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Design of a joint research data platform: A use case for severity assessment.

Talbot SR, Bruch S, Kießling F, Marschollek M, Jandric B, Tolba RH, Bleich A.

Lab Anim. 2019 Sep 5:23677219872228. doi: 10.1177/0023677219872228. [Epub ahead of print]


Severity assessment in pigs after partial liver resection: evaluation of a score sheet.

Hagemeister K, Ernst L, Kadaba Srinivasan P, Tanaka H, Fukushima K, Tolba R.

Lab Anim. 2019 Sep 3:23677219871585. doi: 10.1177/0023677219871585. [Epub ahead of print]


Assessment of Chemotherapy-Induced Organ Damage with Ga-68 Labeled Duramycin.

Rix A, Drude NI, Mrugalla A, Baskaya F, Pak KY, Gray B, Kaiser HJ, Tolba RH, Fiegle E, Lederle W, Mottaghy FM, Kiessling F.

Mol Imaging Biol. 2019 Aug 8. doi: 10.1007/s11307-019-01417-3. [Epub ahead of print]


Influence of Vitamin C on Antioxidant Capacity of In Vitro Perfused Porcine Kidneys.

Bleilevens C, Doorschodt BM, Fechter T, Grzanna T, Theißen A, Liehn EA, Breuer T, Tolba RH, Rossaint R, Stoppe C, Boor P, Hill A, Fabry G.

Nutrients. 2019 Aug 1;11(8). pii: E1774. doi: 10.3390/nu11081774.


The Influence of Different Fat Sources on Steatohepatitis and Fibrosis Development in the Western Diet Mouse Model of Non-alcoholic Steatohepatitis (NASH).

Drescher HK, Weiskirchen R, Fülöp A, Hopf C, de San Román EG, Huesgen PF, de Bruin A, Bongiovanni L, Christ A, Tolba R, Trautwein C, Kroy DC.

Front Physiol. 2019 Jun 25;10:770. doi: 10.3389/fphys.2019.00770. eCollection 2019.


Perspective review of optical imaging in welfare assessment in animal-based research.

Pereira C, Kunczik J, Bleich A, Haeger C, Kiessling F, Thum T, Tolba R, Lindauer U, Treue S, Czaplik M.

J Biomed Opt. 2019 Jul;24(7):1-11. doi: 10.1117/1.JBO.24.7.070601.


EIT monitors valid and robust regional ventilation distribution in pathologic ventilation states in porcine study using differential DualEnergy-CT (ΔDECT).

Reinartz SD, Imhoff M, Tolba R, Fischer F, Fischer EG, Teschner E, Koch S, Gärber Y, Isfort P, Gremse F.

Sci Rep. 2019 Jul 5;9(1):9796. doi: 10.1038/s41598-019-45251-7.


The reduction of astrocytes and brain volume loss in anorexia nervosa-the impact of starvation and refeeding in a rodent model.

Frintrop L, Trinh S, Liesbrock J, Leunissen C, Kempermann J, Etdöger S, Kas MJ, Tolba R, Heussen N, Neulen J, Konrad K, Päfgen V, Kiessling F, Herpertz-Dahlmann B, Beyer C, Seitz J.

Transl Psychiatry. 2019 Jun 4;9(1):159. doi: 10.1038/s41398-019-0493-7.


In vivo endothelialization and neointimal hyperplasia assessment after angioplasty of sheep carotid artery with a novel polycarbonate polyurethane patch.

Jalaie H, Steitz J, Afify M, Barbati ME, Hoeft K, Assar MAM, Hermanns-Sachweh B, Tolba RH, Jacobs MJ, Schleimer K.

J Biomater Appl. 2019 Aug;34(2):208-218. doi: 10.1177/0885328219849368. Epub 2019 May 14. No abstract available.


Perfusion-related changes in intestinal diffusion detected by NMR-MOUSE® monitoring in minipigs.

