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Items: 1 to 50 of 332

1.

Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals.

Kasahara T, Kubota-Sakashita M, Nagatsuka Y, Hirabayashi Y, Hanasaka T, Tohyama K, Kato T.

FASEB J. 2020 Jan;34(1):1465-1480. doi: 10.1096/fj.201901598R. Epub 2019 Dec 2.

PMID:
31914590
2.

mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.

Thumkeo D, Katsura Y, Nishimura Y, Kanchanawong P, Tohyama K, Ishizaki T, Kitajima S, Takahashi C, Hirata T, Watanabe N, Krummel MF, Narumiya S.

Sci Adv. 2020 Jan 1;6(1):eaay2432. doi: 10.1126/sciadv.aay2432. eCollection 2020 Jan.

3.

Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities.

Sato S, Tohyama K, Kosugi Y.

Eur J Pharm Sci. 2020 Jan 15;142:105119. doi: 10.1016/j.ejps.2019.105119. Epub 2019 Nov 1.

PMID:
31682973
4.

Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792.

Sasaki M, Miyahisa I, Itono S, Yashiro H, Hiyoshi H, Tsuchimori K, Hamagami KI, Moritoh Y, Watanabe M, Tohyama K, Sasaki M, Sakamoto JI, Kawamoto T.

Pharmacol Res Perspect. 2019 Sep 4;7(5):e00517. doi: 10.1002/prp2.517. eCollection 2019 Oct.

5.

[Concurrent CALR and SF3B1 gene mutations in a patient with myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis].

Nakao K, Oka S, Utsumi T, Yamada S, Kondo T, Tohyama K, Asagoe K.

Rinsho Ketsueki. 2019;60(8):915-919. doi: 10.11406/rinketsu.60.915. Japanese.

PMID:
31484889
6.

Serum ferritin levels at diagnosis predict prognosis in patients with low blast count myelodysplastic syndromes.

Kawabata H, Usuki K, Shindo-Ueda M, Kanda J, Tohyama K, Matsuda A, Araseki K, Hata T, Suzuki T, Kayano H, Shimbo K, Chiba S, Ishikawa T, Arima N, Nohgawa M, Miyazaki Y, Kurokawa M, Arai S, Mitani K, Takaori-Kondo A; Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes.

Int J Hematol. 2019 Nov;110(5):533-542. doi: 10.1007/s12185-019-02710-1. Epub 2019 Jul 29.

PMID:
31359362
7.

Binimetinib, a novel MEK1/2 inhibitor, exerts anti-leukemic effects under inactive status of PI3Kinase/Akt pathway.

Sakakibara K, Tsujioka T, Kida JI, Kurozumi N, Nakahara T, Suemori SI, Kitanaka A, Arao Y, Tohyama K.

Int J Hematol. 2019 Aug;110(2):213-227. doi: 10.1007/s12185-019-02667-1. Epub 2019 May 25.

PMID:
31129802
8.

The augmented expression of the cytidine deaminase gene by 5-azacytidine predicts therapeutic efficacy in myelodysplastic syndromes.

Murakami Y, Kimura Y, Kawahara A, Mitsuyasu S, Miyake H, Tohyama K, Endo Y, Yoshida N, Imamura Y, Watari K, Ono M, Okamura T, Kuwano M.

Oncotarget. 2019 Mar 19;10(23):2270-2281. doi: 10.18632/oncotarget.26784. eCollection 2019 Mar 19.

9.

Relationship of MATE1 Inhibition and Cytotoxicity in Nephrotoxicity: Application for Safety Evaluation in Early Drug Discovery.

Tohyama K, Chisaki I, Takai Y, Handa Y, Miyamoto M, Amano N.

Toxicol Sci. 2019 Jul 1;170(1):223-233. doi: 10.1093/toxsci/kfz093.

PMID:
31020312
10.

Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys.

Iwasaki S, Yamamoto S, Sano N, Tohyama K, Kosugi Y, Furuta A, Hamada T, Igari T, Fujioka Y, Hirabayashi H, Amano N.

Pharm Res. 2019 Apr 1;36(5):76. doi: 10.1007/s11095-019-2613-8.

