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Sildenafil preserves exercise capacity in patients with idiopathic pulmonary fibrosis and right-sided ventricular dysfunction.

Han MK, Bach DS, Hagan PG, Yow E, Flaherty KR, Toews GB, Anstrom KJ, Martinez FJ; IPFnet Investigators.

Chest. 2013 Jun;143(6):1699-1708. doi: 10.1378/chest.12-1594.


Early induction of CCL7 downstream of TLR9 signaling promotes the development of robust immunity to cryptococcal infection.

Qiu Y, Zeltzer S, Zhang Y, Wang F, Chen GH, Dayrit J, Murdock BJ, Bhan U, Toews GB, Osterholzer JJ, Standiford TJ, Olszewski MA.

J Immunol. 2012 Apr 15;188(8):3940-8. doi: 10.4049/jimmunol.1103053. Epub 2012 Mar 14.


Significance of the microbiome in obstructive lung disease.

Han MK, Huang YJ, Lipuma JJ, Boushey HA, Boucher RC, Cookson WO, Curtis JL, Erb-Downward J, Lynch SV, Sethi S, Toews GB, Young VB, Wolfgang MC, Huffnagle GB, Martinez FJ.

Thorax. 2012 May;67(5):456-63. doi: 10.1136/thoraxjnl-2011-201183. Epub 2012 Feb 8. Review.


Ecological succession of bacterial communities during conventionalization of germ-free mice.

Gillilland MG 3rd, Erb-Downward JR, Bassis CM, Shen MC, Toews GB, Young VB, Huffnagle GB.

Appl Environ Microbiol. 2012 Apr;78(7):2359-66. doi: 10.1128/AEM.05239-11. Epub 2012 Jan 27.


Interleukin-17 drives pulmonary eosinophilia following repeated exposure to Aspergillus fumigatus conidia.

Murdock BJ, Falkowski NR, Shreiner AB, Sadighi Akha AA, McDonald RA, White ES, Toews GB, Huffnagle GB.

Infect Immun. 2012 Apr;80(4):1424-36. doi: 10.1128/IAI.05529-11. Epub 2012 Jan 17.


Pulmonary fibrosis induced by γ-herpesvirus in aged mice is associated with increased fibroblast responsiveness to transforming growth factor-β.

Naik PN, Horowitz JC, Moore TA, Wilke CA, Toews GB, Moore BB.

J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):714-25. doi: 10.1093/gerona/glr211. Epub 2011 Dec 21.


TLR9-induced interferon β is associated with protection from gammaherpesvirus-induced exacerbation of lung fibrosis.

Luckhardt TR, Coomes SM, Trujillo G, Stoolman JS, Vannella KM, Bhan U, Wilke CA, Moore TA, Toews GB, Hogaboam C, Moore BB.

Fibrogenesis Tissue Repair. 2011 Aug 2;4:18. doi: 10.1186/1755-1536-4-18.


A micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis.

Oak SR, Murray L, Herath A, Sleeman M, Anderson I, Joshi AD, Coelho AL, Flaherty KR, Toews GB, Knight D, Martinez FJ, Hogaboam CM.

PLoS One. 2011;6(6):e21253. doi: 10.1371/journal.pone.0021253. Epub 2011 Jun 21.


Effect of cytokine interplay on macrophage polarization during chronic pulmonary infection with Cryptococcus neoformans.

Arora S, Olszewski MA, Tsang TM, McDonald RA, Toews GB, Huffnagle GB.

Infect Immun. 2011 May;79(5):1915-26. doi: 10.1128/IAI.01270-10. Epub 2011 Mar 7.


Epithelial interactions and local engraftment of lung-resident mesenchymal stem cells.

Badri L, Walker NM, Ohtsuka T, Wang Z, Delmar M, Flint A, Peters-Golden M, Toews GB, Pinsky DJ, Krebsbach PH, Lama VN.

Am J Respir Cell Mol Biol. 2011 Oct;45(4):809-16. doi: 10.1165/rcmb.2010-0446OC. Epub 2011 Mar 4.


Analysis of the lung microbiome in the "healthy" smoker and in COPD.

Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Schmidt LA, Young VB, Toews GB, Curtis JL, Sundaram B, Martinez FJ, Huffnagle GB.

PLoS One. 2011 Feb 22;6(2):e16384. doi: 10.1371/journal.pone.0016384.


Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung infection.

Osterholzer JJ, Chen GH, Olszewski MA, Zhang YM, Curtis JL, Huffnagle GB, Toews GB.