Keschenau PR, Simons N, Klingel H, Reuter S, Foldenauer AC, Vieß J, Weidener D, Andruszkow J, Blümich B, Tolba R, Jacobs MJ, Kalder J.

Microvasc Res. 2019 Sep;125:103876. doi: 10.1016/j.mvr.2019.04.006. Epub 2019 Apr 30.


The Impact of a Nitric Oxide Synthase Inhibitor (L-NAME) on Ischemia⁻Reperfusion Injury of Cholestatic Livers by Pringle Maneuver and Liver Resection after Bile Duct Ligation in Rats.

Iwasaki J, Afify M, Bleilevens C, Klinge U, Weiskirchen R, Steitz J, Vogt M, Yagi S, Nagai K, Uemoto S, Tolba RH.

Int J Mol Sci. 2019 Apr 29;20(9). pii: E2114. doi: 10.3390/ijms20092114.


Sphenopalatine Ganglion Block and Radiofrequency Ablation: Technical Notes and Efficacy.

Tolba R, Weiss AL, Denis DJ.

Ochsner J. 2019 Spring;19(1):32-37. doi: 10.31486/toj.18.0163. Review.


New Large Animal Model for Aortic Aneurysms in the Viscerorenal Segment.

Kalder J, Isfort P, Reinartz SD, Gremse F, Yamoah GG, Gesche V, Kotelis D, Tolba R, Jacobs MJ, Jalaie H.

J Surg Res. 2019 Aug;240:156-164. doi: 10.1016/j.jss.2019.02.054. Epub 2019 Mar 29.


Systematic Review on Characteristics and Reporting Quality of Animal Studies in Liver Regeneration Triggered by Portal Vein Occlusion and Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy: Adherence to the ARRIVE Guidelines.

Tihanyi DK, Szijarto A, Fülöp A, Denecke B, Lurje G, Neumann UP, Czigany Z, Tolba R.

J Surg Res. 2019 Mar;235:578-590. doi: 10.1016/j.jss.2018.10.038. Epub 2018 Dec 5. Review.


The Role of Macrophage Migration Inhibitory Factor in Remote Ischemic Conditioning Induced Hepatoprotection in A Rodent Model of Liver Transplantation.

Emontzpohl C, Stoppe C, Theißen A, Beckers C, Neumann UP, Lurje G, Ju C, Bernhagen J, Tolba RH, Czigany Z.

Shock. 2018 Dec 21. doi: 10.1097/SHK.0000000000001307. [Epub ahead of print]


Evaluation of the NMR-MOUSE as a new method for continuous functional monitoring of the small intestine during different perfusion states in a porcine model.

Keschenau PR, Klingel H, Reuter S, Foldenauer AC, Vieß J, Weidener D, Andruszkow J, Bluemich B, Tolba R, Jacobs MJ, Kalder J.

PLoS One. 2018 Nov 2;13(11):e0206697. doi: 10.1371/journal.pone.0206697. eCollection 2018.


Remote Welfare Monitoring of Rodents Using Thermal Imaging.

Pereira CB, Kunczik J, Zieglowski L, Tolba R, Abdelrahman A, Zechner D, Vollmar B, Janssen H, Thum T, Czaplik M.

Sensors (Basel). 2018 Oct 28;18(11). pii: E3653. doi: 10.3390/s18113653.


Donor liver quality after hypovolemic shock and venous systemic oxygen persufflation in an experimental animal model.

Jafari A, Matthaei H, Branchi V, Bölke E, Tolba RH, Kalff JC, Manekeller S.

Eur J Med Res. 2018 Oct 23;23(1):51. doi: 10.1186/s40001-018-0346-5.


Early local microcirculation is improved after intramedullary nailing in comparison to external fixation in a porcine model with a femur fracture.

Kalbas Y, Qiao Z, Horst K, Teuben M, Tolba RH, Hildebrand F, Pape HC, Pfeifer R; TREAT Research Group.

