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Items: 1 to 50 of 53

1.

Getting in: The structural biology of malaria invasion.

Kumar H, Tolia NH.

PLoS Pathog. 2019 Sep 5;15(9):e1007943. doi: 10.1371/journal.ppat.1007943. eCollection 2019 Sep. No abstract available.

2.

The structure of Acinetobacter-secreted protease CpaA complexed with its chaperone CpaB reveals a novel mode of a T2SS chaperone-substrate interaction.

Urusova DV, Kinsella RL, Salinas ND, Haurat MF, Feldman MF, Tolia NH.

J Biol Chem. 2019 Sep 6;294(36):13344-13354. doi: 10.1074/jbc.RA119.009805. Epub 2019 Jul 18.

PMID:
31320476
3.

Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP.

Urusova D, Carias L, Huang Y, Nicolete VC, Popovici J, Roesch C, Salinas ND, Witkowski B, Ferreira MU, Adams JH, Gross ML, King CL, Tolia NH.

Nat Microbiol. 2019 Sep;4(9):1486-1496. doi: 10.1038/s41564-019-0461-2. Epub 2019 May 27.

PMID:
31133752
4.

Blood-Stage Malaria Parasite Antigens: Structure, Function, and Vaccine Potential.

Salinas ND, Tang WK, Tolia NH.

J Mol Biol. 2019 May 17. pii: S0022-2836(19)30287-6. doi: 10.1016/j.jmb.2019.05.018. [Epub ahead of print] Review.

PMID:
31103771
5.

Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein.

Carias LL, Dechavanne S, Nicolete VC, Sreng S, Suon S, Amaratunga C, Fairhurst RM, Dechavanne C, Barnes S, Witkowski B, Popovici J, Roesch C, Chen E, Ferreira MU, Tolia NH, Adams JH, King CL.

J Immunol. 2019 May 1;202(9):2648-2660. doi: 10.4049/jimmunol.1801631. Epub 2019 Apr 3.

PMID:
30944159
6.

Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes.

Markley JL, Fang L, Gasparrini AJ, Symister CT, Kumar H, Tolia NH, Dantas G, Wencewicz TA.

ACS Infect Dis. 2019 Apr 12;5(4):618-633. doi: 10.1021/acsinfecdis.8b00349. Epub 2019 Mar 5.

PMID:
30835428
7.

Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering.

Zhu J, Muia J, Gupta G, Westfield LA, Vanhoorelbeke K, Tolia NH, Sadler JE.

Blood. 2019 Apr 25;133(17):1909-1918. doi: 10.1182/blood-2018-11-886309. Epub 2019 Jan 28.

PMID:
30692120
8.

Moderately Neutralizing Epitopes in Nonfunctional Regions Dominate the Antibody Response to Plasmodium falciparum EBA-140.

Salinas ND, Paing MM, Adhikari J, Gross ML, Tolia N.

Infect Immun. 2019 Mar 25;87(4). pii: e00716-18. doi: 10.1128/IAI.00716-18. Print 2019 Apr.

PMID:
30642904
9.

Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion.

Paing MM, Salinas ND, Adams Y, Oksman A, Jensen AT, Goldberg DE, Tolia NH.

Elife. 2018 Dec 17;7. pii: e43224. doi: 10.7554/eLife.43224.

10.

Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models.

Zimmerman MI, Hart KM, Sibbald CA, Frederick TE, Jimah JR, Knoverek CR, Tolia NH, Bowman GR.

ACS Cent Sci. 2017 Dec 27;3(12):1311-1321. doi: 10.1021/acscentsci.7b00465. Epub 2017 Nov 21.

11.

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.

Nasamu AS, Glushakova S, Russo I, Vaupel B, Oksman A, Kim AS, Fremont DH, Tolia N, Beck JR, Meyers MJ, Niles JC, Zimmerberg J, Goldberg DE.

