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Items: 1 to 50 of 134

1.

Phase I study of tanespimycin in combination with bortezomib in patients with advanced solid malignancies.

Schenk E, Hendrickson AE, Northfelt D, Toft DO, Ames MM, Menefee M, Satele D, Qin R, Erlichman C.

Invest New Drugs. 2013 Oct;31(5):1251-6. doi: 10.1007/s10637-013-9946-7. Epub 2013 Mar 31.

2.

Characterization of plant p23-like proteins for their co-chaperone activities.

Zhang Z, Sullivan W, Felts SJ, Prasad BD, Toft DO, Krishna P.

Cell Stress Chaperones. 2010 Sep;15(5):703-15. doi: 10.1007/s12192-010-0182-1. Epub 2010 Mar 28.

3.

Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors.

Hubbard J, Erlichman C, Toft DO, Qin R, Stensgard BA, Felten S, Ten Eyck C, Batzel G, Ivy SP, Haluska P.

Invest New Drugs. 2011 Jun;29(3):473-80. doi: 10.1007/s10637-009-9381-y. Epub 2010 Jan 15.

4.

FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells.

Ni L, Yang CS, Gioeli D, Frierson H, Toft DO, Paschal BM.

Mol Cell Biol. 2010 Mar;30(5):1243-53. doi: 10.1128/MCB.01891-08. Epub 2010 Jan 4.

5.

Cisplatin abrogates the geldanamycin-induced heat shock response.

McCollum AK, Lukasiewicz KB, Teneyck CJ, Lingle WL, Toft DO, Erlichman C.

Mol Cancer Ther. 2008 Oct;7(10):3256-64. doi: 10.1158/1535-7163.MCT-08-0157.

6.

P-Glycoprotein-mediated resistance to Hsp90-directed therapy is eclipsed by the heat shock response.

McCollum AK, TenEyck CJ, Stensgard B, Morlan BW, Ballman KV, Jenkins RB, Toft DO, Erlichman C.

Cancer Res. 2008 Sep 15;68(18):7419-27. doi: 10.1158/0008-5472.CAN-07-5175.

7.

Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions.

Smith DF, Toft DO.

Mol Endocrinol. 2008 Oct;22(10):2229-40. doi: 10.1210/me.2008-0089. Epub 2008 May 1. Review.

8.

Recent Advances in the Study of hsp90 Structure and Mechanism of Action.

Toft DO.

Trends Endocrinol Metab. 1998 Aug;9(6):238-43.

PMID:
18406275
9.

GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity.

Chadli A, Felts SJ, Toft DO.

J Biol Chem. 2008 Apr 11;283(15):9509-12. doi: 10.1074/jbc.C800017200. Epub 2008 Feb 19.

10.

Functioning of the Hsp90 machine in chaperoning checkpoint kinase I (Chk1) and the progesterone receptor (PR).

Felts SJ, Karnitz LM, Toft DO.

Cell Stress Chaperones. 2007 Winter;12(4):353-63.

11.

Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism.

McCollum AK, Teneyck CJ, Sauer BM, Toft DO, Erlichman C.

Cancer Res. 2006 Nov 15;66(22):10967-75.

12.

A phase I trial of twice-weekly 17-allylamino-demethoxy-geldanamycin in patients with advanced cancer.

Nowakowski GS, McCollum AK, Ames MM, Mandrekar SJ, Reid JM, Adjei AA, Toft DO, Safgren SL, Erlichman C.

Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6087-93.

13.

Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones.

Arlander SJ, Felts SJ, Wagner JM, Stensgard B, Toft DO, Karnitz LM.

J Biol Chem. 2006 Feb 3;281(5):2989-98. Epub 2005 Dec 5.

14.

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.

Kovacs JJ, Murphy PJ, Gaillard S, Zhao X, Wu JT, Nicchitta CV, Yoshida M, Toft DO, Pratt WB, Yao TP.

Mol Cell. 2005 May 27;18(5):601-7.

15.

Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70.

Carrello A, Allan RK, Morgan SL, Owen BA, Mok D, Ward BK, Minchin RF, Toft DO, Ratajczak T.

Cell Stress Chaperones. 2004 Summer;9(2):167-81.

16.

A novel in situ assay for the identification and characterization of soluble nuclear mobility factors.

Elbi C, Walker DA, Lewis M, Romero G, Sullivan WP, Toft DO, Hager GL, DeFranco DB.

Sci STKE. 2004 Jun 22;2004(238):pl10.

PMID:
15213337
17.

Molecular chaperones function as steroid receptor nuclear mobility factors.

Elbi C, Walker DA, Romero G, Sullivan WP, Toft DO, Hager GL, DeFranco DB.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2876-81. Epub 2004 Feb 20.

18.

p23, a simple protein with complex activities.

Felts SJ, Toft DO.

Cell Stress Chaperones. 2003 Summer;8(2):108-13. Review.

19.

Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress.

Arlander SJ, Eapen AK, Vroman BT, McDonald RJ, Toft DO, Karnitz LM.

J Biol Chem. 2003 Dec 26;278(52):52572-7. Epub 2003 Oct 21.

20.

Novel activation step required for transcriptional competence of progesterone receptor on chromatin templates.

Thackray VG, Toft DO, Nordeen SK.

Mol Endocrinol. 2003 Dec;17(12):2543-53. Epub 2003 Oct 9.

PMID:
14551264
21.

The Hsp90 chaperone complex as a novel target for cancer therapy.

Goetz MP, Toft DO, Ames MM, Erlichman C.

Ann Oncol. 2003 Aug;14(8):1169-76. Review.

PMID:
12881371
22.

