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Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system.

Taniguchi M, Miyamoto H, Tokunaga A, Fumoto S, Tanaka T, Nishida K.

Xenobiotica. 2019 Oct 21:1-29. doi: 10.1080/00498254.2019.1683258. [Epub ahead of print]


Photochromic Reaction by Red Light via Triplet Fusion Upconversion.

Tokunaga A, Uriarte LM, Mutoh K, Fron E, Hofkens J, Sliwa M, Abe J.

J Am Chem Soc. 2019 Oct 12. doi: 10.1021/jacs.9b08219. [Epub ahead of print]


Effect of renal ischaemia/reperfusion-induced acute kidney injury on pharmacokinetics of midazolam in rats.

Tokunaga A, Miyamoto H, Fumoto S, Nishida K.

J Pharm Pharmacol. 2019 Oct 3. doi: 10.1111/jphp.13167. [Epub ahead of print]


Selective inhibition of low-affinity memory CD8+ T cells by corticosteroids.

Tokunaga A, Sugiyama D, Maeda Y, Warner AB, Panageas KS, Ito S, Togashi Y, Sakai C, Wolchok JD, Nishikawa H.

J Exp Med. 2019 Sep 19. pii: jem.20190738. doi: 10.1084/jem.20190738. [Epub ahead of print]


In vivo activation of PEGylated long circulating lipid nanoparticle to achieve efficient siRNA delivery and target gene knock down in solid tumors.

Sasayama Y, Hasegawa M, Taguchi E, Kubota K, Kuboyama T, Naoi T, Yabuuchi H, Shimai N, Asano M, Tokunaga A, Ishii T, Enokizono J.

J Control Release. 2019 Sep 7;311-312:245-256. doi: 10.1016/j.jconrel.2019.09.004. [Epub ahead of print]


Glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma pneumoniae induces infection-related glomerulonephritis

Hirano D, Oda T, Ito A, Yamada A, Kakegawa D, Miwa S, Umeda C, Takemasa Y, Tokunaga A, Wajima T, Nakaminami H, Noguchi N, Ida H.

Clin Nephrol. 2019 Sep 9. doi: 10.5414/CN109786. [Epub ahead of print]


Relationship between parenting stress and children's behavioral characteristics in Japan.

Tokunaga A, Iwanaga R, Yamanishi Y, Higashionna T, Tanaka K, Nakane H, Tanaka G.

Pediatr Int. 2019 Jul;61(7):652-657. doi: 10.1111/ped.13876. Epub 2019 Jul 9.


Enantioselective conjugate addition of an α,α-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)-Pd complexes.

Nakamura S, Tokunaga A, Saito H, Kondo M.

Chem Commun (Camb). 2019 May 10;55(37):5391-5394. doi: 10.1039/c9cc02443c. Epub 2019 Apr 18.


Diffusion-weighted magnetic resonance imaging in the pancreas of fulminant type 1 diabetes.

Tokunaga A, Imagawa A, Nishio H, Hayata S, Shimomura I, Abiru N, Awata T, Ikegami H, Uchigata Y, Oikawa Y, Osawa H, Kajio H, Kawasaki E, Kawabata Y, Kozawa J, Shimada A, Takahashi K, Tanaka S, Chujo D, Fukui T, Miura J, Yasuda K, Yasuda H, Kobayashi T, Hanafusa T; consultation of Japan Diabetes Society Committee on Fulminant Type 1 Diabetes Mellitus Research.

Diabetol Int. 2018 Apr 12;9(4):257-265. doi: 10.1007/s13340-018-0355-1. eCollection 2018 Oct.


Factors associated with preschool workers' willingness to continue working.

Tayama J, Yoshida Y, Iwanaga R, Tokunaga A, Tanaka G, Imamura A, Shimazu A, Shirabe S.

Medicine (Baltimore). 2018 Dec;97(49):e13530. doi: 10.1097/MD.0000000000013530.


Relationship between Motor Coordination, Cognitive Abilities, and Academic Achievement in Japanese Children with Neurodevelopmental Disorders.

Higashionna T, Iwanaga R, Tokunaga A, Nakai A, Tanaka K, Nakane H, Tanaka G.

Hong Kong J Occup Ther. 2017 Dec;30(1):49-55. doi: 10.1016/j.hkjot.2017.10.002. Epub 2017 Dec 6.


Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization.

Fujita H, Tokunaga A, Shimizu S, Whiting AL, Aguilar-Alonso F, Takagi K, Walinda E, Sasaki Y, Shimokawa T, Mizushima T, Ohki I, Ariyoshi M, Tochio H, Bernal F, Shirakawa M, Iwai K.

