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Items: 42

1.

Neuroprotective effects of EpoL against oxidative stress induced by soluble oligomers of Aβ peptide.

Castillo C, Fernández-Mendívil C, Buendia I, Saavedra P, Meza C, Parra NC, Lopez MG, Toledo JR, Fuentealba J.

Redox Biol. 2019 Jun;24:101187. doi: 10.1016/j.redox.2019.101187. Epub 2019 Apr 2.

2.

In vitro immunomodulatory activities of peptides derived from Salmo salar NK-lysin and cathelicidin in fish cells.

Acosta J, Roa F, González-Chavarría I, Astuya A, Maura R, Montesino R, Muñoz C, Camacho F, Saavedra P, Valenzuela A, Sánchez O, Toledo JR.

Fish Shellfish Immunol. 2019 May;88:587-594. doi: 10.1016/j.fsi.2019.03.034. Epub 2019 Mar 16.

PMID:
30885741
3.

Multi-antigenic recombinant subunit vaccine against Lawsonia intracellularis: The etiological agent of porcine proliferative enteropathy.

Montesino R, Gutiérrez N, Camacho F, Farnós O, Andrades S, González A, Acosta J, Cortez-San Martín M, Sánchez O, Ruiz A, Toledo JR.

Vaccine. 2019 Feb 28;37(10):1340-1349. doi: 10.1016/j.vaccine.2019.01.029. Epub 2019 Jan 30.

PMID:
30711318
4.

Activation of membrane-bound and soluble Toll-like Receptors 5 in Salmo salar depends on the MyD88 signalling pathway.

Muñoz-Flores C, Astuya A, Roa FJ, Romero A, Acosta J, Sánchez O, Toledo JR.

Biochim Biophys Acta Gen Subj. 2018 Oct;1862(10):2215-2225. doi: 10.1016/j.bbagen.2018.07.008. Epub 2018 Jul 23. No abstract available.

PMID:
30016688
5.

Quantitative ELISA sandwich for a new vaccine against avian influenza virus H5N1.

Pose AG, Rodríguez ER, Piñeiro MJ, Montesino R, Sánchez O, Toledo JR.

J Immunol Methods. 2018 Aug;459:70-75. doi: 10.1016/j.jim.2018.05.008. Epub 2018 May 24.

PMID:
29803776
6.

LOX-1 activation by oxLDL triggers an epithelial mesenchymal transition and promotes tumorigenic potential in prostate cancer cells.

González-Chavarría I, Fernandez E, Gutierrez N, González-Horta EE, Sandoval F, Cifuentes P, Castillo C, Cerro R, Sanchez O, Toledo JR.

Cancer Lett. 2018 Feb 1;414:34-43. doi: 10.1016/j.canlet.2017.10.035. Epub 2017 Nov 14.

PMID:
29107109
7.

Neuroprotective effects of erythropoietin on neurodegenerative and ischemic brain diseases: the role of erythropoietin receptor.

Hernández CC, Burgos CF, Gajardo AH, Silva-Grecchi T, Gavilan J, Toledo JR, Fuentealba J.

Neural Regen Res. 2017 Sep;12(9):1381-1389. doi: 10.4103/1673-5374.215240. Review.

8.

Neuroprotective effect of a new variant of Epo nonhematopoietic against oxidative stress.

Castillo C, Zaror S, Gonzalez M, Hidalgo A, Burgos CF, Cabezas OI, Hugues F, Jiménez SP, González-Horta E, González-Chavarría I, Gavilán J, Montesino R, Sánchez O, Lopez MG, Fuentealba J, Toledo JR.

Redox Biol. 2018 Apr;14:285-294. doi: 10.1016/j.redox.2017.09.010. Epub 2017 Sep 21.

9.

Transient Expression of Functional Glucocerebrosidase for Treatment of Gaucher's Disease in the Goat Mammary Gland.

Tavares KC, Dias AC, Lazzarotto CR, Gaudencio Neto S, de Sá Carneiro I, Ongaratto FL, Pinto AF, de Aguiar LH, Calderón CE, Toledo JR, Castro FO, Santos DS, Chies JM, Bertolini M, Bertolini LR.

Mol Biotechnol. 2016 Jan;58(1):47-55. doi: 10.1007/s12033-015-9902-1.

PMID:
26589705
10.

Bone stroma-derived cells change coregulators recruitment to androgen receptor and decrease cell proliferation in androgen-sensitive and castration-resistant prostate cancer cells.

Villagran MA, Gutierrez-Castro FA, Pantoja DF, Alarcon JC, Fariña MA, Amigo RF, Muñoz-Godoy NA, Pinilla MG, Peña EA, Gonzalez-Chavarria I, Toledo JR, Rivas CI, Vera JC, McNerney EM, Onate SA.

