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Items: 1 to 50 of 69

1.

Heme and sensory neuropathy: insights from novel mutations in the heme exporter FLVCR1.

Bertino F, Firestone K, Bellacchio E, Jackson KE, Asamoah A, Hersh J, Fiorito V, Destefanis F, Gonser R, Tucker ME, Altruda F, Tolosano E, Chiabrando D.

Pain. 2019 Aug 10. doi: 10.1097/j.pain.0000000000001675. [Epub ahead of print]

PMID:
31408049
2.

Purinergic Calcium Signals in Tumor-Derived Endothelium.

Scarpellino G, Genova T, Avanzato D, Bernardini M, Bianco S, Petrillo S, Tolosano E, de Almeida Vieira JR, Bussolati B, Fiorio Pla A, Munaron L.

Cancers (Basel). 2019 Jun 1;11(6). pii: E766. doi: 10.3390/cancers11060766.

3.

Investigating the Connection Between Endogenous Heme Accumulation and COX2 Activity in Cancer Cells.

Destefanis F, Fiorito V, Altruda F, Tolosano E.

Front Oncol. 2019 Mar 19;9:162. doi: 10.3389/fonc.2019.00162. eCollection 2019.

4.

Temporal and age-dependent effects of haptoglobin deletion on intracerebral hemorrhage-induced brain damage and neurobehavioral outcomes.

Leclerc JL, Li C, Jean S, Lampert AS, Amador CL, Diller MA, Tolosano E, Doré S.

Exp Neurol. 2019 Jul;317:22-33. doi: 10.1016/j.expneurol.2019.01.011. Epub 2019 Feb 19.

PMID:
30790555
5.

Unraveling the Role of Heme in Neurodegeneration.

Chiabrando D, Fiorito V, Petrillo S, Tolosano E.

Front Neurosci. 2018 Oct 9;12:712. doi: 10.3389/fnins.2018.00712. eCollection 2018. Review.

6.

Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis.

Beneduce E, Matte A, De Falco L, Mbiandjeu S, Chiabrando D, Tolosano E, Federti E, Petrillo S, Mohandas N, Siciliano A, Babu W, Menon V, Ghaffari S, Iolascon A, De Franceschi L.

Am J Hematol. 2019 Jan;94(1):10-20. doi: 10.1002/ajh.25295. Epub 2018 Oct 25.

PMID:
30252956
7.

Characterization of Human Mesenchymal Stem Cells Isolated from the Testis.

De Chiara L, Famulari ES, Fagoonee S, van Daalen SKM, Buttiglieri S, Revelli A, Tolosano E, Silengo L, van Pelt AMM, Altruda F.

Stem Cells Int. 2018 Sep 3;2018:4910304. doi: 10.1155/2018/4910304. eCollection 2018.

8.

Mitochondrial Targeting in Neurodegeneration: A Heme Perspective.

Fiorito V, Chiabrando D, Tolosano E.

Pharmaceuticals (Basel). 2018 Sep 18;11(3). pii: E87. doi: 10.3390/ph11030087. Review.

9.

Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles.

Merle NS, Grunenwald A, Rajaratnam H, Gnemmi V, Frimat M, Figueres ML, Knockaert S, Bouzekri S, Charue D, Noe R, Robe-Rybkine T, Le-Hoang M, Brinkman N, Gentinetta T, Edler M, Petrillo S, Tolosano E, Miescher S, Le Jeune S, Houillier P, Chauvet S, Rabant M, Dimitrov JD, Fremeaux-Bacchi V, Blanc-Brude OP, Roumenina LT.

JCI Insight. 2018 Jun 21;3(12). pii: 96910. doi: 10.1172/jci.insight.96910. eCollection 2018 Jun 21.

10.

Targeting Metabolism to Counteract Tumor Angiogenesis: A Review of Patent Literature.

Petrillo S, Tolosano E, Munaron L, Genova T.

Recent Pat Anticancer Drug Discov. 2018;13(4):422-427. doi: 10.2174/1574892813666180528105023. Review.

11.

Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis.

Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, Mussano F, Carossa S, Silengo L, Altruda F, Merlo GR, Munaron L, Tolosano E.

