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Items: 1 to 50 of 261

1.

Identification of linear polyubiquitin chain immunoreactivity in tau pathology of Alzheimer's disease.

Nakayama Y, Sakamoto S, Tsuji K, Ayaki T, Tokunaga F, Ito H.

Neurosci Lett. 2019 Jun 11;703:53-57. doi: 10.1016/j.neulet.2019.03.017. Epub 2019 Mar 15.

PMID:
30885635
2.

Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling.

Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga F.

Biochem Biophys Res Commun. 2019 Feb 12;509(3):700-706. doi: 10.1016/j.bbrc.2018.12.164. Epub 2019 Jan 2.

PMID:
30611571
3.

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.

Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G, Ishitani R, Tokunaga F, Nureki O.

Nat Commun. 2018 Oct 24;9(1):4424. doi: 10.1038/s41467-018-06922-7.

4.

Generation of Rat Monoclonal Antibodies Against a Deubiquitinase, Ovarian Tumor Domain-Containing Protein 1.

Oikawa D, Shiota M, Goto E, Komakura K, Wanibuchi H, Tokunaga F.

Monoclon Antib Immunodiagn Immunother. 2018 Aug;37(4):180-184. doi: 10.1089/mab.2018.0023. Epub 2018 Aug 21.

PMID:
30130141
5.

High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors Using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System.

Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.

SLAS Discov. 2018 Dec;23(10):1018-1029. doi: 10.1177/2472555218793066. Epub 2018 Aug 2.

PMID:
30071751
6.

Generation of Rat Monoclonal Antibodies Specific for DZIP3.

Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.

Monoclon Antib Immunodiagn Immunother. 2018 Jun;37(3):153-157. doi: 10.1089/mab.2018.0005. Epub 2018 May 29.

PMID:
29812999
7.

In-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.

Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki SI, Wakamatsu K, Tokunaga F, Shimizu A.

J Dermatol Sci. 2018 Jul;91(1):35-42. doi: 10.1016/j.jdermsci.2018.03.012. Epub 2018 Mar 21.

PMID:
29631773
8.

Survey of the awareness of adult rheumatologists regarding transitional care for patients with juvenile idiopathic arthritis in Japan.

Matsui T, Matsumoto T, Hirano F, Tokunaga F, Okamoto K, Tohma S, Morio T, Kohsaka H, Mori M.

Mod Rheumatol. 2018 Nov;28(6):981-985. doi: 10.1080/14397595.2018.1430546. Epub 2018 Feb 8.

PMID:
29347862
9.

Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency.

Kuriyama Y, Hattori M, Mitsui T, Nakano H, Oikawa D, Tokunaga F, Ishikawa O, Shimizu A.

J Dermatol. 2018 May;45(5):e108-e109. doi: 10.1111/1346-8138.14149. Epub 2017 Nov 27. No abstract available.

PMID:
29178327
10.

Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.

Goto E, Tokunaga F.

Biochem Biophys Res Commun. 2017 Mar 25;485(1):152-159. doi: 10.1016/j.bbrc.2017.02.040. Epub 2017 Feb 9.

PMID:
28189684
11.

Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in Mice.

Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, Sakoda H.

Int J Mol Sci. 2017 Feb 4;18(2). pii: E326. doi: 10.3390/ijms18020326.

12.

Endoplasmic reticulum stress in the pathogenesis of pretibial dystrophic epidermolysis bullosa.

Hattori M, Shimizu A, Oikawa D, Kamei K, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Tokunaga F, Ishikawa O.

Br J Dermatol. 2017 Oct;177(4):e92-e93. doi: 10.1111/bjd.15342. Epub 2017 Aug 27. No abstract available.

PMID:
28122411
13.

HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.

Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue JI.

PLoS Pathog. 2017 Jan 19;13(1):e1006162. doi: 10.1371/journal.ppat.1006162. eCollection 2017 Jan.

14.

Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide.

Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, Nureki O.

Sci Rep. 2016 Oct 10;6:34756. doi: 10.1038/srep34756.

15.

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.

Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F.

Nat Commun. 2016 Aug 24;7:12547. doi: 10.1038/ncomms12547.

16.

Increased C-reactive protein and fever in Japanese infants with food protein-induced enterocolitis syndrome.

Kimura M, Ito Y, Tokunaga F, Meguro T, Shimomura M, Morishita H, Seto S.

Pediatr Int. 2016 Sep;58(9):826-30. doi: 10.1111/ped.12938. Epub 2016 May 16.

PMID:
26824628
17.

The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.

Kumanomidou T, Nishio K, Takagi K, Nakagawa T, Suzuki A, Yamane T, Tokunaga F, Iwai K, Murakami A, Yoshida Y, Tanaka K, Mizushima T.

PLoS One. 2015 Oct 13;10(10):e0140366. doi: 10.1371/journal.pone.0140366. eCollection 2015.

