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Items: 1 to 50 of 223

1.

Synthesis of Propargylic Ethers by Gold-Mediated Reaction of Terminal Alkynes with Acetals.

Furuta M, Sugiyama K, Yamaguchi M, Ueda H, Tokuyama H.

Chem Pharm Bull (Tokyo). 2019;67(8):872-876. doi: 10.1248/cpb.c19-00322.

2.

Acute Interstitial Nephritis With Karyomegalic Epithelial Cells After Nivolumab Treatment-Two Case Reports.

Ryuzaki M, Tokuyama H, Uchiyama K, Nakaya H, Hasegawa K, Miyashita K, Konishi K, Hashiguchi A, Wakino S, Itoh H.

Clin Med Insights Case Rep. 2019 Jun 13;12:1179547619853647. doi: 10.1177/1179547619853647. eCollection 2019.

3.

Total Synthesis of (+)-CC-1065 Utilizing Ring Expansion Reaction of Benzocyclobutenone Oxime Sulfonate.

Imaizumi T, Yamashita Y, Nakazawa Y, Okano K, Sakata J, Tokuyama H.

Org Lett. 2019 Aug 16;21(16):6185-6189. doi: 10.1021/acs.orglett.9b01690. Epub 2019 Jun 12.

PMID:
31188001
4.

Construction of Indole Structure on Pyrroloindolines via AgNTf2-Mediated Amination/Cyclization Cascade: Application to Total Synthesis of (+)-Pestalazine B.

Hakamata H, Ueda H, Tokuyama H.

Org Lett. 2019 Jun 7;21(11):4205-4209. doi: 10.1021/acs.orglett.9b01399. Epub 2019 May 22.

PMID:
31117711
5.

Rapid Assembly of Protoilludane Skeleton through Tandem Catalysis: Total Synthesis of Paesslerin A and Its Structural Revision.

Mogi Y, Inanaga K, Tokuyama H, Ihara M, Yamaoka Y, Yamada KI, Takasu K.

Org Lett. 2019 Jun 7;21(11):3954-3958. doi: 10.1021/acs.orglett.9b01089. Epub 2019 May 22.

PMID:
31117698
6.

A Case Report of Autosomal Dominant Polycystic Kidney Disease Under Peritoneal Dialysis With Cyst Infection and Culture-Positive Peritoneal Fluid.

Yasuda I, Hasegawa K, Tokuyama H, Washida N, Shinozuka K, Yasuda M, Ryuzaki M, Urai H, Wakino S, Itoh H.

Clin Med Insights Case Rep. 2019 Apr 29;12:1179547619846860. doi: 10.1177/1179547619846860. eCollection 2019.

7.

Comparing the effects of ipragliflozin versus metformin on visceral fat reduction and metabolic dysfunction in Japanese patients with type 2 diabetes treated with sitagliptin: A prospective, multicentre, open-label, blinded-endpoint, randomized controlled study (PRIME-V study).

Koshizaka M, Ishikawa K, Ishibashi R, Maezawa Y, Sakamoto K, Uchida D, Nakamura S, Yamaga M, Yokoh H, Kobayashi A, Onishi S, Kobayashi K, Ogino J, Hashimoto N, Tokuyama H, Shimada F, Ohara E, Ishikawa T, Shoji M, Ide S, Ide K, Baba Y, Hattori A, Kitamoto T, Horikoshi T, Shimofusa R, Takahashi S, Nagashima K, Sato Y, Takemoto M, Newby LK, Yokote K; PRIME-V Study Group.

Diabetes Obes Metab. 2019 Aug;21(8):1990-1995. doi: 10.1111/dom.13750. Epub 2019 May 8.

PMID:
30993861
8.

Role of Nampt-Sirt6 Axis in Renal Proximal Tubules in Extracellular Matrix Deposition in Diabetic Nephropathy.

Muraoka H, Hasegawa K, Sakamaki Y, Minakuchi H, Kawaguchi T, Yasuda I, Kanda T, Tokuyama H, Wakino S, Itoh H.

Cell Rep. 2019 Apr 2;27(1):199-212.e5. doi: 10.1016/j.celrep.2019.03.024.

9.

β-hydroxybutyrate attenuates renal ischemia-reperfusion injury through its anti-pyroptotic effects.