Am J Pathol. 2011 Jan;178(1):198-211. doi: 10.1016/j.ajpath.2010.11.006. Epub 2010 Dec 23.


Mesenchymal stromal cells in bronchoalveolar lavage as predictors of bronchiolitis obliterans syndrome.

Badri L, Murray S, Liu LX, Walker NM, Flint A, Wadhwa A, Chan KM, Toews GB, Pinsky DJ, Martinez FJ, Lama VN.

Am J Respir Crit Care Med. 2011 Apr 15;183(8):1062-70. doi: 10.1164/rccm.201005-0742OC. Epub 2010 Dec 17.


Pulmonary function measures predict mortality differently in IPF versus combined pulmonary fibrosis and emphysema.

Schmidt SL, Nambiar AM, Tayob N, Sundaram B, Han MK, Gross BH, Kazerooni EA, Chughtai AR, Lagstein A, Myers JL, Murray S, Toews GB, Martinez FJ, Flaherty KR.

Eur Respir J. 2011 Jul;38(1):176-83. doi: 10.1183/09031936.00114010. Epub 2010 Dec 9.


TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis.

Trujillo G, Meneghin A, Flaherty KR, Sholl LM, Myers JL, Kazerooni EA, Gross BH, Oak SR, Coelho AL, Evanoff H, Day E, Toews GB, Joshi AD, Schaller MA, Waters B, Jarai G, Westwick J, Kunkel SL, Martinez FJ, Hogaboam CM.

Sci Transl Med. 2010 Nov 10;2(57):57ra82. doi: 10.1126/scitranslmed.3001510.


Coevolution of TH1, TH2, and TH17 responses during repeated pulmonary exposure to Aspergillus fumigatus conidia.

Murdock BJ, Shreiner AB, McDonald RA, Osterholzer JJ, White ES, Toews GB, Huffnagle GB.

Infect Immun. 2011 Jan;79(1):125-35. doi: 10.1128/IAI.00508-10. Epub 2010 Nov 1.


Latent infection by γherpesvirus stimulates profibrotic mediator release from multiple cell types.

Stoolman JS, Vannella KM, Coomes SM, Wilke CA, Sisson TH, Toews GB, Moore BB.

Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L274-85. doi: 10.1152/ajplung.00028.2010. Epub 2010 Oct 29.


Dual roles of CD40 on microbial containment and the development of immunopathology in response to persistent fungal infection in the lung.

Chen GH, Osterholzer JJ, Choe MY, McDonald RA, Olszewski MA, Huffnagle GB, Toews GB.

Am J Pathol. 2010 Nov;177(5):2459-71. doi: 10.2353/ajpath.2010.100141. Epub 2010 Sep 23.


Workshop on idiopathic pulmonary fibrosis in older adults.

Castriotta RJ, Eldadah BA, Foster WM, Halter JB, Hazzard WR, Kiley JP, King TE Jr, Horne FM, Nayfield SG, Reynolds HY, Schmader KE, Toews GB, High KP.

Chest. 2010 Sep;138(3):693-703. doi: 10.1378/chest.09-3006.


TLR9 signaling is required for generation of the adaptive immune protection in Cryptococcus neoformans-infected lungs.

Zhang Y, Wang F, Bhan U, Huffnagle GB, Toews GB, Standiford TJ, Olszewski MA.

Am J Pathol. 2010 Aug;177(2):754-65. doi: 10.2353/ajpath.2010.091104. Epub 2010 Jun 25.


The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice.

Bauman KA, Wettlaufer SH, Okunishi K, Vannella KM, Stoolman JS, Huang SK, Courey AJ, White ES, Hogaboam CM, Simon RH, Toews GB, Sisson TH, Moore BB, Peters-Golden M.

J Clin Invest. 2010 Jun;120(6):1950-60. doi: 10.1172/JCI38369. Epub 2010 May 24.


Latent herpesvirus infection augments experimental pulmonary fibrosis.

Vannella KM, Luckhardt TR, Wilke CA, van Dyk LF, Toews GB, Moore BB.

Am J Respir Crit Care Med. 2010 Mar 1;181(5):465-77. doi: 10.1164/rccm.200905-0798OC. Epub 2009 Dec 10.


Clinical predictors of a diagnosis of idiopathic pulmonary fibrosis.

Fell CD, Martinez FJ, Liu LX, Murray S, Han MK, Kazerooni EA, Gross BH, Myers J, Travis WD, Colby TV, Toews GB, Flaherty KR.

Am J Respir Crit Care Med. 2010 Apr 15;181(8):832-7. doi: 10.1164/rccm.200906-0959OC. Epub 2010 Jan 7.


