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Glutathione has a more important role than metallothionein-I/II against inorganic mercury-induced acute renal toxicity.

Tokumoto M, Lee JY, Shimada A, Tohyama C, Satoh M.

J Toxicol Sci. 2018;43(4):275-280. doi: 10.2131/jts.43.275.


Vocalization as a novel endpoint of atypical attachment behavior in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed infant mice.

Kimura E, Tohyama C.

Arch Toxicol. 2018 May;92(5):1741-1749. doi: 10.1007/s00204-018-2176-1. Epub 2018 Feb 14.


Roles of cytosolic phospholipase A2α in reproductive and systemic toxicities in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed mice.

Fujisawa N, Yoshioka W, Yanagisawa H, Tohyama C.

Arch Toxicol. 2018 Feb;92(2):789-801. doi: 10.1007/s00204-017-2081-z. Epub 2017 Oct 17.


Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse.

Kimura E, Kubo KI, Endo T, Ling W, Nakajima K, Kakeyama M, Tohyama C.

PLoS One. 2017 Aug 18;12(8):e0183497. doi: 10.1371/journal.pone.0183497. eCollection 2017.


Towards comprehensive health risk assessments of chemicals for occupational and environmental health.

Tohyama C.

Ind Health. 2017;55(3):199-200. doi: 10.2486/indhealth.55-199. No abstract available.


Association of impaired neuronal migration with cognitive deficits in extremely preterm infants.

Kubo KI, Deguchi K, Nagai T, Ito Y, Yoshida K, Endo T, Benner S, Shan W, Kitazawa A, Aramaki M, Ishii K, Shin M, Matsunaga Y, Hayashi K, Kakeyama M, Tohyama C, Tanaka KF, Tanaka K, Takashima S, Nakayama M, Itoh M, Hirata Y, Antalffy B, Armstrong DD, Yamada K, Inoue K, Nakajima K.

JCI Insight. 2017 May 18;2(10). pii: 88609. doi: 10.1172/jci.insight.88609. [Epub ahead of print]


Methylated site display (MSD)-AFLP, a sensitive and affordable method for analysis of CpG methylation profiles.

Aiba T, Saito T, Hayashi A, Sato S, Yunokawa H, Maruyama T, Fujibuchi W, Kurita H, Tohyama C, Ohsako S.

BMC Mol Biol. 2017 Mar 9;18(1):7. doi: 10.1186/s12867-017-0083-2.


Embryonic and Postnatal Expression of Aryl Hydrocarbon Receptor mRNA in Mouse Brain.

Kimura E, Tohyama C.

Front Neuroanat. 2017 Feb 7;11:4. doi: 10.3389/fnana.2017.00004. eCollection 2017.


Excessive activation of AhR signaling disrupts neuronal migration in the hippocampal CA1 region in the developing mouse.

Kimura E, Kubo KI, Endo T, Nakajima K, Kakeyama M, Tohyama C.

J Toxicol Sci. 2017;42(1):25-30. doi: 10.2131/jts.42.25.


Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver.

Amenya HZ, Tohyama C, Ohsako S.

Sci Rep. 2016 Oct 7;6:34989. doi: 10.1038/srep34989.


Polyuria-associated hydronephrosis induced by xenobiotic chemical exposure in mice.

Yoshioka W, Kawaguchi T, Nishimura N, Akagi T, Fujisawa N, Yanagisawa H, Matsumura F, Tohyama C.

Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F752-F762. doi: 10.1152/ajprenal.00001.2016. Epub 2016 Jul 20.


In utero and Lactational Exposure to Acetamiprid Induces Abnormalities in Socio-Sexual and Anxiety-Related Behaviors of Male Mice.

Sano K, Isobe T, Yang J, Win-Shwe TT, Yoshikane M, Nakayama SF, Kawashima T, Suzuki G, Hashimoto S, Nohara K, Tohyama C, Maekawa F.

Front Neurosci. 2016 Jun 3;10:228. doi: 10.3389/fnins.2016.00228. eCollection 2016.


In utero and lactational dioxin exposure induces Sema3b and Sema3g gene expression in the developing mouse brain.

