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Items: 30


Light-based control of metabolic flux through assembly of synthetic organelles.

Zhao EM, Suek N, Wilson MZ, Dine E, Pannucci NL, Gitai Z, Avalos JL, Toettcher JE.

Nat Chem Biol. 2019 Jun;15(6):589-597. doi: 10.1038/s41589-019-0284-8. Epub 2019 May 13.


Signaling Dynamics Control Cell Fate in the Early Drosophila Embryo.

Johnson HE, Toettcher JE.

Dev Cell. 2019 Feb 11;48(3):361-370.e3. doi: 10.1016/j.devcel.2019.01.009.


Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds.

Bracha D, Walls MT, Wei MT, Zhu L, Kurian M, Avalos JL, Toettcher JE, Brangwynne CP.

Cell. 2019 Jan 10;176(1-2):407. doi: 10.1016/j.cell.2018.12.026. No abstract available.


A size-invariant bud-duration timer enables robustness in yeast cell size control.

Allard CAH, Decker F, Weiner OD, Toettcher JE, Graziano BR.

PLoS One. 2018 Dec 21;13(12):e0209301. doi: 10.1371/journal.pone.0209301. eCollection 2018.


A bright future: optogenetics to dissect the spatiotemporal control of cell behavior.

Goglia AG, Toettcher JE.

Curr Opin Chem Biol. 2019 Feb;48:106-113. doi: 10.1016/j.cbpa.2018.11.010. Epub 2018 Dec 5. Review.


Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds.

Bracha D, Walls MT, Wei MT, Zhu L, Kurian M, Avalos JL, Toettcher JE, Brangwynne CP.

Cell. 2018 Nov 29;175(6):1467-1480.e13. doi: 10.1016/j.cell.2018.10.048. Erratum in: Cell. 2019 Jan 10;176(1-2):407.


Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway.

Bugaj LJ, Sabnis AJ, Mitchell A, Garbarino JE, Toettcher JE, Bivona TG, Lim WA.

Science. 2018 Aug 31;361(6405). pii: eaao3048. doi: 10.1126/science.aao3048.


P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer.

Barrio-Real L, Lopez-Haber C, Casado-Medrano V, Goglia AG, Toettcher JE, Caloca MJ, Kazanietz MG.

Oncotarget. 2018 Jun 19;9(47):28612-28624. doi: 10.18632/oncotarget.25584. eCollection 2018 Jun 19.


Four Key Steps Control Glycolytic Flux in Mammalian Cells.

Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD.

Cell Syst. 2018 Jul 25;7(1):49-62.e8. doi: 10.1016/j.cels.2018.06.003. Epub 2018 Jun 27.


Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection.

Winer BY, Shirvani-Dastgerdi E, Bram Y, Sellau J, Low BE, Johnson H, Huang T, Hrebikova G, Heller B, Sharon Y, Giersch K, Gerges S, Seneca K, Pais MA, Frankel AS, Chiriboga L, Cullen J, Nahass RG, Lutgehetmann M, Toettcher JE, Wiles MV, Schwartz RE, Ploss A.

Sci Transl Med. 2018 Jun 27;10(447). pii: eaap9328. doi: 10.1126/scitranslmed.aap9328.


Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli.

Dine E, Gil AA, Uribe G, Brangwynne CP, Toettcher JE.

Cell Syst. 2018 Jun 27;6(6):655-663.e5. doi: 10.1016/j.cels.2018.05.002. Epub 2018 May 30.


Optogenetic regulation of engineered cellular metabolism for microbial chemical production.

Zhao EM, Zhang Y, Mehl J, Park H, Lalwani MA, Toettcher JE, Avalos JL.

Nature. 2018 Mar 29;555(7698):683-687. doi: 10.1038/nature26141. Epub 2018 Mar 21.


Illuminating developmental biology with cellular optogenetics.

Johnson HE, Toettcher JE.

Curr Opin Biotechnol. 2018 Aug;52:42-48. doi: 10.1016/j.copbio.2018.02.003. Epub 2018 Mar 2. Review.


