1016/j.ijsu.2019.02.001. Epub 2019 Feb 12.

PMID:
30769215
11.

[Transarterial embolisation for gastrointestinal bleeding caused by an ulcer].

Rasmussen IR, Gögenur I, Tolstrup MB.

Ugeskr Laeger. 2019 Feb 4;181(6). pii: V05180369. Danish.

PMID:
30729917
12.

Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption.

Vibholm LK, Lorenzi JCC, Pai JA, Cohen YZ, Oliveira TY, Barton JP, Garcia Noceda M, Lu CL, Ablanedo-Terrazas Y, Del Rio Estrada PM, Reyes-Teran G, Tolstrup M, Denton PW, Damsgaard T, Søgaard OS, Nussenzweig MC.

J Virol. 2019 Apr 3;93(8). pii: e01920-18. doi: 10.1128/JVI.01920-18. Print 2019 Apr 15.

13.

Reduced rate of incisional hernia after standardized fascial closure in emergency laparotomy.

Thorup T, Tolstrup MB, Gögenur I.

Hernia. 2019 Apr;23(2):341-346. doi: 10.1007/s10029-019-01893-0. Epub 2019 Jan 25.

PMID:
30684103
14.

Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs.

Frich CK, Krüger F, Walther R, Domar C, Andersen AHF, Tvilum A, Dagnæs-Hansen F, Denton PW, Tolstrup M, Paludan SR, Münch J, Zelikin AN.

J Control Release. 2019 Jan 28;294:298-310. doi: 10.1016/j.jconrel.2018.12.016. Epub 2018 Dec 12.

PMID:
30552954
15.

Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals.

Moron-Lopez S, Kim P, Søgaard OS, Tolstrup M, Wong JK, Yukl SA.

AIDS. 2019 Mar 1;33(3):425-431. doi: 10.1097/QAD.0000000000002083.

PMID:
30531314
16.

Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules.

Nissen SK, Christiansen M, Helleberg M, Kjær K, Jørgensen SE, Gerstoft J, Katzenstein TL, Benfield T, Kronborg G, Larsen CS, Laursen A, Pedersen G, Jakobsen MR, Tolstrup M, Mogensen TH.

Sci Rep. 2018 Oct 15;8(1):15253. doi: 10.1038/s41598-018-33481-0.

17.

Chronic Pain, Quality of Life and Functional Impairment After Emergency Laparotomy.

Tolstrup MB, Thorup T, Gögenur I.

World J Surg. 2019 Jan;43(1):161-168. doi: 10.1007/s00268-018-4778-4.

PMID:
30178128
18.

[Mortality rate after acute laparotomy can be reduced].

Skovsen AP, Burcharth J, Tolstrup MB, Gögenur I.

Ugeskr Laeger. 2018 Jul 30;180(31). pii: V09170639. Review. Danish.

PMID:
30064620
19.

Differences in antiretroviral regimens do not impact safety or level of latency reversal in persons receiving romidepsin.

Jørgensen S, Leth S, Sommerfelt M, Østergaard L, Tolstrup M, Søgaard OS.

AIDS. 2018 Jul 31;32(12):1729-1731. doi: 10.1097/QAD.0000000000001904. No abstract available.

PMID:
30001247
20.

Genetic characterization of the HIV-1 reservoir after Vacc-4x and romidepsin therapy in HIV-1-infected individuals.

Winckelmann A, Morcilla V, Shao W, Schleimann MH, Hojen JF, Schlub TE, Denton PW, Østergaard L, Søgaard OS, Tolstrup M, Palmer S.

AIDS. 2018 Aug 24;32(13):1793-1802. doi: 10.1097/QAD.0000000000001861.

21.

Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors.

Nissen SK, Pedersen JG, Helleberg M, Kjær K, Thavachelvam K, Obel N, Tolstrup M, Jakobsen MR, Mogensen TH.

J Immunol. 2018 May 15;200(10):3372-3382. doi: 10.4049/jimmunol.1701284. Epub 2018 Apr 9.

22.

Levels of regulatory B cells do not predict serological responses to hepatitis B vaccine.