Cell Death Differ. 2018 Mar;25(3):573-588. doi: 10.1038/s41418-017-0001-7. Epub 2017 Dec 11.

12.

Posterior column ataxia with retinitis pigmentosa coexisting with sensory-autonomic neuropathy and leukemia due to the homozygous p.Pro221Ser FLVCR1 mutation.

Castori M, Morlino S, Ungelenk M, Pareyson D, Salsano E, Grammatico P, Tolosano E, Kurth I, Chiabrando D.

Am J Med Genet B Neuropsychiatr Genet. 2017 Oct;174(7):732-739. doi: 10.1002/ajmg.b.32570. Epub 2017 Aug 2.

PMID:
28766925
13.

Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency.

Herrera Sanchez MB, Previdi S, Bruno S, Fonsato V, Deregibus MC, Kholia S, Petrillo S, Tolosano E, Critelli R, Spada M, Romagnoli R, Salizzoni M, Tetta C, Camussi G.

Stem Cell Res Ther. 2017 Jul 27;8(1):176. doi: 10.1186/s13287-017-0628-9.

14.

Data demonstrating the anti-oxidant role of hemopexin in the heart.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Data Brief. 2017 May 13;13:69-76. doi: 10.1016/j.dib.2017.05.026. eCollection 2017 Aug.

15.

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Free Radic Biol Med. 2017 Jul;108:452-464. doi: 10.1016/j.freeradbiomed.2017.04.003. Epub 2017 Apr 8.

16.

IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.

Sakamoto K, Kim YG, Hara H, Kamada N, Caballero-Flores G, Tolosano E, Soares MP, Puente JL, Inohara N, Núñez G.

Sci Immunol. 2017 Feb;2(8). pii: eaai8371. doi: 10.1126/sciimmunol.aai8371. Epub 2017 Feb 3.

17.

The RNA-binding protein ESRP1 promotes human colorectal cancer progression.

Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfò I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F.

Oncotarget. 2017 Feb 7;8(6):10007-10024. doi: 10.18632/oncotarget.14318.

18.

Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception.

Chiabrando D, Castori M, di Rocco M, Ungelenk M, Gießelmann S, Di Capua M, Madeo A, Grammatico P, Bartsch S, Hübner CA, Altruda F, Silengo L, Tolosano E, Kurth I.

PLoS Genet. 2016 Dec 6;12(12):e1006461. doi: 10.1371/journal.pgen.1006461. eCollection 2016 Dec.

19.

Age-Dependent Effects of Haptoglobin Deletion in Neurobehavioral and Anatomical Outcomes Following Traumatic Brain Injury.

Glushakov AV, Arias RA, Tolosano E, Doré S.

Front Mol Biosci. 2016 Jul 19;3:34. doi: 10.3389/fmolb.2016.00034. eCollection 2016.

20.

Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage.

Ma B, Day JP, Phillips H, Slootsky B, Tolosano E, Doré S.

J Neuroinflammation. 2016 Feb 1;13:26. doi: 10.1186/s12974-016-0490-1.

21.

Hemoglobin - a novel ligand of hepatocyte ectopic F1-ATPase.

Gburek J, Konopska B, Juszczynska K, Piwowar A, Dziegiel P, Borska S, Tolosano E, Golab K.

J Physiol Pharmacol. 2015 Dec;66(6):823-30.

22.

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.

Vinchi F, Costa da Silva M, Ingoglia G, Petrillo S, Brinkman N, Zuercher A, Cerwenka A, Tolosano E, Muckenthaler MU.

Blood. 2016 Jan 28;127(4):473-86. doi: 10.1182/blood-2015-08-663245. Epub 2015 Dec 16.

23.

Long Term Liver Engraftment of Functional Hepatocytes Obtained from Germline Cell-Derived Pluripotent Stem Cells.

Fagoonee S, Famulari ES, Silengo L, Tolosano E, Altruda F.

PLoS One. 2015 Aug 31;10(8):e0136762. doi: 10.1371/journal.pone.0136762. eCollection 2015.

24.

Crucial Role of FLVCR1a in the Maintenance of Intestinal Heme Homeostasis.

Fiorito V, Forni M, Silengo L, Altruda F, Tolosano E.