CD11c+ cells are required to prevent progression from local acute lung injury to multiple organ failure and death.

Milam JE, Erb-Downward JR, Chen GH, Osuchowski MF, McDonald R, Chensue SW, Toews GB, Huffnagle GB, Olszewski MA.

Am J Pathol. 2010 Jan;176(1):218-26. doi: 10.2353/ajpath.2010.081027. Epub 2009 Nov 30.


Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes.

Osterholzer JJ, Chen GH, Olszewski MA, Curtis JL, Huffnagle GB, Toews GB.

J Immunol. 2009 Dec 15;183(12):8044-53. doi: 10.4049/jimmunol.0902823.


Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99.

Zhang Y, Wang F, Tompkins KC, McNamara A, Jain AV, Moore BB, Toews GB, Huffnagle GB, Olszewski MA.

Am J Pathol. 2009 Dec;175(6):2489-500. doi: 10.2353/ajpath.2009.090530. Epub 2009 Nov 5.


Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary Cryptococcus neoformans infection.

Jain AV, Zhang Y, Fields WB, McNamara DA, Choe MY, Chen GH, Erb-Downward J, Osterholzer JJ, Toews GB, Huffnagle GB, Olszewski MA.

Infect Immun. 2009 Dec;77(12):5389-99. doi: 10.1128/IAI.00809-09. Epub 2009 Sep 14.


Role of dendritic cells and alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus neoformans.

Osterholzer JJ, Milam JE, Chen GH, Toews GB, Huffnagle GB, Olszewski MA.

Infect Immun. 2009 Sep;77(9):3749-58. doi: 10.1128/IAI.00454-09. Epub 2009 Jun 29.


Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung.

Osterholzer JJ, Surana R, Milam JE, Montano GT, Chen GH, Sonstein J, Curtis JL, Huffnagle GB, Toews GB, Olszewski MA.

Am J Pathol. 2009 Mar;174(3):932-43. doi: 10.2353/ajpath.2009.080673. Epub 2009 Feb 13.


Serum CC-chemokine ligand 18 concentration predicts outcome in idiopathic pulmonary fibrosis.

Prasse A, Probst C, Bargagli E, Zissel G, Toews GB, Flaherty KR, Olschewski M, Rottoli P, Müller-Quernheim J.

Am J Respir Crit Care Med. 2009 Apr 15;179(8):717-23. doi: 10.1164/rccm.200808-1201OC. Epub 2009 Jan 29.


The prognostic value of cardiopulmonary exercise testing in idiopathic pulmonary fibrosis.

Fell CD, Liu LX, Motika C, Kazerooni EA, Gross BH, Travis WD, Colby TV, Murray S, Toews GB, Martinez FJ, Flaherty KR.

Am J Respir Crit Care Med. 2009 Mar 1;179(5):402-7. doi: 10.1164/rccm.200802-241OC. Epub 2008 Dec 12.


Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator.

Jarvinen L, Badri L, Wettlaufer S, Ohtsuka T, Standiford TJ, Toews GB, Pinsky DJ, Peters-Golden M, Lama VN.

J Immunol. 2008 Sep 15;181(6):4389-96.


TLR9 is expressed in idiopathic interstitial pneumonia and its activation promotes in vitro myofibroblast differentiation.

Meneghin A, Choi ES, Evanoff HL, Kunkel SL, Martinez FJ, Flaherty KR, Toews GB, Hogaboam CM.

Histochem Cell Biol. 2008 Nov;130(5):979-92. doi: 10.1007/s00418-008-0466-z. Epub 2008 Jul 17.


Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation.

Ballinger MN, Hubbard LL, McMillan TR, Toews GB, Peters-Golden M, Paine R 3rd, Moore BB.

Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L114-22. doi: 10.1152/ajplung.00309.2007. Epub 2008 May 2.


Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model.

Chen GH, McNamara DA, Hernandez Y, Huffnagle GB, Toews GB, Olszewski MA.

Infect Immun. 2008 Jun;76(6):2379-91. doi: 10.1128/IAI.01143-07. Epub 2008 Apr 7.


Sex differences in physiological progression of idiopathic pulmonary fibrosis.

Han MK, Murray S, Fell CD, Flaherty KR, Toews GB, Myers J, Colby TV, Travis WD, Kazerooni EA, Gross BH, Martinez FJ.

Eur Respir J. 2008 Jun;31(6):1183-8. doi: 10.1183/09031936.00165207. Epub 2008 Mar 5.


Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus.

McMillan TR, Moore BB, Weinberg JB, Vannella KM, Fields WB, Christensen PJ, van Dyk LF, Toews GB.

