Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 125

1.

Hepatocyte Elovl6 determines ceramide acyl-chain length and hepatic insulin sensitivity in mice.

Matsuzaka T, Kuba M, Koyasu S, Yamamoto Y, Motomura K, Arulmozhiraja S, Ohno H, Sharma R, Shimura T, Okajima Y, Han SI, Aita Y, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H.

Hepatology. 2019 Sep 17. doi: 10.1002/hep.30953. [Epub ahead of print]

PMID:
31529722
2.

Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening.

Yamada S, Kawasaki M, Fujihara M, Watanabe M, Takamura Y, Takioku M, Nishioka H, Takeuchi Y, Makishima M, Motoyama T, Ito S, Tokiwa H, Nakano S, Kakuta H.

J Med Chem. 2019 Oct 10;62(19):8809-8818. doi: 10.1021/acs.jmedchem.9b00995. Epub 2019 Sep 18.

PMID:
31483660
3.

Total Synthesis of Termicalcicolanone A via Organocatalysis and Regioselective Claisen Rearrangement.

Ito S, Kitamura T, Arulmozhiraja S, Manabe K, Tokiwa H, Suzuki Y.

Org Lett. 2019 Apr 19;21(8):2777-2781. doi: 10.1021/acs.orglett.9b00731. Epub 2019 Apr 8.

PMID:
30958681
4.

Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα).

Miyashita Y, Numoto N, Arulmozhiraja S, Nakano S, Matsuo N, Shimizu K, Shibahara O, Fujihara M, Kakuta H, Ito S, Ikura T, Ito N, Tokiwa H.

FEBS Lett. 2019 Jan;593(2):242-250. doi: 10.1002/1873-3468.13301. Epub 2018 Dec 21.

PMID:
30565665
5.

Development of an Analysis Toolkit, AnalysisFMO, to Visualize Interaction Energies Generated by Fragment Molecular Orbital Calculations.

Tokiwa T, Nakano S, Yamamoto Y, Ishikawa T, Ito S, Sladek V, Fukuzawa K, Mochizuki Y, Tokiwa H, Misaizu F, Shigeta Y.

J Chem Inf Model. 2019 Jan 28;59(1):25-30. doi: 10.1021/acs.jcim.8b00649. Epub 2018 Dec 20.

PMID:
30517784
6.

Protein Residue Networks from Energetic and Geometric Data: Are They Identical?

Sladek V, Tokiwa H, Shimano H, Shigeta Y.

J Chem Theory Comput. 2018 Dec 11;14(12):6623-6631. doi: 10.1021/acs.jctc.8b00733. Epub 2018 Nov 30.

PMID:
30500196
7.

25 S-Adamantyl-23-yne-26,27-dinor-1α,25-dihydroxyvitamin D3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex.

Otero R, Ishizawa M, Numoto N, Ikura T, Ito N, Tokiwa H, Mouriño A, Makishima M, Yamada S.

J Med Chem. 2018 Aug 9;61(15):6658-6673. doi: 10.1021/acs.jmedchem.8b00427. Epub 2018 Jul 23.

PMID:
29989817
8.

Benchmark Analysis of Native and Artificial NAD+-Dependent Enzymes Generated by a Sequence-Based Design Method with or without Phylogenetic Data.

Nakano S, Motoyama T, Miyashita Y, Ishizuka Y, Matsuo N, Tokiwa H, Shinoda S, Asano Y, Ito S.

Biochemistry. 2018 Jul 3;57(26):3722-3732. doi: 10.1021/acs.biochem.8b00339. Epub 2018 Jun 4.

9.

Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα.

Yamamoto Y, Takei K, Arulmozhiraja S, Sladek V, Matsuo N, Han SI, Matsuzaka T, Sekiya M, Tokiwa T, Shoji M, Shigeta Y, Nakagawa Y, Tokiwa H, Shimano H.

Biochem Biophys Res Commun. 2018 May 5;499(2):239-245. doi: 10.1016/j.bbrc.2018.03.135. Epub 2018 Mar 22.

PMID:
29567478
10.