Cell Rep. 2018 Apr 24;23(4):1192-1204. doi: 10.1016/j.celrep.2018.03.112.


Reversible Valence Photoisomerization between Closed-Shell Quinoidal and Open-Shell Biradical Forms.

Tokunaga A, Mutoh K, Hasegawa T, Abe J.

J Phys Chem Lett. 2018 Apr 19;9(8):1833-1837. doi: 10.1021/acs.jpclett.8b00916. Epub 2018 Mar 29.


Early diagnosis using canonical discriminant analysis of innate immune receptor gene expression profiles in a murine infectious or sterile systemic inflammation model.

Tajima G, Tokunaga A, Umehara T, Ikematsu K, Miyamoto J, Sato S, Tasaki O.

J Trauma Acute Care Surg. 2018 Apr;84(4):583-589. doi: 10.1097/TA.0000000000001789.


Independent Risk Factors and 2-Year Outcomes of Acute Kidney Injury after Surgery for Congenital Heart Disease.

Hirano D, Ito A, Yamada A, Kakegawa D, Miwa S, Umeda C, Chiba K, Takemasa Y, Tokunaga A, Ida H.

Am J Nephrol. 2017;46(3):204-209. doi: 10.1159/000480358. Epub 2017 Sep 1.


Influence of vasomodulators and tumor transplantation on the disposition of 5-fluorouracil after application to the liver surface in rats.

Kodama Y, Horishita M, Tokunaga A, Miyamoto H, Fumoto S, Sasaki H, Nakamura J, Nishida K.

Biopharm Drug Dispos. 2017 Sep;38(6):367-372. doi: 10.1002/bdd.2073. Epub 2017 May 23.


Effectiveness of Earmuffs and Noise-cancelling Headphones for Coping with Hyper-reactivity to Auditory Stimuli in Children with Autism Spectrum Disorder: A Preliminary Study.

Ikuta N, Iwanaga R, Tokunaga A, Nakane H, Tanaka K, Tanaka G.

Hong Kong J Occup Ther. 2016 Dec;28(1):24-32. doi: 10.1016/j.hkjot.2016.09.001. Epub 2016 Dec 30.


Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma.

Hijiya N, Tsukamoto Y, Nakada C, Tung Nguyen L, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, Moriyama M.

Cancer Res. 2016 May 1;76(9):2612-25. doi: 10.1158/0008-5472.CAN-15-1846. Epub 2016 Mar 3.


Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway.

Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, Daa T, Iha H, Takahashi M, Nomura T, Sato F, Mimata H, Ikawa M, Seto M, Matsuura K, Moriyama M.

J Pathol. 2016 May;239(1):97-108. doi: 10.1002/path.4706. Epub 2016 Mar 30.


Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma.

Takahashi M, Tsukamoto Y, Kai T, Tokunaga A, Nakada C, Hijiya N, Uchida T, Daa T, Nomura T, Sato F, Mimata H, Matsuura K, Moriyama M.

Cancer Sci. 2016 Apr;107(4):417-23. doi: 10.1111/cas.12892. Epub 2016 Mar 4.


Macrominerals and Trace Element Requirements for Beef Cattle.

Costa e Silva LF, Valadares Filho Sde C, Engle TE, Rotta PP, Marcondes MI, Silva FA, Martins EC, Tokunaga AT.

PLoS One. 2015 Dec 14;10(12):e0144464. doi: 10.1371/journal.pone.0144464. eCollection 2015.


Mechanisms of gene targeting in higher eukaryotes.

Tokunaga A, Anai H, Hanada K.

Cell Mol Life Sci. 2016 Feb;73(3):523-33. doi: 10.1007/s00018-015-2073-1. Epub 2015 Oct 27. Review.


Prevention of Incisional Surgical Site Infection Using a Subcuticular Absorbable Suture in Elective Surgery for Gastrointestinal Cancer.

Bou H, Suzuki H, Maejima K, Uchida E, Tokunaga A.

Int Surg. 2015 Jun;100(6):999-1003. doi: 10.9738/INTSURG-D-14-00185.1.


Soliton's eigenvalue based analysis on the generation mechanism of rogue wave phenomenon in optical fibers exhibiting weak third order dispersion.

Weerasekara G, Tokunaga A, Terauchi H, Eberhard M, Maruta A.

Opt Express. 2015 Jan 12;23(1):143-53. doi: 10.1364/OE.23.000143.


Strong water isotopic anomalies in the martian atmosphere: probing current and ancient reservoirs.

