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Items: 1 to 50 of 166

1.

Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.

Hoelzl MA, Heby-Henricson K, Gerling M, Dias JM, Kuiper RV, Trünkle C, Bergström Å, Ericson J, Toftgård R, Teglund S.

Dev Biol. 2017 Sep 1;429(1):132-146. doi: 10.1016/j.ydbio.2017.06.037. Epub 2017 Jul 5.

2.

Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.

Blaas L, Pucci F, Messal HA, Andersson AB, Josue Ruiz E, Gerling M, Douagi I, Spencer-Dene B, Musch A, Mitter R, Bhaw L, Stone R, Bornhorst D, Sesay AK, Jonkers J, Stamp G, Malanchi I, Toftgård R, Behrens A.

Nat Cell Biol. 2016 Dec;18(12):1346-1356. doi: 10.1038/ncb3434. Epub 2016 Oct 31.

3.

Erratum: Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth.

Gerling M, Büller NVJA, Kirn LM, Joost S, Frings O, Englert B, Bergström Å, Kuiper RV, Blaas L, Wielenga MCB, Almer S, Kühl AA, Fredlund E, van den Brink GR, Toftgård R.

Nat Commun. 2016 Sep 13;7:12936. doi: 10.1038/ncomms12936. No abstract available.

4.

Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth.

Gerling M, Büller NV, Kirn LM, Joost S, Frings O, Englert B, Bergström Å, Kuiper RV, Blaas L, Wielenga MC, Almer S, Kühl AA, Fredlund E, van den Brink GR, Toftgård R.

Nat Commun. 2016 Aug 5;7:12321. doi: 10.1038/ncomms12321. Erratum in: Nat Commun. 2016 Sep 13;7:12936.

5.

Isolation and Fluorescence-Activated Cell Sorting of Mouse Keratinocytes Expressing β-Galactosidase.

Kasper M, Toftgård R, Jaks V.

Methods Mol Biol. 2016;1453:123-36. doi: 10.1007/978-1-4939-3786-8_13.

PMID:
27431252
6.

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.

Raducu M, Fung E, Serres S, Infante P, Barberis A, Fischer R, Bristow C, Thézénas ML, Finta C, Christianson JC, Buffa FM, Kessler BM, Sibson NR, Di Marcotullio L, Toftgård R, D'Angiolella V.

EMBO J. 2016 Jul 1;35(13):1400-16. doi: 10.15252/embj.201593374. Epub 2016 May 27.

7.

FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.

Bosma M, Gerling M, Pasto J, Georgiadi A, Graham E, Shilkova O, Iwata Y, Almer S, Söderman J, Toftgård R, Wermeling F, Boström EA, Boström PA.

Nat Commun. 2016 Apr 12;7:11314. doi: 10.1038/ncomms11314.

8.

Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.

Füllgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A, Linnarsson S, Simons BD, Clevers H, Toftgård R, Kasper M.

Stem Cell Reports. 2015 Nov 10;5(5):843-855. doi: 10.1016/j.stemcr.2015.09.013.

9.

Suppressor of Fused Plays an Important Role in Regulating Mesodermal Differentiation of Murine Embryonic Stem Cells In Vivo.

Hoelzl MA, Heby-Henricson K, Bilousova G, Rozell B, Kuiper RV, Kasper M, Toftgård R, Teglund S.

Stem Cells Dev. 2015 Nov 1;24(21):2547-60. doi: 10.1089/scd.2015.0050. Epub 2015 Aug 18.

PMID:
26176320
10.

A conditional transgenic mouse line for targeted expression of the stem cell marker LGR5.

Norum JH, Bergström Å, Andersson AB, Kuiper RV, Hoelzl MA, Sørlie T, Toftgård R.

Dev Biol. 2015 Aug 15;404(2):35-48. doi: 10.1016/j.ydbio.2015.05.002. Epub 2015 May 21.

11.

Alberto Gulino MD, PhD (1952-2014).