Product Release Mechanism Associated with Structural Changes in Monomeric l-Threonine 3-Dehydrogenase.

Motoyama T, Nakano S, Yamamoto Y, Tokiwa H, Asano Y, Ito S.

Biochemistry. 2017 Oct 31;56(43):5758-5770. doi: 10.1021/acs.biochem.7b00832. Epub 2017 Oct 19.

PMID:
28992410
11.

In silico analysis of interaction pattern switching in ligandreceptor binding in Golgi α-mannosidase II induced by the protonated states of inhibitors.

Sladek V, Kóňa J, Tokiwa H.

Phys Chem Chem Phys. 2017 May 21;19(19):12527-12537. doi: 10.1039/c7cp01200d. Epub 2017 May 4.

PMID:
28470253
12.

Comparative Binding Analysis of Dipeptidyl Peptidase IV (DPP-4) with Antidiabetic Drugs - An Ab Initio Fragment Molecular Orbital Study.

Arulmozhiraja S, Matsuo N, Ishitsubo E, Okazaki S, Shimano H, Tokiwa H.

PLoS One. 2016 Nov 10;11(11):e0166275. doi: 10.1371/journal.pone.0166275. eCollection 2016.

13.

Origin of Stereoselectivity and Substrate/Ligand Recognition in an FAD-Dependent R-Selective Amine Oxidase.

Nakano S, Yasukawa K, Tokiwa T, Ishikawa T, Ishitsubo E, Matsuo N, Ito S, Tokiwa H, Asano Y.

J Phys Chem B. 2016 Oct 20;120(41):10736-10743. doi: 10.1021/acs.jpcb.6b09328. Epub 2016 Oct 10.

PMID:
27648606
14.

A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions.

Sriwilaijaroen N, Magesh S, Imamura A, Ando H, Ishida H, Sakai M, Ishitsubo E, Hori T, Moriya S, Ishikawa T, Kuwata K, Odagiri T, Tashiro M, Hiramatsu H, Tsukamoto K, Miyagi T, Tokiwa H, Kiso M, Suzuki Y.

J Med Chem. 2016 May 26;59(10):4563-77. doi: 10.1021/acs.jmedchem.5b01863. Epub 2016 May 4.

PMID:
27095056
15.

Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds.

Watarai Y, Ishizawa M, Ikura T, Zacconi FC, Uno S, Ito N, Mouriño A, Tokiwa H, Makishima M, Yamada S.

J Med Chem. 2015 Dec 24;58(24):9510-21. doi: 10.1021/acs.jmedchem.5b00792. Epub 2015 Dec 15.

PMID:
26613420
16.

Structural and computational analysis of peptide recognition mechanism of class-C type penicillin binding protein, alkaline D-peptidase from Bacillus cereus DF4-B.

Nakano S, Okazaki S, Ishitsubo E, Kawahara N, Komeda H, Tokiwa H, Asano Y.

Sci Rep. 2015 Sep 15;5:13836. doi: 10.1038/srep13836.

17.

[Possibility of New Medicinal Chemistry Based on "Wet-Dry" Interfaced Pharmaceutical Category].

Tokiwa H.

Yakugaku Zasshi. 2015;135(9):1001-2. doi: 10.1248/yakushi.15-00175-F. Japanese. No abstract available.

18.

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells.

Suhara Y, Hirota Y, Hanada N, Nishina S, Eguchi S, Sakane R, Nakagawa K, Wada A, Takahashi K, Tokiwa H, Okano T.

J Med Chem. 2015 Sep 10;58(17):7088-92. doi: 10.1021/acs.jmedchem.5b00999. Epub 2015 Aug 31.

PMID:
26305288
19.

Anti-MRSA activity of isoplagiochin-type macrocyclic bis(bibenzyl)s is mediated through cell membrane damage.

Onoda K, Sawada H, Morita D, Fujii K, Tokiwa H, Kuroda T, Miyachi H.

Bioorg Med Chem. 2015 Jul 1;23(13):3309-16. doi: 10.1016/j.bmc.2015.04.047. Epub 2015 May 6.