Eur J Trauma Emerg Surg. 2018 Oct;44(5):689-696. doi: 10.1007/s00068-018-0991-y. Epub 2018 Aug 22.


Machine perfusion for liver transplantation in the era of marginal organs-New kids on the block.

Czigany Z, Lurje I, Tolba RH, Neumann UP, Tacke F, Lurje G.

Liver Int. 2019 Feb;39(2):228-249. doi: 10.1111/liv.13946. Epub 2018 Sep 29. Review.


Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo.

Glowka TR, Paschenda P, Czaplik M, Kalff JC, Tolba RH.

J Vis Exp. 2018 Aug 4;(138). doi: 10.3791/57355.


Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury.

Tamaki I, Hata K, Okamura Y, Nigmet Y, Hirao H, Kubota T, Inamoto O, Kusakabe J, Goto T, Tajima T, Yoshikawa J, Tanaka H, Tsuruyama T, Tolba RH, Uemoto S.

Liver Transpl. 2018 Nov;24(11):1589-1602. doi: 10.1002/lt.25326.


Cell-enrichment with olfactory ensheathing cells has limited local extra beneficial effects on nerve regeneration supported by the nerve guide Perimaix.

Boecker AH, Bozkurt A, Kim BS, Altinova H, Tank J, Deumens R, Tolba R, Weis J, Brook GA, Pallua N, van Neerven SGA.

J Tissue Eng Regen Med. 2018 Nov;12(11):2125-2137. doi: 10.1002/term.2731. Epub 2018 Sep 12.


Sheep models for evaluation of novel patch and prosthesis material in vascular surgery: tips and tricks to avoid possible pitfalls.

Schleimer K, Jalaie H, Afify M, Woitok A, Barbati ME, Hoeft K, Jacobs M, Tolba RH, Steitz J.

Acta Vet Scand. 2018 Jul 5;60(1):42. doi: 10.1186/s13028-018-0397-1.


Limb remote ischemic conditioning of the recipient protects the liver in a rat model of arterialized orthotopic liver transplantation.

Czigany Z, Bleilevens C, Beckers C, Stoppe C, Möhring M, Fülöp A, Szijarto A, Lurje G, Neumann UP, Tolba RH.

PLoS One. 2018 Apr 4;13(4):e0195507. doi: 10.1371/journal.pone.0195507. eCollection 2018.


The Opioid Epidemic and Pain Medicine Specialists: Where to Begin and What Is Next?

Tolba R, Meselhy E, Guerra CE.

Ochsner J. 2018 Spring;18(1):20-22. No abstract available.


Hemostatic Efficacy and Safety of the Novel Medical Adhesive, MAR VIVO-107, in a Rabbit Liver Resection Model.

Fukushima K, Tanaka H, Kadaba Srinivasan P, Pawlowsky K, Kögel B, Uemoto S, Ku Y, Tolba RH.

Eur Surg Res. 2018;59(1-2):48-57. doi: 10.1159/000481818. Epub 2018 Feb 20.


Effect of strontium surface-functionalized implants on early and late osseointegration: A histological, spectrometric and tomographic evaluation.

Offermanns V, Andersen OZ, Riede G, Sillassen M, Jeppesen CS, Almtoft KP, Talasz H, Öhman-Mägi C, Lethaus B, Tolba R, Kloss F, Foss M.

Acta Biomater. 2018 Mar 15;69:385-394. doi: 10.1016/j.actbio.2018.01.049. Epub 2018 Feb 7.


Epidemiology of dermatophyte infections among school children in Menoufia Governorate, Egypt.

Farag AGA, Hammam MA, Ibrahem RA, Mahfouz RZ, Elnaidany NF, Qutubuddin M, Tolba RRE.

Mycoses. 2018 May;61(5):321-325. doi: 10.1111/myc.12743. Epub 2018 Jan 23.


Bone regeneration using composite non-demineralized xenogenic dentin with beta-tricalcium phosphate in experimental alveolar cleft repair in a rabbit model.

