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Items: 36

1.

Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression.

Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K.

Sci Transl Med. 2018 Sep 12;10(458). pii: eaan0724. doi: 10.1126/scitranslmed.aan0724.

PMID:
30209242
2.

X-ray diffraction imaging of cardiac cells and tissue.

Nicolas JD, Bernhardt M, Schlick SF, Tiburcy M, Zimmermann WH, Khan A, Markus A, Alves F, Toischer K, Salditt T.

Prog Biophys Mol Biol. 2018 Jun 15. pii: S0079-6107(18)30064-6. doi: 10.1016/j.pbiomolbio.2018.05.012. [Epub ahead of print]

3.

A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.

Iyer LM, Nagarajan S, Woelfer M, Schoger E, Khadjeh S, Zafiriou MP, Kari V, Herting J, Pang ST, Weber T, Rathjens FS, Fischer TH, Toischer K, Hasenfuss G, Noack C, Johnsen SA, Zelarayán LC.

Nucleic Acids Res. 2018 Apr 6;46(6):2850-2867. doi: 10.1093/nar/gky049.

4.

T helper cells with specificity for an antigen in cardiomyocytes promote pressure overload-induced progression from hypertrophy to heart failure.

Gröschel C, Sasse A, Röhrborn C, Monecke S, Didié M, Elsner L, Kruse V, Bunt G, Lichtman AH, Toischer K, Zimmermann WH, Hasenfuß G, Dressel R.

Sci Rep. 2017 Nov 22;7(1):15998. doi: 10.1038/s41598-017-16147-1.

5.

The contractile adaption to preload depends on the amount of afterload.

Schotola H, Sossalla ST, Renner A, Gummert J, Danner BC, Schott P, Toischer K.

ESC Heart Fail. 2017 Nov;4(4):468-478. doi: 10.1002/ehf2.12164. Epub 2017 Apr 19.

6.

Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload.

Toischer K, Zhu W, Hünlich M, Mohamed BA, Khadjeh S, Reuter SP, Schäfer K, Ramanujam D, Engelhardt S, Field LJ, Hasenfuss G.

J Clin Invest. 2017 Dec 1;127(12):4285-4296. doi: 10.1172/JCI81870. Epub 2017 Oct 30.

7.

Echocardiographic evaluation of diastolic function in mouse models of heart disease.

Schnelle M, Catibog N, Zhang M, Nabeebaccus AA, Anderson G, Richards DA, Sawyer G, Zhang X, Toischer K, Hasenfuss G, Monaghan MJ, Shah AM.

J Mol Cell Cardiol. 2018 Jan;114:20-28. doi: 10.1016/j.yjmcc.2017.10.006. Epub 2017 Oct 19.

8.

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.

Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake LW, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH.

Circulation. 2017 May 9;135(19):1832-1847. doi: 10.1161/CIRCULATIONAHA.116.024145. Epub 2017 Feb 6.

9.

Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival.

Volland C, Bremer S, Hellenkamp K, Hartmann N, Dybkova N, Khadjeh S, Kutschenko A, Liebetanz D, Wagner S, Unsöld B, Didié M, Toischer K, Sossalla S, Hasenfuß G, Seidler T.

Sci Rep. 2016 Sep 26;6:33853. doi: 10.1038/srep33853.

10.

Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure.

Haddad S, Wang Y, Galy B, Korf-Klingebiel M, Hirsch V, Baru AM, Rostami F, Reboll MR, Heineke J, Flögel U, Groos S, Renner A, Toischer K, Zimmermann F, Engeli S, Jordan J, Bauersachs J, Hentze MW, Wollert KC, Kempf T.

Eur Heart J. 2017 Feb 1;38(5):362-372. doi: 10.1093/eurheartj/ehw333.

PMID:
27545647
11.

Proteomic analysis of short-term preload-induced eccentric cardiac hypertrophy.

Mohamed BA, Asif AR, Schnelle M, Qasim M, Khadjeh S, Lbik D, Schott P, Hasenfuss G, Toischer K.

J Transl Med. 2016 May 27;14(1):149. doi: 10.1186/s12967-016-0898-5.

12.

Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome.

Dudek J, Cheng IF, Chowdhury A, Wozny K, Balleininger M, Reinhold R, Grunau S, Callegari S, Toischer K, Wanders RJ, Hasenfuß G, Brügger B, Guan K, Rehling P.

EMBO Mol Med. 2016 Feb 1;8(2):139-54. doi: 10.15252/emmm.201505644.

13.

Molecular and structural transition mechanisms in long-term volume overload.

Mohamed BA, Schnelle M, Khadjeh S, Lbik D, Herwig M, Linke WA, Hasenfuss G, Toischer K.

