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Role of B-cell receptors for B-cell development and antigen-induced differentiation.

Yam-Puc JC, Zhang L, Zhang Y, Toellner KM.

F1000Res. 2018 Apr 6;7:429. doi: 10.12688/f1000research.13567.1. eCollection 2018. Review.


Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells.

Zhang Y, Tech L, George LA, Acs A, Durrett RE, Hess H, Walker LSK, Tarlinton DM, Fletcher AL, Hauser AE, Toellner KM.

J Exp Med. 2018 Apr 2;215(4):1227-1243. doi: 10.1084/jem.20160832. Epub 2018 Mar 16.


IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates.

Schager AE, Dominguez-Medina CC, Necchi F, Micoli F, Goh YS, Goodall M, Flores-Langarica A, Bobat S, Cook CNL, Arcuri M, Marini A, King LDW, Morris FC, Anderson G, Toellner KM, Henderson IR, López-Macías C, MacLennan CA, Cunningham AF.

MBio. 2018 Mar 6;9(2). pii: e02379-17. doi: 10.1128/mBio.02379-17.


CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin.

Flores-Langarica A, Müller Luda K, Persson EK, Cook CN, Bobat S, Marshall JL, Dahlgren MW, Hägerbrand K, Toellner KM, Goodall MD, Withers DR, Henderson IR, Johansson Lindbom B, Cunningham AF, Agace WW.

Mucosal Immunol. 2018 May;11(3):681-692. doi: 10.1038/mi.2017.105. Epub 2017 Dec 20.


IgG1 Is Required for Optimal Protection after Immunization with the Purified Porin OmpD from Salmonella Typhimurium.

Zhang Y, Dominguez-Medina C, Cumley NJ, Heath JN, Essex SJ, Bobat S, Schager A, Goodall M, Kracker S, Buckley CD, May RC, Kingsley RA, MacLennan CA, López-Macías C, Cunningham AF, Toellner KM.

J Immunol. 2017 Dec 15;199(12):4103-4109. doi: 10.4049/jimmunol.1700952. Epub 2017 Nov 10.


TFR cells trump autoimmune antibody responses to limit sedition.

Linterman MA, Toellner KM.

Nat Immunol. 2017 Oct 18;18(11):1185-1186. doi: 10.1038/ni.3856. No abstract available.


What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? A Role for Antibody Feedback.

Toellner KM, Sze DM, Zhang Y.

Cold Spring Harb Perspect Biol. 2018 May 1;10(5). pii: a028795. doi: 10.1101/cshperspect.a028795. Review.


Detecting Gene Expression in Lymphoid Microenvironments by Laser Microdissection and Quantitative RT-PCR.

Zhang Y, Garcia-Ibanez L, Brown G, Toellner KM.

Methods Mol Biol. 2017;1623:21-36. doi: 10.1007/978-1-4939-7095-7_2.


Selective Expression of Flt3 within the Mouse Hematopoietic Stem Cell Compartment.

Mooney CJ, Cunningham A, Tsapogas P, Toellner KM, Brown G.

Int J Mol Sci. 2017 May 12;18(5). pii: E1037. doi: 10.3390/ijms18051037.


Corrigendum to 'Morning vaccination enhances antibody response over afternoon vaccination: A cluster-randomised trial' [Vaccine 34 (2016) 2679-2685].

Long JE, Drayson MT, Taylor AE, Toellner KM, Lord JM, Phillips AC.

Vaccine. 2016 Sep 14;34(40):4842. doi: 10.1016/j.vaccine.2016.08.031. Epub 2016 Aug 16. No abstract available.


Antagonizing Retinoic Acid Receptors Increases Myeloid Cell Production by Cultured Human Hematopoietic Stem Cells.

Brown G, Marchwicka A, Cunningham A, Toellner KM, Marcinkowska E.

Arch Immunol Ther Exp (Warsz). 2017 Feb;65(1):69-81. doi: 10.1007/s00005-016-0411-0. Epub 2016 Jul 13.


Morning vaccination enhances antibody response over afternoon vaccination: A cluster-randomised trial.

Long JE, Drayson MT, Taylor AE, Toellner KM, Lord JM, Phillips AC.

Vaccine. 2016 May 23;34(24):2679-85. doi: 10.1016/j.vaccine.2016.04.032. Epub 2016 Apr 26. Erratum in: Vaccine. 2016 Sep 14;34(40):4842.


Regulation of germinal center B-cell differentiation.