Kamal M, Andersson L, Tolba R, Al-Asfour A, Bartella AK, Gremse F, Rosenhain S, Hölzle F, Kessler P, Lethaus B.

J Transl Med. 2017 Dec 23;15(1):263. doi: 10.1186/s12967-017-1369-3.


How can we assess their suffering? German research consortium aims at defining a severity assessment framework for laboratory animals.

Bleich A, Tolba RH.

Lab Anim. 2017 Dec;51(6):667. doi: 10.1177/0023677217733010. No abstract available.


Hypothermic oxygenated machine perfusion (HOPE) for orthotopic liver transplantation of human liver allografts from extended criteria donors (ECD) in donation after brain death (DBD): a prospective multicentre randomised controlled trial (HOPE ECD-DBD).

Czigany Z, Schöning W, Ulmer TF, Bednarsch J, Amygdalos I, Cramer T, Rogiers X, Popescu I, Botea F, Froněk J, Kroy D, Koch A, Tacke F, Trautwein C, Tolba RH, Hein M, Koek GH, Dejong CHC, Neumann UP, Lurje G.

BMJ Open. 2017 Oct 10;7(10):e017558. doi: 10.1136/bmjopen-2017-017558.


Analysis of skeletal muscle microcirculation in a porcine polytrauma model with haemorrhagic shock.

Qiao Z, Horst K, Teuben M, Greven J, Yin L, Kalbas Y, Tolba RH, Pape HC, Hildebrand F, Pfeifer R; TREAT group.

J Orthop Res. 2018 May;36(5):1377-1382. doi: 10.1002/jor.23759. Epub 2018 Mar 14.


Establishment of a chronic activity-based anorexia rat model.

Frintrop L, Trinh S, Liesbrock J, Paulukat L, Kas MJ, Tolba R, Konrad K, Herpertz-Dahlmann B, Beyer C, Seitz J.

J Neurosci Methods. 2018 Jan 1;293:191-198. doi: 10.1016/j.jneumeth.2017.09.018. Epub 2017 Sep 29.


Novel synthetic adhesive as an effective alternative to Fibrin based adhesives.

Srinivasan PK, Sperber V, Afify M, Tanaka H, Fukushima K, Kögel B, Gremse F, Tolba R.

World J Hepatol. 2017 Aug 28;9(24):1030-1039. doi: 10.4254/wjh.v9.i24.1030.


Defining Standards in Experimental Microsurgical Training: Recommendations of the European Society for Surgical Research (ESSR) and the International Society for Experimental Microsurgery (ISEM).

Tolba RH, Czigány Z, Osorio Lujan S, Oltean M, Axelsson M, Akelina Y, Di Cataldo A, Miko I, Furka I, Dahmen U, Kobayashi E, Ionac M, Nemeth N.

Eur Surg Res. 2017;58(5-6):246-262. doi: 10.1159/000479005. Epub 2017 Jul 26. Review.


Efficacy of the Novel Medical Adhesive, MAR-VIVO-107, in an Acute Porcine Liver Resection Model.

Tanaka H, Fukushima K, Srinivasan PK, Pawlowsky K, Koegel B, Hata K, Ku Y, Uemoto S, Tolba RH.

Surg Innov. 2017 Oct;24(5):423-431. doi: 10.1177/1553350617720993. Epub 2017 Jul 17.


Argon and helium plasma coagulation of porcine liver tissue.

Glowka TR, Standop J, Paschenda P, Czaplik M, Kalff JC, Tolba RH.

J Int Med Res. 2017 Oct;45(5):1505-1517. doi: 10.1177/0300060517706576. Epub 2017 Jun 29.


The Aachen Minipig: Phenotype, Genotype, Hematological and Biochemical Characterization, and Comparison to the Göttingen Minipig.

Pawlowsky K, Ernst L, Steitz J, Stopinski T, Kögel B, Henger A, Kluge R, Tolba R.

