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Items: 39

1.

The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis.

Tolar M, Abushakra S, Sabbagh M.

Alzheimers Dement. 2019 Nov 4. pii: S1552-5260(19)35450-0. doi: 10.1016/j.jalz.2019.09.075. [Epub ahead of print]

2.

Correction to: Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain.

Hey JA, Kocis P, Hort J, Abushakra S, Power A, Vyhnálek M, Yu JY, Tolar M.

CNS Drugs. 2018 Dec;32(12):1185. doi: 10.1007/s40263-018-0585-6.

3.

Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain.

Hey JA, Kocis P, Hort J, Abushakra S, Power A, Vyhnálek M, Yu JY, Tolar M.

CNS Drugs. 2018 Sep;32(9):849-861. doi: 10.1007/s40263-018-0554-0. Erratum in: CNS Drugs. 2018 Dec;32(12):1185.

4.

Lipoxin A4 Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2.

Gaudin A, Tolar M, Peters OA.

Sci Rep. 2018 Jun 11;8(1):8921. doi: 10.1038/s41598-018-27194-7.

5.

Clinical Effects of Tramiprosate in APOE4/4 Homozygous Patients with Mild Alzheimer's Disease Suggest Disease Modification Potential.

Abushakra S, Porsteinsson A, Scheltens P, Sadowsky C, Vellas B, Cummings J, Gauthier S, Hey JA, Power A, Wang P, Shen L, Tolar M.

J Prev Alzheimers Dis. 2017;4(3):149-156. doi: 10.14283/jpad.2017.26.

PMID:
29182706
6.

Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease.

Hey JA, Yu JY, Versavel M, Abushakra S, Kocis P, Power A, Kaplan PL, Amedio J, Tolar M.

Clin Pharmacokinet. 2018 Mar;57(3):315-333. doi: 10.1007/s40262-017-0608-3.

7.

Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer's Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data.

Kocis P, Tolar M, Yu J, Sinko W, Ray S, Blennow K, Fillit H, Hey JA.

CNS Drugs. 2017 Jun;31(6):495-509. doi: 10.1007/s40263-017-0434-z.

8.

US immigration order strikes against biotech.

Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forrester R, Francois C, Franklin H, Freeman MW, Furst H, Gage LP, Galakatos N, Gallagher BM, Geraghty JA, Gill S, Goeddel DV, Goldsmith MA, Gowen M, Goyal V, Graney T, Grayzel D, Greene B, Grint P, Gutierrez-Ramos JC, Haney B, Ha-Ngoc T, Harris T, Hasnain F, Hata YS, Hecht P, Henshaw L, Heyman R, Hoppenot H, Horvitz HR, Hughes TE, Hutton WS, Isaacs ST, Jenkins A, Jonker J, Kaplan J, Karsen P, Keiper J, Kim J, Kindler J, King R, King V, Kjellson N, Koenig S, Koenig G, Kolchinsky P, Laikind P, Langer RB, Lee JJ, Leff JS, Leicher BA, Leschly N, Levin A, Levin M, Levine AJ, Levy A, Liu DR, Lodish HF, Lopatin U, Love TW, Macdonald G, Maderis GJ, Mahadevia A, Mahanthappa NK, Martin JF, Martin A, Martucci WE, McArthur JG, McCann CM, McCarthy SA, McDonough CG, Mendlein J, Miller L, Miralles D, Moch KI, More B, Myers AG, Narachi MA, Nashat A, Nelson W, Newell WJ, Olle B, Osborn JE, Owens JC, Pande A, Papadopoulos S, Parker HS, Parmar KM, Patterson MR, Paul SM, Perez R, Perry M, Pfeffer CG, Powell M, Pruzanski M, Purcell DJ, Rakhit A, Ramamoorthi K, Rastetter W, Rawcliffe AA, Reid LE, Renaud RC, Rhodes JP, Rieflin WJ, Robins C, Rocklage SM, Rosenblatt M, Rosin JG, Rutter WJ, Saha S, Samuels C, Sato VL, Scangos G, Scarlett JA, Schenkein D, Schreiber SL, Schwab A, Sekhri P, Shah R, Shenk T, Siegall CB, Simon NJ, Simonian N, Stein J, Su M, Szela MT, Taglietti M, Tandon N, Termeer H, Thornberry NA, Tolar M, Ulevitch R, Vaishnaw AK, VanLent A, Varsavsky M, Vlasuk GP, Vounatsos M, Waksal SG, Warma N, Watts RJ, Werber Y, Westphal C, Wierenga W, Williams DE, Williams LR, Xanthopoulos KG, Zohar D, Zweifach SS.