Zhang Y, Garcia-Ibanez L, Toellner KM.

Immunol Rev. 2016 Mar;270(1):8-19. doi: 10.1111/imr.12396. Review. Erratum in: Immunol Rev. 2016 Jul;272(1):202.


FOXP1 inhibits plasma cell differentiation.

Toellner KM.

Blood. 2015 Oct 29;126(18):2076-7. doi: 10.1182/blood-2015-09-666529. No abstract available.


IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs.

Barone F, Nayar S, Campos J, Cloake T, Withers DR, Toellner KM, Zhang Y, Fouser L, Fisher B, Bowman S, Rangel-Moreno J, Garcia-Hernandez Mde L, Randall TD, Lucchesi D, Bombardieri M, Pitzalis C, Luther SA, Buckley CD.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11024-9. doi: 10.1073/pnas.1503315112. Epub 2015 Aug 18.


Versatility of stem and progenitor cells and the instructive actions of cytokines on hematopoiesis.

Brown G, Mooney CJ, Alberti-Servera L, Muenchow Lv, Toellner KM, Ceredig R, Rolink A.

Crit Rev Clin Lab Sci. 2015;52(4):168-79. doi: 10.3109/10408363.2015.1021412. Epub 2015 Jul 27. Review.


Inflammation-induced formation of fat-associated lymphoid clusters.

Bénézech C, Luu NT, Walker JA, Kruglov AA, Loo Y, Nakamura K, Zhang Y, Nayar S, Jones LH, Flores-Langarica A, McIntosh A, Marshall J, Barone F, Besra G, Miles K, Allen JE, Gray M, Kollias G, Cunningham AF, Withers DR, Toellner KM, Jones ND, Veldhoen M, Nedospasov SA, McKenzie ANJ, Caamaño JH.

Nat Immunol. 2015 Aug;16(8):819-828. doi: 10.1038/ni.3215. Epub 2015 Jun 29.


Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production.

Flores-Langarica A, Bobat S, Marshall JL, Yam-Puc JC, Cook CN, Serre K, Kingsley RA, Flores-Romo L, Uematsu S, Akira S, Henderson IR, Toellner KM, Cunningham AF.

Eur J Immunol. 2015 Aug;45(8):2299-311. doi: 10.1002/eji.201545564. Epub 2015 Jun 24.


Robo4 vaccines induce antibodies that retard tumor growth.

Zhuang X, Ahmed F, Zhang Y, Ferguson HJ, Steele JC, Steven NM, Nagy Z, Heath VL, Toellner KM, Bicknell R.

Angiogenesis. 2015 Jan;18(1):83-95. doi: 10.1007/s10456-014-9448-z. Epub 2014 Oct 28.


Cognate interactions: extrafollicular IL-4 drives germinal-center reactions, a new role for an old cytokine.

Toellner KM.

Eur J Immunol. 2014 Jul;44(7):1917-20. doi: 10.1002/eji.201444825.


Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.

Caganova M, Carrisi C, Varano G, Mainoldi F, Zanardi F, Germain PL, George L, Alberghini F, Ferrarini L, Talukder AK, Ponzoni M, Testa G, Nojima T, Doglioni C, Kitamura D, Toellner KM, Su IH, Casola S.

J Clin Invest. 2013 Dec;123(12):5009-22. doi: 10.1172/JCI70626. Epub 2013 Nov 8. Erratum in: J Clin Invest. 2014 Apr 1;124(4):1869.


Dose-dependent induction of murine Th1/Th2 responses to sheep red blood cells occurs in two steps: antigen presentation during second encounter is decisive.

Stamm C, Barthelmann J, Kunz N, Toellner KM, Westermann J, Kalies K.

PLoS One. 2013 Jun 28;8(6):e67746. doi: 10.1371/journal.pone.0067746. Print 2013.


Germinal center B cells govern their own fate via antibody feedback.

Zhang Y, Meyer-Hermann M, George LA, Figge MT, Khan M, Goodall M, Young SP, Reynolds A, Falciani F, Waisman A, Notley CA, Ehrenstein MR, Kosco-Vilbois M, Toellner KM.

J Exp Med. 2013 Mar 11;210(3):457-64. doi: 10.1084/jem.20120150. Epub 2013 Feb 18.


The capsular polysaccharide Vi from Salmonella typhi is a B1b antigen.