PMID:
30937626
11.

Improvement of pulmonary arterial hypertension, inflammatory response, and epithelium injury by dual activation of cAMP/cGMP pathway in a rat model of monocrotaline-induced pulmonary hypertension.

Muraki Y, Naito T, Tohyama K, Shibata S, Kuniyeda K, Nio Y, Hazama M, Matsuo T.

Biosci Biotechnol Biochem. 2019 Jun;83(6):1000-1010. doi: 10.1080/09168451.2019.1584520. Epub 2019 Mar 5.

PMID:
30835622
12.

Mechanostress resistance involving formin homology proteins: G- and F-actin homeostasis-driven filament nucleation and helical polymerization-mediated actin polymer stabilization.

Watanabe N, Tohyama K, Yamashiro S.

Biochem Biophys Res Commun. 2018 Nov 25;506(2):323-329. doi: 10.1016/j.bbrc.2018.09.189. Epub 2018 Oct 9. Review.

PMID:
30309655
13.

KIF20A, highly expressed in immature hematopoietic cells, supports the growth of HL60 cell line.

Morita H, Matsuoka A, Kida JI, Tabata H, Tohyama K, Tohyama Y.

Int J Hematol. 2018 Dec;108(6):607-614. doi: 10.1007/s12185-018-2527-y. Epub 2018 Sep 4.

PMID:
30182171
14.

Cathepsin C modulates myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.

Durose WW, Shimizu T, Li J, Abe M, Sakimura K, Chetsawang B, Tanaka KF, Suzumura A, Tohyama K, Ikenaka K.

J Neurochem. 2019 Feb;148(3):413-425. doi: 10.1111/jnc.14581. Epub 2018 Dec 3.

PMID:
30152001
15.

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.

Sun J, He X, Zhu Y, Ding Z, Dong H, Feng Y, Du J, Wang H, Wu X, Zhang L, Yu X, Lin A, McDonald T, Zhao D, Wu H, Hua WK, Zhang B, Feng L, Tohyama K, Bhatia R, Oberdoerffer P, Chung YJ, Aplan PD, Boultwood J, Pellagatti A, Khaled S, Kortylewski M, Pichiorri F, Kuo YH, Carlesso N, Marcucci G, Jin H, Li L.

Cell Stem Cell. 2018 Sep 6;23(3):355-369.e9. doi: 10.1016/j.stem.2018.07.018. Epub 2018 Aug 23.

16.

An MDS-derived cell line and a series of its sublines serve as an in vitro model for the leukemic evolution of MDS.

Kida JI, Tsujioka T, Suemori SI, Okamoto S, Sakakibara K, Takahata T, Yamauchi T, Kitanaka A, Tohyama Y, Tohyama K.

Leukemia. 2018 Aug;32(8):1846-1850. doi: 10.1038/s41375-018-0189-7. Epub 2018 Jun 28. No abstract available.

PMID:
29955132
17.

Phosphodiesterase 4 inhibition reduces lung fibrosis following targeted type II alveolar epithelial cell injury.

Sisson TH, Christensen PJ, Muraki Y, Dils AJ, Chibucos L, Subbotina N, Tohyama K, Horowitz JC, Matsuo T, Bailie M, Nikam S, Hazama M.

Physiol Rep. 2018 Jun;6(12):e13753. doi: 10.14814/phy2.13753.

18.

Utility of a Fluorescence Microscopy Imaging System for Analyzing the DNA Ploidy of Pathological Megakaryocytes Including 5q- Syndrome.

Nakahara T, Suemori S, Tsujioka T, Kataoka M, Kataoka H, Shibakura M, Tohyama K.

Acta Med Okayama. 2018 Jun;72(3):249-256. doi: 10.18926/AMO/56070.

19.

Interobserver concordance of assessments of dysplasia and blast counts for the diagnosis of patients with cytopenia: From the Japanese central review study.

Matsuda A, Kawabata H, Tohyama K, Maeda T, Araseki K, Hata T, Suzuki T, Kayano H, Shimbo K, Usuki K, Chiba S, Ishikawa T, Arima N, Nohgawa M, Ohta A, Miyazaki Y, Nakao S, Ozawa K, Arai S, Kurokawa M, Mitani K, Takaori-Kondo A; Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes.