Nat Biotechnol. 2017 Mar 7;35(3):204-206. doi: 10.1038/nbt.3824. No abstract available.

PMID:
28267733
9.

Clinical Benefits of Tramiprosate in Alzheimer's Disease Are Associated with Higher Number of APOE4 Alleles: The "APOE4 Gene-Dose Effect".

Abushakra S, Porsteinsson A, Vellas B, Cummings J, Gauthier S, Hey JA, Power A, Hendrix S, Wang P, Shen L, Sampalis J, Tolar M.

J Prev Alzheimers Dis. 2016;3(4):219-228. doi: 10.14283/jpad.2016.115.

PMID:
29199323
10.

Effects of two calcium silicate cements on cell viability, angiogenic growth factor release and related gene expression in stem cells from the apical papilla.

Peters OA, Galicia J, Arias A, Tolar M, Ng E, Shin SJ.

Int Endod J. 2016 Dec;49(12):1132-1140. doi: 10.1111/iej.12571. Epub 2015 Dec 1.

PMID:
26539648
11.

A living band-aid for epidermolysis bullosa.

Tolar J, Tolar M.

Blood Transfus. 2015 Jan;13(1):1-2. doi: 10.2450/2014.0289-14. No abstract available.

12.

Socio-technical issues and challenges in implementing safe patient handovers: insights from ethnographic case studies.

Balka E, Tolar M, Coates S, Whitehouse S.

Int J Med Inform. 2013 Dec;82(12):e345-57. doi: 10.1016/j.ijmedinf.2012.11.001. Epub 2012 Dec 6.

PMID:
23218926
13.

Interactions between immune system and mesenchymal stem cells in dental pulp and periapical tissues.

Leprince JG, Zeitlin BD, Tolar M, Peters OA.

Int Endod J. 2012 Aug;45(8):689-701. doi: 10.1111/j.1365-2591.2012.02028.x. Epub 2012 Mar 19. Review.

PMID:
22429087
14.

Reinventing mesenchymal stromal cells.

Tolar J, Tolar M.

Cytotherapy. 2012 Apr;14(4):388-90. doi: 10.3109/14653249.2012.665631. No abstract available.

PMID:
22420833
15.

Caring for individual patients and beyond: enhancing care through secondary use of data in a general practice setting.

Tolar M, Balka E.

Int J Med Inform. 2012 Jul;81(7):461-74. doi: 10.1016/j.ijmedinf.2012.01.003. Epub 2012 Jan 29.

PMID:
22285076
16.

Everyday ethical dilemmas arising with electronic record use in primary care.

Balka E, Tolar M.

Stud Health Technol Inform. 2011;169:285-9.

PMID:
21893758
17.

Beyond individual patient care: enhanced use of EMR data in a primary care setting.

Tolar M, Balka E.

Stud Health Technol Inform. 2011;164:143-7.

PMID:
21335702
18.

Spatial navigation and APOE in amnestic mild cognitive impairment.

Laczó J, Andel R, Vlček K, Macoška V, Vyhnálek M, Tolar M, Bojar M, Hort J.

Neurodegener Dis. 2011;8(4):169-77. doi: 10.1159/000321581. Epub 2010 Dec 3.

PMID:
21124005
19.

Socio-technical challenges in implementing safe patient handovers.

Balka E, Tolar M, Coates S, Whitehouse S.

Stud Health Technol Inform. 2010;157:206-12.

PMID:
20543390
20.

Human analogue of the morris water maze for testing subjects at risk of Alzheimer's disease.

Laczó J, Andel R, Vyhnalek M, Vlcek K, Magerova H, Varjassyova A, Tolar M, Hort J.