Toftgård R, Ruiz I Altaba A.

Cell Death Differ. 2015 Jun;22(6):887. doi: 10.1038/cdd.2015.29. No abstract available.

12.

β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma.

Zinke J, Schneider FT, Harter PN, Thom S, Ziegler N, Toftgård R, Plate KH, Liebner S.

Mol Cancer. 2015 Feb 3;14:17. doi: 10.1186/s12943-015-0294-4.

13.

Think inside the BOCs: a mechanism underlying medulloblastoma progression.

Lauth M, Toftgard R.

Dev Cell. 2014 Oct 13;31(1):1-2. doi: 10.1016/j.devcel.2014.09.017.

PMID:
25313956
14.

Regulated splicing of the α6 integrin cytoplasmic domain determines the fate of breast cancer stem cells.

Goel HL, Gritsko T, Pursell B, Chang C, Shultz LD, Greiner DL, Norum JH, Toftgard R, Shaw LM, Mercurio AM.

Cell Rep. 2014 May 8;7(3):747-61. doi: 10.1016/j.celrep.2014.03.059. Epub 2014 Apr 24.

15.

Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.

Cherry AL, Finta C, Karlström M, Jin Q, Schwend T, Astorga-Wells J, Zubarev RA, Del Campo M, Criswell AR, de Sanctis D, Jovine L, Toftgård R.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2563-79. doi: 10.1107/S0907444913028473. Epub 2013 Nov 19.

16.

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice.

Kumari S, Bonnet MC, Ulvmar MH, Wolk K, Karagianni N, Witte E, Uthoff-Hachenberg C, Renauld JC, Kollias G, Toftgard R, Sabat R, Pasparakis M, Haase I.

Immunity. 2013 Nov 14;39(5):899-911. doi: 10.1016/j.immuni.2013.10.009. Epub 2013 Nov 7.

17.

Breast cancer biology and the future of tailored therapies. Introduction.

Bergh J, Hall P, Östman A, Toftgård R.

J Intern Med. 2013 Aug;274(2):102-4. doi: 10.1111/joim.12101. No abstract available.

18.

Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis.

Chari NS, Romano RA, Koster MI, Jaks V, Roop D, Flores ER, Teglund S, Sinha S, Gruber W, Aberger F, Medeiros LJ, Toftgard R, McDonnell TJ.

Cell Death Differ. 2013 Aug;20(8):1080-8. doi: 10.1038/cdd.2013.41. Epub 2013 May 17.

19.

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing.

Longati P, Jia X, Eimer J, Wagman A, Witt MR, Rehnmark S, Verbeke C, Toftgård R, Löhr M, Heuchel RL.

BMC Cancer. 2013 Feb 27;13:95. doi: 10.1186/1471-2407-13-95.

20.

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.

Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM.

EMBO Mol Med. 2013 Apr;5(4):488-508. doi: 10.1002/emmm.201202078. Epub 2013 Feb 21.

21.

Smoothing out drug resistance.

Kasper M, Toftgård R.

Cancer Cell. 2013 Jan 14;23(1):3-5. doi: 10.1016/j.ccr.2012.12.011.

22.

Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma.

Asklund T, Henriksson R, Axelsson J, Bergström Å, Kasper M, Ögren M, Toftgård R, Riklund KÅ.

Acta Oncol. 2013 May;52(4):862-6. doi: 10.3109/0284186X.2012.724537. Epub 2012 Sep 27. No abstract available.

PMID:
23013267
23.

Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus.

van Dop WA, Rosekrans SL, Uhmann A, Jaks V, Offerhaus GJ, van den Bergh Weerman MA, Kasper M, Heijmans J, Hardwick JC, Verspaget HW, Hommes DW, Toftgård R, Hahn H, van den Brink GR.

Gut. 2013 Mar;62(3):348-57. doi: 10.1136/gutjnl-2011-301141. Epub 2012 Apr 13.

