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Items: 1 to 50 of 378

1.

In rheumatoid arthritis, changes in autoantibody levels reflect intensity of immunosuppression, not subsequent treatment response.

de Moel EC, Derksen VFAM, Trouw LA, Bang H, Collée G, Lard LR, Ramiro S, Huizinga TWJ, Allaart CF, Toes REM, van der Woude D.

Arthritis Res Ther. 2019 Jan 18;21(1):28. doi: 10.1186/s13075-019-1815-0.

2.

Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis.

Koppejan H, Jansen DTSL, Hameetman M, Thomas R, Toes REM, van Gaalen FA.

Arthritis Res Ther. 2019 Jan 5;21(1):3. doi: 10.1186/s13075-018-1799-1.

3.

Autoantibody Development under Treatment with Immune-Checkpoint Inhibitors.

de Moel EC, Rozeman EA, Kapiteijn EH, Verdegaal EME, Grummels A, Bakker JA, Huizinga TWJ, Haanen JB, Toes REM, van der Woude D.

Cancer Immunol Res. 2019 Jan;7(1):6-11. doi: 10.1158/2326-6066.CIR-18-0245. Epub 2018 Nov 13.

PMID:
30425107
4.

Effects of anticoagulants and storage conditions on clinical oxylipid levels in human plasma.

Jonasdottir HS, Brouwers H, Toes REM, Ioan-Facsinay A, Giera M.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Dec;1863(12):1511-1522. doi: 10.1016/j.bbalip.2018.10.003. Epub 2018 Oct 9.

5.

Sequential Prodrug Strategy To Target and Eliminate ACPA-Selective Autoreactive B Cells.

Lelieveldt LPWM, Kristyanto H, Pruijn GJM, Scherer HU, Toes REM, Bonger KM.

Mol Pharm. 2018 Oct 26. doi: 10.1021/acs.molpharmaceut.8b00741. [Epub ahead of print]

6.

Generation and Characterization of Anti-Citrullinated Protein Antibody-Producing B Cell Clones From Rheumatoid Arthritis Patients.

Germar K, Fehres CM, Scherer HU, van Uden N, Pollastro S, Yeremenko N, Hansson M, Kerkman PF, van der Voort EIH, Reed E, Maassen H, Kwakkenbos MJ, Bakker AQ, Klareskog L, Malmström V, de Vries N, Toes REM, Lundberg K, Spits H, Baeten DL.

Arthritis Rheumatol. 2018 Oct 1. doi: 10.1002/art.40739. [Epub ahead of print]

PMID:
30277007
7.

Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.

Ge C, Xu B, Liang B, Lönnblom E, Lundström SL, Zubarev RA, Ayoglu B, Nilsson P, Skogh T, Kastbom A, Malmström V, Klareskog L, Toes REM, Rispens T, Dobritzsch D, Holmdahl R.

Arthritis Rheumatol. 2019 Feb;71(2):210-221. doi: 10.1002/art.40698. Epub 2019 Jan 4.

PMID:
30152126
8.

Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production.

Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM, Ramming A, Rauber S, Schett G, Jones GW, Jones SA, Rossi FW, de Paulis A, Marone G, El Shikh MEM, Humby F, Pitzalis C.

Ann Rheum Dis. 2018 Dec;77(12):1773-1781. doi: 10.1136/annrheumdis-2018-213418. Epub 2018 Aug 20.

PMID:
30127058
9.

Secretory form of rheumatoid arthritis-associated autoantibodies in serum are mainly of the IgM isotype, suggesting a continuous reactivation of autoantibody responses at mucosal surfaces.

van Delft MAM, van der Woude D, Toes REM, Trouw LA.

Ann Rheum Dis. 2019 Jan;78(1):146-148. doi: 10.1136/annrheumdis-2018-213724. Epub 2018 Aug 14. No abstract available.

PMID:
30108046
10.

In RA, becoming seronegative over the first year of treatment does not translate to better chances of drug-free remission.

de Moel EC, Derksen VFAM, Trouw LA, Bang H, Goekoop-Ruiterman YPM, Steup-Beekman GM, Huizinga TWJ, Allaart CF, Toes REM, van der Woude D.

Ann Rheum Dis. 2018 Dec;77(12):1836-1838. doi: 10.1136/annrheumdis-2018-213823. Epub 2018 Jul 25. No abstract available.

PMID:
30045852
11.