Tajima T, Yoshifuji A, Matsui A, Itoh T, Uchiyama K, Kanda T, Tokuyama H, Wakino S, Itoh H.

Kidney Int. 2019 May;95(5):1120-1137. doi: 10.1016/j.kint.2018.11.034. Epub 2019 Feb 28.

PMID:
30826015
10.

Motion-Based Detection of Lanthanides(III) Using Self-Propelled Droplets.

Ban T, Sugiyama M, Nagatsu Y, Tokuyama H.

J Phys Chem B. 2018 Nov 21;122(46):10647-10651. doi: 10.1021/acs.jpcb.8b08748. Epub 2018 Nov 12.

PMID:
30362751
11.

Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell.

Sugisawa N, Ohnuma S, Ueda H, Murakami M, Sugiyama K, Ohsawa K, Kano K, Tokuyama H, Doi T, Aoki J, Ishida M, Kudoh K, Naitoh T, Ambudkar SV, Unno M.

Mol Pharm. 2018 Sep 4;15(9):4021-4030. doi: 10.1021/acs.molpharmaceut.8b00457. Epub 2018 Aug 13.

PMID:
30052463
12.

NNMT activation can contribute to the development of fatty liver disease by modulating the NAD + metabolism.

Komatsu M, Kanda T, Urai H, Kurokochi A, Kitahama R, Shigaki S, Ono T, Yukioka H, Hasegawa K, Tokuyama H, Kawabe H, Wakino S, Itoh H.

Sci Rep. 2018 Jun 5;8(1):8637. doi: 10.1038/s41598-018-26882-8.

13.

High Basolateral Glucose Increases Sodium-Glucose Cotransporter 2 and Reduces Sirtuin-1 in Renal Tubules through Glucose Transporter-2 Detection.

Umino H, Hasegawa K, Minakuchi H, Muraoka H, Kawaguchi T, Kanda T, Tokuyama H, Wakino S, Itoh H.

Sci Rep. 2018 May 1;8(1):6791. doi: 10.1038/s41598-018-25054-y.

14.

Immobilization of Azospira sp. strain I13 by gel entrapment for mitigation of N2O from biological wastewater treatment plants: Biokinetic characterization and modeling.

Suenaga T, Aoyagi R, Sakamoto N, Riya S, Ohashi H, Hosomi M, Tokuyama H, Terada A.

J Biosci Bioeng. 2018 Aug;126(2):213-219. doi: 10.1016/j.jbiosc.2018.02.014. Epub 2018 Apr 19.

PMID:
29680367
15.

Oral adsorbent AST-120 ameliorates gut environment and protects against the progression of renal impairment in CKD rats.

Yoshifuji A, Wakino S, Irie J, Matsui A, Hasegawa K, Tokuyama H, Hayashi K, Itoh H.

Clin Exp Nephrol. 2018 Oct;22(5):1069-1078. doi: 10.1007/s10157-018-1577-z. Epub 2018 Apr 19.

16.

Penile calciphylaxis in a patient on combined peritoneal dialysis and hemodialysis.

Kasai T, Washida N, Muraoka H, Fujii K, Uchiyama K, Shinozuka K, Morimoto K, Tokuyama H, Wakino S, Itoh H.

CEN Case Rep. 2018 Nov;7(2):204-207. doi: 10.1007/s13730-018-0327-0. Epub 2018 Mar 28.

17.

Non-Tuberculous Mycobacterial Infections Related to Peritoneal Dialysis.

Inoue H, Washida N, Morimoto K, Shinozuka K, Kasai T, Uchiyama K, Tokuyama H, Wakino S, Itoh H.

Perit Dial Int. 2018 Mar-Apr;38(2):147-149. doi: 10.3747/pdi.2017.00172.

PMID:
29563276
18.

N-3 polyunsaturated fatty acids improve lipoprotein particle size and concentration in Japanese patients with type 2 diabetes and hypertriglyceridemia: a pilot study.

Ide K, Koshizaka M, Tokuyama H, Tokuyama T, Ishikawa T, Maezawa Y, Takemoto M, Yokote K.

Lipids Health Dis. 2018 Mar 15;17(1):51. doi: 10.1186/s12944-018-0706-8.