Leuk Res. 2018 Nov;74:137-143. doi: 10.1016/j.leukres.2018.06.003. Epub 2018 Jun 7.

PMID:
29914726
20.

Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium.

Evers R, Piquette-Miller M, Polli JW, Russel FGM, Sprowl JA, Tohyama K, Ware JA, de Wildt SN, Xie W, Brouwer KLR; International Transporter Consortium.

Clin Pharmacol Ther. 2018 Nov;104(5):900-915. doi: 10.1002/cpt.1115. Epub 2018 Jul 12.

22.

Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment.

Matsumoto N, Sekiya M, Tohyama K, Ishiyama-Matsuura E, Sun-Wada GH, Wada Y, Futai M, Nakanishi-Matsui M.

Sci Rep. 2018 Apr 30;8(1):6701. doi: 10.1038/s41598-018-24918-7.

23.

Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning.

Sano T, Kohyama-Koganeya A, Kinoshita MO, Tatsukawa T, Shimizu C, Oshima E, Yamada K, Le TD, Akagi T, Tohyama K, Nagao S, Hirabayashi Y.

Neurosci Res. 2018 Nov;136:33-47. doi: 10.1016/j.neures.2018.02.006. Epub 2018 Feb 23.

PMID:
29481883
24.

Combination effects of alogliptin and pioglitazone on steatosis and hepatic fibrosis formation in a mouse model of non-alcoholic steatohepatitis.

Amano Y, Tsuchiya S, Imai M, Tohyama K, Matsukawa J, Isono O, Yasuno H, Enya K, Koumura E, Nagabukuro H.

Biochem Biophys Res Commun. 2018 Feb 26;497(1):207-213. doi: 10.1016/j.bbrc.2018.02.055. Epub 2018 Feb 9.

PMID:
29428719
25.

Pre-clinical Characterization of Absorption, Distribution, Metabolism and Excretion Properties of TAK-063.

Tohyama K, Sudo M, Morohashi A, Kato S, Takahashi J, Tagawa Y.

Basic Clin Pharmacol Toxicol. 2018 Jun;122(6):577-587. doi: 10.1111/bcpt.12964. Epub 2018 Feb 26.

26.

Fluorescent Imaging Analysis for Distribution of Fluorescent Dye Labeled- or Encapsulated-Liposome in Monocrotaline-Induced Pulmonary Hypertension Model Rat.

Muraki Y, Yamasaki M, Takeuchi H, Tohyama K, Sano N, Matsuo T.

Chem Pharm Bull (Tokyo). 2018 Mar 1;66(3):270-276. doi: 10.1248/cpb.c17-00811. Epub 2018 Jan 6.

27.

Mechanism for Covalent Binding of MLN3126, an Oral Chemokine C-C Motif Receptor 9 Antagonist, to Serum Albumins.

Narita N, Morohashi A, Tohyama K, Takeuchi T, Tagawa Y, Kondo T, Asahi S.

Drug Metab Dispos. 2018 Mar;46(3):204-213. doi: 10.1124/dmd.117.078782. Epub 2017 Dec 21.

PMID:
29269409
28.

Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A.

Oben KZ, Alhakeem SS, McKenna MK, Brandon JA, Mani R, Noothi SK, Jinpeng L, Akunuru S, Dhar SK, Singh IP, Liang Y, Wang C, Abdel-Latif A, Stills HF Jr, St Clair DK, Geiger H, Muthusamy N, Tohyama K, Gupta RC, Bondada S.

Oncotarget. 2017 Aug 24;8(44):77436-77452. doi: 10.18632/oncotarget.20497. eCollection 2017 Sep 29.

29.

Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available Δ-5 Desaturase (D5D) Inhibitors.

Fujimoto J, Okamoto R, Noguchi N, Hara R, Masada S, Kawamoto T, Nagase H, Tamura YO, Imanishi M, Takagahara S, Kubo K, Tohyama K, Iida K, Andou T, Miyahisa I, Matsui J, Hayashi R, Maekawa T, Matsunaga N.