Science. 2017 Oct 27;358(6362):518-522. doi: 10.1126/science.aan1478.

12.

An engineered vaccine of the Plasmodium vivax Duffy binding protein enhances induction of broadly neutralizing antibodies.

Ntumngia FB, Pires CV, Barnes SJ, George MT, Thomson-Luque R, Kano FS, Alves JRS, Urusova D, Pereira DB, Tolia NH, King CL, Carvalho LH, Adams JH.

Sci Rep. 2017 Oct 23;7(1):13779. doi: 10.1038/s41598-017-13891-2.

13.

Defining the interaction of the protease CpaA with its type II secretion chaperone CpaB and its contribution to virulence in Acinetobacter species.

Kinsella RL, Lopez J, Palmer LD, Salinas ND, Skaar EP, Tolia NH, Feldman MF.

J Biol Chem. 2017 Dec 1;292(48):19628-19638. doi: 10.1074/jbc.M117.808394. Epub 2017 Oct 5.

14.

Liposome Disruption Assay to Examine Lytic Properties of Biomolecules.

Jimah JR, Schlesinger PH, Tolia NH.

Bio Protoc. 2017 Aug 5;7(15). pii: e2433. doi: 10.21769/BioProtoc.2433.

15.

Membrane Lipid Screen to Identify Molecular Targets of Biomolecules.

Jimah JR, Schlesinger PH, Tolia NH.

Bio Protoc. 2017 Aug 5;7(15). pii: e2427. doi: 10.21769/BioProtoc.2427.

16.

Native Mass Spectrometry, Ion mobility, and Collision-Induced Unfolding Categorize Malaria Antigen/Antibody Binding.

Huang Y, Salinas ND, Chen E, Tolia NH, Gross ML.

J Am Soc Mass Spectrom. 2017 Nov;28(11):2515-2518. doi: 10.1007/s13361-017-1782-0. Epub 2017 Sep 5.

17.

DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism.

Ovchynnikova E, Aglialoro F, Bentlage AEH, Vidarsson G, Salinas ND, von Lindern M, Tolia NH, van den Akker E.

Blood. 2017 Sep 21;130(12):1441-1444. doi: 10.1182/blood-2017-03-774364. Epub 2017 Jul 28.

18.

Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.

Park J, Gasparrini AJ, Reck MR, Symister CT, Elliott JL, Vogel JP, Wencewicz TA, Dantas G, Tolia NH.

Nat Chem Biol. 2017 Jul;13(7):730-736. doi: 10.1038/nchembio.2376. Epub 2017 May 8.

19.

Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion.

Koch M, Wright KE, Otto O, Herbig M, Salinas ND, Tolia NH, Satchwell TJ, Guck J, Brooks NJ, Baum J.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4225-4230. doi: 10.1073/pnas.1620843114. Epub 2017 Apr 3.

20.

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.

Kalas V, Pinkner JS, Hannan TJ, Hibbing ME, Dodson KW, Holehouse AS, Zhang H, Tolia NH, Gross ML, Pappu RV, Janetka J, Hultgren SJ.

Sci Adv. 2017 Feb 10;3(2):e1601944. doi: 10.1126/sciadv.1601944. eCollection 2017 Feb.

21.

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion.

Sisquella X, Nebl T, Thompson JK, Whitehead L, Malpede BM, Salinas ND, Rogers K, Tolia NH, Fleig A, O'Neill J, Tham WH, David Horgen F, Cowman AF.

Elife. 2017 Feb 22;6. pii: e21083. doi: 10.7554/eLife.21083.

22.

Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption.

Jimah JR, Salinas ND, Sala-Rabanal M, Jones NG, Sibley LD, Nichols CG, Schlesinger PH, Tolia NH.

Elife. 2016 Dec 1;5. pii: e20621. doi: 10.7554/eLife.20621.

23.

Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD.