Eur Surg Res. 2017;58(5-6):193-203. doi: 10.1159/000471483. Epub 2017 Apr 22.


Atypical Facial Pain: a Comprehensive, Evidence-Based Review.

Weiss AL, Ehrhardt KP, Tolba R.

Curr Pain Headache Rep. 2017 Feb;21(2):8. doi: 10.1007/s11916-017-0609-9. Review.


A rabbit model for experimental alveolar cleft grafting.

Kamal M, Andersson L, Tolba R, Bartella A, Gremse F, Hölzle F, Kessler P, Lethaus B.

J Transl Med. 2017 Feb 24;15(1):50. doi: 10.1186/s12967-017-1155-2.


Reduced astrocyte density underlying brain volume reduction in activity-based anorexia rats

Frintrop L, Liesbrock J, Paulukat L, Johann S, Kas MJ, Tolba R, Heussen N, Neulen J, Konrad K, Herpertz-Dahlmann B, Beyer C, Seitz J.

World J Biol Psychiatry. 2018 Apr;19(3):225-235. doi: 10.1080/15622975.2016.1273552. Epub 2017 Jan 30.


Two differentially structured collagen scaffolds for potential urinary bladder augmentation: proof of concept study in a Göttingen minipig model.

Leonhäuser D, Stollenwerk K, Seifarth V, Zraik IM, Vogt M, Srinivasan PK, Tolba RH, Grosse JO.

J Transl Med. 2017 Jan 4;15(1):3. doi: 10.1186/s12967-016-1112-5.


RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer.

Schneider AT, Gautheron J, Feoktistova M, Roderburg C, Loosen SH, Roy S, Benz F, Schemmer P, Büchler MW, Nachbur U, Neumann UP, Tolba R, Luedde M, Zucman-Rossi J, Panayotova-Dimitrova D, Leverkus M, Preisinger C, Tacke F, Trautwein C, Longerich T, Vucur M, Luedde T.

Cancer Cell. 2017 Jan 9;31(1):94-109. doi: 10.1016/j.ccell.2016.11.009. Epub 2016 Dec 22.


Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma.

Horst K, Simon TP, Pfeifer R, Teuben M, Almahmoud K, Zhi Q, Santos SA, Wembers CC, Leonhardt S, Heussen N, Störmann P, Auner B, Relja B, Marzi I, Haug AT, van Griensven M, Kalbitz M, Huber-Lang M, Tolba R, Reiss LK, Uhlig S, Marx G, Pape HC, Hildebrand F.

Sci Rep. 2016 Dec 21;6:39659. doi: 10.1038/srep39659.


Severity assessment in rabbits after partial hepatectomy: Part II.

Drude N, Pawlowsky K, Tanaka H, Fukushima K, Kögel B, Tolba RH.

Lab Anim. 2016 Dec;50(6):468-475.


Recommendation for severity assessment following liver resection and liver transplantation in rats: Part I.

Kanzler S, Rix A, Czigany Z, Tanaka H, Fukushima K, Kögel B, Pawlowsky K, Tolba RH.

Lab Anim. 2016 Dec;50(6):459-467.


Protective Effects of Adenosine Receptor Agonist in a Cirrhotic Liver Resection Model.

Iskandarov E, Kadaba Srinivasan P, Xin W, Bleilevens C, Afify M, Hamza A, Wei L, Hata K, Agayev B, Tolba R.

Hepat Mon. 2016 Jul 24;16(8):e36821. eCollection 2016 Aug.


Cyclooxygenase Inhibitors as a New Therapeutic Strategy in Small Bowel Transplantation.

Schildberg FA, Liu B, Afify M, Steitz J, Paschenda P, Schäfer N, Kalff JC, Minor T, Tolba RH.

Transplantation. 2016 Nov;100(11):2324-2331.


IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.

Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T.

Hepatology. 2016 Oct;64(4):1217-31. doi: 10.1002/hep.28723. Epub 2016 Aug 11.


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