Bolther M, Andersen KLD, Tolstrup M, Visvanathan K, Woolley I, Skinner N, Millen R, Warner N, Østergaard L, Jensen-Fangel S.

Hum Vaccin Immunother. 2018 Jun 3;14(6):1483-1488. doi: 10.1080/21645515.2018.1441653. Epub 2018 Apr 11.

23.

Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses.

Brinkmann CR, Højen JF, Rasmussen TA, Kjær AS, Olesen R, Denton PW, Østergaard L, Ouyang Z, Lichterfeld M, Yu X, Søgaard OS, Dinarello C, Tolstrup M.

mSphere. 2018 Feb 14;3(1). pii: e00616-17. doi: 10.1128/mSphere.00616-17. eCollection 2018 Jan-Feb.

24.

Macromolecular prodrugs of ribavirin: Polymer backbone defines blood safety, drug release, and efficacy of anti-inflammatory effects.

Zuwala K, Riber CF, Løvschall KB, Andersen AHF, Sørensen L, Gajda P, Tolstrup M, Zelikin AN.

J Control Release. 2018 Apr 10;275:53-66. doi: 10.1016/j.jconrel.2018.02.012. Epub 2018 Feb 9.

PMID:
29432822
25.

Cellular immunogenicity of human papillomavirus vaccines Cervarix and Gardasil in adults with HIV infection.

Zurek Munk-Madsen M, Toft L, Kube T, Richter R, Ostergaard L, Søgaard OS, Tolstrup M, Kaufmann AM.

Hum Vaccin Immunother. 2018 Apr 3;14(4):909-916. doi: 10.1080/21645515.2017.1407896. Epub 2017 Dec 20.

26.

Estimating Initial Viral Levels during Simian Immunodeficiency Virus/Human Immunodeficiency Virus Reactivation from Latency.

Pinkevych M, Fennessey CM, Cromer D, Tolstrup M, Søgaard OS, Rasmussen TA, Keele BF, Davenport MP.

J Virol. 2018 Jan 2;92(2). pii: e01667-17. doi: 10.1128/JVI.01667-17. Print 2018 Jan 15.

27.

Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses.

Schandock F, Riber CF, Röcker A, Müller JA, Harms M, Gajda P, Zuwala K, Andersen AHF, Løvschall KB, Tolstrup M, Kreppel F, Münch J, Zelikin AN.

Adv Healthc Mater. 2017 Dec;6(23). doi: 10.1002/adhm.201700748. Epub 2017 Sep 25.

PMID:
28945945
28.

Sequential Vacc-4x and romidepsin during combination antiretroviral therapy (cART): Immune responses to Vacc-4x regions on p24 and changes in HIV reservoirs.

Tapia G, Højen JF, Ökvist M, Olesen R, Leth S, Nissen SK, VanBelzen DJ, O'Doherty U, Mørk A, Krogsgaard K, Søgaard OS, Østergaard L, Tolstrup M, Pantaleo G, Sommerfelt MA.

J Infect. 2017 Dec;75(6):555-571. doi: 10.1016/j.jinf.2017.09.004. Epub 2017 Sep 14.

PMID:
28917661
29.

A5 Peripheral blood cells contribute to HIV-1 viremia induced by romidepsin.

Winckelmann A, Barton K, Hiener B, Shao W, Østergaard L, Rasmussen T, Søgaard O, Tolstrup M, Palmer S.

Virus Evol. 2017 Mar 5;3(Suppl 1). pii: vew036.004. doi: 10.1093/ve/vew036.004. eCollection 2017 Mar. No abstract available.

30.

HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal.

Wu G, Swanson M, Talla A, Graham D, Strizki J, Gorman D, Barnard RJ, Blair W, Søgaard OS, Tolstrup M, Østergaard L, Rasmussen TA, Sekaly RP, Archin NM, Margolis DM, Hazuda DJ, Howell BJ.

JCI Insight. 2017 Aug 17;2(16). pii: 92901. doi: 10.1172/jci.insight.92901. eCollection 2017 Aug 17.

31.