Eur J Heart Fail. 2016 Apr;18(4):362-71. doi: 10.1002/ejhf.465. Epub 2015 Dec 23.

14.

Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload.

Montes-Cobos E, Li X, Fischer HJ, Sasse A, Kügler S, Didié M, Toischer K, Fassnacht M, Dressel R, Reichardt HM.

PLoS One. 2015 Nov 25;10(11):e0143954. doi: 10.1371/journal.pone.0143954. eCollection 2015.

15.

p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts.

Ongherth A, Pasch S, Wuertz CM, Nowak K, Kittana N, Weis CA, Jatho A, Vettel C, Tiburcy M, Toischer K, Hasenfuss G, Zimmermann WH, Wieland T, Lutz S.

J Mol Cell Cardiol. 2015 Nov;88:39-54. doi: 10.1016/j.yjmcc.2015.09.009. Epub 2015 Sep 21.

PMID:
26392029
16.

Effects of ranolazine on torsades de pointes tachycardias in a healthy isolated rabbit heart model.

Sossalla S, Wallisch N, Toischer K, Sohns C, Vollmann D, Seegers J, Lüthje L, Maier LS, Zabel M.

Cardiovasc Ther. 2014 Aug;32(4):170-7. doi: 10.1111/1755-5922.12078.

17.

Genetic background defines the regulation of postnatal cardiac growth by 17β-estradiol through a β-catenin mechanism.

Kararigas G, Nguyen BT, Zelarayan LC, Hassenpflug M, Toischer K, Sanchez-Ruderisch H, Hasenfuss G, Bergmann MW, Jarry H, Regitz-Zagrosek V.

Endocrinology. 2014 Jul;155(7):2667-76. doi: 10.1210/en.2013-2180. Epub 2014 Apr 14.

PMID:
24731099
18.

Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology.

Fischer TH, Herting J, Tirilomis T, Renner A, Neef S, Toischer K, Ellenberger D, Förster A, Schmitto JD, Gummert J, Schöndube FA, Hasenfuss G, Maier LS, Sossalla S.

Circulation. 2013 Aug 27;128(9):970-81. doi: 10.1161/CIRCULATIONAHA.113.001746. Epub 2013 Jul 19.

PMID:
23877259
19.

Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease.

Toischer K, Hartmann N, Wagner S, Fischer TH, Herting J, Danner BC, Sag CM, Hund TJ, Mohler PJ, Belardinelli L, Hasenfuss G, Maier LS, Sossalla S.

J Mol Cell Cardiol. 2013 Aug;61:111-22. doi: 10.1016/j.yjmcc.2013.03.021. Epub 2013 Apr 6.

20.

Regulation of cyclic adenosine monophosphate release by selective β2-adrenergic receptor stimulation in human terminal failing myocardium before and after ventricular assist device support.

Kassner A, Toischer K, Bohms B, Kolkhof P, Abraham G, Hasenfuβ G, Morshuis M, Schulte Eistrup S, El-Banayosy A, Gummert J, Milting H.

J Heart Lung Transplant. 2012 Oct;31(10):1127-35. doi: 10.1016/j.healun.2012.07.005.

PMID:
22975104
21.

Mild metabolic acidosis impairs the β-adrenergic response in isolated human failing myocardium.

Schotola H, Toischer K, Popov AF, Renner A, Schmitto JD, Gummert J, Quintel M, Bauer M, Maier LS, Sossalla S.

Crit Care. 2012 Aug 13;16(4):R153. doi: 10.1186/cc11468.

22.

Mechanical load-dependent cardiac ER stress in vitro and in vivo: effects of preload and afterload.

Toischer K, Kochhäuser S, Nguyen van P, Leineweber K, Hasenfuss G, Kögler H.

FEBS Lett. 2012 May 7;586(9):1363-9. doi: 10.1016/j.febslet.2012.03.055. Epub 2012 Apr 12.

23.

Influence of mild metabolic acidosis on cardiac contractility and isoprenaline response in isolated ovine myocardium.

Schotola H, Sossalla S, Rajab TK, Toischer K, Quintel M, Bauer M, Schmitto JD.

Artif Organs. 2011 Nov;35(11):1065-74. doi: 10.1111/j.1525-1594.2011.01390.x.

PMID:
22097981
24.

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.

Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR.

Circ Res. 2011 Sep 16;109(7):758-69. doi: 10.1161/CIRCRESAHA.111.245787. Epub 2011 Jul 28.

25.

Effects of different proton pump inhibitors on cardiac contractility in isolated human failing myocardium.

Sossalla S, Schotola H, Schmitto J, Toischer K, Sohns C, Schwörer H, Hasenfuss G, Maier L, Schillinger W.