Antioxid Redox Signal. 2015 Dec 20;23(18):1410-23. doi: 10.1089/ars.2014.6216. Epub 2015 Jul 20.

25.

Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis.

Tolosano E.

Haematologica. 2015 May;100(5):565-6. doi: 10.3324/haematol.2015.124966. No abstract available.

26.

The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation.

Mercurio S, Petrillo S, Chiabrando D, Bassi ZI, Gays D, Camporeale A, Vacaru A, Miniscalco B, Valperga G, Silengo L, Altruda F, Baron MH, Santoro MM, Tolosano E.

Haematologica. 2015 Jun;100(6):720-9. doi: 10.3324/haematol.2014.114488. Epub 2015 Mar 20.

27.

Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development.

Schaer DJ, Vinchi F, Ingoglia G, Tolosano E, Buehler PW.

Front Physiol. 2014 Oct 28;5:415. doi: 10.3389/fphys.2014.00415. eCollection 2014. Review.

28.

Heme and erythropoieis: more than a structural role.

Chiabrando D, Mercurio S, Tolosano E.

Haematologica. 2014 Jun;99(6):973-83. doi: 10.3324/haematol.2013.091991. Review.

29.

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes.

Chiabrando D, Vinchi F, Fiorito V, Mercurio S, Tolosano E.

Front Pharmacol. 2014 Apr 8;5:61. doi: 10.3389/fphar.2014.00061. eCollection 2014. Review.

30.

Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1.

Fiorito V, Neri F, Pala V, Silengo L, Oliviero S, Altruda F, Tolosano E.

Biochim Biophys Acta. 2014;1839(4):259-64. doi: 10.1016/j.bbagrm.2014.02.010. Epub 2014 Feb 24.

31.

Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.

Vinchi F, Ingoglia G, Chiabrando D, Mercurio S, Turco E, Silengo L, Altruda F, Tolosano E.

Gastroenterology. 2014 May;146(5):1325-38. doi: 10.1053/j.gastro.2014.01.053. Epub 2014 Jan 31.

32.

Alumina-zirconia composites functionalized with laminin-1 and laminin-5 for dentistry: effect of protein adsorption on cellular response.

Vallée A, Faga MG, Mussano F, Catalano F, Tolosano E, Carossa S, Altruda F, Martra G.

Colloids Surf B Biointerfaces. 2014 Feb 1;114:284-93. doi: 10.1016/j.colsurfb.2013.09.053. Epub 2013 Oct 17.

PMID:
24216619
33.

Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development.

Rolla S, Ingoglia G, Bardina V, Silengo L, Altruda F, Novelli F, Tolosano E.

J Immunol. 2013 Dec 1;191(11):5451-9. doi: 10.4049/jimmunol.1203076. Epub 2013 Oct 23.

34.

Renal cells from spermatogonial germline stem cells protect against kidney injury.

De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F.

J Am Soc Nephrol. 2014 Feb;25(2):316-28. doi: 10.1681/ASN.2013040367. Epub 2013 Oct 17.

35.

The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells.

Fagoonee S, Bearzi C, Di Cunto F, Clohessy JG, Rizzi R, Reschke M, Tolosano E, Provero P, Pandolfi PP, Silengo L, Altruda F.

PLoS One. 2013 Aug 27;8(8):e72300. doi: 10.1371/journal.pone.0072300. eCollection 2013.

36.

Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake.

Fiorito V, Geninatti Crich S, Silengo L, Aime S, Altruda F, Tolosano E.

PLoS One. 2013 Jun 27;8(6):e68146. doi: 10.1371/journal.pone.0068146. Print 2013.

37.

Therapeutic approaches to limit hemolysis-driven endothelial dysfunction: scavenging free heme to preserve vasculature homeostasis.

Vinchi F, Tolosano E.

Oxid Med Cell Longev. 2013;2013:396527. doi: 10.1155/2013/396527. Epub 2013 May 27. Review.

38.

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.

Vinchi F, De Franceschi L, Ghigo A, Townes T, Cimino J, Silengo L, Hirsch E, Altruda F, Tolosano E.

Circulation. 2013 Mar 26;127(12):1317-29. doi: 10.1161/CIRCULATIONAHA.112.130179. Epub 2013 Feb 27.

39.

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation.