Biochem Biophys Res Commun. 2015 Nov 27;467(4):1039-45. doi: 10.1016/j.bbrc.2015.10.009. Epub 2015 Oct 20.

PMID:
26494300
11.

Expression and purification of the surface proteins from Andes virus.

Beltrán-Ortiz CE, Starck-Mendez MF, Fernández Y, Farnós O, González EE, Rivas CI, Camacho F, Zuñiga FA, Toledo JR, Sánchez O.

Protein Expr Purif. 2017 Nov;139:63-70. doi: 10.1016/j.pep.2015.09.013. Epub 2015 Sep 12.

PMID:
26374989
12.

Post-translational modification of a chimeric EPO-Fc hormone is more important than its molecular size in defining its in vivo hematopoietic activity.

Salgado ER, Montesino R, Jiménez SP, González M, Hugues F, Cabezas OI, Maura-Perez R, Saavedra P, Lamazares E, Salas-Burgos A, Vera JC, Sánchez O, Toledo JR.

Biochim Biophys Acta. 2015 Sep;1850(9):1685-93. doi: 10.1016/j.bbagen.2015.04.012. Epub 2015 May 7.

PMID:
25960389
13.

Cis-regulatory elements involved in species-specific transcriptional regulation of the SVCT1 gene in rat and human hepatoma cells.

Muñoz A, Villagrán M, Guzmán P, Solíz C, Gatica M, Aylwin C, Sweet K, Maldonado M, Escobar E, Reyes AM, Toledo JR, Sánchez O, Oñate SA, Carlos Vera J, Rivas CI.

Free Radic Biol Med. 2015 Aug;85:183-96. doi: 10.1016/j.freeradbiomed.2015.04.024. Epub 2015 Apr 28.

PMID:
25933589
14.

Endothelium trans differentiated from Wharton's jelly mesenchymal cells promote tissue regeneration: potential role of soluble pro-angiogenic factors.

Aguilera V, Briceño L, Contreras H, Lamperti L, Sepúlveda E, Díaz-Perez F, León M, Veas C, Maura R, Toledo JR, Fernández P, Covarrubias A, Zuñiga FA, Radojkovic C, Escudero C, Aguayo C.

PLoS One. 2014 Nov 20;9(11):e111025. doi: 10.1371/journal.pone.0111025. eCollection 2014.

15.

Secretion and assembly of calicivirus-like particles in high-cell-density yeast fermentations: strategies based on a recombinant non-specific BPTI-Kunitz-type protease inhibitor.

Fernández E, Toledo JR, Mansur M, Sánchez O, Gil DF, González-González Y, Lamazares E, Fernández Y, Parra F, Farnós O.

Appl Microbiol Biotechnol. 2015 May;99(9):3875-86. doi: 10.1007/s00253-014-6171-z. Epub 2014 Nov 18.

PMID:
25403337
16.

Effectiveness of the E2-classical swine fever virus recombinant vaccine produced and formulated within whey from genetically transformed goats.

Sánchez O, Barrera M, Farnós O, Parra NC, Salgado ER, Saavedra PA, Meza CD, Rivas CI, Cortez-San Martín M, Toledo JR.

Clin Vaccine Immunol. 2014 Dec;21(12):1628-34. doi: 10.1128/CVI.00416-14. Epub 2014 Oct 1.

17.

Lectin-like oxidized LDL receptor-1 is an enhancer of tumor angiogenesis in human prostate cancer cells.

González-Chavarría I, Cerro RP, Parra NP, Sandoval FA, Zuñiga FA, Omazábal VA, Lamperti LI, Jiménez SP, Fernandez EA, Gutiérrez NA, Rodriguez FS, Onate SA, Sánchez O, Vera JC, Toledo JR.

PLoS One. 2014 Aug 29;9(8):e106219. doi: 10.1371/journal.pone.0106219. eCollection 2014.

18.

Microemulsification: an approach for analytical determinations.

Lima RS, Shiroma LY, Teixeira AV, de Toledo JR, do Couto BC, de Carvalho RM, Carrilho E, Kubota LT, Gobbi AL.

Anal Chem. 2014 Sep 16;86(18):9082-90. doi: 10.1021/ac5025914. Epub 2014 Sep 2.

PMID:
25148857
19.

Emergence of antigenic variants of Foot-and-Mouth Disease Virus serotype O in Ecuador and preliminary evaluation of a field strain as a vaccine candidate.

Maradei E, Malirat V, Beascoechea CP, Espinoza AM, Novo SG, Smitsaart E, Salgado G, Mattion N, Toledo JR, Bergmann IE.

Vaccine. 2014 May 1;32(21):2446-51. doi: 10.1016/j.vaccine.2014.02.092. Epub 2014 Mar 10.