J Med Chem. 2017 Nov 9;60(21):8963-8981. doi: 10.1021/acs.jmedchem.7b01210. Epub 2017 Oct 31.

PMID:
29023121
30.

Serum gamma-glutamyltransferase is inversely associated with dietary total and coffee-derived polyphenol intakes in apparently healthy Japanese men.

Taguchi C, Kishimoto Y, Kondo K, Tohyama K, Goda T.

Eur J Nutr. 2018 Dec;57(8):2819-2826. doi: 10.1007/s00394-017-1549-1. Epub 2017 Oct 7.

PMID:
28988315
31.

A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study).

Kobayashi T, Nannya Y, Ichikawa M, Oritani K, Kanakura Y, Tomita A, Kiyoi H, Kobune M, Kato J, Kawabata H, Shindo M, Torimoto Y, Yonemura Y, Hanaoka N, Nakakuma H, Hasegawa D, Manabe A, Fujishima N, Fujii N, Tanimoto M, Morita Y, Matsuda A, Fujieda A, Katayama N, Ohashi H, Nagai H, Terada Y, Hino M, Sato K, Obara N, Chiba S, Usuki K, Ohta M, Imataki O, Uemura M, Takaku T, Komatsu N, Kitanaka A, Shimoda K, Watanabe K, Tohyama K, Takaori-Kondo A, Harigae H, Arai S, Miyazaki Y, Ozawa K, Kurokawa M; for National Research Group on Idiopathic Bone Marrow Failure Syndromes.

Am J Hematol. 2017 Dec;92(12):1324-1332. doi: 10.1002/ajh.24905. Epub 2017 Sep 28.

32.

Utility of Göttingen minipigs for Prediction of Human Pharmacokinetic Profiles After Dermal Drug Application.

Yamamoto S, Karashima M, Sano N, Fukushi C, Tohyama K, Arai Y, Hirabayashi H, Amano N.

Pharm Res. 2017 Nov;34(11):2415-2424. doi: 10.1007/s11095-017-2247-7. Epub 2017 Aug 21.

PMID:
28828717
33.

β-Catenin Is a Candidate Therapeutic Target for Myeloid Neoplasms with del(5q).

Li L, Sheng Y, Li W, Hu C, Mittal N, Tohyama K, Seba A, Zhao YY, Ozer H, Zhu T, Qian Z.

Cancer Res. 2017 Aug 1;77(15):4116-4126. doi: 10.1158/0008-5472.CAN-17-0202. Epub 2017 Jun 13.

34.

Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival.

Kougioumtzidou E, Shimizu T, Hamilton NB, Tohyama K, Sprengel R, Monyer H, Attwell D, Richardson WD.

Elife. 2017 Jun 13;6. pii: e28080. doi: 10.7554/eLife.28080.

35.

Validation of the revised International Prognostic Scoring System in patients with myelodysplastic syndrome in Japan: results from a prospective multicenter registry.

Kawabata H, Tohyama K, Matsuda A, Araseki K, Hata T, Suzuki T, Kayano H, Shimbo K, Zaike Y, Usuki K, Chiba S, Ishikawa T, Arima N, Nogawa M, Ohta A, Miyazaki Y, Mitani K, Ozawa K, Arai S, Kurokawa M, Takaori-Kondo A; Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes.

Int J Hematol. 2017 Sep;106(3):375-384. doi: 10.1007/s12185-017-2250-0. Epub 2017 May 11.

PMID:
28497239
36.

Prediction of Human Pharmacokinetic Profile After Transdermal Drug Application Using Excised Human Skin.

Yamamoto S, Karashima M, Arai Y, Tohyama K, Amano N.

J Pharm Sci. 2017 Sep;106(9):2787-2794. doi: 10.1016/j.xphs.2017.03.003. Epub 2017 Mar 16.

PMID:
28315690
37.

The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model.

Shimizu T, Wisessmith W, Li J, Abe M, Sakimura K, Chetsawang B, Sahara Y, Tohyama K, Tanaka KF, Ikenaka K.

Glia. 2017 Jun;65(6):917-930. doi: 10.1002/glia.23134. Epub 2017 Mar 2.

