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Items: 38

1.

Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW.

Nature. 2018 Sep;561(7723):420. doi: 10.1038/s41586-018-0284-y.

2.

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, Eheim AL, Stoeckigt D, Maxcy KL, Cobert JM, Bachand J, Szekely BA, Mukherjee S, Sklar LA, Kotz JD, Clish CB, Sadreyev RI, Clemons PA, Janzer A, Schreiber SL, Scadden DT.

Cell. 2016 Sep 22;167(1):171-186.e15. doi: 10.1016/j.cell.2016.08.057. Epub 2016 Sep 15.

3.

Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.

de Waal L, Lewis TA, Rees MG, Tsherniak A, Wu X, Choi PS, Gechijian L, Hartigan C, Faloon PW, Hickey MJ, Tolliday N, Carr SA, Clemons PA, Munoz B, Wagner BK, Shamji AF, Koehler AN, Schenone M, Burgin AB, Schreiber SL, Greulich H, Meyerson M.

Nat Chem Biol. 2016 Feb;12(2):102-8. doi: 10.1038/nchembio.1984. Epub 2015 Dec 14.

4.

Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW.

Nature. 2015 Oct 22;526(7574):596. doi: 10.1038/nature15370. Epub 2015 Sep 16. No abstract available.

PMID:
26375002
5.

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.

Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, Hideshima T, Dančík V, Majireck MM, Hussain MM, Singh S, Quiroz R, Iaconelli J, Karmacharya R, Tolliday NJ, Clemons PA, Moore MAS, Stern AM, Shamji AF, Ebert BL, Golub TR, Raje NS, Scadden DT, Schreiber SL.

Cell Rep. 2015 Feb 10;10(5):755-770. doi: 10.1016/j.celrep.2015.01.017. Epub 2015 Feb 5.

6.

A Candidate Cell-Selective Anticancer Agent.

Lewis TA, de Waal L, Youngsaye W, Gechijian L, Hickey M, Faloon P, Mikse O, Dandapani S, Wong K, Tolliday N, Munoz B, Palmer M, Greulich H, Meyerson ML, Schreiber SL.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Dec 12 [updated 2014 Sep 18].

7.

Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity.

Kawasumi M, Bradner JE, Tolliday N, Thibodeau R, Sloan H, Brummond KM, Nghiem P.

Cancer Res. 2014 Dec 15;74(24):7534-45. doi: 10.1158/0008-5472.CAN-14-2650. Epub 2014 Oct 21.

8.

Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.

Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P.

Nature. 2014 Jun 26;510(7506):547-51. doi: 10.1038/nature13267. Epub 2014 May 25.

9.

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

Gutierrez A, Pan L, Groen RW, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, VerPlank L, An F, Burbank J, Norton S, Tolliday N, Steen H, Weng AP, Yuan H, Bradner JE, Mitsiades C, Look AT, Aster JC.

J Clin Invest. 2014 Feb;124(2):644-55. doi: 10.1172/JCI65093. Epub 2014 Jan 9.

10.

A small-molecule inducer of PDX1 expression identified by high-throughput screening.

Yuan Y, Hartland K, Boskovic Z, Wang Y, Walpita D, Lysy PA, Zhong C, Young DW, Kim YK, Tolliday NJ, Sokal EM, Schreiber SL, Wagner BK.

Chem Biol. 2013 Dec 19;20(12):1513-22. doi: 10.1016/j.chembiol.2013.10.013. Epub 2013 Nov 27. Erratum in: Chem Biol. 2014 Feb 20;21(2):306.

11.

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.

Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, Hasaka T, Narayan R, Dai M, Huang C, Shterental S, Chu LP, Haydu JE, Shieh JH, Steensma DP, Munoz B, Bittker JA, Shamji AF, Clemons PA, Tolliday NJ, Carpenter AE, Gilliland DG, Stern AM, Moore MAS, Scadden DT, Schreiber SL, Ebert BL, Golub TR.

Nat Chem Biol. 2013 Dec;9(12):840-848. doi: 10.1038/nchembio.1367. Epub 2013 Oct 27.

12.

Analysis of the activities of RAD54, a SWI2/SNF2 protein, using a specific small-molecule inhibitor.