PMID:
24625343
20.

Conformational and thermal stability improvements for the large-scale production of yeast-derived rabbit hemorrhagic disease virus-like particles as multipurpose vaccine.

Fernández E, Toledo JR, Méndez L, González N, Parra F, Martín-Alonso JM, Limonta M, Sánchez K, Cabrales A, Estrada MP, Rodríguez-Mallón A, Farnós O.

PLoS One. 2013;8(2):e56417. doi: 10.1371/journal.pone.0056417. Epub 2013 Feb 27.

21.

Characterization of a type O foot-and-mouth disease virus re-emerging in the year 2011 in free areas of the Southern Cone of South America and cross-protection studies with the vaccine strain in use in the region.

Maradei E, Malirat V, Beascoechea CP, Benitez EO, Pedemonte A, Seki C, Novo SG, Balette CI, D'Aloia R, La Torre JL, Mattion N, Toledo JR, Bergmann IE.

Vet Microbiol. 2013 Mar 23;162(2-4):479-90. doi: 10.1016/j.vetmic.2012.10.035. Epub 2012 Nov 7.

PMID:
23182909
22.

First report of bovine herpesvirus 5 in bull semen.

Rodríguez M, Barrera M, Sánchez O, Rodríguez EC, Martínez N, Parra NC, Toledo JR.

Arch Virol. 2012 Sep;157(9):1775-8. doi: 10.1007/s00705-012-1334-7. Epub 2012 May 24.

PMID:
22622433
23.

Single dose adenovirus vectored vaccine induces a potent and long-lasting immune response against rabbit hemorrhagic disease virus after parenteral or mucosal administration.

Fernández E, Toledo JR, Chiong M, Parra F, Rodríguez E, Montero C, Méndez L, Capucci L, Farnós O.

Vet Immunol Immunopathol. 2011 Aug 15;142(3-4):179-88. doi: 10.1016/j.vetimm.2011.05.007. Epub 2011 May 7.

PMID:
21621855
24.

Human αIFN co-formulated with milk derived E2-CSFV protein induce early full protection in vaccinated pigs.

Toledo JR, Barrera M, Farnós O, Gómez S, Rodríguez MP, Aguero F, Ormazabal V, Parra NC, Suárez L, Sánchez O.

Vaccine. 2010 Nov 23;28(50):7907-14. doi: 10.1016/j.vaccine.2010.09.073. Epub 2010 Oct 8.

PMID:
20933567
25.

Early onset and long lasting protection in pigs provided by a classical swine fever E2-vaccine candidate produced in the milk of goats.

Barrera M, Sánchez O, Farnós O, Rodríguez MP, Domínguez P, Tait H, Frías M, Avila M, Vega E, Toledo JR.

Vet Immunol Immunopathol. 2010 Jan 15;133(1):25-32. doi: 10.1016/j.vetimm.2009.06.015. Epub 2009 Jun 30.

PMID:
19640591
26.

Thermal stress treatment does not affect the stability and protective capacity of goat milk derived E2-marker vaccine formulation against CSFV.

Barrera M, Sanchez O, Prieto Y, Castell S, Naranjo P, Rodriguez MP, Farnós O, Aguilera A, Frias M, Fonseca O, Figueredo JM, Aguero F, Montesino R, Toledo JR.

Vet Immunol Immunopathol. 2009 Feb 15;127(3-4):325-31. doi: 10.1016/j.vetimm.2008.10.330. Epub 2008 Nov 5.

PMID:
19100629
27.

N-glycosylation pattern of E2 glycoprotein from classical swine fever virus.

Montesino R, Toledo JR, Sanchez O, Zamora Y, Barrera M, Royle L, Rudd PM, Dwek RA, Harvey DJ, Cremata JA.

J Proteome Res. 2009 Feb;8(2):546-55. doi: 10.1021/pr800725v.

PMID:
19093875
28.

Polyethylenimine-based transfection method as a simple and effective way to produce recombinant lentiviral vectors.

Toledo JR, Prieto Y, Oramas N, Sánchez O.

Appl Biochem Biotechnol. 2009 Jun;157(3):538-44. doi: 10.1007/s12010-008-8381-2. Epub 2008 Dec 17.

PMID:
19089654
29.

Biochemical and structural characterization of RHDV capsid protein variants produced in Pichia pastoris: advantages for immunization strategies and vaccine implementation.

Farnós O, Fernández E, Chiong M, Parra F, Joglar M, Méndez L, Rodríguez E, Moya G, Rodríguez D, Lleonart R, González EM, Alonso A, Alfonso P, Suárez M, Rodríguez MP, Toledo JR.

Antiviral Res. 2009 Jan;81(1):25-36. doi: 10.1016/j.antiviral.2008.08.007. Epub 2008 Sep 25.