PMID:
22504664
24.

Basal cell carcinoma - molecular biology and potential new therapies.

Kasper M, Jaks V, Hohl D, Toftgård R.

J Clin Invest. 2012 Feb;122(2):455-63. doi: 10.1172/JCI58779. Epub 2012 Feb 1. Review.

25.

Targeted expression of GLI1 in the salivary glands results in an altered differentiation program and hyperplasia.

Fiaschi M, Kolterud A, Nilsson M, Toftgård R, Rozell B.

Am J Pathol. 2011 Nov;179(5):2569-79. doi: 10.1016/j.ajpath.2011.07.033. Epub 2011 Sep 18.

26.

Loss of Trp53 promotes medulloblastoma development but not skin tumorigenesis in Sufu heterozygous mutant mice.

Heby-Henricson K, Bergström A, Rozell B, Toftgård R, Teglund S.

Mol Carcinog. 2012 Sep;51(9):754-60. doi: 10.1002/mc.20852. Epub 2011 Aug 31.

27.

Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway.

Tostar U, Toftgård R, Zaphiropoulos PG, Shimokawa T.

Genes Cancer. 2010 Sep;1(9):941-51. doi: 10.1177/1947601910385449.

28.

Hedgehog signaling and pancreatic tumor development.

Lauth M, Toftgård R.

Adv Cancer Res. 2011;110:1-17. doi: 10.1016/B978-0-12-386469-7.00001-3. Review.

PMID:
21704226
29.

Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.

Massinen S, Hokkanen ME, Matsson H, Tammimies K, Tapia-Páez I, Dahlström-Heuser V, Kuja-Panula J, Burghoorn J, Jeppsson KE, Swoboda P, Peyrard-Janvid M, Toftgård R, Castrén E, Kere J.

PLoS One. 2011;6(6):e20580. doi: 10.1371/journal.pone.0020580. Epub 2011 Jun 16.

30.

Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.

Kasper M, Jaks V, Are A, Bergström Å, Schwäger A, Svärd J, Teglund S, Barker N, Toftgård R.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4099-104. doi: 10.1073/pnas.1014489108. Epub 2011 Feb 14. Erratum in: Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5548. Svärd, Jessica [added]; Teglund, Stephan [added].

31.

Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels.

Lauth M, Rohnalter V, Bergström A, Kooshesh M, Svenningsson P, Toftgård R.

Mol Pharmacol. 2010 Sep;78(3):486-96. doi: 10.1124/mol.110.066431. Epub 2010 Jun 17. Erratum in: Mol Pharmacol. 2011 Apr;79(4):793.

PMID:
20558592
32.

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.

Lauth M, Bergström A, Shimokawa T, Tostar U, Jin Q, Fendrich V, Guerra C, Barbacid M, Toftgård R.

Nat Struct Mol Biol. 2010 Jun;17(6):718-25. doi: 10.1038/nsmb.1833. Epub 2010 May 30.

PMID:
20512148
33.

The hair follicle-a stem cell zoo.

Jaks V, Kasper M, Toftgård R.

Exp Cell Res. 2010 May 1;316(8):1422-8. doi: 10.1016/j.yexcr.2010.03.014. Epub 2010 Mar 23. Review.

PMID:
20338163
34.

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.

Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H.

Science. 2010 Mar 12;327(5971):1385-9. doi: 10.1126/science.1184733.

35.

Hedgehog beyond medulloblastoma and basal cell carcinoma.

Teglund S, Toftgård R.

Biochim Biophys Acta. 2010 Apr;1805(2):181-208. doi: 10.1016/j.bbcan.2010.01.003. Epub 2010 Jan 18. Review.

PMID:
20085802
36.

Two sides to cilia in cancer.

Toftgård R.

Nat Med. 2009 Sep;15(9):994-6. doi: 10.1038/nm0909-994. No abstract available.

PMID:
19734870
37.

MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer.