Villanueva GL, Mumma MJ, Novak RE, Käufl HU, Hartogh P, Encrenaz T, Tokunaga A, Khayat A, Smith MD.

Science. 2015 Apr 10;348(6231):218-21. doi: 10.1126/science.aaa3630. Epub 2015 Mar 5.


The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators.

Kawakami E, Tokunaga A, Ozawa M, Sakamoto R, Yoshida N.

Mech Dev. 2015 Feb;135:31-42. doi: 10.1016/j.mod.2014.10.001. Epub 2014 Oct 30.


Simultaneous quantification of intracellular and secreted active and inactive glucagon-like peptide-1 from cultured cells.

Amao M, Kitahara Y, Tokunaga A, Shimbo K, Eto Y, Yamada N.

Anal Biochem. 2015 Mar 1;472:45-51. doi: 10.1016/j.ab.2014.11.009. Epub 2014 Nov 20.


Relationship between Sympathetic Skin Responses and Auditory Hypersensitivity to Different Auditory Stimuli.

Kato F, Iwanaga R, Chono M, Fujihara S, Tokunaga A, Murata J, Tanaka K, Nakane H, Tanaka G.

J Phys Ther Sci. 2014 Jul;26(7):1087-91. doi: 10.1589/jpts.26.1087. Epub 2014 Jul 30.


Weight lifting can facilitate appreciative comprehension for museum exhibits.

Yamada Y, Harada S, Choi W, Fujino R, Tokunaga A, Gao Y, Miura K.

Front Psychol. 2014 Apr 14;5:307. doi: 10.3389/fpsyg.2014.00307. eCollection 2014.


Intraoperative measurements of femoral anterior tangent (FAT) line for determining the rotational alignment of femoral component of total knee arthroplasty.

Watanabe H, Gejo R, Tokunaga A, Hirano N, Kimura T.

J Arthroplasty. 2013 Dec;28(10):1757-9. doi: 10.1016/j.arth.2013.06.016. Epub 2013 Aug 6.


PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus.

Shibasaki T, Tokunaga A, Sakamoto R, Sagara H, Noguchi S, Sasaoka T, Yoshida N.

Cereb Cortex. 2013 Aug;23(8):1824-35. doi: 10.1093/cercor/bhs161. Epub 2012 Jun 15.


Botch promotes neurogenesis by antagonizing Notch.

Chi Z, Zhang J, Tokunaga A, Harraz MM, Byrne ST, Dolinko A, Xu J, Blackshaw S, Gaiano N, Dawson TM, Dawson VL.

Dev Cell. 2012 Apr 17;22(4):707-20. doi: 10.1016/j.devcel.2012.02.011. Epub 2012 Mar 22.


Polypyrimidine tract-binding protein regulates the cell cycle through IRES-dependent translation of CDK11(p58) in mouse embryonic stem cells.

Ohno S, Shibayama M, Sato M, Tokunaga A, Yoshida N.

Cell Cycle. 2011 Nov 1;10(21):3706-13. doi: 10.4161/cc.10.21.17903. Epub 2011 Nov 1. Retraction in: Cell Cycle. 2016 Nov;15(21):2992.


Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2011 edition.

Minakami H, Hiramatsu Y, Koresawa M, Fujii T, Hamada H, Iitsuka Y, Ikeda T, Ishikawa H, Ishimoto H, Itoh H, Kanayama N, Kasuga Y, Kawabata M, Konishi I, Matsubara S, Matsuda H, Murakoshi T, Ohkuchi A, Okai T, Saito S, Sakai M, Satoh S, Sekizawa A, Suzuki M, Takahashi T, Tokunaga A, Tsukahara Y, Yoshikawa H; Japan Society of Obstetrics and Gynecology; Japan Association of Obstetricians and Gynecologists.

J Obstet Gynaecol Res. 2011 Sep;37(9):1174-97. doi: 10.1111/j.1447-0756.2011.01653.x. Epub 2011 Sep 15.


Mitochondrial DNA alterations in colorectal cancer cell lines.

Chihara N, Amo T, Tokunaga A, Yuzuriha R, Wolf AM, Asoh S, Suzuki H, Uchida E, Ohta S.

J Nippon Med Sch. 2011;78(1):13-21.


Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.

Fukuda T, Tokunaga A, Sakamoto R, Yoshida N.

Mol Cell Neurosci. 2011 Mar;46(3):614-24. doi: 10.1016/j.mcn.2011.01.001. Epub 2011 Jan 8.


T tube drainage for spontaneous perforation of the extrahepatic bile duct.