19.

A Cell-Targeted Non-Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium-Containing Cationic Radical Initiator.

Uchiyama S, Tsuji T, Kawamoto K, Okano K, Fukatsu E, Noro T, Ikado K, Yamada S, Shibata Y, Hayashi T, Inada N, Kato M, Koizumi H, Tokuyama H.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5413-5417. doi: 10.1002/anie.201801495. Epub 2018 Apr 6.

PMID:
29537622
20.

Persistent fever and destructive arthritis caused by dialysis-related amyloidosis: A case report.

Matsumoto K, Kikuchi J, Kaneko Y, Yasuoka H, Suzuki K, Tokuyama H, Kameyama K, Yamaoka K, Takeuchi T.

Medicine (Baltimore). 2018 Jan;97(1):e9359. doi: 10.1097/MD.0000000000009359.

21.

Cordybislactone, a stereoisomer of the 14-membered bislactone clonostachydiol, from the hopper pathogenic fungus Cordyceps sp. BCC 49294: revision of the absolute configuration of clonostachydiol.

Ojima KI, Yangchum A, Laksanacharoen P, Tasanathai K, Thanakitpipattana D, Tokuyama H, Isaka M.

J Antibiot (Tokyo). 2018 Mar;71(3):351-358. doi: 10.1038/s41429-017-0008-9. Epub 2018 Jan 18.

PMID:
29348525
22.

Effects of tolvaptan on urine output in hospitalized heart failure patients with hypoalbuminemia or proteinuria.

Takagi K, Sato N, Ishihara S, Sone M, Tokuyama H, Nakama K, Omote T, Kikuchi A, Ishikawa M, Amitani K, Takahashi N, Maruyama Y, Imura H, Shimizu W.

Heart Vessels. 2018 Apr;33(4):413-420. doi: 10.1007/s00380-017-1066-4. Epub 2017 Oct 23.

23.

AgNTf2-Mediated Allylation with Allylsilanes at C3a-Position of Hexahydropyrroloindoles: Application to Total Syntheses of Amauromine Alkaloids.

Hakamata H, Sato S, Ueda H, Tokuyama H.

Org Lett. 2017 Oct 6;19(19):5308-5311. doi: 10.1021/acs.orglett.7b02602. Epub 2017 Sep 19.

PMID:
28926277
24.

High-pressure tolerance of earthworm fibrinolytic and digestive enzymes.

Akazawa SI, Tokuyama H, Sato S, Watanabe T, Shida Y, Ogasawara W.

J Biosci Bioeng. 2018 Feb;125(2):155-159. doi: 10.1016/j.jbiosc.2017.08.011. Epub 2017 Sep 12.

PMID:
28916302
25.

Total Synthesis of Actinophyllic Acid.

Yoshii Y, Tokuyama H, Chen DY.

Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12277-12281. doi: 10.1002/anie.201706312. Epub 2017 Aug 24.

PMID:
28836325
26.

Laparoscopic Sleeve Gastrectomy Resolves Low GHRP-2-Stimulated Growth Hormone Levels in Obese Patients.

Ohara E, Tokuyama H, Kitamoto T, Kitahara A, Hayashi A, Hayashi H, Takemoto M, Yokote K.

Obes Surg. 2017 Aug;27(8):2214-2217. doi: 10.1007/s11695-017-2769-4.

PMID:
28623445
27.

A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score.

Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T, Higashi M, Umino H, Makishi G, Numaguchi A, Matsushima S, Tokuyama H, Nakamura M, Matsui S.

Scand J Trauma Resusc Emerg Med. 2017 May 10;25(1):49. doi: 10.1186/s13049-017-0392-y.

28.

Outcomes of laparoscopic sleeve gastrectomy in elderly obese Japanese patients.

Hayashi A, Maeda Y, Takemoto M, Tokuyama H, Koide H, Kitahara A, Hayashi H, Kitamoto T, Yamaga M, Kobayashi K, Yokote K.

Geriatr Gerontol Int. 2017 Nov;17(11):2068-2073. doi: 10.1111/ggi.13022. Epub 2017 Mar 30.

PMID:
28371292
29.