Neurodegener Dis. 2010;7(1-3):148-52. doi: 10.1159/000289226. Epub 2010 Mar 3.

PMID:
20197695
21.

Spatial navigation testing discriminates two types of amnestic mild cognitive impairment.

Laczó J, Vlcek K, Vyhnálek M, Vajnerová O, Ort M, Holmerová I, Tolar M, Andel R, Bojar M, Hort J.

Behav Brain Res. 2009 Sep 14;202(2):252-9. doi: 10.1016/j.bbr.2009.03.041. Epub 2009 Apr 5.

PMID:
19463709
22.

Pacific Craniofacial Team and Cleft Prevention Program.

Tolarová MM, Poulton D, Aubert MM, Oh H, Ellerhorst T, Mosby T, Tolar M, Boyd RL.

J Calif Dent Assoc. 2006 Oct;34(10):823-30.

PMID:
17087397
23.

alpha7 integrin expressing human fetal myogenic progenitors have stem cell-like properties and are capable of osteogenic differentiation.

Ozeki N, Lim M, Yao CC, Tolar M, Kramer RH.

Exp Cell Res. 2006 Dec 10;312(20):4162-80. Epub 2006 Sep 23.

24.

Imaging is superior to cognitive testing for early diagnosis of Alzheimer's disease.

Zamrini E, De Santi S, Tolar M.

Neurobiol Aging. 2004 May-Jun;25(5):685-91. Review.

PMID:
15172748
25.

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity.

Tolar M, Keller JN, Chan S, Mattson MP, Marques MA, Crutcher KA.

J Neurosci. 1999 Aug 15;19(16):7100-10.

26.
27.

Flexor tendon repair using a stainless steel internal anchor. Biomechanical study on human cadaver tendons.

Gordon L, Tolar M, Rao KT, Ritchie RO, Rabinowitz S, Lamb RP.

J Hand Surg Br. 1998 Feb;23(1):37-40.

PMID:
9571477
28.
29.

A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity.

Marques MA, Tolar M, Harmony JA, Crutcher KA.

Neuroreport. 1996 Nov 4;7(15-17):2529-32.

PMID:
8981417
30.

Neurite degeneration elicited by apolipoprotein E peptides.

Crutcher KA, Clay MA, Scott SA, Tian X, Tolar M, Harmony JA.

Exp Neurol. 1994 Nov;130(1):120-6.

PMID:
7821387
31.

Single K+ currents during differentiation of embryonic muscle cells in vitro.

Zemková H, Vyskocil F, Tolar M, Vlachová V, Ujec E.

Biochim Biophys Acta. 1989 Nov 17;986(1):146-50.

PMID:
2510830
32.

Effect of exercise on muscle fibre composition and enzyme activities of skeletal muscles in young rats.

Melichna J, Macková EV, Semiginovský B, Tolar M, Stichová J, Slavícek A, Vanková S, Bartůnĕk Z.

Physiol Bohemoslov. 1987;36(4):321-8.

PMID:
2958891
33.
34.

[Skeletal muscle cells].

Tolar M.

Cesk Fysiol. 1980;29(6):551-5. Czech. No abstract available.

PMID:
7460051
35.
36.

Growth-promoting alpha-globulin and ageing.

Michl J, Tolar M, Spurná V, Rezácová D.

Adv Exp Med Biol. 1975;53:137-46. No abstract available.

PMID:
47217
37.

Influence of cold on size of L-fibroblasts.

Baudysová M, Tolar M.

Physiol Bohemoslov. 1974;23(6):549-54. No abstract available.

PMID:
4280088
38.

[METHODS OF KARYOTYPE DETERMINATION].

CERNY M, TOLAR M.

Acta Univ Carol Med (Praha). 1964;Suppl 18:99+. Czech. No abstract available.

PMID:
14317365
39.

[BASIC STATISTICAL METHODS IN CLINICAL GENETICS].

CERNY M, SOUKUP F, TOLAR M.

Lek Veda Zahr. 1963 Sep 20;21:174-81. Review. Czech. No abstract available.

PMID:
14055626

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