Deakyne JS, Huang F, Negri J, Tolliday N, Cocklin S, Mazin AV.

J Biol Chem. 2013 Nov 1;288(44):31567-80. doi: 10.1074/jbc.M113.502195. Epub 2013 Sep 16.

13.

Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation.

Frumm SM, Fan ZP, Ross KN, Duvall JR, Gupta S, VerPlank L, Suh BC, Holson E, Wagner FF, Smith WB, Paranal RM, Bassil CF, Qi J, Roti G, Kung AL, Bradner JE, Tolliday N, Stegmaier K.

Chem Biol. 2013 May 23;20(5):713-25. doi: 10.1016/j.chembiol.2013.03.020.

14.

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway.

Li G, Diogo D, Wu D, Spoonamore J, Dancik V, Franke L, Kurreeman F, Rossin EJ, Duclos G, Hartland C, Zhou X, Li K, Liu J, De Jager PL, Siminovitch KA, Zhernakova A, Raychaudhuri S, Bowes J, Eyre S, Padyukov L, Gregersen PK, Worthington J; Rheumatoid Arthritis Consortium International (RACI), Gupta N, Clemons PA, Stahl E, Tolliday N, Plenge RM.

PLoS Genet. 2013 May;9(5):e1003487. doi: 10.1371/journal.pgen.1003487. Epub 2013 May 16.

15.

An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries.

Mulrooney CA, Lahr DL, Quintin MJ, Youngsaye W, Moccia D, Asiedu JK, Mulligan EL, Akella LB, Marcaurelle LA, Montgomery P, Bittker JA, Clemons PA, Brudz S, Dandapani S, Duvall JR, Tolliday NJ, De Souza A.

J Comput Aided Mol Des. 2013 May;27(5):455-68. doi: 10.1007/s10822-013-9641-y. Epub 2013 Apr 13.

16.

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.

Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Goldberg L, Birger Y, Izraeli S, Gamis AS, Smith FO, Woods WG, Taub J, Scherer CA, Bradner JE, Goh BC, Mercher T, Carpenter AE, Gould RJ, Clemons PA, Carr SA, Root DE, Schreiber SL, Stern AM, Crispino JD.

Cell. 2012 Aug 3;150(3):575-89. doi: 10.1016/j.cell.2012.06.032.

17.

Screening for inhibitors of an essential chromatin remodeler in mouse embryonic stem cells by monitoring transcriptional regulation.

Dykhuizen EC, Carmody LC, Tolliday N, Crabtree GR, Palmer MA.

J Biomol Screen. 2012 Oct;17(9):1221-30. Epub 2012 Aug 1.

18.

A chemical screen probing the relationship between mitochondrial content and cell size.

Kitami T, Logan DJ, Negri J, Hasaka T, Tolliday NJ, Carpenter AE, Spiegelman BM, Mootha VK.

PLoS One. 2012;7(3):e33755. doi: 10.1371/journal.pone.0033755. Epub 2012 Mar 29.

19.

The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia.

Banerji V, Frumm SM, Ross KN, Li LS, Schinzel AC, Hahn CK, Kakoza RM, Chow KT, Ross L, Alexe G, Tolliday N, Inguilizian H, Galinsky I, Stone RM, DeAngelo DJ, Roti G, Aster JC, Hahn WC, Kung AL, Stegmaier K.

J Clin Invest. 2012 Mar;122(3):935-47. doi: 10.1172/JCI46465. Epub 2012 Feb 13.

20.

Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW.

Nature. 2011 Jul 13;475(7355):231-4. doi: 10.1038/nature10167. Erratum in: Nature. 2012 Jan 26;481(7382):534. Nature. 2015 Oct 22;526(7574):596. Retraction in: Nature. 2018 Sep;561(7723):420.

21.

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress.

Shaw AT, Winslow MM, Magendantz M, Ouyang C, Dowdle J, Subramanian A, Lewis TA, Maglathin RL, Tolliday N, Jacks T.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8773-8. doi: 10.1073/pnas.1105941108. Epub 2011 May 9.

22.

High-throughput assessment of Mammalian cell viability by determination of adenosine triphosphate levels.