The anti-carbamylated protein antibody response is of overall low avidity despite extensive isotype switching.

van Delft MAM, Verheul MK, Burgers LE, Rantapää-Dahlqvist S, van der Helm-van Mil AHM, Huizinga TWJ, Toes REM, Trouw LA.

Rheumatology (Oxford). 2018 Sep 1;57(9):1583-1591. doi: 10.1093/rheumatology/key135.

PMID:
29846726
12.

Triple Positivity for Anti-Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti-Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis: Implications for Very Early Identification of At-Risk Individuals.

Verheul MK, Böhringer S, van Delft MAM, Jones JD, Rigby WFC, Gan RW, Holers VM, Edison JD, Deane KD, Janssen KMJ, Westra J, Brink M, Rantapää-Dahlqvist S, Huizinga TWJ, van der Helm-van Mil AHM, van der Woude D, Toes REM, Trouw LA.

Arthritis Rheumatol. 2018 Nov;70(11):1721-1731. doi: 10.1002/art.40562. Epub 2018 Sep 16.

PMID:
29781231
13.

Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG.

Knopf J, Magorivska I, Maler JM, Spitzer P, Bilyy R, Biermann MHC, Hychka K, Bondt A, Wuhrer M, Toes REM, Schett G, Herrmann M, Muñoz LE.

J Neuroimmunol. 2018 Jul 15;320:19-24. doi: 10.1016/j.jneuroim.2018.04.010. Epub 2018 Apr 16.

PMID:
29759137
14.

Inflammation functions as a key mediator in the link between ACPA and erosion development: an association study in Clinically Suspect Arthralgia.

Ten Brinck RM, Toes REM, van der Helm-van Mil AHM.

Arthritis Res Ther. 2018 May 3;20(1):89. doi: 10.1186/s13075-018-1574-3.

15.

Conversion to seronegative status after abatacept treatment in patients with early and poor prognostic rheumatoid arthritis is associated with better radiographic outcomes and sustained remission: post hoc analysis of the AGREE study.

Jansen DTSL, Emery P, Smolen JS, Westhovens R, Le Bars M, Connolly SE, Ye J, Toes REM, Huizinga TWJ.

RMD Open. 2018 Mar 30;4(1):e000564. doi: 10.1136/rmdopen-2017-000564. eCollection 2018.

16.

The NET-effect of combining rituximab with belimumab in severe systemic lupus erythematosus.

Kraaij T, Kamerling SWA, de Rooij ENM, van Daele PLA, Bredewold OW, Bakker JA, Bajema IM, Scherer HU, Toes REM, Huizinga TJW, Rabelink TJ, van Kooten C, Teng YKO.

J Autoimmun. 2018 Jul;91:45-54. doi: 10.1016/j.jaut.2018.03.003. Epub 2018 Apr 7.

PMID:
29636274
17.

Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA.

Kraaij T, Kamerling SWA, van Dam LS, Bakker JA, Bajema IM, Page T, Brunini F, Pusey CD, Toes REM, Scherer HU, Rabelink TJ, van Kooten C, Teng YKO.

Kidney Int. 2018 Jul;94(1):139-149. doi: 10.1016/j.kint.2018.01.013. Epub 2018 Mar 30.

PMID:
29606398
18.

Comment on "Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis".

Volkov M, Dekkers J, Loos BG, Bizzarro S, Huizinga TWJ, Praetorius HA, Toes REM, van der Woude D.

Sci Transl Med. 2018 Mar 21;10(433). pii: eaan8349. doi: 10.1126/scitranslmed.aan8349.

PMID:
29563322
19.

Baseline autoantibody profile in rheumatoid arthritis is associated with early treatment response but not long-term outcomes.

de Moel EC, Derksen VFAM, Stoeken G, Trouw LA, Bang H, Goekoop RJ, Speyer I, Huizinga TWJ, Allaart CF, Toes REM, van der Woude D.

Arthritis Res Ther. 2018 Feb 26;20(1):33. doi: 10.1186/s13075-018-1520-4.

20.

Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation.

Falkenburg WJJ, Kempers AC, Dekkers G, Ooijevaar-de Heer P, Bentlage AEH, Vidarsson G, van Schaardenburg D, Toes REM, Scherer HU, Rispens T.

Rheumatology (Oxford). 2018 Apr 1;57(4):771. doi: 10.1093/rheumatology/key056. No abstract available.

PMID:
29481646
21.

Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region.

van de Bovenkamp FS, Derksen NIL, Ooijevaar-de Heer P, van Schie KA, Kruithof S, Berkowska MA, van der Schoot CE, IJspeert H, van der Burg M, Gils A, Hafkenscheid L, Toes REM, Rombouts Y, Plomp R, Wuhrer M, van Ham SM, Vidarsson G, Rispens T.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1901-1906. doi: 10.1073/pnas.1711720115. Epub 2018 Feb 5.

22.

The B cell response to citrullinated antigens in the development of rheumatoid arthritis.

Scherer HU, Huizinga TWJ, Krönke G, Schett G, Toes REM.

Nat Rev Rheumatol. 2018 Mar;14(3):157-169. doi: 10.1038/nrrheum.2018.10. Epub 2018 Feb 8. Review.

PMID:
29416134
23.

Fc gamma receptor binding profile of anti-citrullinated protein antibodies in immune complexes suggests a role for FcγRI in the pathogenesis of synovial inflammation.

Kempers AC, Nejadnik MR, Rombouts Y, Ioan-Facsinay A, van Oosterhout M, Jiskoot W, Huizinga TWJ, Toes REM, Scherer HU.

Clin Exp Rheumatol. 2018 Mar-Apr;36(2):284-293. Epub 2018 Jan 15.

24.

Functional and phenotypical analysis of IL-6-secreting CD4+ T cells in human adipose tissue.

de Jong AJ, Pollastro S, Kwekkeboom JC, Andersen SN, Dorjée AL, Bakker AM, Alzaid F, Soprani A, Nelissen RGHH, Mullers JB, Venteclef N, de Vries N, Kloppenburg M, Toes REM, Ioan-Facsinay A.

Eur J Immunol. 2018 Mar;48(3):471-481. doi: 10.1002/eji.201747037. Epub 2018 Jan 29.

25.

Pitfalls in the detection of citrullination and carbamylation.

Verheul MK, van Veelen PA, van Delft MAM, de Ru A, Janssen GMC, Rispens T, Toes REM, Trouw LA.

Autoimmun Rev. 2018 Feb;17(2):136-141. doi: 10.1016/j.autrev.2017.11.017. Epub 2017 Dec 2. Review.

26.

Antisense Long Non-Coding RNAs Are Deregulated in Skin Tissue of Patients with Systemic Sclerosis.

Messemaker TC, Chadli L, Cai G, Goelela VS, Boonstra M, Dorjée AL, Andersen SN, Mikkers HMM, van 't Hof P, Mei H, Distler O, Draisma HHM, Johnson ME, Orzechowski NM, Simms RW, Toes REM, Aarbiou J, Huizinga TW, Whitfield ML, DeGroot J, de Vries-Bouwstra J, Kurreeman F.

J Invest Dermatol. 2018 Apr;138(4):826-835. doi: 10.1016/j.jid.2017.09.053. Epub 2017 Nov 24.

27.

Response to: 'Acquiring new N-glycosylation sites in variable regions of immunoglobulin genes by somatic hypermutation is a common feature of autoimmune diseases' by Visser et al.

Vergroesen RD, Slot LM, Hafkenscheid L, Koning MT, Scherer HU, Toes REM.

Ann Rheum Dis. 2018 Oct;77(10):e70. doi: 10.1136/annrheumdis-2017-212583. Epub 2017 Nov 23. No abstract available.

PMID:
29170200
28.

Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis.

Verheul MK, Vierboom MPM, 't Hart BA, Toes REM, Trouw LA.

Arthritis Res Ther. 2017 Nov 2;19(1):246. doi: 10.1186/s13075-017-1455-1.

29.

Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation.

Falkenburg WJJ, Kempers AC, Dekkers G, Ooijevaar-de Heer P, Bentlage AEH, Vidarsson G, van Schaardenburg D, Toes REM, Scherer HU, Rispens T.

Rheumatology (Oxford). 2017 Nov 1;56(11):2025-2030. doi: 10.1093/rheumatology/kex284. Erratum in: Rheumatology (Oxford). 2018 Apr 1;57(4):771.

PMID:
28977504
30.

The risk of individual autoantibodies, autoantibody combinations and levels for arthritis development in clinically suspect arthralgia.

Ten Brinck RM, van Steenbergen HW, van Delft MAM, Verheul MK, Toes REM, Trouw LA, van der Helm-van Mil AHM.

Rheumatology (Oxford). 2017 Dec 1;56(12):2145-2153. doi: 10.1093/rheumatology/kex340.