PMID:
25999206
20.

The main occluding area in normal occlusion and mandibular prognathism.

Kurokawa M, Kanzaki H, Tokiwa H, Handa H, Nakaoka K, Hamada Y, Kato H, Nakamura Y.

Angle Orthod. 2016 Jan;86(1):87-93. doi: 10.2319/111114-807.1. Epub 2015 Apr 22.

PMID:
25902183
21.

Amino acid substitutions contributing to α2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase.

Fukushima K, Takahashi T, Ueyama H, Takaguchi M, Ito S, Oishi K, Minami A, Ishitsubo E, Tokiwa H, Takimoto T, Suzuki T.

FEBS Lett. 2015 May 8;589(11):1278-82. doi: 10.1016/j.febslet.2015.03.036. Epub 2015 Apr 11.

22.

RXR partial agonist produced by side chain repositioning of alkoxy RXR full agonist retains antitype 2 diabetes activity without the adverse effects.

Kawata K, Morishita K, Nakayama M, Yamada S, Kobayashi T, Furusawa Y, Arimoto-Kobayashi S, Oohashi T, Makishima M, Naitou H, Ishitsubo E, Tokiwa H, Tai A, Kakuta H.

J Med Chem. 2015 Jan 22;58(2):912-26. doi: 10.1021/jm501863r. Epub 2014 Dec 17.

PMID:
25486327
23.

Trifluoromethanesulfonyloxy-group-directed regioselective (3 + 2) cycloadditions of benzynes for the synthesis of functionalized benzo-fused heterocycles.

Ikawa T, Kaneko H, Masuda S, Ishitsubo E, Tokiwa H, Akai S.

Org Biomol Chem. 2015 Jan 14;13(2):520-6. doi: 10.1039/c4ob01627k.

PMID:
25378144
24.

Molecular dynamics study-guided identification of cyclic amine structures as novel hydrophobic tail components of hPPARγ agonists.

Tanaka Y, Gamo K, Oyama T, Ohashi M, Waki M, Matsuno K, Matsuura N, Tokiwa H, Miyachi H.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):4001-5. doi: 10.1016/j.bmcl.2014.06.023. Epub 2014 Jun 24.

PMID:
25017035
25.

Computational design of a sulfoglucuronide derivative fitting into a hydrophobic pocket of dengue virus E protein.

Abe T, Sando A, Teraoka F, Otsubo T, Morita K, Tokiwa H, Ikeda K, Suzuki T, Hidari KI.

Biochem Biophys Res Commun. 2014 Jun 20;449(1):32-7. doi: 10.1016/j.bbrc.2014.04.122. Epub 2014 May 2.

PMID:
24796674
26.

Combination of triple bond and adamantane ring on the vitamin D side chain produced partial agonists for vitamin D receptor.

Kudo T, Ishizawa M, Maekawa K, Nakabayashi M, Watarai Y, Uchida H, Tokiwa H, Ikura T, Ito N, Makishima M, Yamada S.

J Med Chem. 2014 May 22;57(10):4073-87. doi: 10.1021/jm401989c. Epub 2014 May 7.

PMID:
24773565
27.

Binding of NAD+ and L-threonine induces stepwise structural and flexibility changes in Cupriavidus necator L-threonine dehydrogenase.

Nakano S, Okazaki S, Tokiwa H, Asano Y.

J Biol Chem. 2014 Apr 11;289(15):10445-54. doi: 10.1074/jbc.M113.540773. Epub 2014 Feb 20.

28.

Structure-anti-MRSA activity relationship of macrocyclic bis(bibenzyl) derivatives.

Sawada H, Onoda K, Morita D, Ishitsubo E, Matsuno K, Tokiwa H, Kuroda T, Miyachi H.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6563-8. doi: 10.1016/j.bmcl.2013.10.069. Epub 2013 Nov 6.

PMID:
24239015
29.

Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands.

Nakabayashi M, Tsukahara Y, Iwasaki-Miyamoto Y, Mihori-Shimazaki M, Yamada S, Inaba S, Oda M, Shimizu M, Makishima M, Tokiwa H, Ikura T, Ito N.