Price KE, Armstrong CM, Imlay LS, Hodge DM, Pidathala C, Roberts NJ, Park J, Mikati M, Sharma R, Lawrenson AS, Tolia NH, Berry NG, O'Neill PM, John AR.

Sci Rep. 2016 Nov 18;6:36777. doi: 10.1038/srep36777.

24.

Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein.

Chen E, Salinas ND, Huang Y, Ntumngia F, Plasencia MD, Gross ML, Adams JH, Tolia NH.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):6277-82. doi: 10.1073/pnas.1600488113. Epub 2016 May 18.

25.

Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.

26.

Red cell receptors as access points for malaria infection.

Salinas ND, Tolia NH.

Curr Opin Hematol. 2016 May;23(3):215-23. doi: 10.1097/MOH.0000000000000219. Review.

27.

Cap-domain closure enables diverse substrate recognition by the C2-type haloacid dehalogenase-like sugar phosphatase Plasmodium falciparum HAD1.

Park J, Guggisberg AM, Odom AR, Tolia NH.

Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1824-34. doi: 10.1107/S1399004715012067. Epub 2015 Aug 25.

28.

Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii.

Behnke MS, Khan A, Lauron EJ, Jimah JR, Wang Q, Tolia NH, Sibley LD.

PLoS Genet. 2015 Aug 20;11(8):e1005434. doi: 10.1371/journal.pgen.1005434. eCollection 2015 Aug.

29.

Structural analysis of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for Plasmodium vivax malaria vaccine design.

Chen E, Salinas ND, Ntumngia FB, Adams JH, Tolia NH.

PLoS Negl Trop Dis. 2015 Mar 20;9(3):e0003644. doi: 10.1371/journal.pntd.0003644. eCollection 2015 Mar.

30.

Comparison of Type 1 D-3-phosphoglycerate dehydrogenases reveals unique regulation in pathogenic Mycobacteria.

Xu XL, Chen S, Salinas ND, Tolia NH, Grant GA.

Arch Biochem Biophys. 2015 Mar 15;570:32-9. doi: 10.1016/j.abb.2015.02.008. Epub 2015 Feb 16.

PMID:
25698123
31.

White blood cells levels and PCOS: direct and indirect relationship with obesity and insulin resistance, but not with hyperandogenemia.

Papalou O, Livadas S, Karachalios A, Tolia N, Kokkoris P, Tripolitakis K, Diamanti-Kandarakis E.

Hormones (Athens). 2015 Jan-Mar;14(1):91-100. doi: 10.14310/horm.2002.1563.

32.

Allosteric activation of ADAMTS13 by von Willebrand factor.

Muia J, Zhu J, Gupta G, Haberichter SL, Friedman KD, Feys HB, Deforche L, Vanhoorelbeke K, Westfield LA, Roth R, Tolia NH, Heuser JE, Sadler JE.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18584-9. doi: 10.1073/pnas.1413282112. Epub 2014 Dec 15.

33.
34.

A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites.

Guggisberg AM, Park J, Edwards RL, Kelly ML, Hodge DM, Tolia NH, Odom AR.

Nat Commun. 2014 Jul 24;5:4467. doi: 10.1038/ncomms5467.

35.

Multimeric assembly of host-pathogen adhesion complexes involved in apicomplexan invasion.

Paing MM, Tolia NH.

PLoS Pathog. 2014 Jun 12;10(6):e1004120. doi: 10.1371/journal.ppat.1004120. eCollection 2014 Jun. No abstract available.

36.

Prevalence and impact of hyperandrogenemia in 1,218 women with polycystic ovary syndrome.

Livadas S, Pappas C, Karachalios A, Marinakis E, Tolia N, Drakou M, Kaldrymides P, Panidis D, Diamanti-Kandarakis E.

Endocrine. 2014 Nov;47(2):631-8. doi: 10.1007/s12020-014-0200-7. Epub 2014 Apr 22.

PMID:
24752393
37.

Malaria adhesins: structure and function.