Marshall JL, Flores-Langarica A, Kingsley RA, Hitchcock JR, Ross EA, López-Macías C, Lakey J, Martin LB, Toellner KM, MacLennan CA, MacLennan IC, Henderson IR, Dougan G, Cunningham AF.

J Immunol. 2012 Dec 15;189(12):5527-32. doi: 10.4049/jimmunol.1103166. Epub 2012 Nov 16.


CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines.

Serre K, Cunningham AF, Coughlan RE, Lino AC, Rot A, Hub E, Moser K, Manz R, Ferraro A, Bird R, Toellner KM, Demengeot J, MacLennan IC, Mohr E.

Blood. 2012 Nov 29;120(23):4552-9. doi: 10.1182/blood-2012-03-417733. Epub 2012 Oct 11.


A theory of germinal center B cell selection, division, and exit.

Meyer-Hermann M, Mohr E, Pelletier N, Zhang Y, Victora GD, Toellner KM.

Cell Rep. 2012 Jul 26;2(1):162-74. doi: 10.1016/j.celrep.2012.05.010. Epub 2012 Jun 28.


Early B blasts acquire a capacity for Ig class switch recombination that is lost as they become plasmablasts.

Marshall JL, Zhang Y, Pallan L, Hsu MC, Khan M, Cunningham AF, MacLennan IC, Toellner KM.

Eur J Immunol. 2011 Dec;41(12):3506-12. doi: 10.1002/eji.201141762. Epub 2011 Nov 10.


Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis.

Yeo L, Toellner KM, Salmon M, Filer A, Buckley CD, Raza K, Scheel-Toellner D.

Ann Rheum Dis. 2011 Nov;70(11):2022-8. doi: 10.1136/ard.2011.153312. Epub 2011 Jul 8.


Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.

Serre K, Bénézech C, Desanti G, Bobat S, Toellner KM, Bird R, Chan S, Kastner P, Cunningham AF, Maclennan IC, Mohr E.

PLoS One. 2011;6(6):e20731. doi: 10.1371/journal.pone.0020731. Epub 2011 Jun 3.


Noxa mediates p18INK4c cell-cycle control of homeostasis in B cells and plasma cell precursors.

Bretz J, Garcia J, Huang X, Kang L, Zhang Y, Toellner KM, Chen-Kiang S.

Blood. 2011 Feb 17;117(7):2179-88. doi: 10.1182/blood-2010-06-288027. Epub 2010 Dec 16.


Trypanosoma cruzi infection induces a massive extrafollicular and follicular splenic B-cell response which is a high source of non-parasite-specific antibodies.

Bermejo DA, Amezcua Vesely MC, Khan M, Acosta Rodríguez EV, Montes CL, Merino MC, Toellner KM, Mohr E, Taylor D, Cunningham AF, Gruppi A.

Immunology. 2011 Jan;132(1):123-33. doi: 10.1111/j.1365-2567.2010.03347.x. Epub 2010 Sep 28.


IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine.

Mohr E, Cunningham AF, Toellner KM, Bobat S, Coughlan RE, Bird RA, MacLennan IC, Serre K.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17292-7. doi: 10.1073/pnas.1004879107. Epub 2010 Sep 20.


B1 cells promote pancreas infiltration by autoreactive T cells.

Ryan GA, Wang CJ, Chamberlain JL, Attridge K, Schmidt EM, Kenefeck R, Clough LE, Dunussi-Joannopoulos K, Toellner KM, Walker LS.

J Immunol. 2010 Sep 1;185(5):2800-7. doi: 10.4049/jimmunol.1000856. Epub 2010 Jul 30.


Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.

Garin A, Meyer-Hermann M, Contie M, Figge MT, Buatois V, Gunzer M, Toellner KM, Elson G, Kosco-Vilbois MH.

Immunity. 2010 Jul 23;33(1):84-95. doi: 10.1016/j.immuni.2010.07.005.


SLC6A4 expression and anti-proliferative responses to serotonin transporter ligands chlomipramine and fluoxetine in primary B-cell malignancies.

Chamba A, Holder MJ, Jarrett RF, Shield L, Toellner KM, Drayson MT, Barnes NM, Gordon J.

Leuk Res. 2010 Aug;34(8):1103-6. doi: 10.1016/j.leukres.2010.03.007. Epub 2010 Apr 2.


IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism.

Zotos D, Coquet JM, Zhang Y, Light A, D'Costa K, Kallies A, Corcoran LM, Godfrey DI, Toellner KM, Smyth MJ, Nutt SL, Tarlinton DM.