J Med Chem. 2013 Sep 12;56(17):6745-60. doi: 10.1021/jm400537h. Epub 2013 Aug 29.

PMID:
23944708
30.

Catalytic preference of Salmonella typhimurium LT2 sialidase for N-acetylneuraminic acid residues over N-glycolylneuraminic acid residues.

Minami A, Ishibashi S, Ikeda K, Ishitsubo E, Hori T, Tokiwa H, Taguchi R, Ieno D, Otsubo T, Matsuda Y, Sai S, Inada M, Suzuki T.

FEBS Open Bio. 2013 May 29;3:231-6. doi: 10.1016/j.fob.2013.05.002. Print 2013.

31.

Reconstruction of a collapsed dental arch in a patient with severe periodontitis.

Nakamura Y, Gomi K, Oikawa T, Tokiwa H, Sekiya T.

Am J Orthod Dentofacial Orthop. 2013 May;143(5):704-12. doi: 10.1016/j.ajodo.2012.04.025.

PMID:
23631972
32.

Regiocomplementary cycloaddition reactions of boryl- and silylbenzynes with 1,3-dipoles: selective synthesis of benzo-fused azole derivatives.

Ikawa T, Takagi A, Goto M, Aoyama Y, Ishikawa Y, Itoh Y, Fujii S, Tokiwa H, Akai S.

J Org Chem. 2013 Apr 5;78(7):2965-83. doi: 10.1021/jo302802b. Epub 2013 Mar 8.

PMID:
23428206
33.

Novel homodimer model of the β-adrenergic receptor in complex with free fatty acids and cholesterol: first-principles calculation studies.

Nakano Y, Watanabe Y, Ito Y, Yamada S, Tokiwa H.

Bioinformation. 2012;8(25):1245-8. doi: 10.6026/97320630081245. Epub 2012 Dec 19.

34.

[Structure-activity relationship of novel vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists].

Suhara Y, Motoyoshi S, Hirota Y, Sawada N, Nakagawa K, Tokiwa H, Okano T.

Yakugaku Zasshi. 2012;132(8):881-6. Review. Japanese.

35.

[Modern chemistry & multiscale simulations that support current drug design].

Tokiwa H.

Yakugaku Zasshi. 2012;132(8):861-2. Japanese. No abstract available.

36.

3-O-sulfated glucuronide derivative as a potential anti-dengue virus agent.

Hidari KI, Ikeda K, Watanabe I, Abe T, Sando A, Itoh Y, Tokiwa H, Morita K, Suzuki T.

Biochem Biophys Res Commun. 2012 Aug 3;424(3):573-8. doi: 10.1016/j.bbrc.2012.07.002. Epub 2012 Jul 7.

PMID:
22776202
37.

Origin of the inhibitory activity of 4-O-substituted sialic derivatives of human parainfluenza virus.

Itoh Y, Sando A, Ikeda K, Suzuki T, Tokiwa H.

Glycoconj J. 2012 May;29(4):231-7. doi: 10.1007/s10719-012-9384-3. Epub 2012 May 13.

PMID:
22581169
38.

Differential expression and function of alternative splicing variants of human liver X receptor α.

Endo-Umeda K, Uno S, Fujimori K, Naito Y, Saito K, Yamagishi K, Jeong Y, Miyachi H, Tokiwa H, Yamada S, Makishima M.

Mol Pharmacol. 2012 Jun;81(6):800-10. doi: 10.1124/mol.111.077206. Epub 2012 Mar 7.

PMID:
22399489
39.

Structure-activity relationship of novel menaquinone-4 analogues: modification of the side chain affects their biological activities.

Suhara Y, Hanada N, Okitsu T, Sakai M, Watanabe M, Nakagawa K, Wada A, Takeda K, Takahashi K, Tokiwa H, Okano T.

J Med Chem. 2012 Feb 23;55(4):1553-8. doi: 10.1021/jm2013166. Epub 2012 Feb 7.