Kimura E, Endo T, Yoshioka W, Ding Y, Ujita W, Kakeyama M, Tohyama C.

Biochem Biophys Res Commun. 2016 Jul 22;476(2):108-13. doi: 10.1016/j.bbrc.2016.05.048. Epub 2016 May 10.


Prenatal Exposure to Arsenic Impairs Behavioral Flexibility and Cortical Structure in Mice.

Aung KH, Kyi-Tha-Thu C, Sano K, Nakamura K, Tanoue A, Nohara K, Kakeyama M, Tohyama C, Tsukahara S, Maekawa F.

Front Neurosci. 2016 Mar 31;10:137. doi: 10.3389/fnins.2016.00137. eCollection 2016.


In Utero Bisphenol A Exposure Induces Abnormal Neuronal Migration in the Cerebral Cortex of Mice.

Ling W, Endo T, Kubo K, Nakajima K, Kakeyama M, Tohyama C.

Front Endocrinol (Lausanne). 2016 Feb 1;7:7. doi: 10.3389/fendo.2016.00007. eCollection 2016.


Developmental neurotoxicity test guidelines: problems and perspectives.

Tohyama C.

J Toxicol Sci. 2016;41(Spec):SP69-SP79. doi: 10.2131/jts.41.SP69. Review.


Developmental origin of abnormal dendritic growth in the mouse brain induced by in utero disruption of aryl hydrocarbon receptor signaling.

Kimura E, Kubo K, Matsuyoshi C, Benner S, Hosokawa M, Endo T, Ling W, Kohda M, Yokoyama K, Nakajima K, Kakeyama M, Tohyama C.

Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt A):42-50. doi: 10.1016/ Epub 2015 Oct 23.


Neuronal Heterotopias Affect the Activities of Distant Brain Areas and Lead to Behavioral Deficits.

Ishii K, Kubo K, Endo T, Yoshida K, Benner S, Ito Y, Aizawa H, Aramaki M, Yamanaka A, Tanaka K, Takata N, Tanaka KF, Mimura M, Tohyama C, Kakeyama M, Nakajima K.

J Neurosci. 2015 Sep 9;35(36):12432-45. doi: 10.1523/JNEUROSCI.3648-14.2015.


Application of NeuroTrace staining in the fresh frozen brain samples to laser microdissection combined with quantitative RT-PCR analysis.

Benner S, Kakeyama M, Endo T, Yoshioka W, Tohyama C.

BMC Res Notes. 2015 Jun 20;8:252. doi: 10.1186/s13104-015-1222-9.


Environmental insults in early life and submissiveness later in life in mouse models.

Benner S, Endo T, Kakeyama M, Tohyama C.

Front Neurosci. 2015 Mar 31;9:91. doi: 10.3389/fnins.2015.00091. eCollection 2015. Review.


Prenatal exposure to bisphenol A impacts neuronal morphology in the hippocampal CA1 region in developing and aged mice.

Kimura E, Matsuyoshi C, Miyazaki W, Benner S, Hosokawa M, Yokoyama K, Kakeyama M, Tohyama C.

Arch Toxicol. 2016 Mar;90(3):691-700. doi: 10.1007/s00204-015-1485-x. Epub 2015 Mar 25.


Early deprivation induces competitive subordinance in C57BL/6 male mice.

Benner S, Endo T, Endo N, Kakeyama M, Tohyama C.

Physiol Behav. 2014 Oct;137:42-52. doi: 10.1016/j.physbeh.2014.06.018. Epub 2014 Jul 30.


A mouse strain less responsive to dioxin-induced prostaglandin E2 synthesis is resistant to the onset of neonatal hydronephrosis.

Aida-Yasuoka K, Yoshioka W, Kawaguchi T, Ohsako S, Tohyama C.

Toxicol Sci. 2014 Oct;141(2):465-74. doi: 10.1093/toxsci/kfu142. Epub 2014 Jul 11.


Predominant role of cytosolic phospholipase A2α in dioxin-induced neonatal hydronephrosis in mice.

Yoshioka W, Kawaguchi T, Fujisawa N, Aida-Yasuoka K, Shimizu T, Matsumura F, Tohyama C.