18.

A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsunomiya A, Watanabe T, Yamaoka S.

Leukemia. 2016 Mar;30(3):716-27. doi: 10.1038/leu.2015.267. Epub 2015 Oct 6.

PMID:
26437781
19.

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.

Matsunaga Y, Nakatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S, Tsuchiya Y, Kamata H, Tokunaga F, Iwai K, Asano T.

Mediators Inflamm. 2015;2015:125380. doi: 10.1155/2015/125380. Epub 2015 Jun 10.

20.

Close Positive Correlation between the Lymphocyte Response to Hen Egg White and House Dust Mites in Infants with Atopic Dermatitis.

Kimura M, Meguro T, Ito Y, Tokunaga F, Hashiguchi A, Seto S.

Int Arch Allergy Immunol. 2015;166(3):161-9. doi: 10.1159/000381057. Epub 2015 Apr 11.

21.

Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.

Sato Y, Goto E, Shibata Y, Kubota Y, Yamagata A, Goto-Ito S, Kubota K, Inoue J, Takekawa M, Tokunaga F, Fukai S.

Nat Struct Mol Biol. 2015 Mar;22(3):222-9. doi: 10.1038/nsmb.2970. Epub 2015 Feb 16.

PMID:
25686088
22.

[Evaluation of the allergenicity of β-casein in Japanese children with cow milk allergy by using the basophil activation test].

Ito Y, Shimomura M, Tokunaga F, Meguro T, Seto S, Hashiguchi A, Kimura M.

Arerugi. 2014 Dec;63(10):1330-7. Japanese.

PMID:
25634458
23.

An autosomal recessive mutation of DSG4 causes monilethrix through the ER stress response.

Kato M, Shimizu A, Yokoyama Y, Kaira K, Shimomura Y, Ishida-Yamamoto A, Kamei K, Tokunaga F, Ishikawa O.

J Invest Dermatol. 2015 May;135(5):1253-1260. doi: 10.1038/jid.2015.12. Epub 2015 Jan 23.

24.

Structural and functional analyses of DNA-sensing and immune activation by human cGAS.

Kato K, Ishii R, Goto E, Ishitani R, Tokunaga F, Nureki O.

PLoS One. 2013 Oct 7;8(10):e76983. doi: 10.1371/journal.pone.0076983. eCollection 2013.

25.

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.

Fujita N, Morita E, Itoh T, Tanaka A, Nakaoka M, Osada Y, Umemoto T, Saitoh T, Nakatogawa H, Kobayashi S, Haraguchi T, Guan JL, Iwai K, Tokunaga F, Saito K, Ishibashi K, Akira S, Fukuda M, Noda T, Yoshimori T.

J Cell Biol. 2013 Oct 14;203(1):115-28. doi: 10.1083/jcb.201304188. Epub 2013 Oct 7.

26.

Linear ubiquitination-mediated NF-κB regulation and its related disorders.

Tokunaga F.

J Biochem. 2013 Oct;154(4):313-23. doi: 10.1093/jb/mvt079. Epub 2013 Aug 21. Review.

PMID:
23969028
27.

[Linear ubiquitination-mediated NF-κB regulation and its related diseases].

Tokunaga F.

Seikagaku. 2013 Jun;85(6):414-22. Review. Japanese. No abstract available.

PMID:
23875468
28.

Raman Optical Activity Probing Structural Deformations of the 4-Hydroxycinnamyl Chromophore in Photoactive Yellow Protein.

Shingae T, Kubota K, Kumauchi M, Tokunaga F, Unno M.

J Phys Chem Lett. 2013 Apr 18;4(8):1322-7. doi: 10.1021/jz400454j. Epub 2013 Apr 8.

PMID:
26282147
29.

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation.

Tokunaga F, Nishimasu H, Ishitani R, Goto E, Noguchi T, Mio K, Kamei K, Ma A, Iwai K, Nureki O.

EMBO J. 2012 Oct 3;31(19):3856-70. doi: 10.1038/emboj.2012.241. Epub 2012 Aug 28.

30.

Spatial arrangement of rhodopsin in retinal rod outer segment membranes studied by spin-labeling and pulsed electron double resonance.

Yasuda S, Hara H, Tokunaga F, Arata T.

Biochem Biophys Res Commun. 2012 Aug 24;425(2):134-7. doi: 10.1016/j.bbrc.2012.07.040. Epub 2012 Jul 24.

PMID:
22842041
31.

Hematological- and Neurological-Expressed Sequence 1 Gene Products in Progenitor Cells during Newt Retinal Development.

Goto T, Tokunaga F, Hisatomi O.

Stem Cells Int. 2012;2012:436042. doi: 10.1155/2012/436042. Epub 2012 Jun 6.

32.
33.

Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.

Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I.

J Biol Chem. 2012 Jul 6;287(28):23626-34. doi: 10.1074/jbc.M112.347195. Epub 2012 May 17.