PMID:
18824033
30.

Classical swine fever virus E2 glycoprotein antigen produced in adenovirally transduced PK-15 cells confers complete protection in pigs upon viral challenge.

Sánchez O, Barrera M, Rodríguez MP, Frías MT, Figueroa NE, Naranjo P, Montesino R, Farnos O, Castell S, Venereo A, Ganges L, Borroto C, Toledo JR.

Vaccine. 2008 Feb 13;26(7):988-97. doi: 10.1016/j.vaccine.2007.11.014. Epub 2007 Nov 26.

PMID:
18192093
31.

Monosialylated biantennary N-glycoforms containing GalNAc-GlcNAc antennae predominate when human EPO is expressed in goat milk.

Montesino R, Toledo JR, Sánchez O, Sánchez A, Harvey DJ, Royle L, Dwek RA, Rudd PM, Gerwig GJ, Kamerling JP, Cremata JA.

Arch Biochem Biophys. 2008 Feb 15;470(2):163-75. Epub 2007 Dec 5.

PMID:
18083109
32.

Highly protective E2-CSFV vaccine candidate produced in the mammary gland of adenoviral transduced goats.

Toledo JR, Sánchez O, Montesino R, Farnos O, Rodríguez MP, Alfonso P, Oramas N, Rodríguez E, Santana E, Vega E, Ganges L, Frias MT, Cremata J, Barrera M.

J Biotechnol. 2008 Feb 1;133(3):370-6. Epub 2007 Oct 5.

PMID:
18045719
33.

The goat mammary glandular epithelial (GMGE) cell line promotes polyfucosylation and N,N'-diacetyllactosediaminylation of N-glycans linked to recombinant human erythropoietin.

Sánchez O, Montesino R, Toledo JR, Rodríguez E, Díaz D, Royle L, Rudd PM, Dwek RA, Gerwig GJ, Kamerling JP, Harvey DJ, Cremata JA.

Arch Biochem Biophys. 2007 Aug 15;464(2):322-34. Epub 2007 May 15.

PMID:
17570337
34.

Molecular and antigenic characterization of rabbit hemorrhagic disease virus isolated in Cuba indicates a distinct antigenic subtype.

Farnós O, Rodríguez D, Valdés O, Chiong M, Parra F, Toledo JR, Fernández E, Lleonart R, Suárez M.

Arch Virol. 2007;152(6):1215-21. Epub 2007 Mar 5.

PMID:
17334949
35.

High expression level of recombinant human erythropoietin in the milk of non-transgenic goats.

Toledo JR, Sánchez O, Seguí RM, García G, Montañez M, Zamora PA, Rodríguez MP, Cremata JA.

J Biotechnol. 2006 May 17;123(2):225-35. Epub 2005 Dec 9.

PMID:
16338016
36.

Differential in vitro and in vivo glycosylation of human erythropoietin expressed in adenovirally transduced mouse mammary epithelial cells.

Toledo JR, Sánchez O, Montesino Seguí R, Fernández García Y, Rodríguez MP, Cremata JA.

Biochim Biophys Acta. 2005 Oct 30;1726(1):48-56. Epub 2005 Jun 27.

PMID:
16098677
37.

Adenoviral vector mediates high expression levels of human growth hormone in the milk of mice and goats.

Sánchez O, Toledo JR, Rodríguez MP, Castro FO.

J Biotechnol. 2004 Oct 19;114(1-2):89-97.

PMID:
15464602
38.

Computed tomographic study of cervical carotid calcification.

Culebras A, Otero C, Toledo JR, Rubin BS.

Stroke. 1989 Nov;20(11):1472-6.

PMID:
2815180
39.

Endorphins and placebo fear reduction.

Paulman R, Rimm DC, Kooken R, Toledo JR.

Psychol Rep. 1982 Dec;51(3 Pt 2):1175-81. No abstract available.

PMID:
6300951
40.

Management of non-compliance to medical regimen: a suggested methodological approach.

Toledo JR, Hughes H, Sims J.

Int J Health Educ. 1979;22(4):232-41. No abstract available.

PMID:
525034
41.

Congenital idiopathic hypertrophic subaortic stenosis associated with a phenotypic Turner's syndrome.

Nghiem QX, Toledo JR, Schreiber MH, Harris LC, Lockhart LL, Tyson KR.

Am J Cardiol. 1972 Nov 8;30(6):683-9. No abstract available.

PMID:
4673346
42.

Newborn emergency: pulmonary atresia or severe pulmonary stenosis with intact ventricular septum.

Toledo JR, Nghiem QX, Harris LC.

Tex Med. 1971 Aug;67(8):78-83. No abstract available.

PMID:
5095877

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