PMID:
22250752
40.

[Current trends of theoretical and medicinal chemistry. Foreword].

Tokiwa H.

Yakugaku Zasshi. 2011;131(8):1149-50. Japanese. No abstract available.

41.

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: insights into the biological role of the side chain part of vitamin K.

Suhara Y, Watanabe M, Motoyoshi S, Nakagawa K, Wada A, Takeda K, Takahashi K, Tokiwa H, Okano T.

J Med Chem. 2011 Jul 14;54(13):4918-22. doi: 10.1021/jm200201k. Epub 2011 Jun 20.

PMID:
21618996
42.

Flexible ligand recognition of peroxisome proliferator-activated receptor-gamma (PPARgamma).

Yamagishi K, Yamamoto K, Mochizuki Y, Nakano T, Yamada S, Tokiwa H.

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3344-7. doi: 10.1016/j.bmcl.2010.04.031. Epub 2010 Apr 14.

PMID:
20444603
43.

Ligand-dependent conformation change reflects steric structure and interactions of a vitamin D receptor/ligand complex: a fragment molecular orbital study.

Motoyoshi S, Yamagishi K, Yamada S, Tokiwa H.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):56-9. doi: 10.1016/j.jsbmb.2010.03.024. Epub 2010 Mar 15.

PMID:
20236615
44.

Interactions between 1alpha,25(OH)2D3 and residues in the ligand-binding pocket of the vitamin D receptor: a correlated fragment molecular orbital study.

Yamagishi K, Tokiwa H, Makishima M, Yamada S.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):63-7. doi: 10.1016/j.jsbmb.2010.03.028. Epub 2010 Mar 15.

PMID:
20236613
45.

Anatomical location of various condylar points for jaw movement analysis in Japanese women.

Tokiwa H, Nakazawa F, Ozaki M, Nakamura Y.

J Oral Rehabil. 2010 Apr;37(4):235-41. doi: 10.1111/j.1365-2842.2009.02049.x. Epub 2010 Jan 13.

PMID:
20074118
46.

Crystal structures of rat vitamin D receptor bound to adamantyl vitamin D analogs: structural basis for vitamin D receptor antagonism and partial agonism.

Nakabayashi M, Yamada S, Yoshimoto N, Tanaka T, Igarashi M, Ikura T, Ito N, Makishima M, Tokiwa H, DeLuca HF, Shimizu M.

J Med Chem. 2008 Sep 11;51(17):5320-9. doi: 10.1021/jm8004477. Epub 2008 Aug 19.

PMID:
18710208
47.

Ab initio fragment molecular orbital studies of influenza virus hemagglutinin-sialosaccharide complexes toward chemical clarification about the virus host range determination.

Sawada T, Hashimoto T, Tokiwa H, Suzuki T, Nakano H, Ishida H, Kiso M, Suzuki Y.

Glycoconj J. 2008 Dec;25(9):805-15. doi: 10.1007/s10719-008-9141-9. Epub 2008 Jun 24.

PMID:
18574690
48.

Ab initio fragment molecular orbital study of ligand binding to human progesterone receptor ligand-binding domain.

Harada T, Yamagishi K, Nakano T, Kitaura K, Tokiwa H.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):607-15. doi: 10.1007/s00210-008-0268-9. Epub 2008 Mar 11.

PMID:
18330543
49.

Ab initio base fragment molecular orbital studies of influenza viral hemagglutinin HA1 full-domains in complex with sialoside receptors.

Sawada T, Hashimoto T, Tokiwa H, Suzuki T, Nakano H, Ishida H, Kiso M, Suzuki Y.

J Mol Genet Med. 2008 Nov 26;3(1):133-42.

50.

A major factor in gravitropism in radish hypocotyls is the suppression of growth on the upper side of hypocotyls.

Tokiwa H, Hasegawa T, Yamada K, Shigemori H, Hasegawa K.

J Plant Physiol. 2006 Dec;163(12):1267-72. Epub 2005 Nov 17.

PMID:
17126730

Supplemental Content

Loading ...
Support Center