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Inactivation of the pgmA Gene in Streptococcus mutans Significantly Decreases Biofilm-Associated Antimicrobial Tolerance.

Nilsson M, Givskov M, Twetman S, Tolker-Nielsen T.

Microorganisms. 2019 Sep 3;7(9). pii: E310. doi: 10.3390/microorganisms7090310.


Sub-lethal antimicrobial photodynamic inactivation affects Pseudomonas aeruginosa PAO1 quorum sensing and cyclic di-GMP regulatory systems.

Hendiani S, Rybtke ML, Tolker-Nielsen T, Kashef N.

Photodiagnosis Photodyn Ther. 2019 Sep;27:467-473. doi: 10.1016/j.pdpdt.2019.07.025. Epub 2019 Jul 27.


Two FtsH Proteases Contribute to Fitness and Adaptation of Pseudomonas aeruginosa Clone C Strains.

Kamal SM, Rybtke ML, Nimtz M, Sperlein S, Giske C, Trček J, Deschamps J, Briandet R, Dini L, Jänsch L, Tolker-Nielsen T, Lee C, Römling U.

Front Microbiol. 2019 Jul 9;10:1372. doi: 10.3389/fmicb.2019.01372. eCollection 2019.


Visualizing biofilm by targeting eDNA with long wavelength probe CDr15.

Kwon HY, Kim JY, Liu X, Lee JY, Yam JKH, Dahl Hultqvist L, Xu W, Rybtke M, Tolker-Nielsen T, Heo W, Kim JJ, Kang NY, Joo T, Yang L, Park SJ, Givskov M, Chang YT.

Biomater Sci. 2019 Aug 20;7(9):3594-3598. doi: 10.1039/c9bm00152b.


Transposon Mutagenesis in Streptococcus Species.

Nilsson M, Givskov M, Tolker-Nielsen T.

Methods Mol Biol. 2019;2016:39-49. doi: 10.1007/978-1-4939-9570-7_4.


Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents-How P. aeruginosa Can Escape Antibiotics.

Ciofu O, Tolker-Nielsen T.

Front Microbiol. 2019 May 3;10:913. doi: 10.3389/fmicb.2019.00913. eCollection 2019. Review.


P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination.

Henriksen K, Rørbo N, Rybtke ML, Martinet MG, Tolker-Nielsen T, Høiby N, Middelboe M, Ciofu O.

Pathog Dis. 2019 Mar 1;77(2). pii: ftz011. doi: 10.1093/femspd/ftz011.


Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia.

Richter AM, Fazli M, Schmid N, Shilling R, Suppiger A, Givskov M, Eberl L, Tolker-Nielsen T.

Front Microbiol. 2019 Jan 10;9:3286. doi: 10.3389/fmicb.2018.03286. eCollection 2018.


Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms.

Nilsson M, Jakobsen TH, Givskov M, Twetman S, Tolker-Nielsen T.

Microbiology. 2019 Mar;165(3):334-342. doi: 10.1099/mic.0.000773. Epub 2019 Jan 21.


High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content.

Almblad H, Rybtke M, Hendiani S, Andersen JB, Givskov M, Tolker-Nielsen T.

Microbiology. 2019 Mar;165(3):324-333. doi: 10.1099/mic.0.000772. Epub 2019 Jan 21.


Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells.

Teh WK, Dramsi S, Tolker-Nielsen T, Yang L, Givskov M.

J Bacteriol. 2019 Feb 25;201(6). pii: e00597-18. doi: 10.1128/JB.00597-18. Print 2019 Mar 15.


CDy14: a novel biofilm probe targeting exopolysaccharide Psl.

Kwon HY, Kim JY, Lee JY, Yam JKH, Hultqvist LD, Xu W, Rybtke M, Tolker-Nielsen T, Kim JJ, Kang NY, Yang L, Park SJ, Givskov M, Chang YT.

Chem Commun (Camb). 2018 Oct 18;54(84):11865-11868. doi: 10.1039/c8cc05544k.


Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α-synuclein and modulates its effect on biofilm formation.

Andersen KK, Vad BS, Kjaer L, Tolker-Nielsen T, Christiansen G, Otzen DE.

FEBS Lett. 2018 May;592(9):1484-1496. doi: 10.1002/1873-3468.13038. Epub 2018 Apr 10.