Sitagliptin but not alpha glucosidase inhibitor reduced the serum soluble CD163, a marker for activated macrophage, in individuals with type 2 diabetes mellitus.

Hattori A, Takemoto M, Tokuyama H, Koshizaka M, Yokote K.

Diabetes Res Clin Pract. 2017 Apr;126:138-143. doi: 10.1016/j.diabres.2017.02.010. Epub 2017 Feb 16.

PMID:
28237860
30.

Combination of cilostazol and probucol protected podocytes from lipopolysaccharide-induced injury by both anti-inflammatory and anti-oxidative mechanisms.

He P, Kawamura H, Takemoto M, Maezawa Y, Ishikawa T, Ishibashi R, Sakamoto K, Shoji M, Hattori A, Yamaga M, Ide S, Ide K, Hayashi A, Tokuyama H, Kobayashi K, Yokote K.

J Nephrol. 2017 Aug;30(4):531-541. doi: 10.1007/s40620-016-0361-y. Epub 2016 Dec 22.

PMID:
28005239
31.

Total Synthesis of (-)-Histrionicotoxin through a Stereoselective Radical Translocation-Cyclization Reaction.

Sato M, Azuma H, Daigaku A, Sato S, Takasu K, Okano K, Tokuyama H.

Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1087-1091. doi: 10.1002/anie.201609941. Epub 2016 Dec 19.

PMID:
27990730
32.

Structural Determination of (-)-SCH 64874 and Hirsutellomycin by Semisynthesis.

Tokuyama H, Yamada K, Fujiwara H, Sakata J, Okano K, Sappan M, Isaka M.

J Org Chem. 2017 Jan 6;82(1):353-371. doi: 10.1021/acs.joc.6b02452. Epub 2016 Dec 14.

PMID:
27966974
33.

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells.

Angela M, Endo Y, Asou HK, Yamamoto T, Tumes DJ, Tokuyama H, Yokote K, Nakayama T.

Nat Commun. 2016 Nov 30;7:13683. doi: 10.1038/ncomms13683.

34.

An Obtuse-angled Corner Unit for Fluctuating Carbon Nanohoops.

Sun Z, Miyamoto N, Sato S, Tokuyama H, Isobe H.

Chem Asian J. 2017 Jan 17;12(2):271-275. doi: 10.1002/asia.201601614. Epub 2016 Dec 21.

PMID:
27897398
35.

Bioinspired Total Synthesis of the Dimeric Indole Alkaloid (+)-Haplophytine by Direct Coupling and Late-Stage Oxidative Rearrangement.

Satoh H, Ojima KI, Ueda H, Tokuyama H.

Angew Chem Int Ed Engl. 2016 Nov 21;55(48):15157-15161. doi: 10.1002/anie.201609285. Epub 2016 Nov 7.

PMID:
27860178
36.

Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules.

Futatsugi K, Tokuyama H, Shibata S, Naitoh M, Kanda T, Minakuchi H, Yamaguchi S, Hayashi K, Minamishima YA, Yanagita M, Wakino S, Itoh H.

Sci Rep. 2016 Nov 9;6:36533. doi: 10.1038/srep36533.

37.

Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O.

Umehara A, Ueda H, Tokuyama H.

J Org Chem. 2016 Nov 18;81(22):11444-11453. Epub 2016 Nov 1.

PMID:
27767302
38.

CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy.

Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T, Higashi M, Umino H, Makishi G, Numaguchi A, Matsushima S, Tokuyama H, Nakamura M, Matsui S.

Intensive Care Med. 2016 Dec;42(12):2106-2107. doi: 10.1007/s00134-016-4492-3. Epub 2016 Aug 16. No abstract available.

39.

Convergent Synthesis of 2-Aryl-Substituted Quinolines by Gold-Catalyzed Cascade Reaction.

Ueda H, Yamaguchi M, Tokuyama H.

Chem Pharm Bull (Tokyo). 2016;64(7):824-9. doi: 10.1248/cpb.c16-00193.

40.

Conversion of Vindoline into 11-Mesyloxytabersonine.

Han-Ya Y, Inui T, Yokoshima S, Tokuyama H, Fukuyama T.

Chem Pharm Bull (Tokyo). 2016;64(7):800-4. doi: 10.1248/cpb.c16-00175.