Optogenetic Reconstitution for Determining the Form and Function of Membraneless Organelles.

Dine E, Toettcher JE.

Biochemistry. 2018 May 1;57(17):2432-2436. doi: 10.1021/acs.biochem.7b01173. Epub 2018 Jan 26.


Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control.

Wilson MZ, Ravindran PT, Lim WA, Toettcher JE.

Mol Cell. 2017 Sep 7;67(5):757-769.e5. doi: 10.1016/j.molcel.2017.07.016. Epub 2017 Aug 17.


Optogenetic Control of Ras/Erk Signaling Using the Phy-PIF System.

Goglia AG, Wilson MZ, DiGiorno DB, Toettcher JE.

Methods Mol Biol. 2017;1636:3-20. doi: 10.1007/978-1-4939-7154-1_1.


The Spatiotemporal Limits of Developmental Erk Signaling.

Johnson HE, Goyal Y, Pannucci NL, Schüpbach T, Shvartsman SY, Toettcher JE.

Dev Cell. 2017 Jan 23;40(2):185-192. doi: 10.1016/j.devcel.2016.12.002.


Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets.

Shin Y, Berry J, Pannucci N, Haataja MP, Toettcher JE, Brangwynne CP.

Cell. 2017 Jan 12;168(1-2):159-171.e14. doi: 10.1016/j.cell.2016.11.054. Epub 2016 Dec 29.


Engineering dynamical control of cell fate switching using synthetic phospho-regulons.

Gordley RM, Williams RE, Bashor CJ, Toettcher JE, Yan S, Lim WA.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13528-13533. Epub 2016 Nov 7.


The Duty of an Intracellular Signal: Illuminating Calcium's Role in Transcriptional Control.

Johnson HE, Toettcher JE.

Cell Syst. 2016 Apr 27;2(4):223-4. doi: 10.1016/j.cels.2016.04.007. Epub 2016 Apr 27.


Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration.

Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD.

PLoS Biol. 2016 Feb 18;14(2):e1002381. doi: 10.1371/journal.pbio.1002381. eCollection 2016 Feb.


Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module.

Toettcher JE, Weiner OD, Lim WA.

Cell. 2013 Dec 5;155(6):1422-34. doi: 10.1016/j.cell.2013.11.004.


Light-based feedback for controlling intracellular signaling dynamics.

Toettcher JE, Gong D, Lim WA, Weiner OD.

Nat Methods. 2011 Sep 11;8(10):837-9. doi: 10.1038/nmeth.1700.


Light control of plasma membrane recruitment using the Phy-PIF system.

Toettcher JE, Gong D, Lim WA, Weiner OD.

Methods Enzymol. 2011;497:409-23. doi: 10.1016/B978-0-12-385075-1.00017-2.


The promise of optogenetics in cell biology: interrogating molecular circuits in space and time.

Toettcher JE, Voigt CA, Weiner OD, Lim WA.

Nat Methods. 2011 Jan;8(1):35-8. doi: 10.1038/nmeth.f.326. Epub 2010 Dec 20. No abstract available.


A synthetic-natural hybrid oscillator in human cells.

Toettcher JE, Mock C, Batchelor E, Loewer A, Lahav G.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):17047-52. doi: 10.1073/pnas.1005615107. Epub 2010 Sep 13.


Distinct mechanisms act in concert to mediate cell cycle arrest.

Toettcher JE, Loewer A, Ostheimer GJ, Yaffe MB, Tidor B, Lahav G.

Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):785-90. doi: 10.1073/pnas.0806196106. Epub 2009 Jan 12.


Stimulus design for model selection and validation in cell signaling.

Apgar JF, Toettcher JE, Endy D, White FM, Tidor B.

PLoS Comput Biol. 2008 Feb;4(2):e30. doi: 10.1371/journal.pcbi.0040030.


Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity.

Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV.

Cell. 2005 Jul 29;122(2):169-82.

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