Sci Rep. 2014 Feb 10;4:4042. doi: 10.1038/srep04042.


[Clarification of molecular targets of dioxin toxicity].

Tohyama C.

Nihon Eiseigaku Zasshi. 2014;69(1):1-7. Review. Japanese.


Disruption of paired-associate learning in rat offspring perinatally exposed to dioxins.

Kakeyama M, Endo T, Zhang Y, Miyazaki W, Tohyama C.

Arch Toxicol. 2014 Mar;88(3):789-98. doi: 10.1007/s00204-013-1161-y. Epub 2013 Nov 29.


In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin modulates dysregulation of the lipid metabolism in mouse offspring fed a high-calorie diet.

Sugai E, Yoshioka W, Kakeyama M, Ohsako S, Tohyama C.

J Appl Toxicol. 2014 Mar;34(3):296-306. doi: 10.1002/jat.2881. Epub 2013 Jun 10.


The importance of problem formulations in risk assessment: a case study involving dioxin-contaminated soil.

Dourson ML, Gadagbui B, Griffin S, Garabrant DH, Haws LC, Kirman C, Tohyama C.

Regul Toxicol Pharmacol. 2013 Jul;66(2):208-16. doi: 10.1016/j.yrtph.2013.03.010. Epub 2013 Mar 29.


Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds.

van den Berg M, Denison MS, Birnbaum LS, Devito MJ, Fiedler H, Falandysz J, Rose M, Schrenk D, Safe S, Tohyama C, Tritscher A, Tysklind M, Peterson RE.

Toxicol Sci. 2013 Jun;133(2):197-208. doi: 10.1093/toxsci/kft070. Epub 2013 Mar 14.


Executive function deficits and social-behavioral abnormality in mice exposed to a low dose of dioxin in utero and via lactation.

Endo T, Kakeyama M, Uemura Y, Haijima A, Okuno H, Bito H, Tohyama C.

PLoS One. 2012;7(12):e50741. doi: 10.1371/journal.pone.0050741. Epub 2012 Dec 12.


Fluorescence laser microdissection reveals a distinct pattern of gene activation in the mouse hippocampal region.

Yoshioka W, Endo N, Kurashige A, Haijima A, Endo T, Shibata T, Nishiyama R, Kakeyama M, Tohyama C.

Sci Rep. 2012;2:783. doi: 10.1038/srep00783. Epub 2012 Nov 7.


Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene.

Kurita H, Ohsako S, Hashimoto S, Yoshinaga J, Tohyama C.

J Nutr Biochem. 2013 Jan;24(1):256-66. doi: 10.1016/j.jnutbio.2012.05.013. Epub 2012 Aug 20.


Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice.

Yoshioka W, Aida-Yasuoka K, Fujisawa N, Kawaguchi T, Ohsako S, Hara S, Uematsu S, Akira S, Tohyama C.

Toxicol Sci. 2012 Jun;127(2):547-54. doi: 10.1093/toxsci/kfs115. Epub 2012 Mar 19.


Schema-dependent gene activation and memory encoding in neocortex.

Tse D, Takeuchi T, Kakeyama M, Kajii Y, Okuno H, Tohyama C, Bito H, Morris RG.

Science. 2011 Aug 12;333(6044):891-5. doi: 10.1126/science.1205274. Epub 2011 Jul 7.


Involvement of microRNAs in dioxin-induced liver damage in the mouse.

Yoshioka W, Higashiyama W, Tohyama C.

Toxicol Sci. 2011 Aug;122(2):457-65. doi: 10.1093/toxsci/kfr130. Epub 2011 May 20.


Polychlorinated dioxins, furans, and biphenyls in blood of children and adults living in a dioxin-contaminated area in Tokyo.

Tohyama C, Uchiyama I, Hoshi S, Hijiya M, Miyata H, Nagai M, Nakai S, Yauchi M, Ohkubo S.

Environ Health Prev Med. 2011 Jan;16(1):6-15. doi: 10.1007/s12199-010-0156-z. Epub 2010 Jun 15.


Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage.

Endo T, Maekawa F, Võikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.