41.

A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.

Ishibashi R, Takemoto M, Akimoto Y, Ishikawa T, He P, Maezawa Y, Sakamoto K, Tsurutani Y, Ide S, Ide K, Kawamura H, Kobayashi K, Tokuyama H, Tryggvason K, Betsholtz C, Yokote K.

Sci Rep. 2016 May 16;6:25955. doi: 10.1038/srep25955.

42.

Communication from Tubular Epithelial Cells to Podocytes through Sirt1 and Nicotinic Acid Metabolism.

Hasegawa K, Wakino S, Sakamaki Y, Muraoka H, Umino H, Minakuchi H, Yoshifuji A, Naitoh M, Shinozuka K, Futatsugi K, Urai H, Kanda T, Tokuyama H, Hayashi K, Itoh H.

Curr Hypertens Rev. 2016;12(2):95-104. Review.

PMID:
26931474
43.

Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase.

Morita J, Kano K, Kato K, Takita H, Sakagami H, Yamamoto Y, Mihara E, Ueda H, Sato T, Tokuyama H, Arai H, Asou H, Takagi J, Ishitani R, Nishimasu H, Nureki O, Aoki J.

Sci Rep. 2016 Feb 18;6:20995. doi: 10.1038/srep20995.

44.

Total syntheses of codonopsinine and 4-epi-codonopsinine via gold-mediated tandem-catalyzed pyrrole synthesis.

Yamaguchi M, Itagaki D, Ueda H, Tokuyama H.

J Antibiot (Tokyo). 2016 Apr;69(4):253-8. doi: 10.1038/ja.2016.13. Epub 2016 Feb 17.

PMID:
26883393
45.

Propagation Properties of the Precipitation Band in an AlCl₃/NaOH System.

Ban T, Nagatsu Y, Tokuyama H.

Langmuir. 2016 Jan 19;32(2):604-10. doi: 10.1021/acs.langmuir.5b03571. Epub 2016 Jan 7.

PMID:
26720646
46.

Detection of AU(III) ions using a poly(N,N-dimethylacrylamide)-coated QCM sensor.

Tokuyama H, Kitamura E, Seida Y.

Talanta. 2016 Jan 1;146:507-9. doi: 10.1016/j.talanta.2015.09.003. Epub 2015 Sep 8.

PMID:
26695297
47.

Comparison of the effects of low-dose rosuvastatin on plasma levels of cholesterol and oxidized low-density lipoprotein in 3 ultracentrifugally separated low-density lipoprotein subfractions.

Homma K, Homma Y, Ozawa H, Shiina Y, Shibata T, Yoshida T, Hasegawa K, Kanda T, Tokuyama H, Wakino S, Hayashi K, Itoh H, Hori S.

J Clin Lipidol. 2015 Nov-Dec;9(6):751-757. doi: 10.1016/j.jacl.2015.07.013. Epub 2015 Aug 7.

PMID:
26687695
48.

A case of severe osteomalacia caused by Tubulointerstitial nephritis with Fanconi syndrome in asymptomotic primary biliary cirrhosis.

Yamaguchi S, Maruyama T, Wakino S, Tokuyama H, Hashiguchi A, Tada S, Homma K, Monkawa T, Thomas J, Miyashita K, Kurihara I, Yoshida T, Konishi K, Hayashi K, Hayashi M, Itoh H.

BMC Nephrol. 2015 Nov 11;16:187. doi: 10.1186/s12882-015-0184-4.

49.

The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.

Minakuchi H, Wakino S, Hosoya K, Sueyasu K, Hasegawa K, Shinozuka K, Yoshifuji A, Futatsugi K, Komatsu M, Kanda T, Tokuyama H, Hayashi K, Itoh H.

Nephrol Dial Transplant. 2016 Mar;31(3):413-23. doi: 10.1093/ndt/gfv367. Epub 2015 Oct 28.

PMID:
26516203
50.

Total Synthesis of (+)-MPC1001B.

Kurogi T, Okaya S, Fujiwara H, Okano K, Tokuyama H.

Angew Chem Int Ed Engl. 2016 Jan 4;55(1):283-7. doi: 10.1002/anie.201507830. Epub 2015 Oct 23.

PMID:
26493769

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