The Inoculation Method Could Impact the Outcome of Microbiological Experiments.

Kragh KN, Alhede M, Rybtke M, Stavnsberg C, Jensen PØ, Tolker-Nielsen T, Whiteley M, Bjarnsholt T.

Appl Environ Microbiol. 2018 Feb 14;84(5). pii: e02264-17. doi: 10.1128/AEM.02264-17. Print 2018 Mar 1.


A transposon mutant library of Bacillus cereus ATCC 10987 reveals novel genes required for biofilm formation and implicates motility as an important factor for pellicle-biofilm formation.

Okshevsky M, Louw MG, Lamela EO, Nilsson M, Tolker-Nielsen T, Meyer RL.

Microbiologyopen. 2018 Apr;7(2):e00552. doi: 10.1002/mbo3.552. Epub 2017 Nov 22.


Reduced Intracellular c-di-GMP Content Increases Expression of Quorum Sensing-Regulated Genes in Pseudomonas aeruginosa.

Lin Chua S, Liu Y, Li Y, Jun Ting H, Kohli GS, Cai Z, Suwanchaikasem P, Kau Kit Goh K, Pin Ng S, Tolker-Nielsen T, Yang L, Givskov M.

Front Cell Infect Microbiol. 2017 Oct 17;7:451. doi: 10.3389/fcimb.2017.00451. eCollection 2017.


Selective Proteomic Analysis of Antibiotic-Tolerant Cellular Subpopulations in Pseudomonas aeruginosa Biofilms.

Babin BM, Atangcho L, van Eldijk MB, Sweredoski MJ, Moradian A, Hess S, Tolker-Nielsen T, Newman DK, Tirrell DA.

MBio. 2017 Oct 24;8(5). pii: e01593-17. doi: 10.1128/mBio.01593-17.


Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes.

Jakobsen TH, Tolker-Nielsen T, Givskov M.

Int J Mol Sci. 2017 Sep 13;18(9). pii: E1970. doi: 10.3390/ijms18091970. Review.


High-Throughput Screening for Compounds that Modulate the Cellular c-di-GMP Level in Bacteria.

Groizeleau J, Andersen JB, Givskov M, Berthelsen J, Tolker-Nielsen T.

Methods Mol Biol. 2017;1657:455-470. doi: 10.1007/978-1-4939-7240-1_33.


Gauging and Visualizing c-di-GMP Levels in Pseudomonas aeruginosa Using Fluorescence-Based Biosensors.

Rybtke M, Chua SL, Yam JKH, Givskov M, Yang L, Tolker-Nielsen T.

Methods Mol Biol. 2017;1657:87-98. doi: 10.1007/978-1-4939-7240-1_8.


A broad range quorum sensing inhibitor working through sRNA inhibition.

Jakobsen TH, Warming AN, Vejborg RM, Moscoso JA, Stegger M, Lorenzen F, Rybtke M, Andersen JB, Petersen R, Andersen PS, Nielsen TE, Tolker-Nielsen T, Filloux A, Ingmer H, Givskov M.

Sci Rep. 2017 Aug 29;7(1):9857. doi: 10.1038/s41598-017-09886-8.


High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.

Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, Tolker-Nielsen T, Jenal U, Eberl L.

Microbiology. 2017 May;163(5):754-764. doi: 10.1099/mic.0.000452. Epub 2017 May 3.


Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB.

Fazli M, Rybtke M, Steiner E, Weidel E, Berthelsen J, Groizeleau J, Bin W, Zhi BZ, Yaming Z, Kaever V, Givskov M, Hartmann RW, Eberl L, Tolker-Nielsen T.

Microbiologyopen. 2017 Aug;6(4). doi: 10.1002/mbo3.480. Epub 2017 Apr 16.


Importance of the Exopolysaccharide Matrix in Antimicrobial Tolerance of Pseudomonas aeruginosa Aggregates.

Goltermann L, Tolker-Nielsen T.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02696-16. doi: 10.1128/AAC.02696-16. Print 2017 Apr.


Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction.

Hansen GM, Belstrøm D, Nilsson M, Helqvist S, Nielsen CH, Holmstrup P, Tolker-Nielsen T, Givskov M, Hansen PR.