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery.

Pratt WB, Toft DO.

Exp Biol Med (Maywood). 2003 Feb;228(2):111-33. Review.

PMID:
12563018
23.

The influence of ATP and p23 on the conformation of hsp90.

Sullivan WP, Owen BA, Toft DO.

J Biol Chem. 2002 Nov 29;277(48):45942-8. Epub 2002 Sep 24.

24.

The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex.

Hernández MP, Sullivan WP, Toft DO.

J Biol Chem. 2002 Oct 11;277(41):38294-304. Epub 2002 Aug 2.

25.

HSP70 and HSP90 expression in leucocytes after exercise in moderately trained humans.

Shastry S, Toft DO, Joyner MJ.

Acta Physiol Scand. 2002 Jun;175(2):139-46.

PMID:
12028134
26.

Effect of geldanamycin on androgen receptor function and stability.

Vanaja DK, Mitchell SH, Toft DO, Young CY.

Cell Stress Chaperones. 2002 Jan;7(1):55-64.

27.

HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor.

Hernández MP, Chadli A, Toft DO.

J Biol Chem. 2002 Apr 5;277(14):11873-81. Epub 2002 Jan 23.

28.

Regulation of heat shock protein 90 ATPase activity by sequences in the carboxyl terminus.

Owen BA, Sullivan WP, Felts SJ, Toft DO.

J Biol Chem. 2002 Mar 1;277(9):7086-91. Epub 2001 Dec 19.

29.

Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex.

Guo Y, Guettouche T, Fenna M, Boellmann F, Pratt WB, Toft DO, Smith DF, Voellmy R.

J Biol Chem. 2001 Dec 7;276(49):45791-9. Epub 2001 Oct 2.

30.

hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1.

Kanelakis KC, Murphy PJ, Galigniana MD, Morishima Y, Takayama S, Reed JC, Toft DO, Pratt WB.

Biochemistry. 2000 Nov 21;39(46):14314-21.

PMID:
11087380
31.

Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90.

Chadli A, Bouhouche I, Sullivan W, Stensgard B, McMahon N, Catelli MG, Toft DO.

Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12524-9.

32.

Hsp90 chaperone activity requires the full-length protein and interaction among its multiple domains.

Johnson BD, Chadli A, Felts SJ, Bouhouche I, Catelli MG, Toft DO.

J Biol Chem. 2000 Oct 20;275(42):32499-507.

33.

Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone.

Weaver AJ, Sullivan WP, Felts SJ, Owen BA, Toft DO.

J Biol Chem. 2000 Jul 28;275(30):23045-52.

34.
35.

The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties.

Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO.

J Biol Chem. 2000 Feb 4;275(5):3305-12.

36.

Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.

Schulte TW, Akinaga S, Murakata T, Agatsuma T, Sugimoto S, Nakano H, Lee YS, Simen BB, Argon Y, Felts S, Toft DO, Neckers LM, Sharma SV.

Mol Endocrinol. 1999 Sep;13(9):1435-48.

PMID:
10478836
37.

The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes.

Grenert JP, Johnson BD, Toft DO.

J Biol Chem. 1999 Jun 18;274(25):17525-33.

38.

Functional requirement of p23 and Hsp90 in telomerase complexes.

Holt SE, Aisner DL, Baur J, Tesmer VM, Dy M, Ouellette M, Trager JB, Morin GB, Toft DO, Shay JW, Wright WE, White MA.

Genes Dev. 1999 Apr 1;13(7):817-26.

39.

ATP sensitive tryptophans of hsp90.

Bartha BB, Ajtai K, Toft DO, Burghardt TP.

Biophys Chem. 1998 Jun 9;72(3):313-21.

PMID:
9691273
40.

Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants.

Chen S, Sullivan WP, Toft DO, Smith DF.

Cell Stress Chaperones. 1998 Jun;3(2):118-29.

41.

Hsp90-containing multiprotein complexes in the eukaryotic microbe Achlya.

Brunt SA, Perdew GH, Toft DO, Silver JC.

Cell Stress Chaperones. 1998 Mar;3(1):44-56.

42.

Hop modulates Hsp70/Hsp90 interactions in protein folding.

Johnson BD, Schumacher RJ, Ross ED, Toft DO.

J Biol Chem. 1998 Feb 6;273(6):3679-86.

43.

The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation.

Grenert JP, Sullivan WP, Fadden P, Haystead TA, Clark J, Mimnaugh E, Krutzsch H, Ochel HJ, Schulte TW, Sausville E, Neckers LM, Toft DO.

J Biol Chem. 1997 Sep 19;272(38):23843-50.

44.

Steroid receptor interactions with heat shock protein and immunophilin chaperones.

Pratt WB, Toft DO.

Endocr Rev. 1997 Jun;18(3):306-60. Review.

PMID:
9183567
46.
47.

Cooperative action of Hsp70, Hsp90, and DnaJ proteins in protein renaturation.

Schumacher RJ, Hansen WJ, Freeman BC, Alnemri E, Litwack G, Toft DO.

Biochemistry. 1996 Nov 26;35(47):14889-98.

PMID:
8942653
48.

Molecular chaperoning of steroid hormone receptors.

Pratt WB, Gehring U, Toft DO.

EXS. 1996;77:79-95. Review.

PMID:
8856970
49.

Estrogen response in the hFOB 1.19 human fetal osteoblastic cell line stably transfected with the human estrogen receptor gene.

Harris SA, Tau KR, Enger RJ, Toft DO, Riggs BL, Spelsberg TC.

J Cell Biochem. 1995 Oct;59(2):193-201.

PMID:
8904314
50.

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