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Items: 43


Monocytes work harder under pressure.

Tolar P, Wack A.

Nat Immunol. 2019 Oct 8. doi: 10.1038/s41590-019-0523-x. [Epub ahead of print] No abstract available.


MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells.

Merkenschlager J, Eksmond U, Danelli L, Attig J, Young GR, Nowosad C, Tolar P, Kassiotis G.

Blood. 2019 Mar 7;133(10):1108-1118. doi: 10.1182/blood-2018-11-885467. Epub 2019 Jan 30.


Great stretches for your antibody workout.

Tolar P.

Nat Nanotechnol. 2019 Feb;14(2):101-102. doi: 10.1038/s41565-018-0354-1. No abstract available.


Intrinsic properties of human germinal center B cells set antigen affinity thresholds.

Kwak K, Quizon N, Sohn H, Saniee A, Manzella-Lapeira J, Holla P, Brzostowski J, Lu J, Xie H, Xu C, Spillane KM, Tolar P, Pierce SK.

Sci Immunol. 2018 Nov 30;3(29). pii: eaau6598. doi: 10.1126/sciimmunol.aau6598.


Mechanics of antigen extraction in the B cell synapse.

Spillane KM, Tolar P.

Mol Immunol. 2018 Sep;101:319-328. doi: 10.1016/j.molimm.2018.07.018. Epub 2018 Jul 20. Review.


Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens.

Schulz O, Hanč P, Böttcher JP, Hoogeboom R, Diebold SS, Tolar P, Reis E Sousa C.

Cell Rep. 2018 Jul 10;24(2):419-428. doi: 10.1016/j.celrep.2018.06.038.


Myosin IIa Promotes Antibody Responses by Regulating B Cell Activation, Acquisition of Antigen, and Proliferation.

Hoogeboom R, Natkanski EM, Nowosad CR, Malinova D, Menon RP, Casal A, Tolar P.

Cell Rep. 2018 May 22;23(8):2342-2353. doi: 10.1016/j.celrep.2018.04.087.


DNA-Based Probes for Measuring Mechanical Forces in Cell-Cell Contacts: Application to B Cell Antigen Extraction from Immune Synapses.

Spillane KM, Tolar P.

Methods Mol Biol. 2018;1707:69-80. doi: 10.1007/978-1-4939-7474-0_5. Review.


Cytoskeletal control of B cell responses to antigens.

Tolar P.

Nat Rev Immunol. 2017 Oct;17(10):621-634. doi: 10.1038/nri.2017.67. Epub 2017 Jul 10. Review.


Plasma Membrane Sheets for Studies of B Cell Antigen Internalization from Immune Synapses.

Nowosad CR, Tolar P.

Methods Mol Biol. 2017;1584:77-88. doi: 10.1007/978-1-4939-6881-7_6.


B cell antigen extraction is regulated by physical properties of antigen-presenting cells.

Spillane KM, Tolar P.

J Cell Biol. 2017 Jan 2;216(1):217-230. doi: 10.1083/jcb.201607064. Epub 2016 Dec 6.


Germinal center B cells recognize antigen through a specialized immune synapse architecture.

Nowosad CR, Spillane KM, Tolar P.

Nat Immunol. 2016 Jul;17(7):870-7. doi: 10.1038/ni.3458. Epub 2016 May 16.


WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts.

Malinova D, Fritzsche M, Nowosad CR, Armer H, Munro PM, Blundell MP, Charras G, Tolar P, Bouma G, Thrasher AJ.

J Leukoc Biol. 2016 May;99(5):699-710. doi: 10.1189/jlb.2A0215-050RR. Epub 2015 Nov 20.


Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis.

Hoogeboom R, Tolar P.

Curr Top Microbiol Immunol. 2016;393:45-63. doi: 10.1007/82_2015_476. Review.


Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation.

Satpathy S, Wagner SA, Beli P, Gupta R, Kristiansen TA, Malinova D, Francavilla C, Tolar P, Bishop GA, Hostager BS, Choudhary C.

Mol Syst Biol. 2015 Jun 2;11(6):810. doi: 10.15252/msb.20145880.


Force generation in B-cell synapses: mechanisms coupling B-cell receptor binding to antigen internalization and affinity discrimination.

Tolar P, Spillane KM.

Adv Immunol. 2014;123:69-100. doi: 10.1016/B978-0-12-800266-7.00002-9. Review.


Activation of the B cell receptor leads to increased membrane proximity of the Igα cytoplasmic domain.

Lee WY, Tolar P.

PLoS One. 2013 Nov 11;8(11):e79148. doi: 10.1371/journal.pone.0079148. eCollection 2013.


B cells use mechanical energy to discriminate antigen affinities.

Natkanski E, Lee WY, Mistry B, Casal A, Molloy JE, Tolar P.

Science. 2013 Jun 28;340(6140):1587-90. doi: 10.1126/science.1237572. Epub 2013 May 16.


Inside the microcluster: antigen receptor signalling viewed with molecular imaging tools.

Tolar P.

Immunology. 2011 Jul;133(3):271-7. doi: 10.1111/j.1365-2567.2011.03452.x. Epub 2011 May 17. Review.


Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor.

Radaev S, Zou Z, Tolar P, Nguyen K, Nguyen A, Krueger PD, Stutzman N, Pierce S, Sun PD.

Structure. 2010 Aug 11;18(8):934-43. doi: 10.1016/j.str.2010.04.019.


Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling.

Liu W, Meckel T, Tolar P, Sohn HW, Pierce SK.

Immunity. 2010 Jun 25;32(6):778-89. doi: 10.1016/j.immuni.2010.06.006.


It's all about change: the antigen-driven initiation of B-cell receptor signaling.

Liu W, Sohn HW, Tolar P, Pierce SK.

Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a002295. doi: 10.1101/cshperspect.a002295. Epub 2010 Jun 30. Review.


Antigen affinity discrimination is an intrinsic function of the B cell receptor.

Liu W, Meckel T, Tolar P, Sohn HW, Pierce SK.

J Exp Med. 2010 May 10;207(5):1095-111. doi: 10.1084/jem.20092123. Epub 2010 Apr 19.


Antigen-induced oligomerization of the B cell receptor is an early target of Fc gamma RIIB inhibition.

Liu W, Won Sohn H, Tolar P, Meckel T, Pierce SK.

J Immunol. 2010 Feb 15;184(4):1977-89. doi: 10.4049/jimmunol.0902334. Epub 2010 Jan 18.


Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.

Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, Romesser PB, Kohlhammer H, Lamy L, Zhao H, Yang Y, Xu W, Shaffer AL, Wright G, Xiao W, Powell J, Jiang JK, Thomas CJ, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Connors JM, Johnson NA, Rimsza LM, Campo E, Jaffe ES, Wilson WH, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pierce SK, Staudt LM.

Nature. 2010 Jan 7;463(7277):88-92. doi: 10.1038/nature08638.


A conformation-induced oligomerization model for B cell receptor microclustering and signaling.

Tolar P, Pierce SK.

Curr Top Microbiol Immunol. 2010;340:155-69. doi: 10.1007/978-3-642-03858-7_8. Review.


The molecular assembly and organization of signaling active B-cell receptor oligomers.

Tolar P, Sohn HW, Liu W, Pierce SK.

Immunol Rev. 2009 Nov;232(1):34-41. doi: 10.1111/j.1600-065X.2009.00833.x. Review.


Imaging B-cell receptor signaling by single-molecule techniques.

Tolar P, Meckel T.

Methods Mol Biol. 2009;571:437-53. doi: 10.1007/978-1-60761-198-1_29.


Change we can believe in--of the conformational type. Workshop on the Initiation of Antigen Receptor Signaling.

Tolar P, Pierce SK.

EMBO Rep. 2009 Apr;10(4):331-6. doi: 10.1038/embor.2009.26. Epub 2009 Mar 13. Review. No abstract available.


The constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens.

Tolar P, Hanna J, Krueger PD, Pierce SK.

Immunity. 2009 Jan 16;30(1):44-55. doi: 10.1016/j.immuni.2008.11.007.


Membrane heterogeneities in the formation of B cell receptor-Lyn kinase microclusters and the immune synapse.

Sohn HW, Tolar P, Pierce SK.

J Cell Biol. 2008 Jul 28;182(2):367-79. doi: 10.1083/jcb.200802007. Epub 2008 Jul 21.


Viewing the antigen-induced initiation of B-cell activation in living cells.

Tolar P, Sohn HW, Pierce SK.

Immunol Rev. 2008 Feb;221:64-76. doi: 10.1111/j.1600-065X.2008.00583.x. Review.


Fluorescence resonance energy transfer in living cells reveals dynamic membrane changes in the initiation of B cell signaling.

Sohn HW, Tolar P, Jin T, Pierce SK.

Proc Natl Acad Sci U S A. 2006 May 23;103(21):8143-8. Epub 2006 May 11.


Signaling assemblies formed in mast cells activated via Fcepsilon receptor I dimers.

Dráberová L, Lebduska P, Hálová I, Tolar P, Stokrová J, Tolarová H, Korb J, Dráber P.

Eur J Immunol. 2004 Aug;34(8):2209-19.


Isolation of lipid rafts from B lymphocytes.

Cherukuri A, Tzeng SJ, Gidwani A, Sohn HW, Tolar P, Snyder MD, Pierce SK.

Methods Mol Biol. 2004;271:213-24.


Polydipsia and risperidone.

Kar N, Sharma PS, Tolar P, Pai K, Balasubramanian R.

Aust N Z J Psychiatry. 2002 Apr;36(2):268-70. No abstract available.


New monoclonal antibodies recognizing the adaptor protein LAT.

Tolar P, Tůmová M, Dráber P.

Folia Biol (Praha). 2001;47(6):215-7. No abstract available.


Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation.

Kovárová M, Tolar P, Arudchandran R, Dráberová L, Rivera J, Dráber P.

Mol Cell Biol. 2001 Dec;21(24):8318-28.


Protein tyrosine kinase Syk is involved in Thy-1 signaling in rat basophilic leukemia cells.

Tolar P, Dráberová L, Dráber P.

Eur J Immunol. 1997 Dec;27(12):3389-97.


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