J Exp Med. 2010 Feb 15;207(2):365-78. doi: 10.1084/jem.20091777. Epub 2010 Feb 8.


Early simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly responding central-memory-like CD4 T cells.

Serre K, Mohr E, Toellner KM, Cunningham AF, Bird R, Khan M, MacLennan IC.

Eur J Immunol. 2009 Jun;39(6):1573-86. doi: 10.1002/eji.200838922.


Germinal centres seen through the mathematical eye: B-cell models on the catwalk.

Meyer-Hermann M, Figge MT, Toellner KM.

Trends Immunol. 2009 Apr;30(4):157-64. doi: 10.1016/ Epub 2009 Mar 11. Review.


Deriving a germinal center lymphocyte migration model from two-photon data.

Figge MT, Garin A, Gunzer M, Kosco-Vilbois M, Toellner KM, Meyer-Hermann M.

J Exp Med. 2008 Dec 22;205(13):3019-29. doi: 10.1084/jem.20081160. Epub 2008 Dec 1.


Molecular differences between the divergent responses of ovalbumin-specific CD4 T cells to alum-precipitated ovalbumin compared to ovalbumin expressed by Salmonella.

Serre K, Mohr E, Toellner KM, Cunningham AF, Granjeaud S, Bird R, MacLennan IC.

Mol Immunol. 2008 Aug;45(13):3558-66. doi: 10.1016/j.molimm.2008.05.010. Epub 2008 Jun 25.


Ly49H+ NK cells migrate to and protect splenic white pulp stroma from murine cytomegalovirus infection.

Bekiaris V, Timoshenko O, Hou TZ, Toellner K, Shakib S, Gaspal F, McConnell FM, Parnell SM, Withers D, Buckley CD, Sweet C, Yokoyama WM, Anderson G, Lane PJ.

J Immunol. 2008 May 15;180(10):6768-76.


Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues.

Kim MY, Rossi S, Withers D, McConnell F, Toellner KM, Gaspal F, Jenkinson E, Anderson G, Lane PJ.

Immunology. 2008 Jun;124(2):166-74. doi: 10.1111/j.1365-2567.2007.02750.x. Epub 2008 Jan 16.


Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling.

Bauer B, Hartz AM, Pekcec A, Toellner K, Miller DS, Potschka H.

Mol Pharmacol. 2008 May;73(5):1444-53. Epub 2007 Dec 19.


microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.

Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S, Das PP, Miska EA, Rodriguez A, Bradley A, Smith KG, Rada C, Enright AJ, Toellner KM, Maclennan IC, Turner M.

Immunity. 2007 Dec;27(6):847-59. Epub 2007 Dec 6.


Axon growth and guidance genes identify T-dependent germinal centre B cells.

Yu D, Cook MC, Shin DM, Silva DG, Marshall J, Toellner KM, Havran WL, Caroni P, Cooke MP, Morse HC, MacLennan IC, Goodnow CC, Vinuesa CG.

Immunol Cell Biol. 2008 Jan;86(1):3-14. Epub 2007 Oct 16.


Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells.

Luther SA, Serre K, Cunningham AF, Khan M, Acha-Orbea H, MacLennan IC, Toellner KM.

Eur J Immunol. 2007 Jun;37(6):1476-84.


Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infection.

Cunningham AF, Gaspal F, Serre K, Mohr E, Henderson IR, Scott-Tucker A, Kenny SM, Khan M, Toellner KM, Lane PJ, MacLennan IC.

J Immunol. 2007 May 15;178(10):6200-7.


Neonatal and adult CD4+ CD3- cells share similar gene expression profile, and neonatal cells up-regulate OX40 ligand in response to TL1A (TNFSF15).

Kim MY, Toellner KM, White A, McConnell FM, Gaspal FM, Parnell SM, Jenkinson E, Anderson G, Lane PJ.

J Immunol. 2006 Sep 1;177(5):3074-81.


Type I cytokine profiles of human naïve and memory B lymphocytes: a potential for memory cells to impact polarization.

Gagro A, Servis D, Cepika AM, Toellner KM, Grafton G, Taylor DR, Branica S, Gordon J.

Immunology. 2006 May;118(1):66-77.


B cell clones that sustain long-term plasmablast growth in T-independent extrafollicular antibody responses.

Hsu MC, Toellner KM, Vinuesa CG, Maclennan IC.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5905-10. Epub 2006 Apr 3.

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