Boyd S, Virolainen S, Pärssinen J, Skoog T, van Hogerlinden M, Latonen L, Kyllönen L, Toftgard R, Saarialho-Kere U.

Exp Dermatol. 2009 Dec;18(12):1044-52. doi: 10.1111/j.1600-0625.2009.00901.x.

PMID:
19601983
38.

Inhibition of NF-kappaB signaling interferes with phorbol ester-induced growth arrest of keratinocytes in a TNFR1-independent manner.

Sur I, Ulvmar M, Jungedal R, Toftgård R.

J Recept Signal Transduct Res. 2009;29(1):44-51. doi: 10.1080/10799890802679876.

PMID:
19519169
39.

Timed NF-kappaB inhibition in skin reveals dual independent effects on development of HED/EDA and chronic inflammation.

Ulvmar MH, Sur I, Mémet S, Toftgård R.

J Invest Dermatol. 2009 Nov;129(11):2584-93. doi: 10.1038/jid.2009.126. Epub 2009 Jun 11.

40.

Development of mammary tumors by conditional expression of GLI1.

Fiaschi M, Rozell B, Bergström A, Toftgård R.

Cancer Res. 2009 Jun 1;69(11):4810-7. doi: 10.1158/0008-5472.CAN-08-3938. Epub 2009 May 19.

41.

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia.

Jia J, Kolterud A, Zeng H, Hoover A, Teglund S, Toftgård R, Liu A.

Dev Biol. 2009 Jun 15;330(2):452-60. doi: 10.1016/j.ydbio.2009.04.009. Epub 2009 Apr 14.

42.

Hedgehog signalling in breast cancer.

Kasper M, Jaks V, Fiaschi M, Toftgård R.

Carcinogenesis. 2009 Jun;30(6):903-11. doi: 10.1093/carcin/bgp048. Epub 2009 Feb 23. Review.

43.

Hedgehog in Wnterland.

Roop D, Toftgård R.

Nat Genet. 2008 Sep;40(9):1040-1. doi: 10.1038/ng0908-1040. No abstract available.

PMID:
19165916
44.

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

Jaks V, Barker N, Kasper M, van Es JH, Snippert HJ, Clevers H, Toftgård R.

Nat Genet. 2008 Nov;40(11):1291-9. doi: 10.1038/ng.239. Epub 2008 Oct 12.

PMID:
18849992
45.

Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice.

Svärd J, Rozell B, Toftgård R, Teglund S.

Mol Carcinog. 2009 May;48(5):408-19. doi: 10.1002/mc.20479.

46.

Meeting report of the conference on UV-Radiation-Induced Disease--Roles of UVA and UVB.

Emeny J, Hansson J, Toftgård R, Segerbäck D.

J Invest Dermatol. 2008 Aug;128(8):1875-7. doi: 10.1038/jid.2008.180. No abstract available.

47.

The two-faced NF-kappaB in the skin.

Sur I, Ulvmar M, Toftgård R.

Int Rev Immunol. 2008;27(4):205-23. doi: 10.1080/08830180802130319. Review.

PMID:
18574737
48.

Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal.

Shimokawa T, Tostar U, Lauth M, Palaniswamy R, Kasper M, Toftgård R, Zaphiropoulos PG.

J Biol Chem. 2008 May 23;283(21):14345-54. doi: 10.1074/jbc.M800299200. Epub 2008 Mar 31.

49.

Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells.

Barker N, van Es JH, Jaks V, Kasper M, Snippert H, Toftgård R, Clevers H.

Cold Spring Harb Symp Quant Biol. 2008;73:351-6. doi: 10.1101/sqb.2008.72.003.

PMID:
19478326
50.

Tumour suppressors in liver carcinogenesis.

Dufour JF, Huber O, Kozma SC, Lu X, Toftgård R.

J Hepatol. 2007 Dec;47(6):860-7. Epub 2007 Oct 1.

PMID:
17935820

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