Behav Brain Res. 2011 Aug 1;221(1):172-81. doi: 10.1016/j.bbr.2011.02.037. Epub 2011 Mar 4.


Molecular targets that link dioxin exposure to toxicity phenotypes.

Yoshioka W, Peterson RE, Tohyama C.

J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):96-101. doi: 10.1016/j.jsbmb.2010.12.005. Epub 2010 Dec 17. Review.


In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice.

Haijima A, Endo T, Zhang Y, Miyazaki W, Kakeyama M, Tohyama C.

Neurotoxicology. 2010 Aug;31(4):385-90. doi: 10.1016/j.neuro.2010.04.004. Epub 2010 Apr 14.


Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.

Ohsako S, Fukuzawa N, Ishimura R, Kawakami T, Wu Q, Nagano R, Zaha H, Sone H, Yonemoto J, Tohyama C.

Biol Reprod. 2010 Mar;82(3):636-43. doi: 10.1095/biolreprod.109.080812. Epub 2009 Dec 9.


Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effect of di(n-butyl) phthalate.

Alam MS, Ohsako S, Matsuwaki T, Zhu XB, Tsunekawa N, Kanai Y, Sone H, Tohyama C, Kurohmaru M.

Reproduction. 2010 Feb;139(2):427-37. doi: 10.1530/REP-09-0226. Epub 2009 Nov 10.


Severe toxicity and cyclooxygenase (COX)-2 mRNA increase by lithium in the neonatal mouse kidney.

Yoshioka W, Akagi T, Nishimura N, Shimizu H, Watanabe C, Tohyama C.

J Toxicol Sci. 2009 Oct;34(5):519-25.


TCDD-induced cyclooxygenase-2 expression is mediated by the nongenomic pathway in mouse MMDD1 macula densa cells and kidneys.

Dong B, Nishimura N, Vogel CF, Tohyama C, Matsumura F.

Biochem Pharmacol. 2010 Feb 1;79(3):487-97. doi: 10.1016/j.bcp.2009.08.031. Epub 2009 Sep 24.


Aryl hydrocarbon receptor-mediated effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on glucose-stimulated insulin secretion in mice.

Kurita H, Yoshioka W, Nishimura N, Kubota N, Kadowaki T, Tohyama C.

J Appl Toxicol. 2009 Nov;29(8):689-94. doi: 10.1002/jat.1459.


Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-gamma production in mice but does not suppress T(h)2-cytokine production or antibody production.

Nohara K, Suzuki T, Ao K, Murai H, Miyamoto Y, Inouye K, Pan X, Motohashi H, Fujii-Kuriyama Y, Yamamoto M, Tohyama C.

Int Immunol. 2009 Jul;21(7):769-77. doi: 10.1093/intimm/dxp045. Epub 2009 May 21.


Possible involvement of arylhydrocarbon receptor variants in TCDD-induced thymic atrophy and XRE-dependent transcriptional activity in Wistar Hannover GALAS rats.

Kawakami T, Ito T, Ohsako S, Shiizaki K, Murakami Y, Hirowatari K, Sato M, Tohyama C.

J Toxicol Sci. 2009 Apr;34(2):209-20.


Role of metallothionein as a protective factor against radiation carcinogenesis.

Shibuya K, Nishimura N, Suzuki JS, Tohyama C, Naganuma A, Satoh M.

J Toxicol Sci. 2008 Dec;33(5):651-5.


Biological functions of the arylhydrocarbon receptor: beyond induction of cytochrome P450s. Introduction to this special issue.

Matsumura F, Puga A, Tohyama C.

Biochem Pharmacol. 2009 Feb 15;77(4):473. doi: 10.1016/j.bcp.2008.10.037. Epub 2008 Nov 12. No abstract available.


Comparison of immunotoxicity among tetrachloro-, pentachloro-, tetrabromo- and pentabromo-dibenzo-p-dioxins in mice.

Ao K, Suzuki T, Murai H, Matsumoto M, Nagai H, Miyamoto Y, Tohyama C, Nohara K.

Toxicology. 2009 Feb 4;256(1-2):25-31. doi: 10.1016/j.tox.2008.10.024. Epub 2008 Nov 11.


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