PMID:
28968865
31.

Variable domain glycosylation of ACPA-IgG: A missing link in the maturation of the ACPA response?

Kempers AC, Hafkenscheid L, Scherer HU, Toes REM.

Clin Immunol. 2018 Jan;186:34-37. doi: 10.1016/j.clim.2017.09.001. Epub 2017 Sep 5. Review.

32.

B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of N-glycosylation sites during somatic hypermutation.

Vergroesen RD, Slot LM, Hafkenscheid L, Koning MT, van der Voort EIH, Grooff CA, Zervakis G, Veelken H, Huizinga TWJ, Rispens T, Scherer HU, Toes REM.

Ann Rheum Dis. 2018 Jun;77(6):956-958. doi: 10.1136/annrheumdis-2017-212052. Epub 2017 Aug 23. No abstract available.

PMID:
28835463
33.

The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients.

van Delft MAM, Verheul MK, Burgers LE, Derksen VFAM, van der Helm-van Mil AHM, van der Woude D, Huizinga TWJ, Toes REM, Trouw LA.

Arthritis Res Ther. 2017 Aug 15;19(1):190. doi: 10.1186/s13075-017-1392-z.

34.

Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.

Scally SW, Law SC, Ting YT, Heemst JV, Sokolove J, Deutsch AJ, Bridie Clemens E, Moustakas AK, Papadopoulos GK, van der Woude D, Smolik I, Hitchon CA, Robinson DB, Ferucci ED, Bernstein CN, Meng X, Anaparti V, Huizinga T, Kedzierska K, Reid HH, Raychaudhuri S, Toes RE, Rossjohn J, El-Gabalawy H, Thomas R.

Ann Rheum Dis. 2017 Nov;76(11):1915-1923. doi: 10.1136/annrheumdis-2017-211300. Epub 2017 Aug 11.

PMID:
28801345
35.

Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP).

de Jong AJ, Klein-Wieringa IR, Andersen SN, Kwekkeboom JC, Herb-van Toorn L, de Lange-Brokaar BJE, van Delft D, Garcia J, Wei W, van der Heide HJL, Bastiaansen-Jenniskens YM, van Osch GJVM, Zuurmond AM, Stojanovic-Susulic V, Nelissen RGHH, Toes REM, Kloppenburg M, Ioan-Facsinay A.

Arthritis Res Ther. 2017 Aug 11;19(1):186. doi: 10.1186/s13075-017-1395-9.

36.

Inflammatory genes TNFα and IL6 display no signs of increased H3K4me3 in circulating monocytes from untreated rheumatoid arthritis patients.

Messemaker TC, Mikkers HMM, Huizinga TW, Toes REM, van der Helm-van Mil AHM, Kurreeman F.

Genes Immun. 2017 Sep;18(3):191-196. doi: 10.1038/gene.2017.20. Epub 2017 Aug 10.

PMID:
28794503
37.

Inflammatory features of infrapatellar fat pad in rheumatoid arthritis versus osteoarthritis reveal mostly qualitative differences.

de Jong AJ, Klein-Wieringa IR, Kwekkeboom JC, Toes REM, Kloppenburg M, Ioan-Facsinay A.

Ann Rheum Dis. 2018 Jul;77(7):1088-1090. doi: 10.1136/annrheumdis-2017-211673. Epub 2017 Aug 5. No abstract available.

PMID:
28780513
38.

HLA class II and rheumatoid arthritis: the bumpy road of revelation.

Kampstra ASB, Toes REM.

Immunogenetics. 2017 Aug;69(8-9):597-603. doi: 10.1007/s00251-017-0987-5. Epub 2017 Jul 11. Review.

39.

The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical.

Boeters DM, Mangnus L, Ajeganova S, Lindqvist E, Svensson B, Toes REM, Trouw LA, Huizinga TWJ, Berenbaum F, Morel J, Rantapää-Dahlqvist S, van der Helm-van Mil AHM.

Arthritis Res Ther. 2017 May 31;19(1):115. doi: 10.1186/s13075-017-1324-y.

40.

Long-term mortality in patients with ST-segment elevation myocardial infarction is associated with anti-citrullinated protein antibodies.

Hermans MPJ, van der Velden D, Montero Cabezas JM, Putter H, Huizinga TWJ, Kuiper J, Toes REM, Schalij MJ, Wouter Jukema J, van der Woude D.