PLoS One. 2016 Dec 28;11(12):e0168771. doi: 10.1371/journal.pone.0168771. eCollection 2016.


Bacterial biofilm in chronic lesions of hidradenitis suppurativa.

Ring HC, Bay L, Nilsson M, Kallenbach K, Miller IM, Saunte DM, Bjarnsholt T, Tolker-Nielsen T, Jemec GB.

Br J Dermatol. 2017 Apr;176(4):993-1000. doi: 10.1111/bjd.15007. Epub 2017 Feb 19.


The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation.

Groizeleau J, Rybtke M, Andersen JB, Berthelsen J, Liu Y, Yang L, Nielsen TE, Kaever V, Givskov M, Tolker-Nielsen T.

Microbiology. 2016 Oct;162(10):1797-1807. doi: 10.1099/mic.0.000354. Epub 2016 Aug 15.


The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms.

Nilsson M, Rybtke M, Givskov M, Høiby N, Twetman S, Tolker-Nielsen T.

Int J Antimicrob Agents. 2016 Sep;48(3):298-304. doi: 10.1016/j.ijantimicag.2016.06.019. Epub 2016 Jul 28.


Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms.

Chua SL, Yam JK, Hao P, Adav SS, Salido MM, Liu Y, Givskov M, Sze SK, Tolker-Nielsen T, Yang L.

Nat Commun. 2016 Feb 19;7:10750. doi: 10.1038/ncomms10750.


Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients: Results with Use of a High Sensitivity Polymerase Chain Reaction Assay.

Hansen GM, Nilsson M, Nielsen CH, Holmstrup P, Helqvist S, Tolker-Nielsen T, Givskov M, Hansen PR.

PLoS One. 2015 Dec 22;10(12):e0145657. doi: 10.1371/journal.pone.0145657. eCollection 2015.


Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli.

Sun J, Marais JP, Khoo C, LaPlante K, Vejborg RM, Givskov M, Tolker-Nielsen T, Seeram NP, Rowley DC.

J Funct Foods. 2015 Aug;17:235-242.


Functional bacterial amyloid increases Pseudomonas biofilm hydrophobicity and stiffness.

Zeng G, Vad BS, Dueholm MS, Christiansen G, Nilsson M, Tolker-Nielsen T, Nielsen PH, Meyer RL, Otzen DE.

Front Microbiol. 2015 Oct 7;6:1099. doi: 10.3389/fmicb.2015.01099. eCollection 2015.


Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange.

Hmelo LR, Borlee BR, Almblad H, Love ME, Randall TE, Tseng BS, Lin C, Irie Y, Storek KM, Yang JJ, Siehnel RJ, Howell PL, Singh PK, Tolker-Nielsen T, Parsek MR, Schweizer HP, Harrison JJ.

Nat Protoc. 2015 Nov;10(11):1820-41. doi: 10.1038/nprot.2015.115. Epub 2015 Oct 22.


The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface.

Rybtke M, Berthelsen J, Yang L, Høiby N, Givskov M, Tolker-Nielsen T.

Microbiologyopen. 2015 Dec;4(6):917-30. doi: 10.1002/mbo3.301. Epub 2015 Oct 12.


Pigments influence the tolerance of Pseudomonas aeruginosa PAO1 to photodynamically induced oxidative stress.

Orlandi VT, Bolognese F, Chiodaroli L, Tolker-Nielsen T, Barbieri P.

Microbiology. 2015 Dec;161(12):2298-309. doi: 10.1099/mic.0.000193. Epub 2015 Sep 29.


Lipopeptide biosurfactant viscosin enhances dispersal of Pseudomonas fluorescens SBW25 biofilms.

Bonnichsen L, Bygvraa Svenningsen N, Rybtke M, de Bruijn I, Raaijmakers JM, Tolker-Nielsen T, Nybroe O.

Microbiology. 2015 Dec;161(12):2289-97. doi: 10.1099/mic.0.000191. Epub 2015 Sep 28.


In silico analyses of metagenomes from human atherosclerotic plaque samples.

Mitra S, Drautz-Moses DI, Alhede M, Maw MT, Liu Y, Purbojati RW, Yap ZH, Kushwaha KK, Gheorghe AG, Bjarnsholt T, Hansen GM, Sillesen HH, Hougen HP, Hansen PR, Yang L, Tolker-Nielsen T, Schuster SC, Givskov M.