Malpede BM, Tolia NH.

Cell Microbiol. 2014 May;16(5):621-31. doi: 10.1111/cmi.12276. Epub 2014 Mar 6. Review.

38.

Red blood cell invasion by Plasmodium vivax: structural basis for DBP engagement of DARC.

Batchelor JD, Malpede BM, Omattage NS, DeKoster GT, Henzler-Wildman KA, Tolia NH.

PLoS Pathog. 2014 Jan;10(1):e1003869. doi: 10.1371/journal.ppat.1003869. Epub 2014 Jan 9.

39.
40.

Inhibitory humoral responses to the Plasmodium falciparum vaccine candidate EBA-175 are independent of the erythrocyte invasion pathway.

Badiane AS, Bei AK, Ahouidi AD, Patel SD, Salinas N, Ndiaye D, Sarr O, Ndir O, Tolia NH, Mboup S, Duraisingh MT.

Clin Vaccine Immunol. 2013 Aug;20(8):1238-45. doi: 10.1128/CVI.00135-13. Epub 2013 Jun 12.

41.

Structural and functional basis for inhibition of erythrocyte invasion by antibodies that target Plasmodium falciparum EBA-175.

Chen E, Paing MM, Salinas N, Sim BK, Tolia NH.

PLoS Pathog. 2013;9(5):e1003390. doi: 10.1371/journal.ppat.1003390. Epub 2013 May 23.

42.

Molecular basis for sialic acid-dependent receptor recognition by the Plasmodium falciparum invasion protein erythrocyte-binding antigen-140/BAEBL.

Malpede BM, Lin DH, Tolia NH.

J Biol Chem. 2013 Apr 26;288(17):12406-15. doi: 10.1074/jbc.M113.450643. Epub 2013 Mar 18.

43.

Crystal and solution structures of Plasmodium falciparum erythrocyte-binding antigen 140 reveal determinants of receptor specificity during erythrocyte invasion.

Lin DH, Malpede BM, Batchelor JD, Tolia NH.

J Biol Chem. 2012 Oct 26;287(44):36830-6. doi: 10.1074/jbc.M112.409276. Epub 2012 Sep 18.

44.

Screening for gestational diabetes mellitus: a prospective study in a tertiary care institution of North India.

Tripathi R, Tolia N, Gupta VK, Mala YM, Ramji S, Tyagi S.

J Obstet Gynaecol Res. 2012 Feb;38(2):351-7. doi: 10.1111/j.1447-0756.2011.01706.x. Epub 2011 Dec 19.

PMID:
22176476
45.

Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC.

Batchelor JD, Zahm JA, Tolia NH.

Nat Struct Mol Biol. 2011 Jul 10;18(8):908-14. doi: 10.1038/nsmb.2088.

46.

Slicer and the argonautes.

Tolia NH, Joshua-Tor L.

Nat Chem Biol. 2007 Jan;3(1):36-43. Review.

PMID:
17173028
47.

Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.

Yigit E, Batista PJ, Bei Y, Pang KM, Chen CC, Tolia NH, Joshua-Tor L, Mitani S, Simard MJ, Mello CC.

Cell. 2006 Nov 17;127(4):747-57.

48.

Argonaute slicing is required for heterochromatic silencing and spreading.

Irvine DV, Zaratiegui M, Tolia NH, Goto DB, Chitwood DH, Vaughn MW, Joshua-Tor L, Martienssen RA.

Science. 2006 Aug 25;313(5790):1134-7.

49.

Strategies for protein coexpression in Escherichia coli.

Tolia NH, Joshua-Tor L.

Nat Methods. 2006 Jan;3(1):55-64. No abstract available.

PMID:
16369554
50.

Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum.

Tolia NH, Enemark EJ, Sim BK, Joshua-Tor L.

Cell. 2005 Jul 29;122(2):183-93. Erratum in: Cell. 2005 Aug 12;122(3):485.

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