Int J Cardiol. 2017 Aug 1;240:20-24. doi: 10.1016/j.ijcard.2017.04.046. Epub 2017 Apr 25.

PMID:
28487154
41.

Breach of autoreactive B cell tolerance by post-translationally modified proteins.

Dekkers JS, Verheul MK, Stoop JN, Liu B, Ioan-Facsinay A, van Veelen PA, de Ru AH, Janssen GMC, Hegen M, Rapecki S, Huizinga TWJ, Trouw LA, Toes REM.

Ann Rheum Dis. 2017 Aug;76(8):1449-1457. doi: 10.1136/annrheumdis-2016-210772. Epub 2017 Apr 25.

PMID:
28442530
42.

Identification of carbamylated alpha 1 anti-trypsin (A1AT) as an antigenic target of anti-CarP antibodies in patients with rheumatoid arthritis.

Verheul MK, Yee A, Seaman A, Janssen GM, van Veelen PA, Drijfhout JW, Toes REM, Mahler M, Trouw LA.

J Autoimmun. 2017 Jun;80:77-84. doi: 10.1016/j.jaut.2017.02.008. Epub 2017 Mar 11.

PMID:
28291659
43.

Rheumatoid arthritis phenotype at presentation differs depending on the number of autoantibodies present.

Derksen VF, Ajeganova S, Trouw LA, van der Helm-van Mil AH, Hafström I, Huizinga TW, Toes RE, Svensson B, van der Woude D.

Ann Rheum Dis. 2017 Apr;76(4):716-720. doi: 10.1136/annrheumdis-2016-209794. Epub 2016 Nov 9.

PMID:
28283528
44.

Beyond citrullination: other post-translational protein modifications in rheumatoid arthritis.

Trouw LA, Rispens T, Toes REM.

Nat Rev Rheumatol. 2017 Jun;13(6):331-339. doi: 10.1038/nrrheum.2017.15. Epub 2017 Mar 9. Review.

PMID:
28275265
45.

Identification of Lifelines participants at high risk for development of rheumatoid arthritis.

Arends S, Trouw LA, Toes REM, van Zanten A, Roozendaal C, Limburg PC, Bootsma H, Brouwer E.

Ann Rheum Dis. 2017 Nov;76(11):e43. doi: 10.1136/annrheumdis-2017-211256. Epub 2017 Mar 8. No abstract available.

PMID:
28274913
46.

Targeted lipidomics reveals activation of resolution pathways in knee osteoarthritis in humans.

Jónasdóttir HS, Brouwers H, Kwekkeboom JC, van der Linden HMJ, Huizinga T, Kloppenburg M, Toes REM, Giera M, Ioan-Facsinay A.

Osteoarthritis Cartilage. 2017 Jul;25(7):1150-1160. doi: 10.1016/j.joca.2017.01.018. Epub 2017 Feb 8.

47.

Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands.

van Zanten A, Arends S, Roozendaal C, Limburg PC, Maas F, Trouw LA, Toes REM, Huizinga TWJ, Bootsma H, Brouwer E.

Ann Rheum Dis. 2017 Jul;76(7):1184-1190. doi: 10.1136/annrheumdis-2016-209991. Epub 2017 Jan 2.

48.

The contribution of autoantibodies to post-translationally modified proteins to inflammatory arthritis.

van der Woude D, Toes RE.

Curr Opin Rheumatol. 2017 Mar;29(2):195-200. doi: 10.1097/BOR.0000000000000371. Review.

PMID:
27977623
49.

Structural Analysis of Variable Domain Glycosylation of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Reveals the Presence of Highly Sialylated Glycans.

Hafkenscheid L, Bondt A, Scherer HU, Huizinga TW, Wuhrer M, Toes RE, Rombouts Y.

Mol Cell Proteomics. 2017 Feb;16(2):278-287. doi: 10.1074/mcp.M116.062919. Epub 2016 Dec 12.

50.

Smoking is associated with the concurrent presence of multiple autoantibodies in rheumatoid arthritis rather than with anti-citrullinated protein antibodies per se: a multicenter cohort study.

van Wesemael TJ, Ajeganova S, Humphreys J, Terao C, Muhammad A, Symmons DP, MacGregor AJ, Hafström I, Trouw LA, van der Helm-van Mil AH, Huizinga TW, Mimori T, Toes RE, Matsuda F, Svensson B, Verstappen SM, van der Woude D.

Arthritis Res Ther. 2016 Dec 1;18(1):285.

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