The TLR9 agonist MGN1703 triggers a potent type I interferon response in the sigmoid colon.

Krarup AR, Abdel-Mohsen M, Schleimann MH, Vibholm L, Engen PA, Dige A, Wittig B, Schmidt M, Green SJ, Naqib A, Keshavarzian A, Deng X, Olesen R, Petersen AM, Benfield T, Østergaard L, Rasmussen TA, Agnholt J, Nyengaard JR, Landay A, Søgaard OS, Pillai SK, Tolstrup M, Denton PW.

Mucosal Immunol. 2018 Mar;11(2):449-461. doi: 10.1038/mi.2017.59. Epub 2017 Aug 2.

32.

A Description of Deaths Following Emergency Abdominal Surgery.

Wolsted H, Møller AM, Tolstrup MB, Vester-Andersen M.

World J Surg. 2017 Dec;41(12):3105-3110. doi: 10.1007/s00268-017-4109-1.

PMID:
28717904
33.

Adaptive process triage system cannot identify patients with gastrointestinal perforation.

Bohm AM, Tolstrup MB, Gögenur I.

Dan Med J. 2017 Jul;64(7). pii: A5374.

PMID:
28673376
34.

Anti-HIV-1 ADCC Antibodies following Latency Reversal and Treatment Interruption.

Lee WS, Kristensen AB, Rasmussen TA, Tolstrup M, Østergaard L, Søgaard OS, Wines BD, Hogarth PM, Reynaldi A, Davenport MP, Emery S, Amin J, Cooper DA, Kan VL, Fox J, Gruell H, Parsons MS, Kent SJ.

J Virol. 2017 Jul 12;91(15). pii: e00603-17. doi: 10.1128/JVI.00603-17. Print 2017 Aug 1.

35.

Beyond antiretroviral therapy: early interventions to control HIV-1 infection.

Gunst JD, Tolstrup M, Søgaard OS.

AIDS. 2017 Jul 31;31(12):1665-1667. doi: 10.1097/QAD.0000000000001524. No abstract available.

PMID:
28463884
36.

Short-Course Toll-Like Receptor 9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals With Human Immunodeficiency Virus Infection.

Vibholm L, Schleimann MH, Højen JF, Benfield T, Offersen R, Rasmussen K, Olesen R, Dige A, Agnholt J, Grau J, Buzon M, Wittig B, Lichterfeld M, Petersen AM, Deng X, Abdel-Mohsen M, Pillai SK, Rutsaert S, Trypsteen W, De Spiegelaere W, Vandekerchove L, Østergaard L, Rasmussen TA, Denton PW, Tolstrup M, Søgaard OS.

Clin Infect Dis. 2017 Jun 15;64(12):1686-1695. doi: 10.1093/cid/cix201.

37.

Romidepsin-induced HIV-1 viremia during effective antiretroviral therapy contains identical viral sequences with few deleterious mutations.

Winckelmann A, Barton K, Hiener B, Schlub TE, Shao W, Rasmussen TA, Østergaard L, Søgaard OS, Tolstrup M, Palmer S.

AIDS. 2017 Mar 27;31(6):771-779. doi: 10.1097/QAD.0000000000001400.

38.

Reduced Rate of Dehiscence After Implementation of a Standardized Fascial Closure Technique in Patients Undergoing Emergency Laparotomy.

Tolstrup MB, Watt SK, Gögenur I.

Ann Surg. 2017 Apr;265(4):821-826. doi: 10.1097/SLA.0000000000001762.

PMID:
28267697
39.

Macromolecular Prodrugs of Ribavirin: Structure-Function Correlation as Inhibitors of Influenza Infectivity.

Riber CF, Hinton TM, Gajda P, Zuwala K, Tolstrup M, Stewart C, Zelikin AN.

Mol Pharm. 2017 Jan 3;14(1):234-241. doi: 10.1021/acs.molpharmaceut.6b00826. Epub 2016 Nov 23.

PMID:
28043136
40.

30-Day, 90-day and 1-year mortality after emergency colonic surgery.

Pedersen T, Watt SK, Tolstrup MB, Gögenur I.