Chiabrando D, Marro S, Mercurio S, Giorgi C, Petrillo S, Vinchi F, Fiorito V, Fagoonee S, Camporeale A, Turco E, Merlo GR, Silengo L, Altruda F, Pinton P, Tolosano E.

J Clin Invest. 2012 Dec;122(12):4569-79. doi: 10.1172/JCI62422. Epub 2012 Nov 26.

40.

Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.

Chiabrando D, Fiorito V, Marro S, Silengo L, Altruda F, Tolosano E.

Blood Cells Mol Dis. 2013 Jan;50(1):25-30. doi: 10.1016/j.bcmd.2012.08.002. Epub 2012 Aug 24.

41.

Assessment of iron absorption in mice by ICP-MS measurements of (57)Fe levels.

Fiorito V, Geninatti Crich S, Silengo L, Altruda F, Aime S, Tolosano E.

Eur J Nutr. 2012 Oct;51(7):783-9. Epub 2011 Oct 19.

42.

A role for hemopexin in oligodendrocyte differentiation and myelin formation.

Morello N, Bianchi FT, Marmiroli P, Tonoli E, Rodriguez Menendez V, Silengo L, Cavaletti G, Vercelli A, Altruda F, Tolosano E.

PLoS One. 2011;6(5):e20173. doi: 10.1371/journal.pone.0020173. Epub 2011 May 25.

43.

Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice.

Spiller F, Costa C, Souto FO, Vinchi F, Mestriner FL, Laure HJ, Alves-Filho JC, Freitas A, Rosa JC, Ferreira SH, Altruda F, Hirsch E, Greene LJ, Tolosano E, Cunha FQ.

Am J Respir Crit Care Med. 2011 Apr 1;183(7):922-31. doi: 10.1164/rccm.201002-0223OC. Epub 2010 Oct 22.

PMID:
20971829
44.

Diamond Blackfan Anemia at the Crossroad between Ribosome Biogenesis and Heme Metabolism.

Chiabrando D, Tolosano E.

Adv Hematol. 2010;2010:790632. doi: 10.1155/2010/790632. Epub 2010 May 5.

45.

Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro.

Fagoonee S, Hobbs RM, De Chiara L, Cantarella D, Piro RM, Tolosano E, Medico E, Provero P, Pandolfi PP, Silengo L, Altruda F.

Stem Cells Dev. 2010 Aug;19(8):1183-94. doi: 10.1089/scd.2009.0496.

PMID:
20331356
46.

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter.

Marro S, Chiabrando D, Messana E, Stolte J, Turco E, Tolosano E, Muckenthaler MU.

Haematologica. 2010 Aug;95(8):1261-8. doi: 10.3324/haematol.2009.020123. Epub 2010 Feb 23.

47.

Heme scavenging and the other facets of hemopexin.

Tolosano E, Fagoonee S, Morello N, Vinchi F, Fiorito V.

Antioxid Redox Signal. 2010 Feb;12(2):305-20. doi: 10.1089/ars.2009.2787. Review.

PMID:
19650691
48.

Heme-hemopexin complex attenuates neuronal cell death and stroke damage.

Li RC, Saleem S, Zhen G, Cao W, Zhuang H, Lee J, Smith A, Altruda F, Tolosano E, Doré S.

J Cereb Blood Flow Metab. 2009 May;29(5):953-64. doi: 10.1038/jcbfm.2009.19. Epub 2009 Mar 11. Erratum in: J Cereb Blood Flow Metab. 2014 Apr;34(4):736.

49.

Haemopexin affects iron distribution and ferritin expression in mouse brain.

Morello N, Tonoli E, Logrand F, Fiorito V, Fagoonee S, Turco E, Silengo L, Vercelli A, Altruda F, Tolosano E.

J Cell Mol Med. 2009 Oct;13(10):4192-204. doi: 10.1111/j.1582-4934.2008.00611.x.

50.

Lack of plasma protein hemopexin dampens mercury-induced autoimmune response in mice.

Fagoonee S, Caorsi C, Giovarelli M, Stoltenberg M, Silengo L, Altruda F, Camussi G, Tolosano E, Bussolati B.

J Immunol. 2008 Aug 1;181(3):1937-47.

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