34.

A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex.

Yagi H, Ishimoto K, Hiromoto T, Fujita H, Mizushima T, Uekusa Y, Yagi-Utsumi M, Kurimoto E, Noda M, Uchiyama S, Tokunaga F, Iwai K, Kato K.

EMBO Rep. 2012 May 1;13(5):462-8. doi: 10.1038/embor.2012.24.

35.

LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses.

Tokunaga F, Iwai K.

Microbes Infect. 2012 Jul;14(7-8):563-72. doi: 10.1016/j.micinf.2012.01.011. Epub 2012 Jan 25. Review.

PMID:
22309894
36.

Depth perception from image defocus in a jumping spider.

Nagata T, Koyanagi M, Tsukamoto H, Saeki S, Isono K, Shichida Y, Tokunaga F, Kinoshita M, Arikawa K, Terakita A.

Science. 2012 Jan 27;335(6067):469-71. doi: 10.1126/science.1211667.

37.

Backbone and side chain 1H, 13C, and 15N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex.

Uekusa Y, Mimura S, Sasakawa H, Kurimoto E, Sakata E, Olivier S, Yagi H, Tokunaga F, Iwai K, Kato K.

Biomol NMR Assign. 2012 Oct;6(2):177-80. doi: 10.1007/s12104-011-9350-1. Epub 2011 Nov 30.

PMID:
22127525
38.

Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells.

Tomonaga M, Hashimoto N, Tokunaga F, Onishi M, Myoui A, Yoshikawa H, Iwai K.

Int J Oncol. 2012 Feb;40(2):409-17. doi: 10.3892/ijo.2011.1209. Epub 2011 Sep 22.

PMID:
21947385
39.

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.

Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I.

Nature. 2011 Mar 31;471(7340):637-41. doi: 10.1038/nature09814.

40.

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.

Tokunaga F, Nakagawa T, Nakahara M, Saeki Y, Taniguchi M, Sakata S, Tanaka K, Nakano H, Iwai K.

Nature. 2011 Mar 31;471(7340):633-6. doi: 10.1038/nature09815.

PMID:
21455180
41.

Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction.

Inn KS, Gack MU, Tokunaga F, Shi M, Wong LY, Iwai K, Jung JU.

Mol Cell. 2011 Feb 4;41(3):354-65. doi: 10.1016/j.molcel.2010.12.029.

42.

The role of proboscis of the malaria vector mosquito Anopheles stephensi in host-seeking behavior.

Maekawa E, Aonuma H, Nelson B, Yoshimura A, Tokunaga F, Fukumoto S, Kanuka H.

Parasit Vectors. 2011 Jan 27;4:10. doi: 10.1186/1756-3305-4-10.

43.

Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex.

Kumanomidou T, Nakagawa T, Mizushima T, Suzuki A, Tokunaga F, Iwai K, Yoshida Y, Tanaka K, Yamane T.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):95-8. doi: 10.1107/S1744309109050581. Epub 2009 Dec 25.

44.
45.

Linear polyubiquitination: a new regulator of NF-kappaB activation.

Iwai K, Tokunaga F.

EMBO Rep. 2009 Jul;10(7):706-13. doi: 10.1038/embor.2009.144. Epub 2009 Jun 19. Review.

46.

[Involvement of LUBAC-mediated linear polyubiquitination of NEMO in NF-kappaB activation].

Tokunaga F, Iwai K.

Tanpakushitsu Kakusan Koso. 2009 Apr;54(5):635-42. Review. Japanese. No abstract available.

PMID:
19348259
47.

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.

Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao T, Tanaka K, Iwai K.

Nat Cell Biol. 2009 Feb;11(2):123-32. doi: 10.1038/ncb1821. Epub 2009 Jan 11.

PMID:
19136968
48.

Characterization of chemoreceptive protein binding to an oviposition stimulant using a fluorescent micro-binding assay in a butterfly.

Tsuchihara K, Wazawa T, Ishii Y, Yanagida T, Nishida R, Zheng XG, Ishiguro M, Yoshihara K, Hisatomi O, Tokunaga F.

FEBS Lett. 2009 Jan 22;583(2):345-9. doi: 10.1016/j.febslet.2008.12.027. Epub 2008 Dec 25.

49.

Jellyfish vision starts with cAMP signaling mediated by opsin-G(s) cascade.

Koyanagi M, Takano K, Tsukamoto H, Ohtsu K, Tokunaga F, Terakita A.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15576-80. doi: 10.1073/pnas.0806215105. Epub 2008 Oct 1.

50.

The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination.

Miyauchi Y, Kato M, Tokunaga F, Iwai K.

J Biol Chem. 2008 Jun 13;283(24):16622-31. doi: 10.1074/jbc.M710599200. Epub 2008 Apr 18.

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