Eur J Trauma Emerg Surg. 2017 Jun;43(3):299-305. doi: 10.1007/s00068-016-0742-x. Epub 2016 Nov 22.

PMID:
27878343
41.

Complications after emergency laparotomy beyond the immediate postoperative period - a retrospective, observational cohort study of 1139 patients.

Tengberg LT, Cihoric M, Foss NB, Bay-Nielsen M, Gögenur I, Henriksen R, Jensen TK, Tolstrup MB, Nielsen LB.

Anaesthesia. 2017 Mar;72(3):309-316. doi: 10.1111/anae.13721. Epub 2016 Nov 3.

42.

Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trial.

Leth S, Schleimann MH, Nissen SK, Højen JF, Olesen R, Graversen ME, Jørgensen S, Kjær AS, Denton PW, Mørk A, Sommerfelt MA, Krogsgaard K, Østergaard L, Rasmussen TA, Tolstrup M, Søgaard OS.

Lancet HIV. 2016 Oct;3(10):e463-72. doi: 10.1016/S2352-3018(16)30055-8. Epub 2016 Jul 7.

PMID:
27658863
43.

Broad activation of latent HIV-1 in vivo.

Barton K, Hiener B, Winckelmann A, Rasmussen TA, Shao W, Byth K, Lanfear R, Solomon A, McMahon J, Harrington S, Buzon M, Lichterfeld M, Denton PW, Olesen R, Østergaard L, Tolstrup M, Lewin SR, Søgaard OS, Palmer S.

Nat Commun. 2016 Sep 8;7:12731. doi: 10.1038/ncomms12731.

44.

Correction: HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days-Implications for HIV Remission.

Pinkevych M, Cromer D, Tolstrup M, Grimm AJ, Cooper DA, Lewin SR, Søgaard OS, Rasmussen TA, Kent SJ, Kelleher AD, Davenport MP.

PLoS Pathog. 2016 Aug 25;12(8):e1005745. doi: 10.1371/journal.ppat.1005745. eCollection 2016 Aug.

45.

Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5-8 Days.

Pinkevych M, Kent SJ, Tolstrup M, Lewin SR, Cooper DA, Søgaard OS, Rasmussen TA, Kelleher AD, Cromer D, Davenport MP.

PLoS Pathog. 2016 Aug 25;12(8):e1005740. doi: 10.1371/journal.ppat.1005740. eCollection 2016 Aug. No abstract available.

46.

Morbidity and mortality rates after emergency abdominal surgery: an analysis of 4346 patients scheduled for emergency laparotomy or laparoscopy.

Tolstrup MB, Watt SK, Gögenur I.

Langenbecks Arch Surg. 2017 Jun;402(4):615-623. doi: 10.1007/s00423-016-1493-1. Epub 2016 Aug 9.

PMID:
27502400
47.

Immune checkpoints and the HIV-1 reservoir: proceed with caution.

Olesen R, Leth S, Nymann R, Østergaard L, Søgaard OS, Denton PW, Tolstrup M.

J Virus Erad. 2016 Jul 1;2(3):183-6. No abstract available.

48.

International AIDS Society global scientific strategy: towards an HIV cure 2016.

Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F; International AIDS Society Towards a Cure Working Group, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J.

Nat Med. 2016 Aug;22(8):839-50. doi: 10.1038/nm.4108. Epub 2016 Jul 11.

49.

Chronic Pain, Quality of Life, and Functional Impairment After Surgery Due to Small Bowel Obstruction.

Jeppesen M, Tolstrup MB, Gögenur I.

World J Surg. 2016 Sep;40(9):2091-7. doi: 10.1007/s00268-016-3616-9.

PMID:
27384171
50.

Triple Activity of Lamivudine Releasing Sulfonated Polymers against HIV-1.

Danial M, Andersen AH, Zuwala K, Cosson S, Riber CF, Smith AA, Tolstrup M, Moad G, Zelikin AN, Postma A.

Mol Pharm. 2016 Jul 5;13(7):2397-410. doi: 10.1021/acs.molpharmaceut.6b00156. Epub 2016 Jun 15.

PMID:
27244595

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