Tolliday N.

Curr Protoc Chem Biol. 2010 Sep 1;2(3):153-61. doi: 10.1002/9780470559277.ch100045.

PMID:
23839967
23.

Cell-based assays for high-throughput screening.

An WF, Tolliday N.

Mol Biotechnol. 2010 Jun;45(2):180-6. doi: 10.1007/s12033-010-9251-z. Review.

PMID:
20151227
24.

Introduction: cell-based assays for high-throughput screening.

An WF, Tolliday NJ.

Methods Mol Biol. 2009;486:1-12. doi: 10.1007/978-1-60327-545-3_1. Review.

PMID:
19347612
25.

Identifying the proteins to which small-molecule probes and drugs bind in cells.

Ong SE, Schenone M, Margolin AA, Li X, Do K, Doud MK, Mani DR, Kuai L, Wang X, Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub TR, Gould RJ, Schreiber SL, Carr SA.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4617-22. doi: 10.1073/pnas.0900191106. Epub 2009 Mar 2.

26.

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.

Zimmer M, Ebert BL, Neil C, Brenner K, Papaioannou I, Melas A, Tolliday N, Lamb J, Pantopoulos K, Golub T, Iliopoulos O.

Mol Cell. 2008 Dec 26;32(6):838-48. doi: 10.1016/j.molcel.2008.12.004.

27.

ChemBank: a small-molecule screening and cheminformatics resource database.

Seiler KP, George GA, Happ MP, Bodycombe NE, Carrinski HA, Norton S, Brudz S, Sullivan JP, Muhlich J, Serrano M, Ferraiolo P, Tolliday NJ, Schreiber SL, Clemons PA.

Nucleic Acids Res. 2008 Jan;36(Database issue):D351-9. Epub 2007 Oct 18.

28.

Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics.

Tolliday N, Clemons PA, Ferraiolo P, Koehler AN, Lewis TA, Li X, Schreiber SL, Gerhard DS, Eliasof S.

Cancer Res. 2006 Sep 15;66(18):8935-42.

31.

Rho1 directs formin-mediated actin ring assembly during budding yeast cytokinesis.

Tolliday N, VerPlank L, Li R.

Curr Biol. 2002 Oct 29;12(21):1864-70.

32.

Assembly and regulation of the cytokinetic apparatus in budding yeast.

Tolliday N, Bouquin N, Li R.

Curr Opin Microbiol. 2001 Dec;4(6):690-5. Review.

PMID:
11731321
33.

Glutamate dehydrogenases from hyperthermophiles.

Robb FT, Maeder DL, DiRuggiero J, Borges KM, Tolliday N.

Methods Enzymol. 2001;331:26-41. No abstract available.

PMID:
11265468
34.

Structure determination of the glutamate dehydrogenase from the hyperthermophile Thermococcus litoralis and its comparison with that from Pyrococcus furiosus.

Britton KL, Yip KS, Sedelnikova SE, Stillman TJ, Adams MW, Ma K, Maeder DL, Robb FT, Tolliday N, Vetriani C, Rice DW, Baker PJ.

J Mol Biol. 1999 Nov 12;293(5):1121-32.

PMID:
10547290
35.

Pressure-induced thermostabilization of glutamate dehydrogenase from the hyperthermophile Pyrococcus furiosus.

Sun MM, Tolliday N, Vetriani C, Robb FT, Clark DS.

Protein Sci. 1999 May;8(5):1056-63.

36.

Protein thermostability above 100 degreesC: a key role for ionic interactions.

Vetriani C, Maeder DL, Tolliday N, Yip KS, Stillman TJ, Britton KL, Rice DW, Klump HH, Robb FT.

Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12300-5.

37.

Phosphorylation in halobacterial signal transduction.

Rudolph J, Tolliday N, Schmitt C, Schuster SC, Oesterhelt D.

EMBO J. 1995 Sep 1;14(17):4249-57.

38.

Purification and characterization of HSP70 proteins from Torpedo electric organ.

Eichler J, Tolliday N, Toker L, Silman I.

Comp Biochem Physiol B Biochem Mol Biol. 1995 Feb;110(2):409-15. No abstract available.

PMID:
7719645

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