Am J Respir Crit Care Med. 2008 Apr 1;177(7):771-80. doi: 10.1164/rccm.200708-1184OC. Epub 2008 Jan 10.


An essential role for fibronectin extra type III domain A in pulmonary fibrosis.

Muro AF, Moretti FA, Moore BB, Yan M, Atrasz RG, Wilke CA, Flaherty KR, Martinez FJ, Tsui JL, Sheppard D, Baralle FE, Toews GB, White ES.

Am J Respir Crit Care Med. 2008 Mar 15;177(6):638-45. Epub 2007 Dec 20.


Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function.

Vannella KM, McMillan TR, Charbeneau RP, Wilke CA, Thomas PE, Toews GB, Peters-Golden M, Moore BB.

J Immunol. 2007 Dec 1;179(11):7883-90.


Variable prostaglandin E2 resistance in fibroblasts from patients with usual interstitial pneumonia.

Huang SK, Wettlaufer SH, Hogaboam CM, Flaherty KR, Martinez FJ, Myers JL, Colby TV, Travis WD, Toews GB, Peters-Golden M.

Am J Respir Crit Care Med. 2008 Jan 1;177(1):66-74. Epub 2007 Oct 4.


Effect of laparotomy on clearance and cytokine induction in Staphylococcus aureus infected lungs.

Olszewski MA, Falkowski NR, Surana R, Sonstein J, Hartman A, Moore BB, Huffnagle GB, Toews GB.

Am J Respir Crit Care Med. 2007 Nov 1;176(9):921-9. Epub 2007 Aug 16.


Modulation of the pulmonary type 2 T-cell response to Cryptococcus neoformans by intratracheal delivery of a tumor necrosis factor alpha-expressing adenoviral vector.

Milam JE, Herring-Palmer AC, Pandrangi R, McDonald RA, Huffnagle GB, Toews GB.

Infect Immun. 2007 Oct;75(10):4951-8. Epub 2007 Jul 23.


Acute exacerbations of idiopathic pulmonary fibrosis.

Collard HR, Moore BB, Flaherty KR, Brown KK, Kaner RJ, King TE Jr, Lasky JA, Loyd JE, Noth I, Olman MA, Raghu G, Roman J, Ryu JH, Zisman DA, Hunninghake GW, Colby TV, Egan JJ, Hansell DM, Johkoh T, Kaminski N, Kim DS, Kondoh Y, Lynch DA, Müller-Quernheim J, Myers JL, Nicholson AG, Selman M, Toews GB, Wells AU, Martinez FJ; Idiopathic Pulmonary Fibrosis Clinical Research Network Investigators.

Am J Respir Crit Care Med. 2007 Oct 1;176(7):636-43. Epub 2007 Jun 21. Review.


CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis.

Prasse A, Pechkovsky DV, Toews GB, Schäfer M, Eggeling S, Ludwig C, Germann M, Kollert F, Zissel G, Müller-Quernheim J.

Arthritis Rheum. 2007 May;56(5):1685-93.


Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts.

Lama VN, Smith L, Badri L, Flint A, Andrei AC, Murray S, Wang Z, Liao H, Toews GB, Krebsbach PH, Peters-Golden M, Pinsky DJ, Martinez FJ, Thannickal VJ.

J Clin Invest. 2007 Apr;117(4):989-96. Epub 2007 Mar 8.


Course of FEV(1) after onset of bronchiolitis obliterans syndrome in lung transplant recipients.

Lama VN, Murray S, Lonigro RJ, Toews GB, Chang A, Lau C, Flint A, Chan KM, Martinez FJ.

Am J Respir Crit Care Med. 2007 Jun 1;175(11):1192-8. Epub 2007 Mar 8.


Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21.

Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Evanoff H, Flaherty KR, Martinez FJ, Toews GB, Hogaboam CM.

Eur Respir J. 2007 Jun;29(6):1082-93. Epub 2007 Mar 1.


Idiopathic interstitial pneumonia: do community and academic physicians agree on diagnosis?

Flaherty KR, Andrei AC, King TE Jr, Raghu G, Colby TV, Wells A, Bassily N, Brown K, du Bois R, Flint A, Gay SE, Gross BH, Kazerooni EA, Knapp R, Louvar E, Lynch D, Nicholson AG, Quick J, Thannickal VJ, Travis WD, Vyskocil J, Wadenstorer FA, Wilt J, Toews GB, Murray S, Martinez FJ.

Am J Respir Crit Care Med. 2007 May 15;175(10):1054-60. Epub 2007 Jan 25.

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