Microbiome. 2015 Sep 3;3:38. doi: 10.1186/s40168-015-0100-y.


Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response.

Rybtke M, Hultqvist LD, Givskov M, Tolker-Nielsen T.

J Mol Biol. 2015 Nov 20;427(23):3628-45. doi: 10.1016/j.jmb.2015.08.016. Epub 2015 Aug 28. Review.


The bactericidal activity of β-lactam antibiotics is increased by metabolizable sugar species.

Thorsing M, Bentin T, Givskov M, Tolker-Nielsen T, Goltermann L.

Microbiology. 2015 Oct;161(10):1999-2007. doi: 10.1099/mic.0.000152. Epub 2015 Aug 4.


Erratum for Almblad et al., The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP.

Almblad H, Harrison JJ, Rybtke M, Groizeleau J, Givskov M, Parsek MR, Tolker-Nielsen T.

J Bacteriol. 2015 Aug;197(16):2731. doi: 10.1128/JB.00493-15. No abstract available.


In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation.

Chua SL, Hultqvist LD, Yuan M, Rybtke M, Nielsen TE, Givskov M, Tolker-Nielsen T, Yang L.

Nat Protoc. 2015 Aug;10(8):1165-80. doi: 10.1038/nprot.2015.067. Epub 2015 Jul 9.


Biofilm Development.

Tolker-Nielsen T.

Microbiol Spectr. 2015 Apr;3(2):MB-0001-2014. doi: 10.1128/microbiolspec.MB-0001-2014. Review.


C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth.

Chua SL, Sivakumar K, Rybtke M, Yuan M, Andersen JB, Nielsen TE, Givskov M, Tolker-Nielsen T, Cao B, Kjelleberg S, Yang L.

Sci Rep. 2015 May 20;5:10052. doi: 10.1038/srep10052.


The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP.

Almblad H, Harrison JJ, Rybtke M, Groizeleau J, Givskov M, Parsek MR, Tolker-Nielsen T.

J Bacteriol. 2015 Jul;197(13):2190-200. doi: 10.1128/JB.00193-15. Epub 2015 Apr 20. Erratum in: J Bacteriol. 2015 Aug;197(16):2731.


In-Frame and Unmarked Gene Deletions in Burkholderia cenocepacia via an Allelic Exchange System Compatible with Gateway Technology.

Fazli M, Harrison JJ, Gambino M, Givskov M, Tolker-Nielsen T.

Appl Environ Microbiol. 2015 Jun;81(11):3623-30. doi: 10.1128/AEM.03909-14. Epub 2015 Mar 20.


Viable bacteria associated with red blood cells and plasma in freshly drawn blood donations.

Damgaard C, Magnussen K, Enevold C, Nilsson M, Tolker-Nielsen T, Holmstrup P, Nielsen CH.

PLoS One. 2015 Mar 9;10(3):e0120826. doi: 10.1371/journal.pone.0120826. eCollection 2015.


Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa.

Hansen MR, Jakobsen TH, Bang CG, Cohrt AE, Hansen CL, Clausen JW, Le Quement ST, Tolker-Nielsen T, Givskov M, Nielsen TE.

Bioorg Med Chem. 2015 Apr 1;23(7):1638-50. doi: 10.1016/j.bmc.2015.01.038. Epub 2015 Jan 31.


Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in Pseudomonas aeruginosa.

Chen Y, Yuan M, Mohanty A, Yam JK, Liu Y, Chua SL, Nielsen TE, Tolker-Nielsen T, Givskov M, Cao B, Yang L.

Environ Microbiol Rep. 2015 Jun;7(3):498-507. doi: 10.1111/1758-2229.12278. Epub 2015 Apr 8.


Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients.

Ciofu O, Tolker-Nielsen T, Jensen PØ, Wang H, Høiby N.

Adv Drug Deliv Rev. 2015 May;85:7-23. doi: 10.1016/j.addr.2014.11.017. Epub 2014 Dec 2. Review.


Pseudomonas aeruginosa biofilm infections: from molecular biofilm biology to new treatment possibilities.

Tolker-Nielsen T.

APMIS Suppl. 2014 Dec;(138):1-51. doi: 10.1111/apm.12335. Review.


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