J Cardiovasc Surg (Torino). 2011 Jun;52(3):437-44.

PMID:
21577199
26.

Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo.

Grebe C, Klingebiel TM, Grau SP, Toischer K, Didié M, Jacobshagen C, Dullin C, Hasenfuss G, Seidler T.

Cardiovasc Res. 2011 Jun 1;90(3):521-8. doi: 10.1093/cvr/cvr023. Epub 2011 Jan 27.

PMID:
21273244
27.

Differential cardiac remodeling in preload versus afterload.

Toischer K, Rokita AG, Unsöld B, Zhu W, Kararigas G, Sossalla S, Reuter SP, Becker A, Teucher N, Seidler T, Grebe C, Preuss L, Gupta SN, Schmidt K, Lehnart SE, Krüger M, Linke WA, Backs J, Regitz-Zagrosek V, Schäfer K, Field LJ, Maier LS, Hasenfuss G.

Circulation. 2010 Sep 7;122(10):993-1003. doi: 10.1161/CIRCULATIONAHA.110.943431. Epub 2010 Aug 23.

28.

BNP controls early load-dependent regulation of SERCA through calcineurin.

Toischer K, Teucher N, Unsöld B, Kuhn M, Kögler H, Hasenfuss G.

Basic Res Cardiol. 2010 Nov;105(6):795-804. doi: 10.1007/s00395-010-0115-2. Epub 2010 Aug 15.

29.

Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium.

Sossalla S, Kallmeyer B, Wagner S, Mazur M, Maurer U, Toischer K, Schmitto JD, Seipelt R, Schöndube FA, Hasenfuss G, Belardinelli L, Maier LS.

J Am Coll Cardiol. 2010 May 25;55(21):2330-42. doi: 10.1016/j.jacc.2009.12.055.

30.

Impaired Ca(2+)-handling in HIF-1alpha(+/-) mice as a consequence of pressure overload.

Silter M, Kögler H, Zieseniss A, Wilting J, Schäfer K, Toischer K, Rokita AG, Breves G, Maier LS, Katschinski DM.

Pflugers Arch. 2010 Mar;459(4):569-77. doi: 10.1007/s00424-009-0748-x. Epub 2009 Nov 8.

31.

Elevated afterload, neuroendocrine stimulation, and human heart failure increase BNP levels and inhibit preload-dependent SERCA upregulation.

Toischer K, Kögler H, Tenderich G, Grebe C, Seidler T, Van PN, Jung K, Knöll R, Körfer R, Hasenfuss G.

Circ Heart Fail. 2008 Nov;1(4):265-71. doi: 10.1161/CIRCHEARTFAILURE.108.785279. Epub 2008 Sep 17.

PMID:
19808301
32.

Early results of coronary artery bypass grafting with coronary endarterectomy for severe coronary artery disease.

Schmitto JD, Kolat P, Ortmann P, Popov AF, Coskun KO, Friedrich M, Sossalla S, Toischer K, Mokashi SA, Tirilomis T, Baryalei MM, Schoendube FA.

J Cardiothorac Surg. 2009 Sep 22;4:52. doi: 10.1186/1749-8090-4-52.

33.

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum.

Toischer K, Lehnart SE, Tenderich G, Milting H, Körfer R, Schmitto JD, Schöndube FA, Kaneko N, Loughrey CM, Smith GL, Hasenfuss G, Seidler T.

Basic Res Cardiol. 2010 Mar;105(2):279-87. doi: 10.1007/s00395-009-0057-8. Epub 2009 Aug 30.

34.

Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction.

Jacobshagen C, Grüber M, Teucher N, Schmidt AG, Unsöld BW, Toischer K, Nguyen VP, Maier LS, Kögler H, Hasenfuss G.

Eur J Heart Fail. 2008 Apr;10(4):334-42. doi: 10.1016/j.ejheart.2008.02.013. Epub 2008 Mar 17.

35.

Myocardial adaptation of energy metabolism to elevated preload depends on calcineurin activity : a proteomic approach.

Schott P, Asif AR, Gräf C, Toischer K, Hasenfuss G, Kögler H.

Basic Res Cardiol. 2008 May;103(3):232-43. doi: 10.1007/s00395-008-0696-1. Epub 2008 Feb 15.

36.

Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression.

Kögler H, Schott P, Toischer K, Milting H, Van PN, Kohlhaas M, Grebe C, Kassner A, Domeier E, Teucher N, Seidler T, Knöll R, Maier LS, El-Banayosy A, Körfer R, Hasenfuss G.

Circulation. 2006 Jun 13;113(23):2724-32. Epub 2006 Jun 5.

PMID:
16754798

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