PMID:
28251676
38.

Fluid shear stress stimulates MATE2-K expression via Nrf2 pathway activation.

Fukuda Y, Kaishima M, Ohnishi T, Tohyama K, Chisaki I, Nakayama Y, Ogasawara-Shimizu M, Kawamata Y.

Biochem Biophys Res Commun. 2017 Mar 4;484(2):358-364. doi: 10.1016/j.bbrc.2017.01.124. Epub 2017 Jan 25.

39.

Node of Ranvier length as a potential regulator of myelinated axon conduction speed.

Arancibia-Cárcamo IL, Ford MC, Cossell L, Ishida K, Tohyama K, Attwell D.

Elife. 2017 Jan 28;6. pii: e23329. doi: 10.7554/eLife.23329.

40.

Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments.

Yoshikawa F, Sato Y, Tohyama K, Akagi T, Furuse T, Sadakata T, Tanaka M, Shinoda Y, Hashikawa T, Itohara S, Sano Y, Ghandour MS, Wakana S, Furuichi T.

PLoS One. 2016 Nov 17;11(11):e0166732. doi: 10.1371/journal.pone.0166732. eCollection 2016.

41.

[Research Ethics on Handling of Clinical Samples].

Tohyama K.

Rinsho Byori. 2016 Nov;64(11):1290-1295. Review. Japanese.

PMID:
30695311
42.

Astrocyte-mediated infantile-onset leukoencephalopathy mouse model.

Sugio S, Tohyama K, Oku S, Fujiyoshi K, Yoshimura T, Hikishima K, Yano R, Fukuda T, Nakamura M, Okano H, Watanabe M, Fukata M, Ikenaka K, Tanaka KF.

Glia. 2017 Jan;65(1):150-168. doi: 10.1002/glia.23084. Epub 2016 Oct 17.

PMID:
27748972
43.

Total Synthesis of Miuraenamides A and D.

Ojima D, Yasui A, Tohyama K, Tokuzumi K, Toriihara E, Ito K, Iwasaki A, Tomura T, Ojika M, Suenaga K.

J Org Chem. 2016 Oct 21;81(20):9886-9894. Epub 2016 Oct 3.

PMID:
27662058
44.

Association between plasma concentration of tolvaptan and urine volume in acute decompensated heart failure patients with fluid overload.

Kato M, Tohyama K, Ohya T, Hiro T, Hirayama A.

Cardiol J. 2016 Aug 12. doi: 10.5603/CJ.a2016.0055. [Epub ahead of print]

45.

Low neutrophil alkaline phosphatase score is a new aspect of calreticulin-mutated myeloproliferative neoplasms.

Kondo T, Tasaka T, Tomioka N, Sano F, Tokunaga H, Suemori S, Tsujioka T, Matsuhashi Y, Nakanishi H, Wada H, Tohyama K, Sugihara T.

Springerplus. 2016 Jul 22;5(1):1146. doi: 10.1186/s40064-016-2829-6. eCollection 2016.

46.

[How to Treat the Clinical Specimens for Laboratory Testing in Line with Ethical Guidelines - Chairpersons' Remarks -].

Tohyama K, Okubo S.

Rinsho Byori. 2016 Jul;64(7):806-807. Review. Japanese.

PMID:
30695469
47.

Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression.

Okamoto S, Tsujioka T, Suemori S, Kida J, Kondo T, Tohyama Y, Tohyama K.

Cancer Sci. 2016 Sep;107(9):1302-14. doi: 10.1111/cas.12988. Epub 2016 Jul 28.

48.
50.

Prognostic significance of Wilms tumor 1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes.

Kobayashi S, Ueda Y, Nannya Y, Shibayama H, Tamura H, Ogata K, Akatsuka Y, Usuki K, Ito Y, Okada M, Suzuki T, Hata T, Matsuda A, Tohyama K, Kakumoto K, Koga D, Mitani K, Naoe T, Sugiyama H, Takaku F.

Cancer Biomark. 2016 Mar 31;17(1):21-32. doi: 10.3233/CBM-160612.

PMID:
27062571

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