Mizutani S, Yagi A, Watanabe M, Maejima K, Komine O, Yoshino M, Ogata M, Hoshino A, Suzuki H, Tokunaga A, Uchida E.

Med Sci Monit. 2011 Jan;17(1):CS8-11.


Chemosensitivity test for 5-fluorouracil and 5-chloro-2, 4-dihydroxypyridine predicts outcome of gastric cancer patients receiving S-1 postoperatively.

Maejima K, Tokunaga A, Kiyama T, Kanno H, Bou H, Watanabe M, Suzuki H, Uchida E.

Gastric Cancer. 2010 Nov;13(4):231-7. doi: 10.1007/s10120-010-0564-1. Epub 2010 Dec 3.


Total colonoscopy detects early colorectal cancer more frequently than advanced colorectal cancer in patients with fecal occult blood.

Ozaki T, Tokunaga A, Chihara N, Yoshino M, Bou H, Ogata M, Watanabe M, Suzuki H, Uchida E.

J Nippon Med Sch. 2010 Aug;77(4):195-203.


Repeated gamma irradiation attenuates collagen-induced arthritis via up-regulation of regulatory T cells but not by damaging lymphocytes directly.

Nakatsukasa H, Tsukimoto M, Tokunaga A, Kojima S.

Radiat Res. 2010 Sep;174(3):313-24. doi: 10.1667/RR2121.1.


Involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activation.

Tokunaga A, Tsukimoto M, Harada H, Moriyama Y, Kojima S.

J Biol Chem. 2010 Jun 4;285(23):17406-16. doi: 10.1074/jbc.M110.112417. Epub 2010 Apr 9.


BMP-induced REST regulates the establishment and maintenance of astrocytic identity.

Kohyama J, Sanosaka T, Tokunaga A, Takatsuka E, Tsujimura K, Okano H, Nakashima K.

J Cell Biol. 2010 Apr 5;189(1):159-70. doi: 10.1083/jcb.200908048. Epub 2010 Mar 29.


Earth encounters as the origin of fresh surfaces on near-Earth asteroids.

Binzel RP, Morbidelli A, Merouane S, Demeo FE, Birlan M, Vernazza P, Thomas CA, Rivkin AS, Bus SJ, Tokunaga AT.

Nature. 2010 Jan 21;463(7279):331-4. doi: 10.1038/nature08709.


Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved.

Zheng L, Ishii Y, Tokunaga A, Hamashima T, Shen J, Zhao QL, Ishizawa S, Fujimori T, Nabeshima Y, Mori H, Kondo T, Sasahara M.

J Neurosci Res. 2010 May 1;88(6):1273-84. doi: 10.1002/jnr.22302.


Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves.

Yamazaki T, Sabit H, Oya T, Ishii Y, Hamashima T, Tokunaga A, Ishizawa S, Jie S, Kurashige Y, Matsushima T, Furuta I, Noguchi M, Sasahara M.

J Peripher Nerv Syst. 2009 Sep;14(3):165-76. doi: 10.1111/j.1529-8027.2009.00228.x.


Novel PCR-based genotyping method, using genomic variability between repetitive sequences of toxigenic Vibrio cholerae O1 El Tor and O139.

Tokunaga A, Yamaguchi H, Morita M, Arakawa E, Izumiya H, Watanabe H, Osawa R.

Mol Cell Probes. 2010 Apr;24(2):99-103. doi: 10.1016/j.mcp.2009.11.002. Epub 2009 Nov 10.


Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation.

Shibayama M, Ohno S, Osaka T, Sakamoto R, Tokunaga A, Nakatake Y, Sato M, Yoshida N.

FEBS J. 2009 Nov;276(22):6658-68. doi: 10.1111/j.1742-4658.2009.07380.x. Epub 2009 Oct 16.


A case of giant mucinous cystic neoplasm of the pancreas resected with laparoscopic surgery.

Mizutani S, Nakamura Y, Ogata M, Watanabe M, Tokunaga A, Tajiri T.

J Nippon Med Sch. 2009 Aug;76(4):212-6.


Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1.

Murata J, Ohtsuka T, Tokunaga A, Nishiike S, Inohara H, Okano H, Kageyama R.

J Neurosci Res. 2009 Dec;87(16):3521-34. doi: 10.1002/jnr.22169.


Mutations in the mitochondrial genome confer resistance of cancer cells to anticancer drugs.

Mizutani S, Miyato Y, Shidara Y, Asoh S, Tokunaga A, Tajiri T, Ohta S.

Cancer Sci. 2009 Sep;100(9):1680-7. doi: 10.1111/j.1349-7006.2009.01238.x. Epub 2009 Jun 1.

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